Article
Immunology
Siyuan Weng, Zaoqu Liu, Xiaofeng Ren, Hui Xu, Xiaoyong Ge, Yuqing Ren, Yuyuan Zhang, Qin Dang, Long Liu, Chunguang Guo, Richard Beatson, Jinhai Deng, Xinwei Han
Summary: The study identified that the SCG2 gene is closely associated with the chemotherapy response in colorectal cancer patients, with high expression predicting poorer prognosis and showing significantly higher expression in the APC non-mutation group. The SCG2 high expression subgroup is more suitable for immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yiming Ma, Lei Zhan, Jun Yang, Jingdong Zhang
Summary: SLC11A1 plays a crucial role in the tumor microenvironment of colorectal cancer and may serve as a potential biomarker for poor prognosis and immunotherapy efficacy in CRC.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Jiahao Huang, Haizhou Liu, Yang Zhao, Tao Luo, Jungang Liu, Junjie Liu, Xiaoyan Pan, Weizhong Tang
Summary: This study established a miRNA-based signature that accurately predicts TMB levels in patients with CRC, providing a potential new method for assessing response to immune checkpoint inhibitors therapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Xian-wen Guo, Rong-e Lei, Qing-nan Zhou, Guo Zhang, Bang-li Hu, Yun-xiao Liang
Summary: This study investigates the role of tumor microenvironment (TME) in colorectal cancer (CRC) by generating a TME score based on gene expression. The study finds that the TME score is associated with clinical features, prognosis, immune score, gene mutations, and response to immunotherapy in CRC patients. A TME signature is constructed using machine learning methods and validated in independent cohorts. Overall, this study provides valuable insights into TME characteristics in CRC and offers a reliable prognostic biomarker and predictive indicator for immunotherapy.
Article
Genetics & Heredity
Jiateng Zhong, Yu Qin, Pei Yu, Weiyue Xia, Baoru Gu, Xinlai Qian, Yuhan Hu, Wei Su, Zheying Zhang
Summary: Tumor-infiltrating immune cells play an important role in prognosis and immunotherapy of colorectal cancer. The CIBERSORT method was used to analyze immune cell proportions in CRC data and a prognostic model with high specificity and sensitivity was constructed.
FRONTIERS IN GENETICS
(2022)
Article
Medicine, General & Internal
Dengke Fu, Yang Chen, Dongkui Xu
Summary: The study found that circulating miR-449a levels were significantly decreased in CRC patients compared to healthy controls, and low miR-449a levels were significantly associated with CEA and CA19-9 levels as well as a lower 5-year overall survival rate. Low circulating miR-449a levels were also identified as an independent risk factor for CRC.
Article
Immunology
Qin Dang, Zaoqu Liu, Yang Liu, Wenkang Wang, Weitang Yuan, Zhenqiang Sun, Lin Liu, Chengzeng Wang
Summary: This study provides a framework for screening Notch-derived lncRNAs in colorectal cancer (CRC) and identifies clinically significant lncRNAs associated with prognosis. The NLncS model, consisting of six lncRNAs, is shown to be an independent risk factor and a robust biomarker for assessing the prognosis of CRC patients. Patients with high NLncS risk scores exhibit upregulation of immune pathways, strong immunogenicity, CD8+ T-cell infiltration, and potentially higher response rates to CTLA4 blockers, making them suitable candidates for immunotherapy. Additionally, the study identifies dasatinib as a potential agent for high-risk CRC patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Chemistry, Medicinal
Eunsun Jung, Jinhyeon Choi, Jang-Seong Kim, Tae-Su Han
Summary: Research suggests that microRNAs may influence drug response in CRC patients by regulating drug resistance-related target genes, making them potential therapeutic targets or biomarkers. However, challenges exist in the clinical application of miRNAs as biomarkers and treatment targets for CRC.
Article
Cell Biology
Meng-Ling Ye, Si-Qi Li, Yi-Xin Yin, Ke-Zhi Li, Ji-Lin Li, Bang-Li Hu
Summary: Cancer stem cells play crucial roles in colorectal cancer tumorigenesis and treatment response. This study found that the mRNA stemness index (mRNAsi) was associated with the clinical outcome in colorectal cancer (CRC) patients. A stemness-related classification based on mRNAsi scores and RNA sequence data was introduced and showed promise as a prognostic predictor for CRC patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Immunology
Siyuan Weng, Zaoqu Liu, Hui Xu, Xiaoyong Ge, Yuqing Ren, Qin Dang, Long Liu, Jian Zhang, Peng Luo, Jianzhuang Ren, Xinwei Han
Summary: In this study, we identified ALOX12 as a key gene associated with bevacizumab response in colorectal cancer through weighted gene co-expression network analysis and receiver operating characteristic curve analysis. Further research revealed that ALOX12 was closely related to prognosis, tumor proliferation, invasion, and metastasis in colorectal cancer. Additionally, high ALOX12 expression predicted higher immune infiltration and better immunotherapy response.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Jian-yu Shi, Yan-yan Bi, Bian-fang Yu, Qing-feng Wang, Dan Teng, Dong-ning Wu
Summary: The study revealed an adverse association between high-risk AS events and the density of immune cell infiltration, with high AS and TII risks predicting poor prognosis in CRC. Different AS types were correlated with distinct TII risk characteristics. Alternative splicing directly affected CD4T cell concentration, while CD8T cell levels were closely linked to specific AS events. B cells, dendritic cells, macrophages, and neutrophils were strongly correlated with AS events, indicating a clear association between tumor-associated AS and immune cell infiltration events.
FRONTIERS IN ONCOLOGY
(2021)
Article
Genetics & Heredity
Mengjia Huang, Yuqing Ye, Yi Chen, Junkai Zhu, Li Xu, Wenxuan Cheng, Xiaofan Lu, Fangrong Yan
Summary: In this study, a new prognostic signature based on sixteen inflammation-related long non-coding RNAs (lncRNAs) was constructed to improve the outcomes of patients with colorectal cancer (CRC). The results showed that the signature can serve as an effective and independent marker for predicting the survival of CRC patients, outperforming clinical variables and other published signatures.
FRONTIERS IN GENETICS
(2022)
Article
Pharmacology & Pharmacy
Chen Zhang, Tao Liu, Zhennan Yun, Bin Liang, Xue Li, Jiantao Zhang
Summary: This study analyzed alterations in angiogenesis-related genes (ARGs) in 1,214 colorectal cancer samples and correlated them with clinical features, prognosis, and the tumor microenvironment. The study developed an ARGscore prognostic model and validated gene expression using RT-qPCR. The results showed that ARGs expression was associated with prognosis and tumor microenvironment. This study provides insights for better understanding colorectal cancer, assessing prognosis, and developing more effective treatment options.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Immunology
Yufang Hou, Rixin Zhang, Jinbao Zong, Weiqi Wang, Mingxuan Zhou, Zheng Yan, Tiegang Li, Wenqiang Gan, Silin Lv, Zifan Zeng, Min Yang
Summary: In this study, a cancer-immunity cycle-based signature was developed to predict the prognosis and efficacy of immunotherapy for colorectal cancer patients. Low-risk patients showed better prognosis and stronger response to immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Genetics & Heredity
Jianxin Li, Ting Han, Xin Wang, Yinchun Wang, Xuan Chen, Wangsheng Chen, Qingqiang Yang
Summary: This study constructed an immune-related signature for predicting the immune characteristics and prognosis of colorectal cancer (CRC) using RNA-sequencing data and clinical information. By identifying immune-related genes (IRGs) associated with CRC prognosis, 10 genes were filtered out to construct a risk score signature. The high-risk score was correlated with unfavorable survival outcomes and aggressive clinicopathological characteristics. Furthermore, the low-risk group showed higher tumor-infiltrating immune cell abundances and overexpression of immune checkpoint biomarkers.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Zaoqu Liu, Hui Xu, Siyuan Weng, Chunguang Guo, Qin Dang, Yuyuan Zhang, Yuqing Ren, Long Liu, Libo Wang, Xiaoyong Ge, Zhe Xing, Jian Zhang, Peng Luo, Xinwei Han
Summary: A machine learning-based prognostic signature (MLPS) has been developed to predict the prognosis of melanoma patients, showing superior predictive performance compared to clinical traits and other collected signatures.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Cell Biology
Zeyu Wang, Ziyu Dai, Hao Zhang, Nan Zhang, Xisong Liang, Luo Peng, Jian Zhang, Zaoqu Liu, Yun Peng, Quan Cheng, Zhixiong Liu
Summary: In this study, we collected 73 GBM samples and found that the different subtypes of GBM have different prognoses. We also discovered the association between pyroptosis and tumor-microglia interaction and the tumor response to interferon-gamma. Based on pyroptosis-related genes, we grouped GBM samples into cluster 1 and cluster 2, with cluster 1 samples showing worse prognosis and a more complex immune landscape. Machine learning algorithms identified nutlin-3 as a potential treatment for cluster 1 samples.
CELL PROLIFERATION
(2023)
Article
Materials Science, Multidisciplinary
Yanan Zhao, Yiming Liu, Chuan Tian, Zaoqu Liu, Kunpeng Wu, Chengzhi Zhang, Xinwei Han
Summary: This study constructed a nanofiber material with antibacterial and pro-angiogenic effects, which can accelerate wound healing and reduce the occurrence of infection by adding nanosilvers and black phosphorus.
MATERIALS & DESIGN
(2023)
Review
Multidisciplinary Sciences
Zaoqu Liu, Na Li, Qin Dang, Long Liu, Libo Wang, Huanyun Li, Xinwei Han
Summary: Striving to optimize surgical outcomes, the Enhanced Recovery After Surgery (ERAS) pathway mitigates patients' stress through evidence-based practices before, during, and after surgery. The complex ecosystem of intestinal flora, which integrates with the host and the external environment, plays a role in regulating human metabolism and inflammation in ERAS interventions. This review provides new high-quality research support by linking gut microbes and their metabolites with ERAS interventions. ERAS can alter the composition and function of intestinal flora in patients by alleviating various perioperative stress responses.
Review
Biochemistry & Molecular Biology
Zaoqu Liu, Meixin Shi, Yuqing Ren, Hui Xu, Siyuan Weng, Wenjing Ning, Xiaoyong Ge, Long Liu, Chunguang Guo, Mengjie Duo, Lifeng Li, Jing Li, Xinwei Han
Summary: The incidence and mortality of cancer are significant global health issues. While treatments have been developed, the effectiveness of cancer therapies remains unsatisfactory. The introduction of immunotherapy has opened up new possibilities, but limitations and adverse effects need to be overcome. The use of advanced gene editing technology, especially CRISPR-Cas9, shows promise in overcoming the limitations of immunotherapy in cancer treatment.
Review
Biochemistry & Molecular Biology
Zhifei Gao, Yifeng Bai, Anqi Lin, Aimin Jiang, Chaozheng Zhou, Quan Cheng, Zaoqu Liu, Xin Chen, Jian Zhang, Peng Luo
Summary: As a nontraditional T-cell subgroup, gamma delta T cells have shown great potential in immunotherapy for tumors. Immune checkpoint inhibitors (ICIs) have become pioneer drugs in tumor immunotherapy, and studies have shown that targeting ICs can reverse the dysfunctional state of gamma delta T cells in the tumor microenvironment and enhance their antitumor effects. Understanding the functional state of gamma delta T cells and their interaction with ICs will solidify ICIs combined with gamma delta T cells as a viable treatment option.
Article
Biochemistry & Molecular Biology
Feng Zhang, Jie Gao, Xudong Liu, Yaohui Sun, Long Liu, Bowen Hu, Zhihui Wang, Jihua Shi, Wenzhi Guo, Shuijun Zhang
Summary: Abnormal cholesterol synthesis contributes to the development of hepatocellular carcinoma (HCC). The transcription factor SREBP2 is highly expressed in HCC and is associated with poor prognosis. Inhibition of SREBP2 nuclear translocation suppresses HCC cell migration and invasion via the epithelial-mesenchymal transition (EMT) process. The functional activity of LATS regulates the effects of SREBP2 in HCC.
MOLECULAR CARCINOGENESIS
(2023)
Article
Oncology
Libo Wang, Kejun Chen, Siyuan Weng, Hui Xu, Yuqing Ren, Quan Cheng, Peng Luo, Jian Zhang, Zaoqu Liu, Xinwei Han
Summary: This study investigates the role of PI3K pathway mutation in clinical prognosis prediction and its relationship with the immune microenvironment and response rate to immunotherapy in head and neck squamous cell carcinoma (HNSC) patients. The results show that PI3K pathway mutation predicts prolonged overall survival and better immunotherapy outcomes. The mutation group exhibits higher tumor mutation burden, activated immune-related pathways, and richer abundance of immune cells and immunomodulators.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Review
Cell Biology
Hong Luo, Hao Zhang, Jinning Mao, Hui Cao, Yihao Tao, Guanjian Zhao, Zhiwen Zhang, Nan Zhang, Zaoqu Liu, Jian Zhang, Peng Luo, Yuguo Xia, Yuan Cheng, Zongyi Xie, Quan Cheng, Guodong Liu
Summary: Exosomes play a crucial role in cell-to-cell communication by transporting DNA, RNA, bioactive proteins, glucose chains, and metabolites. They have great potential as targeted drug carriers, cancer vaccines, and noninvasive biomarkers. Being highly versatile, exosomes have advantages such as high drug loading capacity, adjustable drug release, enhanced permeation and retention effect, biodegradability, biocompatibility, and low toxicity. With the growing interest in exosome-based therapeutics, this review focuses on the potential use of exosomes in immunotherapy targeting tumor-associated macrophages (TAMs) in glioma, a challenging brain tumor. TAMs contribute to the immunosuppressive microenvironment and strongly influence glioma progression, making them an attractive therapeutic target. Exosomes can serve as both drug delivery vehicles and liquid biopsy biomarkers for TAMs-centered treatment. This review also summarizes recent investigations into the molecular signaling events by TAMs that promote glioma progression.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Siyuan Weng, Minghao Li, Jinhai Deng, Hui Xu, Yuqing Ren, Zhaokai Zhou, Libo Wang, Yuyuan Zhang, Zhe Xing, Lifeng Li, Zaoqu Liu, Xinwei Han
Summary: This study identified and validated four molecular subtypes of gastric cancer based on the analysis of MIRcor and METcor genes, and investigated their impact on prognosis, immune microenvironment, and potential treatment.
CLINICAL EPIGENETICS
(2023)
Article
Immunology
Zeyu Wang, Ziyu Dai, Hao Zhang, Xisong Liang, Xun Zhang, Zhipeng Wen, Peng Luo, Jian Zhang, Zaoqu Liu, Mingyu Zhang, Quan Cheng
Summary: In this study, lactate was found to contribute to the immune suppressive microenvironment in glioblastoma through RNA sequencing and machine learning algorithms. High levels of lactate can affect the migration and infiltration of CD8 T cells in glioblastoma.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Chaozheng Zhou, Shengkun Peng, Anqi Lin, Aimin Jiang, Yuanxi Peng, Tianqi Gu, Zaoqu Liu, Quan Cheng, Jian Zhang, Peng Luo
Summary: With the increasing use of immune checkpoint inhibitors (ICIs) for tumour immunotherapy, psychiatric adverse events associated with ICIs have become a significant concern. This study aims to provide a comprehensive study and summary of psychiatric adverse events associated with ICIs.
Review
Biochemistry & Molecular Biology
Zaoqu Liu, Qimeng Liang, Yuqing Ren, Chunguang Guo, Xiaoyong Ge, Libo Wang, Quan Cheng, Peng Luo, Yi Zhang, Xinwei Han
Summary: Aging is associated with immune dysfunction, chronic inflammation (inflammaging), and increased risk of age-related diseases. Senescent T cells and inflammaging are major drivers of immunosenescence. Investigating the role of immunosenescence in cancer and other age-related diseases is necessary.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
