Endoplasmic reticulum stress manipulates autophagic response that antagonizes polybrominated diphenyl ethers quinone induced cytotoxicity in microglial BV2 cells

Certain ortho-hydroxylated brominated ethers are promiscuous kinase inhibitors that impair neuronal signaling and neurodevelopmental processes

(2020) Robert G. Poston et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IRE1 signaling pathway mediates protective autophagic response against manganese-induced neuronal apoptosis in vivo and in vitro

(2020) Chang Liu et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Exposure pathways, levels and toxicity of polybrominated diphenyl ethers in humans: A review

(2020) Zhineng Wu et al.   ENVIRONMENTAL RESEARCH

Perinatal low-dose PBDE-47 exposure hampered thyroglobulin turnover and induced thyroid cell apoptosis by triggering ER stress and lysosomal destabilization contributing to thyroid toxicity in adult female rats

(2020) Pei Li et al.   JOURNAL OF HAZARDOUS MATERIALS

A novel orally available seleno-purine molecule suppresses triple-negative breast cancer cell proliferation and progression to metastasis by inducing cytostatic autophagy

(2019) Chia-Hao Chang et al.   Autophagy

Endoplasmic reticulum rather than mitochondria plays a major role in the neuronal apoptosis induced by polybrominated diphenyl ether-153

(2019) Xin Li et al.   TOXICOLOGY LETTERS

Polybrominated Diphenyl Ethers Quinone Induces NCOA4-Mediated Ferritinophagy through Selectively Autophagic Degradation of Ferritin

(2019) Wenjing Dong et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Associations of prenatal exposures to low levels of Polybrominated Diphenyl Ether (PBDE) with thyroid hormones in cord plasma and neurobehavioral development in children at 2 and 4 years

(2019) Honglei Ji et al.   ENVIRONMENT INTERNATIONAL

BDE-209 induces autophagy and apoptosis via IRE1α/Akt/mTOR signaling pathway in human umbilical vein endothelial cells

(2019) Yun Hou et al.   ENVIRONMENTAL POLLUTION

Perigestational exposure to low doses of PBDE-47 induces excessive ER stress, defective autophagy and the resultant apoptosis contributing to maternal thyroid toxicity

(2018) Pei Li et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Life, death and autophagy

(2018) Johnna Doherty et al.   NATURE CELL BIOLOGY

Preliminary study of long-range transport of halogenated flame retardants using Antarctic marine mammals

(2018) Òscar Aznar-Alemany et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Polybrominated Diphenyl Ethers Quinone Induced Parthanatos-like Cell Death through a Reactive Oxygen Species-Associated Poly(ADP-ribose) Polymerase 1 Signaling

(2018) Wenjing Dong et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Developmental PBDE Exposure and IQ/ADHD in Childhood: A Systematic Review and Meta-analysis

(2017) Juleen Lam et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Currently used organophosphate and brominated flame retardants in the environment of China and other developing countries (2000–2016)

(2017) Nadeem Ali et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

PBDE-209 exposure damages learning and memory ability in rats potentially through increased autophagy and apoptosis in the hippocampus neuron

(2017) Wen Sun et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Crosstalk of autophagy and apoptosis: Involvement of the dual role of autophagy under ER stress

(2017) Shuling Song et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Japanese encephalitis virus activates autophagy through XBP1 and ATF6 ER stress sensors in neuronal cells

(2017) Manish Sharma et al.   JOURNAL OF GENERAL VIROLOGY

An autophagic process is activated in HepG2 cells to mediate BDE-100-induced toxicity

(2017) Lilian Cristina Pereira et al.   TOXICOLOGY

Quinones Derived from Polychlorinated Biphenyls Induce ROS-Dependent Autophagy by Evoking an Autophagic Flux and Inhibition of mTOR/p70S6k

(2016) Qiong Shi et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Activating Transcription Factor 4 (ATF4)-ATF3-C/EBP Homologous Protein (CHOP) Cascade Shows an Essential Role in the ER Stress-Induced Sensitization of Tetrachlorobenzoquinone-Challenged PC12 Cells to ROS-Mediated Apoptosis via Death Receptor 5 (DR5) Signaling

(2016) Zixuan Liu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Ratiometric analysis of Acridine Orange staining in the study of acidic organelles and autophagy

(2016) Marcos P. Thomé et al.   JOURNAL OF CELL SCIENCE

p62 at the crossroad of the ubiquitin-proteasome system and autophagy

(2016) Victoria Cohen-Kaplan et al.   Oncotarget

Exposure to endocrine disrupting chemicals and neurodevelopmental alterations

(2016) A. Pinson et al.   Andrology

Review on the occurrence and profiles of polybrominated diphenyl ethers in the Philippines

(2015) Susan A. Mackintosh et al.   ENVIRONMENT INTERNATIONAL

Organohalogen Compounds in Pet Dog and Cat: Do Pets Biotransform Natural Brominated Products in Food to Harmful Hydroxlated Substances?

(2015) Hazuki Mizukawa et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

The therapeutic effects of 4-phenylbutyric acid in maintaining proteostasis

(2015) P.S. Kolb et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Bioactive Silica Nanoparticles Promote Osteoblast Differentiation through Stimulation of Autophagy and Direct Association with LC3 and p62

(2014) Shin-Woo Ha et al.   ACS Nano

Cytotoxic effects and oxidative stress response of six PBDE metabolites on human L02 cells

(2013) Yu F. Zhong et al.   JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING

Hidden Behind Autophagy: The Unconventional Roles of ATG Proteins

(2013) Jovanka Bestebroer et al.   TRAFFIC

Changes in physiological responses of an Antarctic fish, the emerald rock cod (Trematomus bernacchii), following exposure to polybrominated diphenyl ethers (PBDEs)

(2012) Ruma Ghosh et al.   AQUATIC TOXICOLOGY

The role of the IRE1 pathway in PBDE-47-induced toxicity in human neuroblastoma SH-SY5Y cells in vitro

(2012) Chunyang Jiang et al.   TOXICOLOGY LETTERS

Microautophagy: lesser-known self-eating

(2011) Wen-wen Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Tuning flux: autophagy as a target of heart disease therapy

(2011) Min Xie et al.   CURRENT OPINION IN CARDIOLOGY

Effects of pre and postnatal exposure to low levels of polybromodiphenyl ethers on neurodevelopment and thyroid hormone levels at 4years of age

(2011) Mireia Gascon et al.   ENVIRONMENT INTERNATIONAL

Neurotoxicity of Brominated Flame Retardants: (In)direct Effects of Parent and Hydroxylated Polybrominated Diphenyl Ethers on the (Developing) Nervous System

(2011) Milou M.L. Dingemans et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Para- and Ortho -Substitutions Are Key Determinants of Polybrominated Diphenyl Ether Activity toward Ryanodine Receptors and Neurotoxicity

(2010) Kyung Ho Kim et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

The involvement of ROS overproduction and mitochondrial dysfunction in PBDE-47-induced apoptosis on Jurkat cells

(2010) Chuan Yan et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

Bromination Pattern of Hydroxylated Metabolites of BDE-47 Affects Their Potency to Release Calcium from Intracellular Stores in PC12 Cells

(2009) Milou M.L. Dingemans et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5

(2009) Kasper M.A. Rouschop et al.   JOURNAL OF CLINICAL INVESTIGATION

ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology

(2009) Antero Salminen et al.   Journal of Neuroinflammation

Hydroxylation Increases the Neurotoxic Potential of BDE-47 to Affect Exocytosis and Calcium Homeostasis in PC12 Cells

(2008) Milou M.L. Dingemans et al.   ENVIRONMENTAL HEALTH PERSPECTIVES