The deubiquitinase USP10 restores PTEN activity and inhibits non–small cell lung cancer cell proliferation

TRIM25 activates AKT/mTOR by inhibiting PTEN via K63-linked polyubiquitination in non-small cell lung cancer

(2021) Yuan-ming He et al.   ACTA PHARMACOLOGICA SINICA

USP10 Promotes Proliferation of Hepatocellular Carcinoma by Deubiquitinating and Stabilizing YAP/TAZ

(2020) Hong Zhu et al.   CANCER RESEARCH

PTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression

(2019) Mi Kyung Park et al.   Nature Communications

PTEN in Lung Cancer: Dealing with the Problem, Building on New Knowledge and Turning the Game Around

(2019) Anastasios Gkountakos et al.   Cancers

The deubiquitinase USP10 regulates KLF4 stability and suppresses lung tumorigenesis

(2019) Xingyun Wang et al.   CELL DEATH AND DIFFERENTIATION

Deubiquitinating enzyme USP10 promotes hepatocellular carcinoma metastasis through deubiquitinating and stabilizing Smad4 protein

(2019) Tao Yuan et al.   Molecular Oncology

Oncogene-induced senescence mediated by c-Myc requires USP10 dependent deubiquitination and stabilization of p14ARF

(2018) Aram Ko et al.   CELL DEATH AND DIFFERENTIATION

PTEN: Tumor Suppressor and Metabolic Regulator

(2018) Chien-Yu Chen et al.   Frontiers in Endocrinology

USP10 suppresses tumor progression by inhibiting mTOR activation in hepatocellular carcinoma

(2018) Chang Lu et al.   CANCER LETTERS

USP10 inhibits lung cancer cell growth and invasion by upregulating PTEN

(2017) Jia Sun et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Ring finger protein 6 promotes breast cancer cell proliferation by stabilizing estrogen receptor alpha

(2017) Yuanying Zeng et al.   Oncotarget

The ubiquitin ligase HERC4 mediates c-Maf ubiquitination and delays the growth of multiple myeloma xenografts in nude mice

(2016) Z. Zhang et al.   BLOOD

The Ring Finger Protein RNF6 Induces Leukemia Cell Proliferation as a Direct Target of Pre-B-cell Leukemia Homeobox 1

(2016) Xin Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of selective phosphatidylinositol 3-kinase inhibitors to treat hematological malignancies

(2015) Jingyu Zhu et al.   DRUG DISCOVERY TODAY

Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

(2015) Silvana Konermann et al.   NATURE

Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis

(2015) Lin Yuan et al.   NATURE CELL BIOLOGY

Ubiquitination of the transcription factor c-MAF is mediated by multiple lysine residues

(2014) Guodong Chen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

A novel PI3K inhibitor displays potent preclinical activity against an androgen-independent and PTEN-deficient prostate cancer model established from the cell line PC3

(2014) Min Shi et al.   TOXICOLOGY LETTERS

Deubiquitylation and stabilization of PTEN by USP13

(2013) Jinsong Zhang et al.   NATURE CELL BIOLOGY

Ataxin-3 Regulates Aggresome Formation of Copper-Zinc Superoxide Dismutase (SOD1) by Editing K63-linked Polyubiquitin Chains

(2012) Hongfeng Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane

(2012) Jian Huang et al.   Nature Communications

E3 Ubiquitin Ligase Cbl-b Regulates Pten via Nedd4 in T Cells Independently of Its Ubiquitin Ligase Activity

(2012) Hui Guo et al.   Cell Reports

Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13

(2011) Junli Liu et al.   CELL

USP10 deubiquitylates the histone variant H2A.Z and both are required for androgen receptor-mediated gene activation

(2011) Ryan Draker et al.   NUCLEIC ACIDS RESEARCH

USP10 Regulates p53 Localization and Stability by Deubiquitinating p53

(2010) Jian Yuan et al.   CELL

The Deubiquitinating Enzyme USP10 Regulates the Post-endocytic Sorting of Cystic Fibrosis Transmembrane Conductance Regulator in Airway Epithelial Cells

(2009) Jennifer M. Bomberger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Breaking the chains: structure and function of the deubiquitinases

(2009) David Komander et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The deubiquitinylation and localization of PTEN are regulated by a HAUSP–PML network

(2008) Min Sup Song et al.   NATURE