Article
Medicine, Research & Experimental
Wen-Hui Huang, Qing Yang, Chuan Zhang
Summary: This study found that circRNA WW domain containing adaptor with coiled-coil (circWAC) promotes the growth, migration, and invasion, and inhibits apoptosis of breast cancer cells through regulating the miR-599/E2F3 pathway. This finding provides a novel potential target for breast cancer therapy.
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Cell Biology
Yang Liu, Ning Liu, Danfeng Xu, Baohui Wu, Xiaosheng Wu, Xia Sun, Yi Yang, Fengqin Yan
Summary: Hsa-miR-599 expression is downregulated in breast cancer tissues and cells, and is negatively correlated with TNM stage and lymph node metastasis. Enhanced hsa-miR-599 expression in breast cancer cells inhibits cell proliferation, migration, and invasion, and promotes cell apoptosis. Hsa-miR-599 may target BRD4 and inhibit breast cancer progression by targeting the Jagged1/Notch1 pathway.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Pathology
Baogen Zhang, Shu Yang, Junping Wang
Summary: This study investigates the role of circ_0084615 in colorectal cancer (CRC) and reveals that circ_0084615 functions as a tumor-promoting circRNA by acting as a competing endogenous RNA to regulate DNMT3A expression through sponging miR-599. This research provides a potential therapeutic target for CRC patients.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Medicine, Research & Experimental
Xiaojia Huang, Weige Tan, Ziteng Liu, Xiaoyan Fu, Zongyan Li, Shengqing Lai, Qian Li, Xiaofang Zhong, Fanli Qu, Huayao Zhang, Haiyan Li
Summary: This study discovered a novel circular RNA, circZFAND6, which was up-regulated in breast cancer tissues and cell lines. Inhibition of circZFAND6 reduced proliferation and metastasis of breast cancer. Mechanistically, circZFAND6 acted as a competing endogenous RNA (ceRNA) to sponge miR-647 and increase fatty acid synthase (FASN) expression. Additionally, EIF4A3 was found to bind to the upstream region of circZFAND6 pre-mRNA transcript, leading to the high expression of circZFAND6 in breast cancer. Inhibition of EIF4A3 also suppressed proliferation and metastasis of breast cancer.
Article
Biochemistry & Molecular Biology
Fan Zhang, Hong Wu
Summary: MiR-599 is significantly downregulated in bladder cancer and its overexpression can inhibit the malignancy of BC cells, with TOP2A identified as a downstream target contributing to enhanced tumorigenesis in BC cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Cell Biology
Yan Zeng, Wei Du, Zhongying Huang, Song Wu, Xueqi Ou, Jinhui Zhang, Cheng Peng, Xiaoqing Sun, Hailin Tang
Summary: Breast cancer is the most common cancer worldwide and is the leading cause of female mortality. Recent studies have shown that circRNAs are associated with the progression of breast cancer. Exploring circRNAs could lead to the development of targeted therapies for breast cancer liver metastasis and improving patient outcomes.
CELL DEATH DISCOVERY
(2023)
Article
Cell Biology
Chenxi Ju, Mingxia Zhou, Dan Du, Chang Wang, Jieqiong Yao, Hongle Li, Yang Luo, Fucheng He, Jing He
Summary: This study found that circ_0042881 is highly expressed in breast cancer and is closely associated with clinical features. The study revealed that circ_0042881 promotes breast cancer progression by sponging miR-217, which activates the RAS protein and initiates downstream signaling pathways.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Tianyi Ma, Tianyu Qiao, Rui Huang, Meng Wang, Hanqing Hu, Ziming Yuan, Yihao Zhu, Hongyu Wu, Xiaoming Zou
Summary: LncRNA-XLOC_006390 plays an oncogenic role in colorectal cancer by regulating the miR-296/ONECUT2 axis. Its overexpression is associated with poor patient survival.
JOURNAL OF ONCOLOGY
(2022)
Article
Oncology
Tianyi Ma, Tianyu Qiao, Rui Huang, Meng Wang, Hanqing Hu, Ziming Yuan, Yihao Zhu, Hongyu Wu, Xiaoming Zou
Summary: LncRNA-XLOC_006390 is overexpressed in colorectal cancer and its high expression is associated with poor patient survival. By modulating the miR-296/ONECUT2 axis, lncRNA-XLOC_006390 promotes colorectal cancer proliferation and metastasis.
JOURNAL OF ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiangqi Zhou, Guangjin Yuan, Yangjie Wu, Sijia Yan, Qingshan Jiang, Sanyuan Tang
Summary: This study found that EIF4A3-induced circFIP1L1 inhibits NPC cell proliferation, promotes NPC cell apoptosis, and enhances NPC radiosensitivity through miR-1253.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Gui Hu, Changwei Lin, Kai Gao, Miao Chen, Fei Long, Buning Tian
Summary: CRC cell-derived exosomal circCOL1A1 promotes angiogenesis by recruiting EIF4A3 and activating Smad2/3 signaling.
MOLECULAR MEDICINE
(2023)
Article
Oncology
Zhan Qu, Ke-Da Yang, Bai-Hua Luo, Fan Zhang
Summary: CAF-derived exosomal cricN4BP2L2 promoted CRC cell stemness and oxaliplatin resistance through the EIF4A3/PI3K/AKT/mTOR pathway.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Oncology
Zhan Qu, Ke-Da Yang, Bai-Hua Luo, Fan Zhang
Summary: In this study, it was found that cancer-associated fibroblasts secreted exosomes (CAFs-exo) play an important role in colorectal cancer (CRC). CAFs-exo promoted CRC cell stemness and oxaliplatin resistance through the EIF4A3/PI3K/AKT/mTOR pathway.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Qun Liu, Huiting Dong
Summary: This study demonstrated that hsa_circ_0088088 is upregulated in breast malignancy, with higher expression associated with unfavorable prognosis. hsa_circ_0088088 promotes cell growth and metastasis in MDA-MB-231 cells by regulating miR-135-5p and EIF4A3. This suggests that EIF4A3-induced hsa_circ_0088088 stimulates the carcinogenic effects of breast tumors by sponging miR-135-5p.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Oncology
Xianguo Meng, Wei Li, Ziqi Meng, Yan Li
Summary: This study reveals the important role of a newly discovered circRNA, circBRWD3, in the tumorigenesis and progression of breast cancer. CircBRWD3 expression is upregulated in breast cancer tissues and is associated with poor prognosis. Mechanistically, circBRWD3 regulates the miR-142-3p, miR-142-5p, and RAC1/PAK1 signaling pathway to promote tumor formation and progression. Additionally, circBRWD3 expression is positively regulated by EIF4A3. These findings provide valuable scientific data for the early diagnosis and therapy of breast cancer patients.