Journal
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
Volume 71, Issue 17, Pages 1334-1344Publisher
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2021.1962877
Keywords
Polycaprolactone; maltodextrin; aspirin; drug delivery; electrospinning; skin tissue regeneration
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The study prepared aspirin-loaded PCL and MD composite nanofibers through electrospinning technique, and experimental results showed potential application of these composite nanofibers in promoting skin tissue regeneration.
In the present study, to advance the skin tissue regeneration process, aspirin (AS)-loaded polycaprolactone (PCL) and maltodextrin (MD) composite nanofiber was prepared via electrospinning technique. The results showed that the composite had more uniform nanofibers and the mean diameter of the nanofibers was reduced from 186 to 96 nm experimentally with increasing AS percentages. Biological evaluations proved that L929 fibroblast cells on the PCL/MD with 2% AS had better cell adhesion and proliferation. The overall results introduce that 2% AS incorporated in the PCL/MD electrospun nanofibers can be applied as a promising candidate for further studies toward skin tissue regeneration.
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