Article
Peripheral Vascular Disease
Daiji Nagayama, Kentaro Fujishiro, Toru Miyoshi, Shigeo Horinaka, Kenji Suzuki, Kazuhiro Shimizu, Atsuhito Saiki, Kohji Shirai
Summary: This study compared the predictive ability of three arterial stiffness parameters (CAVI, haPWV and CAVI(0)) for renal function decline in the Japanese general population. The results showed that CAVI was the only parameter that significantly contributed to renal function decline after controlling for confounding factors.
JOURNAL OF HYPERTENSION
(2022)
Article
Biochemistry & Molecular Biology
Tsuyoshi Tabata, Shuji Sato, Ruiko Ohno, Masahiro Iwakawa, Hajime Kiyokawa, Yukihiro Morinaga, Naoaki Tanji, Toshio Kinoshita, Kazuhiro Shimizu
Summary: Hypertension can affect not only the left ventricular system but also potentially the right ventricular system, although the exact mechanisms are not fully understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Dae Joong Ma, Heesun Lee, Ji Min Choi, Hyo Eun Park, Su-Yeon Choi, Hyuk Jin Choi
Summary: This study found that retinal vessel geometry is associated with the cardio-ankle vascular index (CAVI). High CAVI values were significantly associated with narrower retinal arteriolar caliber, reduced complexity of arteriolar branching, and increased arteriolar bifurcation angle.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Peripheral Vascular Disease
Alessandro Giudici, Ashraf W. Khir, Koen D. Reesink, Tammo Delhaas, Bart Spronck
Summary: Studies indicate that CAVI(0) may enhance the pressure-independent assessment of arterial stiffness compared to CAVI, particularly in the presence of large inter-individual differences in blood pressure.
JOURNAL OF HYPERTENSION
(2021)
Article
Pharmacology & Pharmacy
Ali Riza Akyuz, Sinan Sahin, Omer Faruk Cirakoglua, Selim Kul, Turhan Turan, Hakan Erkan
Summary: This study found a significant correlation between fQRS in electrocardiogram and CAVI, and identified age and fQRS as independent determinants of increased CAVI values. The results suggest that fQRS values in electrocardiogram may provide predictive value for arterial stiffness in asymptomatic subjects.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2021)
Article
Cardiac & Cardiovascular Systems
Hyo Eun Park, Goh Eun Chung, Heesun Lee, Min Joo Kim, Su-Yeon Choi, Wonjae Lee, Ji Won Yoon
Summary: This study evaluated the relationship between low skeletal muscle mass and cardio-ankle vascular index (CAVI) and found a significant and independent association between low muscle mass and increased CAVI. This suggests that low muscle mass should be considered in assessing the risk of atherosclerosis in asymptomatic individuals.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Urology & Nephrology
Jin Seon Jeong, Jung Hee Kim, Dong Ki Kim, Kook-Hwan Oh, Kwon-Wook Joo, Yon Su Kim, Young Min Cho, Seung Seok Han
Summary: The study found that CAVI is an indicator that can predict the risk of ESRD. Higher CAVI values are associated with an increased risk of ESRD.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Medicine, General & Internal
Ting Hung, Jin-You Jhan, Jian-Hong Lin, Kun-Ta Yang, Bang-Gee Hsu, Jui-Chih Chang
Summary: This study aimed to evaluate the relationship between serum MDA-oxLDL levels and CAVI in patients with triple-vessel coronary artery disease who underwent CABG surgery. The results showed a positive correlation between MDA-oxLDL levels and CAVI levels.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Yoshinobu Nagasawa, Akira Shimoda, Hiroki Shiratori, Takenori Morishita, Kiyoshi Sakuma, Tatsuo Chiba, Xin Cao, Satoshi Kawakami, Megumi Aimoto, Chikao Miyazaki, Shuji Sato, Mao Takahashi, Kazuhiro Shimizu, Kohji Shirai, Akira Takahara
Summary: This study investigated the effects of blood volume changes on arterial stiffness and autonomic nervous activity using a rabbit model. The results showed that arterial stiffness acutely responds to changes in intra-aortic blood volume, regardless of the presence of the ganglion blocker hexamethonium.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2022)
Article
Physiology
Shuji Sato, Kazuhiro Shimizu, Mao Takahashi, Motoyuki Masai, Osamu Nagakawa, Junji Uchino, Toshihiro Suzuki, Yuka Sato, Noriko Iwai, Kohji Shirai
Summary: Blood pressure changes are frequently observed during hemodialysis (HD), but the mechanism is not fully understood. The cardio-ankle vascular index (CAVI) reflects arterial stiffness and can be independent of blood pressure. This study aimed to clarify the role of CAVI in regulating blood pressure during HD. The results showed that CAVI increased significantly during HD and correlated with water removal rate and blood pressure changes. Monitoring CAVI during HD may help distinguish the cause of blood pressure changes.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Neuroimaging
Huan Liu, Jinbo Liu, Hongwei Zhao, Hongyu Wang
Summary: The study quantified the cross-sectional association between brain white matter lesions and arterial stiffness (assessed by the cardio-ankle vascular index) in a population of 1176 adults. It was found that arterial stiffness, age, sex, systolic blood pressure, and stroke were independently associated with the presence of brain white matter lesions, suggesting the need for longitudinal studies to predict if arterial stiffness can predict such lesions.
BRAIN IMAGING AND BEHAVIOR
(2021)
Article
Peripheral Vascular Disease
Frances A. Kirkham, Charlotte Mills, Francesco Fantin, Ichiro Tatsuno, Daiji Nagayama, Anna Giani, Mauro Zamboni, Kohji Shirai, John Kennedy Cruickshank, Chakravarthi Rajkumar
Summary: This study compared arterial stiffness between European and Japanese individuals using the cardio-ankle vascular index (CAVI) and investigated how cardiovascular risk factors affect arterial aging across geographic regions. The results showed that Japanese individuals had higher arterial stiffness than Europeans, and cardiovascular risk factors had a greater impact on the Japanese group.
JOURNAL OF HYPERTENSION
(2022)
Article
Cardiac & Cardiovascular Systems
Yaoling Wang, Ruiyun Wang, Lijuan Bai, Yun Liu, Lihua Liu, Linfeng He, Benling Qi
Summary: The study suggests that MLR may be a high-risk factor for arterial stiffness, especially significant in men, with a cutoff point of MLR=0.19 being able to accurately identify arterial stiffness in all participants. The CAVI decision models showed good performance in identifying arterial stiffness with areas under the ROC curve >0.80 in both the training and validation sets.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Peripheral Vascular Disease
Patcharee Rueangjaroen, Suchaya Luewan, Arintaya Phrommintikul, Krit Leemasawat, Theera Tongsong
Summary: Increased cardio-ankle vascular index (CAVI) can be used as a predictor of preeclampsia (PE) and fetal growth restriction (FGR), along with mean arterial pressure (MAP) and uterine artery pulsatility index (Ut-PI). However, the predictive value for gestational diabetes mellitus (GDM) is lower for all three parameters.
JOURNAL OF HYPERTENSION
(2021)
Article
Medicine, General & Internal
Anna Giani, Rocco Micciolo, Elena Zoico, Gloria Mazzali, Mauro Zamboni, Francesco Fantin
Summary: CAVI and CAVI0 can describe arterial stiffness, with CAVI0 showing larger variations in the elderly population. The association between CAVI0 and diastolic blood pressure is modified by age, while the association between CAVI and diastolic blood pressure remains unchanged with age.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Peiyue Zhang, Cuiyuan Huang, Haiyin Liu, Mengting Zhang, Li Liu, Yuhong Zhai, Jing Zhang, Jian Yang, Jun Yang
Summary: NFAT is a widely expressed transcriptional activator that is involved in regulating the immune system, heart and brain development, and mediating pathological processes such as cardiac hypertrophy. Oxidative stress, characterized by excessive production of reactive oxygen species, mitochondrial dysfunction, calcium overload, and subsequent lipid peroxidation, inflammation, and apoptosis, is associated with various pathological processes. Calcium overload activates NFAT through the calcium-calcineurin pathway, which is the main regulatory mode of NFAT factors. This review focuses on the effects of NFAT transcription factors on reactive oxygen species production, calcium overload, mitochondrial dysfunction, redox reactions, lipid peroxidation, inflammation, and apoptosis in response to oxidative stress. The aim is to provide a reference for understanding the functions and characteristics of NFAT in different stages of oxidative stress and related potential targets.
JOURNAL OF CARDIOLOGY
(2024)