Article
Dentistry, Oral Surgery & Medicine
Ali Vafaei, Mahsa Nikookhesal, Leila Erfanparast, Henrik Lovschall, Bahram Ranjkesh
Summary: The study demonstrated that vital pulp therapy using fast-setting calcium silicate cement had a significantly higher success rate compared to slow-setting MTA, with treatment under general anesthesia and restoration with stainless steel crowns influencing the outcome.
JOURNAL OF DENTISTRY
(2022)
Article
Chemistry, Physical
Maria Teresa Xavier, Ana Luisa Costa, Francisco Jose Caramelo, Paulo Jorge Palma, Joao Carlos Ramos
Summary: This study revealed that the clinical variables of adhesive system, application of an additional HBL, and restoration time significantly affected the bond performance and ultra-morphological interface between composite adhesive restoration and CSC, as demonstrated by SBS tests and SEM analysis.
Review
Biochemistry & Molecular Biology
Mihai Andrei, Raluca Paula Vacaru, Anca Coricovac, Radu Ilinca, Andreea Cristiana Didilescu, Ioana Demetrescu
Summary: The vitality of dental pulp is essential for maintaining the health and functionality of the tooth. Hydraulic calcium-silicate cements can stimulate reparative dentinogenesis in direct pulp capping procedures, leading to the formation of new dentin bridges. Different degrees of pulp inflammatory response and dentin bridge formation were observed during pulp healing, showing positive effects on tertiary dentin formation and pulp vitality preservation.
Article
Dentistry, Oral Surgery & Medicine
Byurira Kim, Yong-Hyuk Lee, Ik-Hwan Kim, Ko Eun Lee, Chung-Min Kang, Hyo-Seol Lee, Hyung-Jun Choi, Kyounga Cheon, Je Seon Song, Yooseok Shin
Summary: The biocompatibilities and mineralization potential of new calcium silicate cements (CSCs) were evaluated in this study. NeoMTA Plus and ERRM-FS demonstrated similar biocompatibilities and mineralization potential compared to ProRoot MTA, making them desirable alternatives to ProRoot MTA.
JOURNAL OF DENTAL SCIENCES
(2023)
Review
Dentistry, Oral Surgery & Medicine
K. Kodonas, A. Fardi, C. Gogos, N. Economides
Summary: This scientometric analysis presents the research trends and popular topics in the field of vital pulp therapy, identifying the leading countries, journals, and study designs. The majority of publications are basic science articles published in high impact factor dental journals. The most frequently occurring keywords include pulpotomy, mineral trioxide aggregate, calcium hydroxide, and direct pulp capping.
INTERNATIONAL ENDODONTIC JOURNAL
(2021)
Review
Dentistry, Oral Surgery & Medicine
Henry F. Duncan
Summary: Therapeutic strategies focused on pulp preservation are important in managing deep caries and exposed pulp in vital teeth. While vital pulp treatments (VPTs) have been used for over a century, recent advancements in regenerative endodontics and biologically based therapies have expanded the indications for VPT to include mature cariously affected teeth and teeth with irreversible pulpitis. However, gaps in scientific knowledge and limited educational dissemination among dentists pose challenges in accurately diagnosing the inflammatory state of the pulp and providing consistent treatment options. This review discusses the current status of VPT, identifies the major problems hindering its clinical acceptance, and offers potential solutions for making VPT a more consistently prescribed evidenced-based treatment in dental practice.
INTERNATIONAL ENDODONTIC JOURNAL
(2022)
Article
Materials Science, Ceramics
Carolyn Primus, James L. Gutmann, Franklin R. Tay, Anna B. Fuks
Summary: Calcium silicate cements and calcium aluminate cements are considered excellent materials in dentistry, promoting biomineralization and aiding in the repair of teeth.
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2022)
Review
Pediatrics
Andreea Igna
Summary: Pulpotomy has long been the most common treatment for extensively decayed primary molars, and its success relies heavily on factors such as treatment technique, diagnosis accuracy, caries removal method, pulp dressing material, and operator experience. This paper provides an overview of the history of pulpotomy in primary teeth, including advances in technique, medication, and restoration methods, as well as the challenges and controversies surrounding the subject.
Article
Dentistry, Oral Surgery & Medicine
Nessrin A. Taha, Hanan Al-khatib
Summary: This study aimed to evaluate the pulpal and restorative outcome of full pulpotomy in symptomatic mature permanent teeth over 4 years, and the results showed a high success rate of pulpotomy over the long term, with coronal seal being crucial for long-term survival.
JOURNAL OF ENDODONTICS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Youngseo Joo, Taeyang Lee, Su Jin Jeong, Jae-Ho Lee, Je Seon Song, Chung-Min Kang
Summary: In this study, the non-inferiority of Endocem MTA Premixed and Well-Root PT in pulpotomy for primary molars was verified. The results showed that these materials can confer high success rates in pediatric patients and can be used to predict treatment success and prognosis.
JOURNAL OF DENTISTRY
(2023)
Review
Dentistry, Oral Surgery & Medicine
Dephne Jack Xin Leong, Adrian Ujin Yap
Summary: The umbrella review found that partial pulpotomy and full pulpotomy had higher success rates compared to direct pulp capping in carious pulp-exposed permanent human teeth, with conflicting results for prognostic factors. Factors such as restorative material, age, and study type seemed to have minimal impact on treatment outcomes.
CLINICAL ORAL INVESTIGATIONS
(2021)
Review
Medicine, General & Internal
Joao Miguel Santos, Joana F. Pereira, Andrea Marques, Diana B. Sequeira, Shimon Friedman
Summary: This study evaluated the outcomes of vital pulp therapy performed with hydraulic calcium silicate cements in mature permanent posterior teeth diagnosed with symptomatic irreversible pulpitis, showing success rates mostly ranging from 78% to 90%. Two articles suggested comparable outcomes of vital pulp therapy and root canal treatment at one and five years.
MEDICINA-LITHUANIA
(2021)
Article
Chemistry, Physical
Joanna Metlerska, Irini Fagogeni, Marcin Metlerski, Alicja Nowicka
Summary: Calcium silicate-based cements have a significant impact on tooth coloration, with Ortho MTA, ProRoot MTA, MTA Plus, and Biodentine causing the most color change after 6 months, with Biodentine darkening the shade of the base color.
Article
Dentistry, Oral Surgery & Medicine
Nur Sahin, Suna Saygili, Merve Akcay
Summary: This study evaluated the success of three different pulp-capping materials in one-stage indirect pulp treatment of primary teeth. While the clinical and radiographic success rates were similar among the materials, the histological examination showed that resin-based materials like TheraCal LC may negatively impact pulp status. Resin-free calcium silicate-based materials seem to be more favorable in long-term success of indirect pulp treatment in young-age groups.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Multidisciplinary Sciences
Osman Ata, Kubra Bilge, Semsettin Yildiz, Serkan Dundar, Ilknur Calik, Asime Gezer Ata, Alihan Bozoglan
Summary: The aim of this study was to examine the systemic effects of contemporary calcium silicate cements (CSC) containing different radiopacifiers in rats. The results showed that CSCs with different radiopacifiers had similar and acceptable effects on the histological examination of the kidneys and liver and on serum ALT, AST, urea, and creatinine levels.
Review
Dentistry, Oral Surgery & Medicine
Ana Messias, Duygu Karasan, Pedro Nicolau, Bjarni E. Pjetursson, Fernando Guerra
Summary: This study evaluated outcome measures, methods of assessment, and analysis in clinical studies on the rehabilitation of full-arch edentulism with implant-supported fixed or removable prostheses. The results demonstrated significant heterogeneity in the criteria used to define implant failure or survival and implant success. Patient-reported outcome measures were often reported independently from other outcomes. It is recommended for future studies to establish a set of core outcome variables and standardized methods of measurement.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Rui Falacho, Eliana Azevedo Melo, Joana A. Marques, Joao Carlos Ramos, Fernando Guerra, Markus B. Blatz
Summary: This study evaluated the effect of rubber dam isolation on the shear bond strength of two adhesive systems to enamel. The results showed that rubber dam isolation significantly increased bond strength, and the three-step etch-and-rinse adhesive performed better. Thus, the use of rubber dam isolation is recommended during adhesive procedures.
JOURNAL OF ESTHETIC AND RESTORATIVE DENTISTRY
(2023)
Review
Pharmacology & Pharmacy
Patricia Diogo, M. Amparo F. Faustino, Paulo J. Palma, Akhilesh Rai, Maria Graca P. M. S. Neves, Joao Miguel Santos
Summary: This review article focuses on the mechanism of action of various newly developed nanocarriers (NCs) with antimicrobial properties. Nine types of NCs are discussed, along with nineteen approaches based on in vitro antimicrobial assays. The challenges and limitations of all NCs are highlighted, and it is suggested that further research is needed to evaluate their efficacy in endodontic antimicrobial studies.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Chemistry, Physical
Akhilesh Rai, Sahadevan Seena, Teresa Gagliardi, Paulo J. Palma
Summary: This article introduces nanotechnology-based approaches to therapeutics and diagnostics, including drug release, targeted delivery, drug accumulation enhancement, immunomodulation, antimicrobial action, and high-resolution bioimaging. Gold nanoparticles (Au NPs) have attracted significant attention due to their biocompatibility, easy surface functionalization, and quantification. A comprehensive review is needed to understand the synthesis and applications of amino acid and peptide-capped Au NPs.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Fatma Pertek Hatipoglu, Oemer Hatipoglu, Nessrin Taha, Anna Paulina Lehmann, Thiyezen Abdullah Aldhelai, Ahmed A. Madfa, Afaf Al-Haddad, Silvana Jukic Krmek, Muhammad Qasim Javed, Usman Anwer Bhatti, Milan Drobac, Sugumaran Surendar, Benjamin Martin-Biedma, Paulo J. Palma, Joao Filipe Brochado Martins
Summary: This study aimed to examine the attitudes and practices of endodontists and paediatric dentists regarding regenerative endodontics (RET). The survey results showed deviations from current RET guidelines in all evaluated aspects. Standardizing clinical protocols and adhering to available guidelines would help to ensure more predictable outcomes.
INTERNATIONAL JOURNAL OF PAEDIATRIC DENTISTRY
(2023)
Article
Engineering, Biomedical
Meshal Muhammad Naeem, Huma Sarwar, Aliza Nisar, Shahbaz Ahmed, Juzer Shabbir, Zohaib Khurshid, Paulo J. Palma
Summary: The application of intracanal medicaments such as calcium hydroxide and propolis can affect the physical properties of root dentine. This study compared the effects of propolis and calcium hydroxide on the microhardness of root dentine. It was found that propolis increased the microhardness over time, while calcium hydroxide decreased it.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Mariana Martins, Ana Rafaela Oliveira, Solange Martins, Jose Pedro Vieira, Pedro Perdigao, Ana Rita Fernandes, Luis Pereira de Almeida, Paulo Jorge Palma, Diana Bela Sequeira, Joao Miguel Marques Santos, Frederico Duque, Guiomar Oliveira, Ana Luisa Cardoso, Joao Peca, Catarina Morais Seabra
Summary: This study presents the clinical history of a 12-year-old child with a rare variant in the MBD5 gene, who exhibited psychomotor delay and seizures. By establishing a patient-derived cell line and using CRISPR-Cas9 technology to create an isogenic control, the study found that the patient's neural progenitor cells showed a decrease in the length of primary cilia and the total number of ciliated cells. This study provides insights into the impact of MBD5 haploinsufficiency on neural primary cilia and its role in brain development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Fatma Pertek Hatipoglu, Guldane Magat, Omer Hatipoglu, Hanan Al-khatib, Anas S. Elatrash, Imran Zainal Abidin, Tomasz Kulczyk, Moataz- Bellah Ahmed Mohamed Alkhawas, Glynn Dale Buchanan, Maira Kopbayeva, Sugumaran Surendar, Muhammad Qasim Javed, Ahmed A. Madfa, Sebastian Burklein, Sarah Mimica, Usman Anwer Bhatti, Tulegenova Indira Maratovna, Paulo J. Palma, Joao Filipe Brochado Martins
Summary: This study assessed the prevalence of Distolingual Canal (DLC) and Radix Entomolaris (RE) in Mandibular First Molars (M1Ms) using CBCT images and examined the impact of sociodemographic factors on their prevalence worldwide. The results showed that the overall prevalence of DLC was 22% and RE was 3%. Both DLC and RE exhibited significant bilateral variations.
JOURNAL OF ENDODONTICS
(2023)
Review
Dentistry, Oral Surgery & Medicine
Joana A. Marques, Rui I. Falacho, Joao Miguel Santos, Joao Carlos Ramos, Paulo J. Palma
Summary: This review assesses the structural, chemical, and mechanical properties of coronal dentin after endodontic irrigation. The literature consensus shows that sodium hypochlorite and chelating agents have both deproteinizing and decalcifying effects on coronal dentin, which are concentration- and time-dependent. Understanding the impact of irrigants on coronal dentin is crucial for the success of endodontic treatment.
JOURNAL OF ESTHETIC AND RESTORATIVE DENTISTRY
(2023)
Article
Engineering, Biomedical
Carlos Roberto Emerenciano Bueno, Jimena Lama Sarmiento, Ana Maria Veiga Vasques, Ana Claudia Rodrigues da Silva, Luciano Tavares Angelo Cintra, Joao Miguel Marques Santos, Eloi Dezan-Junior
Summary: This study evaluated the effects of root canal dressings on the inflammatory response, biomineralization, and collagen fiber maturation in the subcutaneous tissue of rats. The results showed that groups containing calcium hydroxide exhibited better biomineralization and tissue repair, while the addition of iodoform delayed tissue healing.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Review
Medicine, General & Internal
Rocco Franco, Ettore Lupi, Enzo Iacomino, Angela Galeotti, Mario Capogreco, Joao Miguel Marques Santos, Maurizio D'Amario
Summary: Oral mucositis is a common side effect of stem cell transplantation in cancer patients, leading to inflammation, ulcers, and various difficulties. This scientific article reviews the efficacy of laser therapy in treating post-transplant mucositis and concludes that it reduces the severity of symptoms.
MEDICINA-LITHUANIA
(2023)
Meeting Abstract
Medicine, General & Internal
Mariana Martins, Ana RafaelaOliveira, Giuseppe Cammarata, Solange Martins, Pedro Perdigao, Ana Luisa Cardoso, Paulo Palma, Diana B. Sequeira, Joao Miguel Santos, Jose Pedro Vieira, Luis P. Almeida, Frederico Duque, Guiomar Oliveira, Joao Peca, Catarina M. Seabra