Review
Cell Biology
Soudeh Ghafouri-Fard, Sajad Najafi, Bashdar Mahmud Hussen, Aryan R. Ganjo, Mohammad Taheri, Mohammad Samadian
Summary: Long non-coding RNAs (lncRNAs) are a heterogeneous group of ncRNAs with a characteristic size of more than 200 nucleotides. DLX6-AS1 is an lncRNA that has been found to be up-regulated in various cancers, and it promotes the oncogenic phenotype of cancer cells by affecting signaling pathways. It is associated with clinicopathological features and shorter survival in cancer patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Mohsen Sheykhhasan, Yaghoub Ahmadyousefi, Reihaneh Seyedebrahimi, Hamid Tanzadehpanah, Hamed Manoochehri, Paola Dama, Nashmin Fayazi Hosseini, Mohammad Akbari, Mohsen Eslami Farsani
Summary: Long non-coding RNAs (lncRNAs) play crucial roles in cancer development, with DLX6-AS1 acting as an oncogene in the development and prognosis of different cancers, affecting various signaling pathways. Different signaling pathways associated with this lncRNA may serve as biomarkers for cancer diagnosis or treatment targets.
EXPERT REVIEWS IN MOLECULAR MEDICINE
(2021)
Article
Endocrinology & Metabolism
Shaojian Lin, Yue Zhu, Chengcheng Ji, Weiming Yu, Cheng Zhang, Langping Tan, Miaoyun Long, Dingyuan Luo, Xinzhi Peng
Summary: This study suggests that the overexpression of METTL3 is associated with malignant behaviors in thyroid carcinoma (TC), and it promotes tumor development and metastasis by regulating the expression levels of miR-222-3p and STK4.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Cell Biology
Yijie Zhang, Qi Pan, Zigong Shao
Summary: This study identified a novel miR-202-3p/KDM3A/HOXA1/MEIS3 pathway in HCC, where miR-202-3p negatively regulated KDM3A, leading to increased expression of HOXA1 and MEIS3, and reduced viability, migration, and invasion of HCC cells. Upregulation of miR-202-3p also inhibited the growth of human HCC cells in vivo, suggesting a potential therapeutic target for HCC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Ting Sun, Linjie Tan, Mimin Liu, Li Zeng, Kaiyue Zhao, Zhongdi Cai, Shengnan Sun, Zhuorong Li, Rui Liu
Summary: This study found that Tilianin from Dracocephalum moldavica L. improves cognitive function in vascular dementia by regulating the expression of miR-193b-3p and miR-152-3p, inhibiting inflammatory signaling and apoptotic pathways.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Hong Zhang, Hong-Liang Duan, Sen Wang, Yang Liu, Guo-Nan Ding, Rui-Xin Lin
Summary: Thyroid cancer has become more prevalent in women and young adults in recent years. MicroRNAs (miRNAs) have been identified as potential epigenetic markers for thyroid cancer progression and metastasis, offering potential therapeutic targets.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Hua Hu, Meng Zhao, Zhaoyang Li, Hongli Nie, Jia He, Zhuo Chen, Jing Yuan, Huan Guo, Xiaomin Zhang, Handong Yang, Tangchun Wu, Meian He
Summary: This study explored the differentially expressed miRNAs in type 2 diabetes and their potential cellular functions. It was found that miR-193b-3p expression increased in type 2 diabetes cases while TPI1 expression decreased. miR-193b-3p may affect glucose metabolism by inhibiting insulin receptor and GLUT2 expression.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medical Laboratory Technology
Lei Dai, Weidong Zhang, Xianjiang Wu, Shuihong Zhou
Summary: Overall, miR-203a-3p inhibits the oncogenic characteristics of TPC-1 and KTC-1 cells via suppressing MAP3K1 and activating autophagy. Our findings might enrich the understanding and the therapeutic strategies of PTC.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Biochemistry & Molecular Biology
Paulina Kober, Beata Joanna Mossakowska, Natalia Rusetska, Szymon Baluszek, Emilia Grecka, Ryszard Konopinski, Ewa Matyja, Artur Ozieblo, Tomasz Mandat, Mateusz Bujko
Summary: This study reveals the involvement of MIR193B gene hypermethylation in the pathogenesis of meningiomas, leading to downregulation of two miRNAs and subsequent inhibition of meningioma cell proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Behavioral Sciences
Lin Liu, Tingting Zhou, Tao Li, Zhanhua Liang, Xiaoguang Luo
Summary: This study discusses the mechanism of lncRNA DLX6-AS1 in the inflammatory response of Parkinson's disease (PD). Through experiments with mice and BV2 microglial cells, it was found that DLX6-AS1 promotes microglial inflammation in PD through the ceRNA mechanism of miR-223-3p/NRP1.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Cell Biology
Jianjun Tan, Weilin Mao, Shuzi Long, Tao Zhang
Summary: A metastasis-related risk model was established in this study to accurately predict the prognosis of LUAD. The metastatic relevance and clinical significance of MRLNRs were validated through various in vitro experiments. The MRRS provided a promising assessing model for clinical decision making and prognosis of LUAD.
Article
Cell Biology
Dong Peng, Wenfa Li, Bojuan Zhang, Xuefen Liu
Summary: The study revealed that overexpression of SLC26A4-AS1 promoted ITPR1 expression by recruiting ETS1, thereby enhancing autophagy and mitigating the progression of PTC. These findings provide insight into potential novel targeted therapies for the clinical treatment of PTC.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Yu-Lai Feng, Ting Ke, Gao-Lei Wang, Hai-Yan Qi, Yang Xiao
Summary: microRNA-200c-3p (miR-200c-3p) has been found to be overexpressed in papillary thyroid carcinoma (PTC), and this increased expression is significantly associated with worse overall survival. Activation of miR-200c-3p promotes malignant behaviors of PTC cells, while its inactivation suppresses cell proliferation, migration, and invasion.
BIOCHEMICAL GENETICS
(2022)
Review
Pharmacology & Pharmacy
Chengyu Hu, Kai Liu, Bei Wang, Wen Xu, Yexiang Ling, Chengfu Yuan
Summary: DLX6-AS1, a newly discovered tumor-related RNA, is found to be aberrantly expressed in various cancers and has regulatory effects on the invasion, translocation, and proliferation of cancer cells. Therefore, DLX6-AS1 may serve as viable markers in tumors or potential therapeutic targets for multiple cancers.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Article
Health Care Sciences & Services
Yi Wang, Yanzhi Zou, Qingmei Zhang, Defu Chen, Lin Lin
Summary: The study found that SBF2-AS1 is highly expressed in NSCLC, while miR-520a-3p expression is decreased. SBF2-AS1 promotes the proliferation, migration, and invasion of NSCLC cells by regulating miR-520a-3p. High expression of SBF2-AS1 is associated with poor overall survival in NSCLC patients.
JOURNAL OF HEALTHCARE ENGINEERING
(2022)