Review
Chemistry, Multidisciplinary
Jingyun Cheng, Hui Huang, Yu Chen, Rong Wu
Summary: This article provides a detailed overview of the three major application branches of nanomedicine in atherosclerosis, as well as summarizing the latest research in the field. It emphasizes the intrinsic interaction/relationship between nanomedicines and atherosclerosis, with a specific focus on the biosafety of nanomedicines. The article concludes by proposing unresolved key scientific issues and sharing the vision and expectation for the future.
Review
Chemistry, Multidisciplinary
Amy G. Robertson, Louis M. Rendina
Summary: According to the World Health Organization, the number of new cancer cases and deaths is expected to rise in the next decade, calling for the development of new and effective cancer treatments and diagnostic tools. Theranostics, particularly those utilizing materials like gadolinium, are showing promise in personalized management of oncology patients, representing a new direction in cancer research.
CHEMICAL SOCIETY REVIEWS
(2021)
Article
Chemistry, Medicinal
Meixuan Liu, Sha Liu, Xiaosu Zhu, Yiying Sun, Linyu Su, Hairong Yu, Deshuai Liu, Ying Li, Yuan Du, Rongxia Liu, Kaoxiang Sun
Summary: The micelles of PPSPEG-RA@TA could effectively inhibit endothelial cell proliferation, reduce the expression of VCAM-1, thereby alleviating inflammation and reducing endothelial cell damage. After one month of intravenous injection, the plaque area in murine aortic vessels was significantly reduced without serious toxic side-effects, showing excellent biocompatibility.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Materials Science, Multidisciplinary
Liyun Zhu, Wanru Xu, Emeli Chatterjee, Guoping Li, Xu Wang, Junjie Xiao, Xuerui Chen, Liming Yang
Summary: Atherosclerosis, caused by fibrofatty lesions in the artery wall, is the basis for heart attacks, strokes, and peripheral artery diseases. Inflammation plays a significant role in the development, progression, and complications of atherosclerosis. Nanomedicine targeted at inflammation could provide individualized monitoring and regulation of inflammatory regulators, as well as diagnostic imaging for atherosclerotic plaques. Rating: 9/10.
MATERIALS & DESIGN
(2023)
Article
Pharmacology & Pharmacy
Huanhuan Cao, Yujie Zhu, Gaofei Hu, Qi Zhang, Lemin Zheng
Summary: The treatment of atherosclerotic cardiovascular disease has mainly focused on decreasing LDL levels and targeting traditional risk factors, but the benefits have plateaued and new therapeutic targets are needed. Accumulating evidence shows that the gut microbiome plays a significant role in cardiovascular health and disease. Gut microbial metabolites, such as trimethylamine oxide (TMAO), bile acids, and amino acid metabolites, impact the development of atherosclerosis. Novel therapeutic strategies involve targeting these microbial metabolites to improve cardiovascular outcomes. Understanding these mechanisms is crucial for developing therapeutic strategies for atherosclerosis.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Xiuwen Zhang, Franco Centurion, Ashish Misra, Sanjay Patel, Zi Gu
Summary: This review article highlights the recent progress in the development of molecularly targeted nanomedicine for imaging detection and treatment of atherosclerosis using inorganic nanoparticles. By delivering imaging contrast nanoparticles to specific molecules in atherogenesis, atherosclerotic plaque development at different stages can be identified and monitored through various molecular imaging modalities. Molecularly targeted therapeutic approaches that target and regulate molecules associated with lipid regulation, inflammation, and apoptosis are also reviewed. The article concludes with a discussion on the current challenges and future development of nanomedicine for atherosclerotic diagnosis and treatment.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Review
Chemistry, Physical
Xue Bao, Yu Mao, Guangxiang Si, Lina Kang, Biao Xu, Ning Gu
Summary: This review summarizes the latest applications of iron oxide nanoparticles (IONPs) in cardiovascular diseases (CVDs), including diagnosis and treatment, and discusses the prospects of integrated application of IONPs in CVDs as well as the translational potential and challenges.
Review
Materials Science, Biomaterials
Nidhi Raval, Rahul Maheshwari, Havish Shukla, Kiran Kalia, Vladimir P. Torchilin, Rakesh K. Tekade
Summary: Polymeric micelles have been a popular research topic in the past decade, particularly in their ability to deliver drugs and diagnostic agents effectively. They offer advantages such as biocompatibility, high loading efficiency, and stability in biological fluids. This technology shows promising potential in cancer treatment but also presents challenges in clinical application.
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Review
Cardiac & Cardiovascular Systems
Jin Chen, Shu Lin, Yiming Zeng
Summary: The research on obstructive sleep apnea (OSA) and its link to atherosclerosis has gained importance as OSA prevalence and mortality rates increase. Despite ongoing debates, further fundamental and clinical research is necessary to better understand the complex mechanism between OSA and atherosclerosis in order to suggest newer diagnostic and treatment options.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Chemistry, Multidisciplinary
Jitender Bariwal, Hairong Ma, Guillermo A. Altenberg, Hongjun Liang
Summary: Cancer therapy faces challenges in drug delivery to cancer cells and non-selective killing of healthy cells. Nano-formulations show promising potential for targeted drug delivery. The shape and size of nanocarriers significantly impact their transport and internalization. Nanodiscs are desirable nano-formulations with enhanced anisotropic character and versatile functionalization potential.
CHEMICAL SOCIETY REVIEWS
(2022)
Review
Materials Science, Biomaterials
Yang Xuan, Yating Gao, Meng Guan, Shubiao Zhang
Summary: Nanotechnology has provided new tools for cancer treatment, particularly with the development of smart multifunctional nanoprobes. Off-On nanoprobes and Charge-Reversal nanoprobes have been the focus of research and offer potential for early diagnosis and treatment of cancer.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Oncology
Yan Gu, Xiao Ma, Jing Li, Yuhong Ma, Yun Zhang
Summary: This study investigated the correlation between circRNAs and atherosclerosis, identified DECs and analyzed their role in the disease progression. Through bioinformatics analysis, potential hub genes and small-molecule compounds interacting with them were identified, providing candidate targets for the diagnosis and treatment of atherosclerosis.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Xianghua Zhong, Qin Fu, Xinchao Liu, Peng Shi
Summary: A smart nanoplatform that can respond to multiple biomarkers has been developed in this study to track the intracellular delivery of a 2D nanosystem in real-time. Our work offers a promising approach to develop an optimized imaging nanoplatform for site-specific imaging and real-time tracking of the delivery process.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Analytical
Suya Zhang, Lulu Ning, Zhihui Song, Xinyue Zhao, Feng Guan, Xiao-Feng Yang, Jianjian Zhang
Summary: This study designs an organic nanoprobe capable of real-time imaging of ClO- in early RA. The probe exhibits high selectivity and low detection limit for ClO- levels, and is able to monitor treatment responses and efficacy in a mouse model. The research proposes a universal molecular design strategy for the detection of ClO-, which holds potential for early diagnosis and drug screening for RA.
ANALYTICAL CHEMISTRY
(2022)
Review
Cardiac & Cardiovascular Systems
Anders Gottsaeter
Summary: This review focuses on the rationale for recommendations on antiplatelet and anticoagulant treatment in PAD patients, suggesting different medication treatment plans for patients with different symptoms, and the need to weigh the pros and cons based on individual circumstances.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Liangxing Tu, Meng Cheng, Yongbing Sun, Yuanying Fang, Jiali Liu, Wan Liu, Jianfang Feng, Yi Jin
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2020)
Article
Pharmacology & Pharmacy
Meng Cheng, Fangying Yuan, Jiali Liu, Wan Liu, Jianfang Feng, Yi Jin, Liangxing Tu
Article
Pharmacology & Pharmacy
Tian'e Chen, Liangxing Tu, Ge Wang, Na Qi, Wei Wu, Wei Zhang, Jianfang Feng
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2020)
Article
Pharmacology & Pharmacy
Jiali Liu, Liangxing Tu, Meng Cheng, Jianfang Feng, Yi Jin
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2020)
Article
Pharmacology & Pharmacy
Jiali Liu, Yongbing Sun, Meng Cheng, Qiaoming Liu, Wan Liu, Chao Gao, Jianfang Feng, Yi Jin, Liangxing Tu
Summary: The study utilized SDS to modify luteolin nanocrystals, enhancing the bioavailability of luteolin. SDS opened the tight junction of caco-2 monolayer, facilitating the transport of luteolin across the intestinal membrane and significantly increasing its bioavailability.
Article
Biochemistry & Molecular Biology
Meng Cheng, Qiaoming Liu, Tiantian Gan, Yuanying Fang, Pengfei Yue, Yongbing Sun, Yi Jin, Jianfang Feng, Liangxing Tu
Summary: Enhancing the in vivo circulation and bioavailability of rapidly metabolized drugs like docetaxel can be achieved through constructing nanocrystal-loaded micelles delivery systems. These systems prolong the retention time of the drugs in circulation, leading to better therapeutic effects.
Article
Pharmacology & Pharmacy
Wan Liu, Meng Cheng, Zhiyang Lu, Haocheng Li, Yulin Feng, Yi Jin, Shilin Yang, Jianfang Feng, Liangxing Tu
Summary: In this study, we synthesized a novel chitosan-based copolymer and modified nanocrystals to enhance the oral absorption of polymer andrographolide. The results showed that the modified nanocrystals exhibited the highest bioavailability and enhanced anti-inflammatory efficacy.
Review
Pharmacology & Pharmacy
Yunjie He, Meng Cheng, Ruyue Yang, Haocheng Li, Zhiyang Lu, Yi Jin, Jianfang Feng, Liangxing Tu
Summary: Improving the stability and penetration ability of drugs in the gastrointestinal tract through a nanoparticle delivery strategy is a research focus in the pharmaceutical field. However, most drugs have not shown significant improvement in oral absorption when using nanoparticles, hindering their clinical application. This paper systematically reviews the behaviors of nanoparticles in the intestinal epithelial cell membrane, focusing on their intracellular mechanisms. The review aims to enhance scientists' understanding of the in vivo performance of nanoparticles and aid in the design of novel strategies to improve their bioavailability.
Article
Nanoscience & Nanotechnology
Qiaoming Liu, Meng Cheng, Jianqin Liang, Yi Jin, Jianfang Feng, Liangxing Tu
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2020)
Article
Pharmacology & Pharmacy
Xueliang Xiu, Shichao Ma, Zhiyong Li, Zhipeng Li, Xuemei Li, Yangtao Ruan, Dezhao Li, Jianwei Wang, Fengsen Ma
Summary: Liposomes are promising delivery vehicles for drugs and vaccines. The use of microfluidic chips for liposome preparation is an effective method. However, traditional liposome preparation technologies hinder their industrial production and clinical application. This study presents a novel three-dimensional integrated microfluidic device for continuous liposome preparation and purification, which shows potential for industrial production of nano-pharmaceutical applications.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2024)
