Article
Environmental Sciences
Yujie Qin, Suli He, Haiyan Peng, Xin Ye, Hongmao Zhang, Shumao Ding
Summary: This study investigated the impact of using multiwalled carbon nanotubes as a carrier for dibutyl phthalate on fetal development and reproductive system in mice. The results showed that the combination of multiwalled carbon nanotubes and dibutyl phthalate increased fetal mortality rate and had adverse effects on the reproductive system of female and male mice.
Article
Environmental Sciences
Tan Ma, Xing Liu, Tianqing Xiong, Hongliang Li, Yue Zhou, Jingyan Liang
Summary: This study investigated the reproductive toxicity of polystyrene nanoparticles (PS-NPs) and dibutyl phthalate (DBP) in mice. Combined exposure to PS-NPs and DBP significantly increased reproductive toxicities, including decreased sperm quality, impaired spermatogenesis, and disrupted blood-testis barrier (BTB). In vitro studies revealed that the combination of DBP and PS-NPs inhibited autophagy in Sertoli cells, leading to increased expression of matrix metalloproteinases (MMPs). The findings provide innovative perspectives on the collective toxicities of PS-NPs and emerging pollutants.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Xiaomei Liu, Jingkang Ma, Saisai Guo, Qingying Shi, Jingchun Tang
Summary: The combined toxicity of nanoplastics and DBP on bacteria was studied, and it was found that the toxicity of nanoplastics decreased when combined with higher concentrations of DBP. The combination of 10 mg/L nanoplastics and 5 mg/L DBP showed the highest impact on bacteria.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Paula Pierozan, Liselott Kaellsten, Eleftheria Theodoropoulou, Radwa Almamoun, Oskar Karlsson
Summary: Increased exposure to manmade chemicals may lead to an increase in immune-related diseases and immune system dysfunction. Specifically, phthalates, which are suspected to disrupt the endocrine system, may influence the immune system. This study found that exposure to dibutyl phthalate (DBP) resulted in decreased total leukocyte count and T helper (Th) cell population, as well as increased non-classical monocyte population.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Hasan Ul Banna, Adiba Anjum, Sheta Biswas, Victor Mondal, Abu Eabrahim Siddique, Apurba Kumar Roy, Farjana Nikkon, Azizul Haque, Seiichiro Himeno, Kazi Abdus Salam, Khaled Hossain, Zahangir Alam Saud
Summary: The study found that continuous exposure to lead from fetus to adult results in more severe impacts on neurobehavioral changes and liver toxicity, including increased anxiety-like behavior, memory and learning impairments, lower BChE activity, higher lead levels in the brain, elevated serum hepatic enzyme activities, and more pronounced hepatic tissue injury compared to adult exposure only.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Reproductive Biology
Xin Ye, Tingting Zhou, Yujie Qin, Suli He, Hongmao Zhang, Shumao Ding
Summary: This study found that DBP adsorbed in MWCNTs can cause damage to the testis of male mice, leading to decreased sperm density, increased sperm deformity rate, atrophy of seminiferous tubules and increased levels of reactive oxygen species. The results also showed differential expression of proteins related to cell division and DNA replication in testicular tissue cells.
REPRODUCTIVE TOXICOLOGY
(2022)
Article
Environmental Sciences
Yan Li, Biao Yan, Yang Wu, Qi Peng, Yaolu Wei, Yenan Chen, Yuping Zhang, Ning Ma, Xu Yang, Ping Ma
Summary: This study investigated the effects and mechanisms of dibutyl phthalate (DBP) on allergic asthma in sensitized mice. It was found that DBP exacerbated allergic asthma and was associated with ferroptosis and lipid peroxidation. These findings suggest that DBP aggravates allergic asthma through ferroptosis and lipid peroxidation, providing a novel pathway for the connection between DBP and allergic asthma.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Food Science & Technology
Zohurul Islam, Jahidul Islam, Selim Reza Tony, Adiba Anjum, Rafia Ferdous, Apurba Kumar Roy, Shakhawoat Hossain, Kazi Abdus Salam, Farjana Nikkon, Khaled Hossain, Zahangir Alam Saud
Summary: Arsenic poisoning has caused a serious environmental catastrophe in Bangladesh, and this study found that mulberry leaves juice can protect against arsenic-induced neurobehavioral and hepatic dysfunctions.
FOOD SCIENCE & NUTRITION
(2022)
Article
Environmental Sciences
Tongtong Zhang, Xiang Zhou, Xu Zhang, Xiaohan Ren, Jiajin Wu, Zhongyuan Wang, Shangqian Wang, Zengjun Wang
Summary: Phthalate, an environmental endocrine disruptor, has been found to cause direct and intergenerational male reproductive damage. This study explored the effects of prenatal exposure to DBP on testicular injury and offspring gut microbiota, revealing a connection between gut dysbiosis and testicular damage in the offspring. Understanding the role of gut microbiota in reproductive function is crucial, and further research is needed to investigate the link between environmental pollution and human health.
Article
Environmental Sciences
Xiangfeng Yao, Jingwen Zhang, Can Wang, Qian Wang, Xianxu Li, Dexin Zhang, Jinhua Wang, Lusheng Zhu, Jun Wang
Summary: This study evaluated the toxic effects of dibutyl phthalate (DBP) on pakchoi (Brassica campestris L.), a typical vegetable crop. DBP exposure reduced the emergence of pakchoi and inhibited plant growth, pigmentation, and quality. DBP also induced oxidative damage, with increased reactive oxygen species levels and activation of antioxidant enzymes. Furthermore, DBP directly interacted with antioxidant enzymes at the molecular level. This study provides important information on the risk of DBP toxicity to vegetable crops.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Christina Jonander, Thomas Backhaus, Ingela Dahllof
Summary: This study investigates the toxicity of di-butyl phthalate (DBP) and sodium dodecyl sulphate (SDS), two contaminants commonly found near heavy industry, on marine zooplankton communities. The research finds that both DBP and SDS have toxic effects on zooplankton, but at concentrations higher than those measured in the environment. The study also highlights the importance of compound-specific effects on the succession of zooplankton communities.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Radwa Almamoun, Paula Pierozan, Lokeshwaran Manoharan, Oskar Karlsson
Summary: This study investigates the impact of di-n-butyl phthalate (DBP) on the gut microbiome and its correlation with immune system changes. DBP exposure significantly alters the composition of the gut microbial community, with increased abundances of Desulfovibrio and Enterorhabdus genera. Moreover, the abundance of certain microbial taxa correlates with the increase in non-classical monocytes observed in DBP-treated animals.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Keyla Rodrigues, Hemily Batista-Silva, Kieiv Resende Sousa de Moura, Glen Van Der Kraak, Fatima Regina Mena Barreto Silva
Summary: This study examined the immediate impacts of dibutyl phthalate (DBP) exposure on energy metabolism and gill histology in zebrafish. In vitro exposure to 10 μM DBP for 60 minutes resulted in altered energy supply in the gill tissue, with decreased lactate content and lactate dehydrogenase (LDH) activity. Higher DBP concentrations (100 μM and 1 mM) increased lactate content and LDH activity, blocked glucose uptake, depleted glycogen content, and caused gill injury and liver damage.
FISH PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Food Science & Technology
Yan Zhang, Yiji Wan, Xinyi Mu, Rufei Gao, Yanqing Geng, Xuemei Chen, Fangfang Li, Junlin He
Summary: This study demonstrated that maternal exposure to dibutyl phthalate (DBP) during gestation may disrupt germ-cell cyst breakdown and primordial follicle assembly in the fetal ovary, impairing female fertility in adulthood. It was also found that DBP affects folliculogenesis through inducing autophagy, which targets the NOTCH2 signaling pathway. This study highlights the potential contribution of environmental chemicals to the development of ovarian dysfunctional diseases.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Environmental Sciences
Ruoru Yang, Jianheng Zheng, Jin Qin, Shaojie Liu, Xinyuan Liu, Yiying Gu, Shuyu Yang, Jun Du, Shuguang Li, Bo Chen, Ruihua Dong
Summary: In this study, the effects of DBP on insulin synthesis and secretion were investigated using an in vitro culture system of rat insulinoma (INS-1) cells. The results showed that DBP significantly decreased insulin synthesis and secretion in INS-1 cells, and caused apoptosis and mitochondrial dysfunction through the mitochondrial apoptotic pathway and oxidative stress. These findings suggest that interference with these two pathways could be considered in the development of preventive protection measures.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Neurosciences
Sanaz Nasoohi, Leila Simani, Fariba Khodagholi, Sara Nikseresht, Mehrdad Faizi, Nima Naderi
NUTRITIONAL NEUROSCIENCE
(2019)
Article
Neurosciences
Mona Khoramjouy, Nima Naderi, Farzad Kobarfard, Elmira Heidarli, Mehrdad Faizi
Summary: Chronic oral exposure to acrolein can lead to neurobehavioral and electrophysiological disturbances, as well as impair learning and memory. There is a direct correlation between acrolein concentration and neurotoxicity.
NEUROTOXICITY RESEARCH
(2021)
Article
Cell Biology
Soheil Ghassemi, Tara Asgari, Hadi Mirzapour-Delavar, Shayan Aliakbari, Hamid Gholami Pourbadie, Christophe Prehaud, Monique Lafon, Alireza Gholami, Kayhan Azadmanesh, Nima Naderi, Mohammad Sayyah
Summary: The study demonstrates that the rabies virus glycoprotein (RVG) affects synaptic function in the hippocampal dentate gyrus of rats, facilitating both short- and long-term synaptic plasticity by potentially involving both pre- and postsynaptic mechanisms to alter synaptic function. Further research is needed to elucidate the underlying mechanisms.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sepideh Khaksar, Mona Salimi, Hadi Zeinoddini, Nima Naderi
Summary: This research investigated the involvement of CB1 and TRPV1 receptors in the protective effects of anandamide in epilepsy. The results showed that anandamide decreased seizure scores, while the TRPV1 and CB1 antagonists had no effect on seizure scores. Co-administration of the antagonists attenuated the protective effect of anandamide. Furthermore, anandamide led to a decrease in the expressions of CREB and p-CREB in hippocampal neurons.
NEUROCHEMICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Azadeh Nasiri, Shaya Mokhtari, Bahram Daraei, Hassan Yazdanpanah, Mehrdad Faizi, Farzad Kobarfard
Summary: Aldehydes are widely used in organic synthesis due to their high reactivity, but caution is needed in medicinal chemistry to avoid undesired reactions with nucleophiles in biological media. Research on spiramycin reveals its transformation in aqueous solution, leading to inaccurate monitoring results based on mass spectrometry methods.
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Zeynab Khosrowpour, Shirin Fahimi, Mehrdad Faizi, Zahra Shaaban, Mojgan Tansaz, Shamim Sahranavard
Summary: This study formulated a herbal syrup based on Iranian traditional medicine and evaluated its effect on a rat model of polycystic ovary syndrome (PCOS). The results showed that the herbal syrup improved hormone levels and restored ovarian morphology in the rats. This syrup could be a potential treatment option for PCOS, deserving further clinical trials.
JUNDISHAPUR JOURNAL OF NATURAL PHARMACEUTICAL PRODUCTS
(2022)
Article
Geriatrics & Gerontology
Fatemeh Sayehmiri, Fariba Khodagholi, Hamid Gholami Pourbadie, Nima Naderi, Faezeh Aliakbarzadeh, Reza Hashemi, Soudabeh Naderi, Fereshteh Motamedi
Summary: This study suggests that succinyl phosphonate (SP) may be a promising therapeutic approach for improving memory impairment in Alzheimer's disease (AD), especially in the early stages. The experimental results show that SP enhances task learning, alleviates the negative effects of Aβ treatment on spatial learning and memory, and reverses the effects of Aβ on key enzyme activities.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Pharmacology & Pharmacy
Reza Jahani, Saskia van Ruth, Yannick Weesepoel, Martin Alewijn, Farzad Kobarfard, Mehrdad Faizi, Mohammad Hossain Shojaee AliAbadi, Arash Mahboubi, Azadeh Nasiri, Hassan Yazdanpanah
Summary: This study demonstrates the feasibility of using NIRS technology in combination with chemometrics methods for fast detection of citric acid-adulterated lime juices. The promising results of portable SW-NIRS combined with SIMCA suggest its potential as a screening tool for on-site analysis of lime juices at various stages of the food supply chain.
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Mona Khoramjouy, Maryam Bayanati, Shokoofe Noori, Mehrdad Faizi, Afshin Zarghi
Summary: This study demonstrates that oral administration of Ziziphus jujuba and Boswellia serrata extracts can slow the progression of osteoarthritis through their anti-nociceptive and anti-inflammatory properties.
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH
(2022)
Article
Plant Sciences
Arezoo Mirahmad, Salar Hafez Ghoran, Pouya Alipour, Fatemeh Taktaz, Sohail Hassan, Moslem Naderian, Asma Moradalipour, Mehrdad Faizi, Farzad Kobarfard, Seyed Abdulmajid Ayatollahi
Summary: This study aimed to investigate the biological screening and chemical components of Oliveria decumbens Vent., a medicinal plant traditionally used for healing inflammation, gastrointestinal disorders, and infections. The results showed that O. decumbens possesses various bioactivities and antibacterial, anti-inflammatory, and insecticidal properties.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Mahshid Daryab, Mehrdad Faizi, Arash Mahboubi, Reza Aboofazeli
Summary: This study developed microemulsion-based gels for transdermal delivery of lidocaine and evaluated their potential for local anesthesia. The results showed that the developed gels had greater potential for lidocaine transdermal delivery and were superior to the commercially available gel product.
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH
(2022)
Article
Biology
Elham Rezaee, Fatemeh Ahmadi, Mahsa Shabaninia, Mona Khoramjouy, Zahra Azizi Farsani, Soraya Shahhosseini, Sayyed Abbas Tabatabai, Mehrdad Faizi
Summary: A series of new benzodiazepine receptor agonist compounds were designed and evaluated for their affinity to the benzodiazepine receptor. The results demonstrated that the affinities of most of the compounds were even higher than diazepam. Compound 6a exhibited good hypnotic activity and weak anticonvulsant and anxiolytic effects.
Article
Pharmacology & Pharmacy
Reza Jahani, Faraz Mojab, Arash Mahboubi, Azadeh Nasiri, Armin Tahamtani, Mehrdad Faizi
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH
(2019)
Article
Pharmacology & Pharmacy
Fatemch Zangeneh, Amir Vazirizadeh, Mohammad Reza Mirshamsi, Amir Fakhri, Mehrdad Faizi, Jalal Pourahmad
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH
(2019)
