Design, synthesis and biological evaluation of dual HDAC and VEGFR inhibitors as multitargeted anticancer agents

Epigenetic Therapies for Cancer

(2020) Susan E. Bates   NEW ENGLAND JOURNAL OF MEDICINE

Lysine Acetylation Goes Global: From Epigenetics to Metabolism and Therapeutics

(2018) Ibraheem Ali et al.   CHEMICAL REVIEWS

Discovery of Novel Pazopanib-Based HDAC and VEGFR Dual Inhibitors Targeting Cancer Epigenetics and Angiogenesis Simultaneously

(2018) Jie Zang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Quantitative phosphoproteomic analysis of acquired cancer drug resistance to pazopanib and dasatinib

(2018) Simon Vyse et al.   Journal of Proteomics

Inhibiting Histone Deacetylase as a Means to Reverse Resistance to Angiogenesis Inhibitors: Phase I Study of Abexinostat Plus Pazopanib in Advanced Solid Tumor Malignancies

(2017) Rahul Aggarwal et al.   JOURNAL OF CLINICAL ONCOLOGY

The Search for Potent, Small-Molecule HDACIs in Cancer Treatment: A Decade After Vorinostat

(2017) Chiara Zagni et al.   MEDICINAL RESEARCH REVIEWS

Chemical and structural biology of protein lysine deacetylases

(2017) Minoru YOSHIDA et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

The HDAC inhibitor AR42 interacts with pazopanib to kill trametinib/dabrafenib-resistant melanoma cells in vitro and in vivo

(2017) Laurence Booth et al.   Oncotarget

Development of Allosteric Hydrazide-Containing Class I Histone Deacetylase Inhibitors for Use in Acute Myeloid Leukemia

(2016) Jesse J. McClure et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cabozantinib versus Everolimus in Advanced Renal-Cell Carcinoma

(2015) Toni K. Choueiri et al.   NEW ENGLAND JOURNAL OF MEDICINE

FDA-approved small-molecule kinase inhibitors

(2015) Peng Wu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Pazopanib and HDAC inhibitors interact to kill sarcoma cells

(2014) Seyedmehrad Tavallai et al.   CANCER BIOLOGY & THERAPY

Belinostat and panobinostat (HDACI): in vitro and in vivo studies in thyroid cancer

(2013) Daniel Chan et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Vascular Endothelial Growth Factor (VEGF) Receptors: Drugs and New Inhibitors

(2012) Francesca Musumeci et al.   JOURNAL OF MEDICINAL CHEMISTRY