Journal
JOURNAL OF IMMUNOLOGY
Volume 207, Issue 6, Pages 1672-1682Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.2100023
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NK cells are blocked and ILC1s are enriched in patients with AML. The skewing of ILCP towards ILC1s due to AML-mediated activation of AHR represents a major mechanism of ILC1 generation. Inhibition of AHR may restore normal NK cell development and function in AML.
NK cells are known to be developmentally blocked and functionally inhibited in patients with acute myeloid leukemia (AML), resulting in poor clinical outcomes. In this study, we demonstrate that whereas NK cells are inhibited, closely related type 1 innate lymphoid cells (ILC1s) are enriched in the bone marrow of leukemic mice and in patients with AML. Because NK cells and ILC1s share a common precursor (ILCP), we asked if AML acts on the ILCP to alter developmental potential. A combination of ex vivo and in vivo studies revealed that AML skewing of the ILCP toward ILC1s and away from NK cells represented a major mechanism of ILC1 generation. This process was driven by AML-mediated activation of the aryl hydrocarbon receptor (AHR), a key transcription factor in ILCs, as inhibition of AHR led to decreased numbers of ILC1s and increased NK cells in the presence of AML. These results demonstrate a mechanism of ILC developmental skewing in AML and support further preclinical study of AHR inhibition in restoring normal NK cell development and function in the setting of AML. The Journal of Immunology, 2021, 207: 1672-1682.
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