Article
Biochemistry & Molecular Biology
Paolo Cameli, Elena Pordon, Miriana d'Alessandro, Maria Laura Marzi, Lucrezia Galasso, Cesare Biuzzi, Laura Bergantini, Elena Bargagli, Sabino Scolletta, Federico Franchi
Summary: This study evaluated the performance of serum MR-proADM as a prognostic biomarker in hospitalized COVID-19 patients. It showed that MR-proADM levels were higher in non-survivors and those requiring respiratory support. The combination of MR-proADM, KL-6, and IL-6 improved the accuracy of predicting death or ICU admission.
Article
Multidisciplinary Sciences
Emanuela Sozio, Carlo Tascini, Martina Fabris, Federica D'Aurizio, Chiara De Carlo, Elena Graziano, Flavio Bassi, Francesco Sbrana, Andrea Ripoli, Alberto Pagotto, Alessandro Giacinta, Valentina Gerussi, Daniela Visentini, Paola De Stefanis, Maria Merelli, Kordo Saeed, Francesco Curcio
Summary: The study revealed an association between MR-proADM levels and the severity of COVID-19, with high levels significantly related to negative outcomes. The combination of MR-proADM with clinical scoring systems may help identify patients at risk of disease progression.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Agustin Clemente-Moragon, Juan Martinez-Milla, Eduardo Oliver, Arnoldo Santos, Javier Flandes, Iker Fernandez, Lorena Rodriguez-Gonzalez, Cristina Serrano del Castillo, Ana-Maria Ioan, Maria Lopez-Alvarez, Sandra Gomez-Talavera, Carlos Galan-Arriola, Valentin Fuster, Cesar Perez-Calvo, Borja Ibanez
Summary: In this study, metoprolol treatment in patients with COVID-19-associated ARDS was shown to be safe and effective in reducing lung inflammation and improving oxygenation, resulting in fewer days on invasive mechanical ventilation. Repurposing metoprolol for COVID-19-associated ARDS could be a cost-effective strategy to alleviate the burden of the pandemic.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Kevin Roedl, Dominik Jarczak, Marlene Fischer, Munif Haddad, Olaf Boenisch, Geraldine de Heer, Christoph Burdelski, Daniel Frings, Barbara Sensen, Mahir Karakas, Stefan Kluge, Axel Nierhaus
Summary: Acute kidney injury requiring renal replacement therapy is common in ICU patients with COVID-19. MR-proADM on admission can predict the need for RRT, which may be helpful for risk stratification and management.
Article
Respiratory System
Cecilia Lopez-Martinez, Paula Martin-Vicente, Juan Gomez de Ona, Ines Lopez-Alonso, Helena Gil-Pena, Elias Cuesta-Llavona, Margarita Fernandez-Rodriguez, Irene Crespo, Estefania Salgado del Riego, Raquel Rodriguez-Garcia, Diego Parra, Javier Fernandez, Javier Rodriguez-Carrio, Francisco Jose Jimeno-Demuth, Alberto Davalos, Luis A. Chapado, Eliecer Coto, Guillermo M. Albaiceta, Laura Amado-Rodriguez
Summary: In this study, researchers identified two transcriptomic clusters in critically ill COVID-19 patients based on peripheral blood transcriptomes. One cluster was characterized by interferon-related expression and the other promoted B-cell activation. These clusters had different ICU outcomes, suggesting different pathogenetic mechanisms. The findings demonstrate the potential of transcriptomics in identifying patient endotypes for personalized therapies in severe COVID-19.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Endocrinology & Metabolism
Ioannis Ilias, Aristidis Diamantopoulos, Efthymia Botoula, Nikolaos Athanasiou, Alexandros Zacharis, Stamatios Tsipilis, Edison Jahaj, Alice G. Vassiliou, Dimitra A. Vassiliadi, Anastasia Kotanidou, Stylianos Tsagarakis, Ioanna Dimopoulou
Summary: The study aimed to measure IGF1 and GH in critically and non-critically ill Covid-19 patients. Results showed that IGF-1 levels were higher in survivors compared to non-survivors, suggesting a potential association between low IGF1 and poor outcomes in Covid-19 patients.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Anthony C. Gordon, Farah Al-Beidh, Kathryn M. Rowan, Alistair D. Nichol, Yaseen M. Arabi, Djillali Annane, Ahi Beane, Wilma Van Bentum-Puijk, Lindsay R. Berry, Zahra Bhimani, Marc J. M. Bonten, Charlotte A. Bradbury, Frank M. Brunkhorst, Adrian Buzgau, Allen C. Cheng, Michelle A. Detry, Eamon J. Duffy, Lise J. Estcourt, Mark Fitzgerald, Herman Goossens, Rashan Haniffa, Alisa M. Higgins, Thomas E. Hills, Christopher M. Horvat, Francois Lamontagne, Patrick R. Lawler, Helen L. Leavis, Kelsey M. Linstrum, Edward Litton, Elizabeth Lorenzi, John C. Marshall, Florian B. Mayr, Daniel F. McAuley, Anna McGlothlin, Shay P. McGuinness, Bryan J. McVerry, Stephanie K. Montgomery, Susan C. Morpeth, Srinivas Murthy, Katrina Orr, Rachael L. Parke, Jane C. Parker, Asad E. Patanwala, Ville Pettill, Emma Rademaker, Marlene S. Santos, Christina T. Saunders, Christopher W. Seymour, Manu Shankar-Hari, Wendy L. Sligl, Alexis F. Turgeon, Anne M. Turner, Frank L. van de Veerdonk, Ryan Zarychanski, Cameron Green, Roger J. Lewis, Derek C. Angus, Colin J. McArthur, Scott Berry, Steve A. Webb, Lennie P. G. Derde
Summary: Interleukin-6 receptor antagonists tocilizumab and sarilumab were found to improve outcomes, including survival, in critically ill patients with Covid-19 receiving organ support in ICUs according to an ongoing international trial. The efficacy of these treatments has been confirmed, with patients benefiting from the therapy.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Review
Immunology
Hamid Nasrollahi, Atefe Ghamar Talepoor, Zahra Saleh, Mahsa Eshkevar Vakili, Paria Heydarinezhad, Narges Karami, Maryam Noroozi, Seppo Meri, Kurosh Kalantar
Summary: The COVID-19 pandemic caused by SARS-CoV-2 has had devastating effects on global health and the economy. The immune system plays a critical role in controlling the infection, but dysregulated inflammatory responses and imbalanced immune function can contribute to tissue damage and disease pathogenesis. Important mechanisms in severe COVID-19 include excessive production of inflammatory cytokines, impaired antiviral response, overactivation of immune cells, decreased frequencies of certain immune cell populations, complement activation, lymphopenia, and dysregulation of B lymphocyte function. Manipulating the immune system has been explored as a therapeutic approach. This review discusses the role of immunity in COVID-19 development and progression, focusing on molecular and cellular aspects of the immune system in mild versus severe forms of the disease. Immune-based therapeutic approaches are also being investigated.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Ewan C. Goligher, Charlotte A. Bradbury, Bryan J. McVerry, Patrick R. Lawler, Jeffrey S. Berger, Michelle N. Gong, Marc Carrier, Harmony R. Reynolds, Anand Kumar, Alexis F. Turgeon, Lucy Z. Kornblith, Susan R. Kahn, John C. Marshall, Keri S. Kim, Brett L. Houston, Lennie P. G. Derde, Mary Cushman, Tobias Tritschler, Derek C. Angus, Lucas C. Godoy, Zoe McQuilten, Bridget-Anne Kirwan, Michael E. Farkouh, Maria M. Brooks, Roger J. Lewis, Lindsay R. Berry, Elizabeth Lorenzi, Anthony C. Gordon, Scott M. Berry, Colin J. McArthur, Matthew D. Neal, Judith S. Hochman, Steven A. Webb, Ryan Zarychanski, Tania Ahuja, Farah Al-Beidh, Djillali Annane, Yaseen M. Arabi, Diptesh Aryal, Lisa Baumann Kreuziger, Abi Beane, Zahra Bhimani, Shailesh Bihari, Henny H. Billett, Lindsay Bond, Marc Bonten, Frank Brunkhorst, Meredith Buxton, Adrian Buzgau, Lana A. Castellucci, Sweta Chekuri, Jen-Ting Chen, Allen C. Cheng, Tamta Chkhikvadze, Benjamin Coiffard, Aira Contreras, Todd W. Costantini, Sophie de Brouwer, Michelle A. Detry, Abhijit Duggal, Vladimir Dzavik, Mark B. Effron, Heather F. Eng, Jorge Escobedo, Lise J. Estcourt, Brendan M. Everett, Dean A. Fergusson, Mark Fitzgerald, Robert A. Fowler, Joshua D. Froess, Zhuxuan Fu, Jean P. Galanaud, Benjamin T. Galen, Sheetal Gandotra, Timothy D. Girard, Andrew L. Goodman, Herman Goossens, Cameron Green, Yonatan Y. Greenstein, Peter L. Gross, Rashan Haniffa, Sheila M. Hegde, Carolyn M. Hendrickson, Alisa M. Higgins, Alexander A. Hindenburg, Aluko A. Hope, James M. Horowitz, Christopher M. Horvat, David T. Huang, Kristin Hudock, Beverley J. Hunt, Mansoor Husain, Robert C. Hyzy, Jeffrey R. Jacobson, Devachandran Jayakumar, Norma M. Keller, Akram Khan, Yuri Kim, Andrei Kindzelski, Andrew J. King, Aaron E. Kornblith, Matthew E. Kutcher, Michael A. Laffan, Francois Lamontagne, Gregoire Le Gal, Christine M. Leeper, Eric S. Leifer, George Lim, Felipe Gallego Lima, Kelsey Linstrum, Edward Litton, Jose Lopez-Sendon, Sylvain A. Lother, Nicole Marten, Andrea Saud Marinez, Mary Martinez, Eduardo Mateos Garcia, Stavroula Mavromichalis, Daniel F. McAuley, Emily G. McDonald, Anna McGlothlin, Shay P. McGuinness, Saskia Middeldorp, Stephanie K. Montgomery, Paul R. Mouncey, Srinivas Murthy, Girish B. Nair, Rahul Nair, Alistair D. Nichol, Jose C. Nicolau, Brenda Nunez-Garcia, John J. Park, Pauline K. Park, Rachael L. Parke, Jane C. Parker, Sam Parnia, Jonathan D. Paul, Mauricio Pompilio, John G. Quigley, Robert S. Rosenson, Natalia S. Rost, Kathryn Rowan, Fernanda O. Santos, Marlene Santos, Mayler O. Santos, Lewis Satterwhite, Christina T. Saunders, Jake Schreiber, Roger E. G. Schutgens, Christopher W. Seymour, Deborah M. Siegal, Delcio G. Silva, Aneesh B. Singhal, Arthur S. Slutsky, Dayna Solvason, Anne M. Turner, Wilma Van Bentum-Puijk, Frank L. van de Veerdonk, Sean van Diepen, Gloria Vazquez-Grande, Lana Wahid, Vanessa Wareham, R. Jay Widmer, Jennifer G. Wilson, Eugene Yuriditsky, Yongqi Zhong
Summary: In critically ill patients with Covid-19, initial therapeutic-dose anticoagulation did not result in improved survival rates or fewer days requiring cardiovascular or respiratory organ support compared to usual-care pharmacologic thromboprophylaxis.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Review
Medicine, General & Internal
Giorgia Montrucchio, Eleonora Balzani, Davide Lombardo, Alice Giaccone, Anna Vaninetti, Giulia D'Antonio, Francesca Rumbolo, Giulio Mengozzi, Luca Brazzi
Summary: MR-proADM levels at ICU admission appear to predict mortality among critical COVID-19 patients. Further prospective studies focused on critically ill patients are needed to establish a reliable cut-off value.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Rebecca Liu, Mary Paz, Layla Siraj, Taylor Boyd, Silvia Salamone, Thuy-Lan Vo Lite, Krystle M. Leung, Josue D. Chirinos, Helen H. Shang, Matthew J. Townsend, Junsung Rho, Peiyun Ni, Kushi Ranganath, April D. Violante, Zezhou Zhao, Casey Silvernale, Imama Ahmad, Nira A. Krasnow, Erica S. Barnett, Mukesh Harisinghani, Braden Kuo, Katharine E. Black, Kyle Staller
Summary: This study characterizes the prevalence, clinical manifestations, and outcomes of feeding intolerance in critically ill patients with COVID-19. Feeding intolerance developed in 56% of the patients and was associated with poor outcomes.
CLINICAL NUTRITION
(2022)
Article
Anesthesiology
Mirjam Bachler, Johannes Boesch, Daniel P. Stuerzel, Tobias Hell, Andreas Giebl, Mathias Stroehle, Sebastian J. Klein, Volker Schaefer, Georg F. Lehner, Michael Joannidis, Claudius Thome, Dietmar Fries
Summary: Critically ill COVID-19 patients exhibit a hypercoagulable state with impaired fibrinolysis, characterized by increased clot firmness and decreased fibrinolytic response in whole blood coagulation tests. This hypofibrinolytic state may be at least partially due to a decreased fibrinolytic response.
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Article
Critical Care Medicine
Niklas Bruse, Emma J. Kooistra, Aron Jansen, Rombout B. E. van Amstel, Nicolette F. de Keizer, Jason N. Kennedy, Christopher Seymour, Lonneke A. van Vught, Peter Pickkers, Matthijs Kox
Summary: Classifying critically ill COVID-19 patients into clinical phenotypes may help with prognostication, treatment efficacy prediction, and personalized medicine. The distribution of phenotypes was similar between COVID-19 and non-COVID-19 viral pneumonia sepsis cohorts, with a higher proportion of patients with the delta-phenotype in bacterial sepsis cohorts. The introduction of dexamethasone treatment was associated with an increased proportion of patients with the delta-phenotype and improved survival.
Review
Critical Care Medicine
Giacomo Grasselli, Emanuele Cattaneo, Gaetano Florio
Summary: This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2021, with more information available at the provided links.
Article
Medicine, General & Internal
Romain Arrestier, Segolene Gendreau, David Mokrani, Jean-Philippe Bastard, Soraya Fellahi, Francois Bagate, Paul Masi, Thomas D'Humieres, Keyvan Razazi, Guillaume Carteaux, Nicolas De Prost, Vincent Audard, Armand Mekontso-Dessap
Summary: AKI is common in COVID-19 patients hospitalized in ICU, and it appears to be related to tubular lesions rather than glomerular injury. Urinary proteinuria profile could be a non-invasive tool to investigate the pathophysiological process underlying AKI in COVID-19 patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Editorial Material
Critical Care Medicine
Hans Flaatten, Bertrand Guidet, Dylan W. de Lange, Michael Beil, Susannah K. Leaver, Jesper Fjolner, Peter Vernon van Heerden, Sviri Sigal, Wojciech Szczeklik, Christian Jung
JOURNAL OF CRITICAL CARE
(2022)
Letter
Critical Care Medicine
Jos A. H. van Oers, Harm-Jan de Grooth, Dylan W. de Lange, Armand R. J. Girbes
JOURNAL OF CRITICAL CARE
(2022)
Article
Cardiac & Cardiovascular Systems
Raphael Romano Bruno, Bernhard Wernly, Georg Wolff, Jesper Fjolner, Antonio Artigas, Bernardo Bollen Pinto, Joerg C. Schefold, Detlef Kindgen-Milles, Philipp Heinrich Baldia, Malte Kelm, Michael Beil, Sigal Sviri, Peter Vernon van Heerden, Wojciech Szczeklik, Arzu Topeli, Muhammed Elhadi, Michael Joannidis, Sandra Oeyen, Eumorfia Kondili, Brian Marsh, Finn H. Andersen, Rui Moreno, Susannah Leaver, Ariane Boumendil, Dylan W. De Lange, Bertrand Guidet, Hans Flaatten, Christian Jung
Summary: Pre-existing chronic heart failure in critically ill older COVID-19 patients was not independently associated with 30-day mortality after adjusting for confounders.
Article
Medical Informatics
Christian Jung, Behrooz Mamandipoor, Jesper Fjolner, Raphael Romano Bruno, Bernhard Wernly, Antonio Artigas, Bernardo Bollen Pinto, Joerg C. Schefold, Georg Wolff, Malte Kelm, Michael Beil, Sigal Sviri, Peter van Heerden, Wojciech Szczeklik, Miroslaw Czuczwar, Muhammed Elhadi, Michael Joannidis, Sandra Oeyen, Tilemachos Zafeiridis, Brian Marsh, Finn H. Andersen, Rui Moreno, Maurizio Cecconi, Susannah Leaver, Dylan W. De Lange, Bertrand Guidet, Hans Flaatten, Venet Osmani
Summary: This study evaluated machine learning-based prognostication models for critically ill elderly COVID-19 patients. The results showed that integrating important clinical events and time-to-event information into the models improved the accuracy of predicting 30-day mortality, compared to models based on admission variables only and conventional ICU prediction models.
JMIR MEDICAL INFORMATICS
(2022)
Article
Veterinary Sciences
Marieke A. Dijkman, Joris H. Robben, Antoinette J. H. P. van Riel, Dylan W. de Lange
Summary: After changes in legislation, there was a significant increase in information requests regarding dogs and cats exposed to alpha-chloralose. A study was conducted to gather additional information on poisoning scenarios and clinical course. Results showed that dogs and especially cats were at risk of poisoning and had mortality rates of 1% and 18% respectively. The study concluded that alpha-chloralose-based rodenticides are not safe for non-professional use.
Article
Medical Informatics
Michael Beil, P. Vernon van Heerden, Dylan W. de Lange, Wojciech Szczeklik, Susannah Leaver, Bertrand Guidet, Hans Flaatten, Christian Jung, Sigal Sviri, Leo Joskowicz
Summary: This study used the framework of information theory to evaluate the uncertainty in decision-making about life-sustaining treatment (LST) in the intensive care unit (ICU). The results showed that information about the severity of the acute illness was the most important, while age, gender, and geriatric characteristics contributed to a lesser degree. This suggests that there is still a gap in fully understanding decision-making about LST and further research is needed.
BMC MEDICAL INFORMATICS AND DECISION MAKING
(2023)
Article
Pharmacology & Pharmacy
Saskia J. Rietjens, Tessa E. van Riemsdijk, Maaike A. Sikma, Dylan W. de Lange
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Arezoo Shajiei, Matthijs S. S. Berends, Christian F. F. Luz, Jos A. A. van Oers, Hermie J. M. Harmsen, Piet Vos, Rob Klont, Bert G. G. Loef, Auke C. C. Reidinga, Laura Bormans-Russell, Kitty Linsen, Tom Dormans, Martine Otten, Akke van der Bij, Albertus Beishuizen, Dylan W. W. de Lange, Evelien de Jong, Maarten W. W. Nijsten
Summary: In this study, researchers assessed the impact of shorter antibiotic treatment on antimicrobial resistance development in critically ill patients. The results showed no significant difference in the incidence of multi-drug resistant or highly resistant organisms between the procalcitonin-guided and control groups.
FRONTIERS IN MEDICINE
(2023)
Article
Critical Care Medicine
Corstiaan den Uil, Fabian Termorshuizen, Wim J. R. Rietdijk, Roos S. G. Sablerolles, Hugo P. M. van der Kuy, Lenneke E. M. Haas, Peter H. J. W. van der Voort, Dylan de Lange, Peter F. Pickkers, Nicolette de Keizer
Summary: An observational cohort study found that a higher BMI is associated with a lower mortality rate among critically ill COVID-19 patients under the age of 45. However, this association is not present in patients who require ICU admission.
CRITICAL CARE MEDICINE
(2023)
Article
Infectious Diseases
Timo Mayerhoefer, Sebastian Klein, Bernhard Wernly, Hans Flaatten, Bertrand Guidet, Dylan W. De Lange, Jesper Fjolner, Susannah Leaver, Michael Beil, Sigal Sviri, Raphael Romano Bruno, Antonio Artigas, Peter Vernon van Heerden, Bernardo Bollen Pinto, Joerg C. Schefold, Rui Moreno, Maurizio Cecconi, Wojciech Szczeklik, Christian Jung, Michael Joannidis
Summary: This study investigated the impact of diabetes mellitus on 90-day mortality in a high-risk cohort of critically ill patients over 70 years of age. The study found that patients with diabetes had a significantly higher 90-day mortality rate compared to those without diabetes. This suggests that diabetes is a relevant risk factor for COVID-19 in old critically ill patients.
Article
Geriatrics & Gerontology
Lenneke E. M. Haas, Fabian Termorshuizen, Corstiaan A. den Uil, Nicolette F. de Keizer, Dylan W. de Lange
Summary: This study aims to compare the outcomes of COVID-19 patients aged 70 years and above with those admitted for bacterial and other viral pneumonias. The severity of COVID-19 in ICU patients aged 70 years and above was found to be higher compared to bacterial or viral pneumonia.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Marieke A. Dijkman, Femke M. J. Gresnigt, Dylan W. de Lange
Summary: Digoxin-specific antibodies are valuable in treating digoxin toxicity. In the Netherlands, they are stored in a national calamity stock and can be obtained through the Dutch Poisons Information Centre. Recent studies have shown that a lower dose of these antibodies is needed for effective treatment. The Dutch Poisons Information Centre recommends a new dosing strategy that is safe, effective, and cost-saving.
NETHERLANDS HEART JOURNAL
(2023)
Letter
Toxicology
Arjen Koppen, Cecile H. J. Bekkers, Gordon H. P. R. Slabbers, Dylan W. de Lange, Robbert B. T. Verkooijen
CLINICAL TOXICOLOGY
(2023)
Meeting Abstract
Toxicology
F. M. J. Gresnigt, Anouk Snik, Eric J. F. Franssen, Joost W. Vanhommerig, Dylan W. de Lange, Robert K. Riezebos
CLINICAL TOXICOLOGY
(2022)
Meeting Abstract
Toxicology
Laura Hondebrink, Johanna J. Nugteren-van Lonkhuyzen, Irma S. van den Hengel-Koot, Dylan W. de lange, Antoinette J. H. P. van Riel
CLINICAL TOXICOLOGY
(2022)
Article
Critical Care Medicine
Christina Boncyk, Kimberly Rengel, Joanna Stollings, Matt Marshall, Xiaoke Feng, Matthew Shotwell, Pratik P. Pandharipande, Christopher G. Hughes
Summary: This study describes the incidence and factors associated with recurrent delirium in the intensive care unit (ICU). The researchers found that over 10% of delirious ICU patients experienced recurrent symptoms, and factors such as age, duration of mechanical ventilation, and medication exposure were associated with recurrence.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Thomas C. Rollinson, Luke A. McDonald, Joleen Rose, Glenn Eastwood, Rahul Costa-Pinto, Lucy Modra, Akinori Maeda, Zoe Bacolas, James Anstey, Samantha Bates, Scott Bradley, Jodi Dumbrell, Craig French, Angaj Ghosh, Kimberley Haines, Tim Haydon, Carol L. Hodgson, Jennifer Holmes, Nina Leggett, Forbes McGain, Cara Moore, Kathleen Nelson, Jeffrey Presneill, Hannah Rotherham, Simone Said, Meredith Young, Peinan Zhao, Andrew Udy, Ary Serpa Neto, Anis Chaba, Rinaldo Bellomo
Summary: Neuromuscular blockers (NMBs) used during prone positioning in COVID-19 ARDS patients can improve oxygenation and have a sustained effect upon returning to supine position.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Kyung Hun Nam, Jason Phua, Bin Du, Shinichiro Ohshimo, Hwa Jung Kim, Chae-Man Lim, Sheila Nainan Myatra, Nik Azman Bin Nik Adib, Yaseen M. Arabi, Ming-Cheng Chan, Mohammad Omar Faruq, Ike Sri Redjeki, Do Ngoc Son, Khalid Mahmood Khan Nafees, Dilshan Priyankara, Boonsong Patjanasoontorn, Jose Emmanuel Palo, Aidos Konkayev, Gentle Sunder Shrestha, Younsuck Koh
Summary: This study investigated the current practices of mechanical ventilation in Asian intensive care units. The results showed that low tidal volume ventilation and sufficient PEEP were underused in patients with ARDS, while intermediate tidal volumes were commonly used in patients without ARDS. Country income, age, and severity of illness were associated with mortality.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Rudolf Likar, Ilia Aroyo, Katrin Bangert, Bjorn Degen, Rainer Dziewas, Oliver Galvan, Michaela Trapl Grundschober, Markus Kostenberger, Paul Muhle, Joerg C. Schefold, Patrick Zuercher
Summary: This article presents expert opinions on the diagnosis and management of dysphagia in ICU patients. The panel suggests adopting clinical algorithms to promote standardized and high-quality care, and proposes two clinical management algorithms to improve early detection and effective treatment of dysphagia in ICU patients.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Pawel Pasieka, Anna Surowka, Jakub Fronczek, Evan Skwara, Miroslaw Czuczwar, Michal Borys, Pawel Krawczyk, Miroslaw Zietkiewicz, Lukasz R. Nowak, Maciej Zukowski, Katarzyna Kotfis, Katarzyna Cwyl, Jacek Skowronek, Joanna Solek-Pastuszka, Jowita Biernawska, Pawel Grudzien, Pawel Nasilowski, Natalia Popek, Waldemar Cyrankiewicz, Katarzyna Sierakowska, Wojciech Mudyna, Szymon Bialka, Dorota Studzinska, Szymon Bernas, Mariusz Piechota, Waldemar Machala, Lukasz Sadowski, Jan Stefaniak, Radoslaw Owczuk, Malgorzata Szymkowiak, Ryszard Gawda, Natalia Kozera, Barbara Adamik, Waldemar Gozdzik, Agnieszka Wieczorek, Jaroslaw Janc, Anna Kluzik, Janusz Trzebicki, Pawel Zatorski, Wojciech Gola, Hubert Hymczak, Lukasz J. Krzych, Szymon Czajka, Urszula Kosciuczuk, Bartosz Kudlinski, Hans Flaatten, Wojciech Szczeklik
Summary: The study aims to evaluate whether there is an increased propensity to limit life-sustaining treatment (LST) among elderly patients in Poland from 2018-2019 compared to 2016-2017. The results show that clinicians in Poland have become more proactive in limiting LST in critically ill patients aged 80 and above during the studied period, although the prevalence of LST limitations in Poland remains low.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Jihad Mallat, Malcolm Lemyze, Marc-Olivier Fischer
Summary: In mechanically ventilated patients with acute circulatory failure, changes in PVI induced by PLR accurately predict fluid responsiveness.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Jingyuan Xu, Yanjie Zhang, Jie Jiang, Yi Yang, Fengmei Guo
Summary: This meta-analysis examined the effect of milrinone on prognosis in adult critically ill patients and found a significant decrease in the incidence of ventricular arrhythmia in patients with cardiac surgery. However, there was no significant reduction in all-cause mortality or the incidence of myocardial infarction. More research is needed to determine the reliable and conclusive evidence for the effects of milrinone.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Zhi-Tao Li, Da-Bing Huang, Jian-Feng Zhao, Hui Li, Shui-Qiao Fu, Wei Wang
Summary: Venous congestion is associated with AKI after cardiac surgery, but not necessarily with CRRT. Among the markers tested, IRVF exhibits the strongest correlation with AKI.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Sarah E. Nelson, Spyridoula Tsetsou, John Liang
Summary: This article discusses a range of issues associated with tracking CLABSI and CAUTI metrics, including lack of evidence, moral distress, and definition problems. It recommends forming a task force consisting of key stakeholders to improve the use of these metrics.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Ross Prager, Eric Walser, Kaan Y. Balta, Anton Nikouline, William R. Leeper, Kelly Vogt, Neil Parry, Robert Arntfield
Summary: Resuscitative TEE has been shown to be a valuable diagnostic tool in trauma care, with the potential to impact treatment strategies and diagnostic approaches for patients in the trauma bay.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Jaeyun Sung, Sanu S. Rajendraprasad, Kemuel L. Philbrick, Brent A. Bauer, Ognjen Gajic, Aditya Shah, Krzysztof Laudanski, Johan S. Bakken, Joseph Skalski, Lioudmila V. Karnatovskaia
Summary: With a large number of cells and genes, the human gut microbiome is crucial for health and disease. Modern living disrupts the balance between the host and its microbiome, leading to adverse impacts on critical illness and patient outcomes. Restoring the gut microbiome shows promise for preventing and treating critical illnesses.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Claire Chaignat, Laurent Lagrost, Karena Moretto, Jean-Paul Pais de Barros, Hadrien Winiszewski, Jacques Grober, Philippe Saas, Gael Piton
Summary: The aim of this study was to investigate the correlation between plasma citrulline levels and plasma lipopolysaccharide (LPS) concentration, as well as the impact of sepsis on gut function in critically ill patients. The results showed no correlation between plasma citrulline concentration and plasma LPS concentration or activity. However, septic patients had significantly lower plasma citrulline levels. Additionally, abdominal sepsis was associated with higher plasma LPS activity compared to extra-abdominal sepsis.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Pyoung Jik Lee, Thomas Hampton
Summary: This study found that smartphone applications with low-cost external microphones can reliably measure average noise levels in both laboratory and field settings, but show significant differences compared to professional equipment when measuring maximum noise levels.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Greg Roberts, James S. Krinsley, Jean-Charles Preiser, Stephen Quinn, Peter R. Rule, Michael Brownlee, Guillermo E. Umpierrez, Irl B. Hirsch
Summary: Relative hypoglycemia was commonly seen in patients with HbA1c ≥ 8% and was independently associated with mortality. Absolute hypoglycemia was associated with mortality regardless of HbA1c.
JOURNAL OF CRITICAL CARE
(2024)
Article
Critical Care Medicine
Katsura Hayakawa, Shigehiko Uchino, Hideki Endo, Kazuki Hasegawa, Kazuya Kiyota
Summary: This study assessed the performance of the APACHE III and JROD models under different conditions of missing variables and found that a higher number of missing physiological variables led to underestimated predicted mortality rates and higher standardized mortality ratios.
JOURNAL OF CRITICAL CARE
(2024)