Article
Nutrition & Dietetics
Nisar Fatima, Fareeha Anwar, Uzma Saleem, Aslam Khan, Bashir Ahmad, Irum Shahzadi, Hammad Ahmad, Tariq Ismail
Summary: The methanolic extract of Brugmansia aurea has potential antidiabetic activity, increasing insulin sensitivity and reducing insulin resistance in diabetic rats. It also lowers blood glucose levels and improves glucose tolerance.
FRONTIERS IN NUTRITION
(2022)
Review
Endocrinology & Metabolism
Maria J. Gonzalez-Rellan, Marcos F. Fondevila, Carlos Dieguez, Ruben Nogueiras
Summary: O-GlcNAcylation, governed by the activity of OGT and OGA enzymes, plays a crucial role in regulating systemic glucose homeostasis. Dysregulation of blood glucose levels can lead to the development of metabolic syndrome and type 2 diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Miguel Vazquez-Moreno, Marian Sandoval-Castillo, Maria Judith Rios-Lugo, Miguel Klunder-Klunder, Miguel Cruz, Israel Martinez-Navarro, Elizabeth Teresita Romero-Guzman, Claudia Ines Victoria-Campos, Jenny Vilchis-Gil, Hector Hernandez-Mendoza
Summary: This study analyzed the association between overweight and obesity status in Mexican schoolchildren and serum copper levels. The results showed that overweight and obese children had higher serum copper levels compared to normal weight children. However, there was no significant association between cardiometabolic traits and serum copper levels.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Review
Cell Biology
Vincenza Frisardi, Carmela Matrone, Maria Elisabeth Street
Summary: Metabolic syndrome is influenced by genetic, environmental, and lifestyle factors, with defects in the autophagy machinery playing a role in its dysfunction; there is a mutual regulation between autophagy and MetS, with the HMGB1 protein playing a key role in this interaction.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Neyla S. Al Akl, Olfa Khalifa, Khaoula Errafii, Abdelilah Arredouani
Summary: The study found a significant association between elevated serum ferritin levels and metabolic disorders such as dyslipidemia, diabetes, insulin resistance, and metabolic syndrome. These associations were more pronounced in women, with a greater impact on dyslipidemia, diabetes, and insulin resistance. Elevated serum ferritin levels were identified as a potential risk biomarker for these metabolic abnormalities in Qatari adults.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Robert Hauffe, Michaela Rath, Mareike Schell, Katrin Ritter, Kai Kappert, Stefanie Deubel, Christiane Ott, Markus Jaehnert, Wenke Jonas, Annette Schuermann, Andre Kleinridders
Summary: The reduction of HSP60 in mice primarily affects adipose tissue homeostasis, leading to beneficial alterations in body weight, body composition, and adipocyte morphology, albeit exhibiting local insulin resistance.
MOLECULAR METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Danize Aparecida Rizzetti, Patricia Corrales, Jose Antonio Uranga-Ocio, Gema Medina-Gomez, Franck Maciel Pecanha, Dalton Valentim Vassallo, Marta Miguel, Giulia Alessandra Wiggers
Summary: The study found that egg white hydrolysate (EWH) can prevent and treat lipid and glycemic metabolism disruption induced by mercury exposure. EWH intake improves antioxidant defenses, inhibits apoptotic pathways, and normalizes the gene expression levels of PPARs and adiponectin.
Article
Environmental Sciences
Yacong Bo, Yongjian Zhu
Summary: This study found that the OPEs compound DMTP might be associated with impaired glucose homeostasis and may increase the prevalence of T2D in U.S. adults.
Article
Nutrition & Dietetics
Cherlyn Ding, Leonie Egli, Nabil Bosco, Lijuan Sun, Hui Jen Goh, Khung Keong Yeo, Jonathan Jiunn Liang Yap, Lucas Actis-Goretta, Melvin Khee-Shing Leow, Faidon Magkos
Summary: The study found that plasma BCAA levels were associated with increased insulin secretion and decreased insulin clearance in healthy Chinese subjects. This suggests that BCAA may play an important role in the regulation of glucose homeostasis.
FRONTIERS IN NUTRITION
(2021)
Article
Medicine, Research & Experimental
Jinxin Liu, Chenzhipeng Nie, Lamei Xue, Ying Yan, Shengnan Liu, Juan Sun, Mingcong Fan, Haifeng Qian, Hao Ying, Li Wang, Yan Li
Summary: The study found that hepatic GHR overexpression was elevated during metabolic disorder, disrupting systemic glucose homeostasis and impairing systemic insulin action. Additionally, hepatic GHR overexpression promoted the circulating levels of RBP4, contributing to impaired systemic insulin action.
Review
Biochemistry & Molecular Biology
Stephanie N. Alu, Evan A. Los, George A. Ford, William L. Stone
Summary: Considerable evidence supports the role of oxidative stress in adult type 2 diabetes (T2D), and this will also affect more and more children. Understanding the factors contributing to oxidative stress and T2D risk may help develop optimal early intervention strategies. The combination of systems medicine and redoxomics holds promise in optimizing future healthcare strategies for T2D patients.
Article
Biochemistry & Molecular Biology
Christopher M. Schaupp, Dianne Botta, Collin C. White, David K. Scoville, Sengkeo Srinouanprachanh, Theo K. Bammler, James MacDonald, Terrance J. Kavanagh
Summary: Antioxidant signaling is a crucial cellular defense pathway, and its importance in aging has been well-documented. This study investigated the effect of aging on the favorable phenotypes observed in young Gclm null mice, including increased antioxidant activity and improved glucose homeostasis. The results showed that these phenotypes persisted into old age and were associated with transcriptional activation of the Nrf2, AMPK, and PPAR gamma pathways.
Review
Endocrinology & Metabolism
Auxiliare Kuretu, Charles Arineitwe, Mamosheledi Mothibe, Phikelelani Ngubane, Andile Khathi, Ntethelelo Sibiya
Summary: Mitochondrial impairment is associated with the development of insulin resistance. Improving mitochondrial function may provide a therapeutic tool for improving insulin sensitivity. Further studies are needed to understand the correlation between drug-induced mitochondrial toxicity and insulin resistance.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xiao Han, Yang Yang, Sujuan Liu, Yanmei Niu, Heng Shao, Li Fu
Summary: Skeletal muscle insulin resistance is closely linked to hyperglycemia and metabolic disorders. Regular exercise can enhance insulin sensitivity in skeletal muscle, and this study aimed to explore the underlying mechanisms. The results showed that SESN3 plays a crucial role in amplifying the beneficial effects of exercise on insulin sensitivity in skeletal muscle and systemic glucose levels. The SESN3/mTORC2/AKT pathway mediated the effects of exercise on skeletal muscle insulin sensitivity.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Endocrinology & Metabolism
Ism Cakir, Colleen K. Hadley, Pauline Lining Pan, Rushita A. Bagchi, Masoud Ghamari-Langroudi, Danielle T. Porter, Qiuyu Wang, Michael J. Litt, Somnath Jana, Susan Hagen, Pil Lee, Andrew White, Jiandie D. Lin, Timothy A. McKinsey, Roger D. Cone
Summary: Inhibiting the cytosolic enzyme histone deacetylase 6 (HDAC6) in the periphery can improve leptin sensitivity and metabolic outcomes in diet-induced obese mice. HDAC6 inhibitors reduce food intake, fat mass, hepatic steatosis, and improve glucose homeostasis in an HDAC6-dependent manner. The effect is mediated by peripheral, but not central, inhibition of HDAC6. Additionally, the anti-obesity effect of HDAC6 inhibitors is attenuated in animals with defective central leptin-melanocortin circuitry.
Article
Engineering, Biomedical
Mona Navaei-Nigjeh, Soheyl Mirzababaei, Mohammad Adel Ghiass, Kaveh Roshanbinfar, Mahdi Gholami, Mohammad Abdollahi
Summary: Islet-laden fibers generated with microfluidic technology can protect pancreatic islet cells from the immune response. Adding mesenchymal stromal cells (MSCs) improves cell function and suppresses the immune response in diabetic rats, leading to better treatment outcomes.
Review
Pharmacology & Pharmacy
Taraneh Mousavi, Shekoufeh Nikfar, Mohammad Abdollahi
Summary: With the rise in aging population and chronic diseases, the use and abuse of opioids have increased worldwide, leading to an increase in opioid-related adverse events, specifically opioid-induced bowel dysfunction. This calls for a rational clinical management strategy.
EXPERT OPINION ON PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Mahban Rahimifard, Maryam Baeeri, Taraneh Mousavi, Asaad Azarnezhad, Hamed Haghi-Aminjan, Mohammad Abdollahi
Summary: Gastric cancer is a medical dilemma with a high economic and global burden. Conventional chemotherapy regimens containing cisplatin have limited effectiveness and cause adverse drug reactions. This study tested the biological efficacy of the cisplatin-resveratrol combination.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Analytical
Mahmood Alizadeh Sani, Gholamreza Jahed-Khaniki, Ali Ehsani, Nabi Shariatifar, Mohammad Hadi Dehghani, Mohammad Hashemi, Hedayat Hosseini, Mohammad Abdollahi, Shokoufeh Hassani, Zahra Bayrami, David Julian McClements
Summary: A simple, label-free, and ultra-sensitive fluorescent platform based on a metal-organic framework (MOF) was developed to detect melamine in milk powder. The fluorescence sensor was fabricated from sensitized terbium (Tb)@NH2-MIL-253 (Al) MOF using a hydrothermal method. It showed high accuracy, sensitivity, and reproducibility compared to the high-performance liquid chromatography (HPLC) method. The sensor had a linear range and lower limit of detection (LLOD) much lower than the maximum residual level (MRL) for melamine detection in infant formula and other foods/feeds.
Article
Neurosciences
Javad Amini, Naser Sanchooli, Mohammad-Hossein Milajerdi, Maryam Baeeri, Mohammad Haddadi, Nima Sanadgol
Summary: This study aimed to investigate the effects of tauopathy on normal brain aging. The results showed that tauopathy caused defects in eye morphology, a decrease in motor function, a decline in olfactory memory performance, and an increase in ethanol sensitivity. Additionally, tauopathy increased cell stress and oxidative stress, as well as affecting autophagy. Overall, tauopathy accelerated brain aging, with redox signaling and autophagy playing important roles.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2023)
Article
Engineering, Environmental
Farzaneh Kefayati, Atoosa Karimi Babaahmadi, Taraneh Mousavi, Mahshid Hodjat, Mohammad Abdollahi
Summary: Environmental toxicants can regulate gene expression through epigenetic mechanisms. This article discusses the impact of three epigenetic modifications on seven important categories of diseases and the influence of eleven main environmental factors on epigenetic modifications. These epigenetic-related mechanisms play a crucial role in the development of common diseases, aiding in diagnosis and treatment, as well as predicting transgenerational and intergenerational effects. However, more well-designed research is needed to determine the precise role of environmentally-induced epigenetic alterations in disease etiology.
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING
(2023)
Article
Toxicology
Marzieh Daniali, Mona Navaei-Nigjeh, Maryam Baeeri, Soheyl Mirzababaei, Mahdi Gholami, Mahban Rahimifard, Mohammad Abdollahi
Summary: In this study, the protective effects of Levosimendan (LEVO) on pancreatic islets exposed to sodium arsenite (NaAsO2) were investigated. The results showed that LEVO improved the viability and functionality of pancreatic islets and modulated oxidative stress and inflammatory biomarkers.
Review
Toxicology
Sara Mostafalou, Mohammad Abdollahi
Summary: This article reviews the role of organophosphorus (OP) compounds in the development of neurological disorders and explores how genetic variations can affect susceptibility to OP pesticide neurotoxicity. It discusses the various neurological disorders associated with OP compound exposure and the pathological mechanisms involved. Specific genetic polymorphisms have been found to increase the risk of developing OP-related neurological disorders.
ARCHIVES OF TOXICOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Shilan Mozaffari, Taraneh Mousavi, Shekoufeh Nikfar, Mohammad Abdollahi
Summary: Polypharmacy is common among elderly patients and can lead to severe drug interactions, posing significant challenges to healthcare providers. Understanding the underlying mechanisms of these interactions and designing personalized treatment plans is crucial.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2023)
Review
Toxicology
Nader Rahimi Kakavandi, Taraneh Mousavi, Tayebeh Asadi, Ayda Moradi, Mahta Esmaeili, Ahmad Habibian Sezavar, Shekoufeh Nikfar, Mohammad Abdollahi
Summary: This study conducted a systematic review and dose-response meta-analysis on the association between arsenic exposure and the risk of type 2 diabetes. The results showed that arsenic in drinking water and urine were significantly associated with the risk of type 2 diabetes.
TOXICOLOGY LETTERS
(2023)
Review
Endocrinology & Metabolism
Marzieh Daniali, Shekoufeh Nikfar, Mohammad Abdollahi
Summary: This study compares diabetes management between pediatric and adult patients and identifies treatment challenges and gaps. Research shows children have lower insulin sensitivity, clearance, and beta cell function than adults. Personalized and precise approaches are crucial in managing diabetes in pediatrics, and more research is necessary to assess the safety and efficacy of different antidiabetic drugs and improve diabetes treatment for children and adolescents.
EXPERT REVIEW OF ENDOCRINOLOGY & METABOLISM
(2023)
Article
Psychiatry
Ali Amirkafi, Faezeh Mohammadi, Arash Tehrani-Banihashemi, Maziar Moradi-Lakeh, Christopher J. L. Murray, Mohsen Naghavi, Ali H. Mokdad
Summary: The study investigates drug use disorders as a significant contributor to Disability Adjusted Life Years (DALYs) in the Eastern Mediterranean Region (EMR). The findings reveal a significant increase in the prevalence of drug use disorders since 1990, with opioid use being the most prevalent disorder. United Arab Emirates, Libya, and Iran are among the countries most affected by drug use disorders in the region.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2023)
Article
Chemistry, Applied
Maryam Keykhaee, Mahban Rahimifard, Alireza Najafi, Maryam Baeeri, Mohammad Abdollahi, Fatemeh Mottaghitalab, Mehdi Farokhi, Mehdi Khoobi
Summary: The study proposes a novel approach using a multifunctional hydrogel to manage diabetic foot ulcers (DFUs). The hydrogel, made from a combination of alginate and gum arabic, is enhanced with nerve growth factor (NGF) immobilized in specially designed mesoporous silica nanoparticles (MSN). The hydrogel shows sustained release of NGF and significantly improves wound healing. The hydrogel also reduces inflammation, increases angiogenesis, and improves tissue pathology. This newly developed composite system holds promise as a potential treatment for non-healing diabetic wounds.
CARBOHYDRATE POLYMERS
(2023)