Journal
JOURNAL OF BACTERIOLOGY
Volume 204, Issue 1, Pages -Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.00341-21
Keywords
proteome; transmembrane proteins; protein evolution; small proteins
Categories
Funding
- Gray lab [R01GM139277]
- Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development in the Storz lab
- German Research Foundation [SPP2002, EXC 2051, 390713860]
- Vallee Foundation
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There has been increased recognition of the importance of small proteins, which were previously overlooked. Small proteins are stable within cells and have regulatory functions. Important questions about small proteins in bacteria and archaea are being addressed, and new identification approaches have been discussed.
In recent years, there has been increased appreciation that a whole category of proteins, small proteins of around 50 amino acids or fewer in length, has been missed by annotation as well as by genetic and biochemical assays. With the increased recognition that small proteins are stable within cells and have regulatory functions, there has been intensified study of these proteins. As a result, important questions about small proteins in bacteria and archaea are coming to the fore. Here, we give an overview of these questions, the initial answers, and the approaches needed to address these questions more fully. More detailed discussions of how small proteins can be identified by ribosome profiling and mass spectrometry approaches are provided by two accompanying reviews (N. Vazquez-Laslop, C. M. Sharma, A. S. Mankin, and A. R. Buskirk, J Bacteriol 204:e00294-21, 2022, https://dolorg/10.1128/JB.00294-21; C. H. Ahrens, J. T. Wade, M. M. Champion, and J. D. Langer, J Bacteriol 204:e00353-21, 2022, https://doi .org/10.1128/JB.00353-21) . We are excited by the prospects of new insights and possible therapeutic approaches coming from this emerging field.
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