Article
Physiology
David Langton, Peter B. Noble, Graham M. Donovan
Summary: Bronchial thermoplasty (BT) is a treatment for moderate-to-severe asthma that can improve quality of life scores without significant changes in lung function. A study using CT scans found that after BT treatment, airways dilated by an average of 6.4%, with a greater response observed in more distal airways.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Allergy
Lei Fang, Junling Li, Eleni Papakonstantinou, Meropi Karakioulaki, Qingzhu Sun, Desiree Schumann, Michael Tamm, Daiana Stolz, Michael Roth
Summary: The study found that bronchial thermoplasty significantly increased the expression of HSP70 and HSP90, playing a role in controlling airway remodeling. For epithelial cells, HSP70 and HSP90 improved their function, while inhibiting ASMC remodeling.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Xuan Li, Shuan-Shuan Xie, Guo-Shu Li, Jie Zeng, Hong-Xia Duan, Chang-Hui Wang
Summary: This study compared the effects of bronchial thermoplasty (BT) and cryoballoon ablation (CBA) therapy on airway smooth muscle (ASM) and found that CBA therapy can effectively ablate ASM with a similar effect to BT but a shorter onset time. Additionally, both BT and CBA therapies involve neural mechanisms.
CHINESE MEDICAL JOURNAL
(2021)
Article
Critical Care Medicine
Annika W. M. Goorsenberg, Julia N. S. D'Hooghe, Karthikan Srikanthan, Nick H. T. Ten Hacken, Els J. M. Weersink, Joris J. T. H. Roelofs, Samuel Kemp, Elisabeth H. Bel, Pallav L. Shah, Jouke T. Annema, Peter Bonta
Summary: The study shows that bronchial thermoplasty can significantly reduce airway smooth muscle mass and treatment response is associated with serum IgE and eosinophil levels, rather than baseline ASM mass.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Cell Biology
Ping Lu, Mai K. ElMallah, Zeyu Liu, Chan Wu, Jun Chen, Lawrence M. Lifshitz, Ronghua ZhuGe
Summary: Bitter taste receptors are found throughout the body and induce biological responses to bitter tastants; Tas2r TKO mice do not require bitter taste receptors for bitter tastant-induced bronchodilation.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Respiratory System
Yuto Yasuda, Lu Wang, Pasquale Chitano, Chun Y. Seow
Summary: Although the effects of deep inspiration (DI) on bronchodilation and bronchoprotection have been observed in healthy individuals, these effects are not seen in individuals with asthma. The relaxation of airway smooth muscle (ASM) is believed to be one of the factors responsible for these effects, along with other factors such as the release or redistribution of pulmonary surfactant, alteration in mucus plugs, and changes in airway heterogeneity. Recent ex vivo sheep lung experiments have shown that DI can cause a significant change in airway diameter, leading to a decrease in ASM contractility. This reduction in ASM contractility may explain the bronchodilatory and bronchoprotective effects of DI.
RESPIRATORY RESEARCH
(2023)
Article
Physiology
David C. Adams, Jasmin A. Holz, Margit Szabari, Lida P. Hariri, Andrew F. Mccrossan, Christopher J. Manley, Sean Fleury, Seamus O'Shaughnessy, Jason Weiner, Melissa J. Suter
Summary: The study demonstrates the use of endoscopic OR-OCT to accurately measure changes to ASM structure following BT. The results show how this technology could play an important role in asthma treatments targeting ASM.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Allergy
Pieta C. Wijsman, Annika W. M. Goorsenberg, Abilash Ravi, Julia N. S. d'Hooghe, Barbara S. Dierdorp, Tamara Dekker, Charlotte C. L. M. van Schaik, Nick H. T. ten Hacken, Pallav L. Shah, Els J. M. Weersink, Elisabeth H. Bel, Jouke T. Annema, Rene Lutter, Peter Bonta
Summary: This study investigates the effects of bronchial thermoplasty (BT) on airway inflammation and treatment response in severe asthma patients. The results show that BT leads to downregulation of genes related to airway inflammation in treated airways. Furthermore, differences in baseline gene expression and eosinophil counts were identified between responders and non-responders.
JOURNAL OF ASTHMA AND ALLERGY
(2022)
Article
Allergy
Yu-Long Luo, Yan-Qiuzi Cheng, Zi-Qing Zhou, Ming-Yue Fan, Di-Fei Chen, Yu Chen, Xiao-Bo Chen, Chang-Hao Zhong, Chun-Li Tang, Shi-Yue Li, Zhu-Quan Su
Summary: Bronchial thermoplasty (BT) can significantly reduce nerves in small airways, but its effect on smooth muscle is not significant.
ALLERGOLOGY INTERNATIONAL
(2022)
Article
Allergy
Satoshi Ano, Norihiro Kikuchi, Masashi Matsuyama, Masayuki Nakajima, Yuzuru Kondo, Michiko Masuda, Hajime Osawa, Yukio Ishii, Nobuyuki Hizawa
Summary: By analyzing RNA samples from bronchial tissues, possible transcriptomic changes were identified that could be used to identify BT responders.
Article
Cardiac & Cardiovascular Systems
Ahmet Baydur, Richard Barbers, Darren May
Summary: Bronchial thermoplasty (BT) reduces bronchoconstriction and symptoms in severe asthmatics, but has little effect on spirometric variables. This study evaluated the changes in lung compliance and resistance before and after BT using the esophageal balloon technique. The results showed improvement in symptoms and variations in dynamic lung compliance and resistance among patients.
RESPIRATORY MEDICINE
(2023)
Article
Cell Biology
Ryan M. Carey, Benjamin M. Hariri, Nithin D. Adappa, James N. Palmer, Robert J. Lee
Summary: Bitter taste receptors (T2Rs) play important roles in ciliated airway epithelial cells and macrophages by activating endothelial nitric oxide (NO) synthase (eNOS) to release NO, enhancing respiratory innate immunity. Heat shock protein 90 (HSP90) serves as a crucial regulator in this process.
Article
Biochemistry & Molecular Biology
Mercedes Alfonso-Prieto
Summary: This article showcases the research achievements of Dr. Mercedes Alfonso-Prieto from Forschungszentrum Julich in the field of chemical sensing, focusing on the molecular modeling methods and research progress of taste and smell receptors.
JOURNAL OF MEMBRANE BIOLOGY
(2021)
Article
Respiratory System
Sarah Svenningsen, Parameswaran Nair, Rachel L. Eddy, Marrissa J. McIntosh, Melanie Kjarsgaard, Hui Fang Lim, David G. McCormack, Gerard Cox, Grace Parraga
Summary: Patient-specific localisation of ventilation defects using hyperpolarised gas MRI can guide bronchial thermoplasty (BT) for severe asthma, reducing the number of radiofrequency activations and improving asthma quality of life and control scores at 12 months with non-inferiority to standard BT.
Letter
Infectious Diseases
B. Bouazza, I. Ramdani, R. Chahed
Summary: COVID-19, a global public health emergency caused by the new coronavirus SARSCoV-2, has led to the repurposing of drugs such as Chloroquine for treatment. Chloroquine, known as a bitter taste receptor agonist, has been reported to relax the airways and may play a role in preventing disease severity in COVID-19 patients with asthma.
NEW MICROBES AND NEW INFECTIONS
(2021)
