Article
Immunology
Yan Ma, Xiaomeng He, Yang Di, Shanshan Liu, Qilin Zhan, Zhihui Bai, Tianyi Qiu, Christopher Corpe, Jin Wang
Summary: The study constructed a novel immune-related prognostic risk model for pancreatic cancer (PaCa) using long noncoding RNAs (lncRNAs) and evaluated the prognostic prediction of these lncRNAs. The results identified four IRlncRNA signatures that may serve as predictors of survival and potential biomarkers for the immune response in PaCa.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Genetics & Heredity
Xiao Guan, Na Lu, Jianping Zhang
Summary: This study assessed the prognostic value of copper-dependent genes, copper-dependent-related genes, and copper-dependent-associated immune-infiltrating cells in pancreatic cancer. Prognostic models were developed and survival-related factors were identified. The results showed that the predictive models had good predictive performance.
FRONTIERS IN GENETICS
(2022)
Article
Endocrinology & Metabolism
Huijun Du, Yumei Tang, Xiaoying Ren, Fan Zhang, Wei Yang, Le Cheng, Yunan Gao
Summary: A prognostic model based on the expression of ferroptosis-related genes was constructed, showing good predictive performance. The mechanism of ferroptosis in cervical cancer was identified, and potential therapeutic targets were revealed.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Genetics & Heredity
Shiyu Zhang, Huiying Yang, Xuelian Xiang, Li Liu, Huali Huang, Guodu Tang
Summary: This study confirmed the correlation between high BGN expression in gastric cancer and poor survival outcomes, highlighting the important role of BGN in tumor initiation and metastasis, making it a potential biomarker for the diagnosis and treatment of gastric cancer.
FRONTIERS IN GENETICS
(2022)
Article
Cell Biology
Gangping Tu, Wenzhe Gao, Ying Li, Yating Dian, Bingyang Xue, Li Niu, Xiao Yu, Hongwei Zhu
Summary: S100A16, highly expressed in pancreatic cancer tissues, might be associated with poor prognosis. By analyzing gene expression differences, clinical characteristics, and establishing a risk score system, the study successfully predicted the survival time of patients with PDAC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Yalu Zhang, Qiaofei Liu, Ming Cui, Mengyi Wang, Surong Hua, Junyi Gao, Quan Liao
Summary: A study found that six FBXOs were upregulated in pancreatic ductal adenocarcinoma (PDAC) and associated with adverse prognosis and clinicopathological features. The expression of these FBXOs was influenced by promoter methylation levels and genetic alterations, and they were involved in ubiquitination-related pathways and other important signaling pathways. Therefore, these six FBXOs may serve as potential targets for diagnosis and treatment of PDAC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Zhijian Huang, Jiasheng Yang, Wenjing Qiu, Jing Huang, Zhirong Chen, Yuanyuan Han, Changsheng Ye
Summary: HAUS5 expression is associated with prognosis in breast cancer, with upregulation correlated with poor clinicopathological characteristics, signaling pathways, immune cell infiltration, and tumor cell stemness.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Xiao Yang, Xingchen Li, Yuan Cheng, Jingyi Zhou, Boqiang Shen, Lijun Zhao, Jianliu Wang
Summary: This study developed a glycolysis-related prognostic signature for endometrial cancer and found its association with immune function. Patients in the high-risk group had worse prognosis, lower immune and ESTIMATE scores, and immune cell imbalance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Dan Tao, Ying Wang, Xin Zhang, Can Wang, Dingyi Yang, Jing Chen, Yanyan Long, Yong Jiang, Xian Zhou, Ningning Zhang
Summary: This study aimed to explore the prognostic value of angiogenesis-related genes (ARGs) and their association with immune cell infiltration (ICI) in breast cancer (BC). The study identified differentially expressed ARGs and developed a prognostic model for predicting BC patient survival. The results showed that the risk score model had good accuracy in determining BC patient survival and significant correlations were found between prognostic biomarkers and different immune cell types.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Immunology
Qi Wang, Zhangzuo Li, Shujing Zhou, Zhengrui Li, Xufeng Huang, Yiwei He, Yuhan Zhang, Xiaoxian Zhao, Yidan Tang, Min Xu
Summary: Recently, the role of NCAPG2 as an essential participant in the process of chromosome cohesion and stabilization in mitosis has been highlighted, particularly in certain tumors. However, there is a lack of detailed studies exploring its potential functions in pan-cancer. In this study, the potential functions of NCAPG2 in pan-cancer were comprehensively elucidated, and it was found to be overexpressed in almost every tumor and showed significant prognostic and diagnostic efficacy. Additionally, the correlation between NCAPG2 and immune features suggests its potential application in guiding immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Chunhui Liu, Yue Gao, Jiaxuan Ni, Saisai Chen, Qiang Hu, Can Wang, Mingjin Hu, Ming Chen
Summary: This study found that high expression of long non-coding RNA HAGLR in breast cancer is positively associated with clinical pathological characteristics, prognosis, and the expression of tumor-related genes. HAGLR overexpression can promote the malignant tumor characteristics of breast cancer by upregulating the expression of proteins related to cell proliferation, invasion, and metastasis.
Article
Oncology
Chuan Lan, Haoyou Tang, Sheng Liu, Lin Ma, Jianshui Li, Xi Wang, Yifu Hou
Summary: This study revealed that CAPN1, 2, 5, 8, and 10 were highly expressed in pancreatic cancer, and their expression levels were correlated with cancer stage and patient survival. Functional enrichment analysis indicated that these CAPNs are involved in various biological processes relevant to cancer progression. These results suggest that CAPN1, 2, 5, 8, and 10 could serve as prognostic biomarkers in pancreatic cancer.
JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2021)
Article
Immunology
Sihui Yu, Xi Li, Jiawen Zhang, Sufang Wu
Summary: A predictive model based on immune infiltration-related gene signature was proposed to predict the prognosis of cervical cancer patients and depict the immune landscape. Analysis of 28 immune cell types identified four immune cell types conducive to patient survival and confirmed their shared differentially expressed genes. The Immunoscore based on four immune-related genes could effectively predict the survival outcome, tumor infiltration status, and immunotherapy efficacy of cervical cancer patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Jie Li, Tian Yu, Juan Sun, Ziyang Zeng, Zhen Liu, Mingwei Ma, Zicheng Zheng, Yixuan He, Weiming Kang
Summary: This study provides insights into the functions of CRIGs in gastric cancer and establishes a robust cuproptosis-related immune biomarker signature to accurately forecast the long-term survival of gastric cancer patients.
Article
Oncology
Taoufik Nedjadi, Mohamed Eldigire Ahmed, Hifzur R. Ansari, Sihem Aouabdi, Jaudah Al-Maghrabi
Summary: This study aimed to investigate the expression profile, clinical significance, prognostic value, and relationship with immune infiltration of SPP1 in bladder cancer. The results showed that SPP1 is differentially expressed at an early stage of bladder cancer development and is associated with an unfavorable prognosis. The interaction between SPP1 and other proteins/genes and immune cell infiltrates may play an important role in the pathogenesis of bladder cancer and could serve as a potential therapeutic target.