Phase 1 dose escalation study of seribantumab (MM-121), an anti-HER3 monoclonal antibody, in patients with advanced solid tumors

The Anti-HER3 mAb Seribantumab Effectively Inhibits Growth of Patient-Derived and Isogenic Cell Line and Xenograft Models with Oncogenic NRG1 Fusions

(2021) Igor Odintsov et al.   CLINICAL CANCER RESEARCH

NRG1 fusion-driven cancers: A systematic literature review and meta-analysis.

(2020) Viktoriya Stalbovskaya et al.   JOURNAL OF CLINICAL ONCOLOGY

NRG1 fusion-driven tumors: biology, detection and the therapeutic role of afatinib and other ErbB-targeting agents

(2020) J. Laskin et al.   ANNALS OF ONCOLOGY

Detection of NRG1 Gene Fusions in Solid Tumors

(2019) Sushma Jonna et al.   CLINICAL CANCER RESEARCH

NRG1 gene fusions are recurrent, clinically actionable gene rearrangements in KRAS wild-type pancreatic ductal adenocarcinoma

(2019) Martin R Jones et al.   CLINICAL CANCER RESEARCH

Detection of NRG1 Fusions in Solid Tumors: Rare Gold?

(2019) Anastasios Dimou et al.   CLINICAL CANCER RESEARCH

Response to ERBB3-Directed Targeted Therapy in NRG1 -Rearranged Cancers

(2018) Alexander Drilon et al.   Cancer Discovery

Understanding the biology of HER3 receptor as a therapeutic target in human cancer

(2018) Hui Lyu et al.   Acta Pharmaceutica Sinica B

Current and Future Molecular Testing in NSCLC, What Can We Expect from New Sequencing Technologies?

(2018) Simon Garinet et al.   Journal of Clinical Medicine

Phase Ib Study of Safety and Pharmacokinetics of the PI3K Inhibitor SAR245408 with the HER3-Neutralizing Human Antibody SAR256212 in Patients with Solid Tumors

(2016) Vandana G. Abramson et al.   CLINICAL CANCER RESEARCH

Randomized Phase II Trial of Seribantumab in Combination With Paclitaxel in Patients With Advanced Platinum-Resistant or -Refractory Ovarian Cancer

(2016) Joyce F. Liu et al.   JOURNAL OF CLINICAL ONCOLOGY

Oncogenic function and clinical implications of SLC3A2-NRG1 fusion in invasive mucinous adenocarcinoma of the lung

(2016) Dong Hoon Shin et al.   Oncotarget

ERBB Receptors: From Oncogene Discovery to Basic Science to Mechanism-Based Cancer Therapeutics

(2014) Carlos L. Arteaga et al.   CANCER CELL

Molecular Pathways: Targeting NRG1 Fusions in Lung Cancer

(2014) L. Fernandez-Cuesta et al.   CLINICAL CANCER RESEARCH

CD74-NRG1 Fusions in Lung Adenocarcinoma

(2014) L. Fernandez-Cuesta et al.   Cancer Discovery

Toward the Prognostic Significance and Therapeutic Potential of HER3 Receptor Tyrosine Kinase in Human Colon Cancer

(2011) A. Beji et al.   CLINICAL CANCER RESEARCH

A Central Role for HER3 in HER2-Amplified Breast Cancer: Implications for Targeted Therapy

(2008) S. T. Lee-Hoeflich et al.   CANCER RESEARCH