N-Acetylmannosamine-6-phosphate 2-epimerase uses a novel substrate-assisted mechanism to catalyze amino sugar epimerization

Mechanism of NanR gene repression and allosteric induction of bacterial sialic acid metabolism

(2021) Christopher R. Horne et al.   Nature Communications

The basis for non-canonical ROK family function in the N-acetylmannosamine kinase from the pathogen Staphylococcus aureus

(2020) David Coombes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Through the looking glass: Chiral recognition of substrates and products at the active sites of racemases and epimerases

(2020) Stephen L. Bearne   CHEMISTRY-A EUROPEAN JOURNAL

Uncovering a novel molecular mechanism for scavenging sialic acids in bacteria

(2020) Andrew Bell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quaternary variations in the structural assembly of N ‐acetylglucosamine‐6‐phosphate deacetylase from Pasteurella multocida

(2020) Lavanyaa Manjunath et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Multi-wavelength analytical ultracentrifugation as a tool to characterise protein–DNA interactions in solution

(2020) Christopher R. Horne et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Structure and Function of N-Acetylmannosamine Kinases from Pathogenic Bacteria

(2020) Thanuja Gangi Setty et al.   ACS Omega

On the structure and function of Escherichia coli YjhC: An oxidoreductase involved in bacterial sialic acid metabolism

(2019) Christopher R. Horne et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Crystal structures and kinetic analyses of N-acetylmannosamine-6-phosphate 2-epimerases from Fusobacterium nucleatum and Vibrio cholerae

(2018) Lavanyaa Manjunath et al.   Acta Crystallographica Section F-Structural Biology Communications

The Sodium Sialic Acid Symporter From Staphylococcus aureus Has Altered Substrate Specificity

(2018) Rachel A. North et al.   Frontiers in Chemistry

Functional and solution structure studies of amino sugar deacetylase and deaminase enzymes from Staphylococcus aureus

(2018) James S. Davies et al.   FEBS LETTERS

Structure and inhibition of N -acetylneuraminate lyase from methicillin-resistant Staphylococcus aureus

(2016) Rachel A. North et al.   FEBS LETTERS

Host-Derived Sialic Acids Are an Important Nutrient Source Required for Optimal Bacterial Fitness In Vivo

(2016) Nathan D. McDonald et al.   mBio

Mechanism and inhibition of human UDP-GlcNAc 2-epimerase, the key enzyme in sialic acid biosynthesis

(2016) Sheng-Chia Chen et al.   Scientific Reports

A structural classification of carbohydrate epimerases: From mechanistic insights to practical applications

(2015) Stevie Van Overtveldt et al.   BIOTECHNOLOGY ADVANCES

Structural and Functional Characterization of theClostridium perfringens N-Acetylmannosamine-6-phosphate 2-Epimerase Essential for the Sialic Acid Salvage Pathway

(2014) Marie-Cécile Pélissier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deciphering key features in protein structures with the new ENDscript server

(2014) Xavier Robert et al.   NUCLEIC ACIDS RESEARCH

Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis ofN-acetylmannosamine-6-phosphate 2-epimerase from methicillin-resistantStaphylococcus aureus

(2014) Rachel A. North et al.   Acta Crystallographica Section F-Structural Biology Communications

Sialic Acid Catabolism in Staphylococcus aureus

(2013) M. E. Olson et al.   JOURNAL OF BACTERIOLOGY

Control of the Escherichia coli Sialoregulon by Transcriptional Repressor NanR

(2013) K. A. Kalivoda et al.   JOURNAL OF BACTERIOLOGY

Structural insights into the regulation of sialic acid catabolism by the Vibrio vulnificus transcriptional repressor NanR

(2013) J. Hwang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Towards automated crystallographic structure refinement withphenix.refine

(2012) Pavel V. Afonine et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

An introduction to data reduction: space-group determination, scaling and intensity statistics

(2011) Philip R. Evans   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Improved Treatment of Ligands and Coupling Effects in Empirical Calculation and Rationalization of pKaValues

(2011) Chresten R. Søndergaard et al.   Journal of Chemical Theory and Computation

PROPKA3: Consistent Treatment of Internal and Surface Residues in Empirical pKaPredictions

(2011) Mats H. M. Olsson et al.   Journal of Chemical Theory and Computation

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

electronic Ligand Builder and Optimization Workbench(eLBOW): a tool for ligand coordinate and restraint generation

(2009) Nigel W. Moriarty et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Sialic Acid Catabolism Confers a Competitive Advantage to Pathogenic Vibrio cholerae in the Mouse Intestine

(2009) S. Almagro-Moreno et al.   INFECTION AND IMMUNITY

The Capability of Catabolic Utilization of N-Acetylneuraminic Acid, a Sialic Acid, Is Essential for Vibrio vulnificus Pathogenesis

(2009) H. G. Jeong et al.   INFECTION AND IMMUNITY

Short strong hydrogen bonds in proteins: a case study of rhamnogalacturonan acetylesterase

(2008) Annette Langkilde et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY