Journal
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Volume 41, Issue 12, Pages 3200-3212Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0271678X211039598
Keywords
Cerebral ischemia; inflammation; exercise; microbiota; neuroprotection
Categories
Funding
- Center of Excellence for Aging and Brain Repair at the University of South Florida Morsani College of Medicine, Tampa, Florida, USA
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Exercise before stroke in rats improved behavior, reduced infarct size and increased cell survival, while decreasing levels of inflammatory microbiota and markers in central and peripheral organs. These findings suggest that specific inflammatory microbiota could serve as biomarkers and therapeutic targets for stroke.
Stroke remains a significant unmet need in the clinic with few therapeutic options. We, and others, have implicated the role of inflammatory microbiota in stroke secondary cell death. Elucidating this inflammation microbiome as a biomarker may improve stroke diagnosis and treatment. Here, adult Sprague-Dawley rats performed 30 minutes of exercise on a motorized treadmill for 3 consecutive days prior to transient middle cerebral artery occlusion (MCAO). Stroke animals that underwent exercise showed 1) robust behavioral improvements, 2) significantly smaller infarct sizes and increased peri-infarct cell survival and 3) decreasing trends of inflammatory microbiota BAC303, EREC482, and LAB158 coupled with significantly reduced levels of inflammatory markers ionized calcium binding adaptor molecule 1, tumor necrosis factor alpha, and mouse monoclonal MHC Class II RT1B in the brain, gut, spleen, and thymus compared to non-exercised stroke rats. These results suggest that a specific set of inflammatory microbiota exists in central and peripheral organs and can serve as a disease biomarker and a therapeutic target for stroke.
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