Bupropion Inhibits Oxidant Status and Inflammation in Ethanol-Induced Chronic Gastritis in Rats

Background and Objective: Chronic gastritis, today, is a significant disorder amongst chronic gastritis digestive system diseases manifesting itself as anorexia and stomach ache. Despite it is known that dopamine antagonists induce ulcers and dopamine agonists to help to treat ulcers the protective effects of bupropion on ethanol-induced gastritis were not clarified completely. This study was conducted to assess the potential protective activity of bupropion on ethanol-induced chronic gastritis. Materials and Methods: Chronic gastritis model was established by administering 56% ethanol to rats for four weeks. Bupropion (30 and 60 mg kg(-1)) was orally administered for seven days to assess the healing effect. Results: At the end of the study, the changes in biochemical, histopathologic and proinflammatory cytokines showed that bupropion healed ethanol-induced gastritis. Conclusion: The study findings showed that bupropion suppressed lipid peroxidation and inflammatory response, on the other hand, relieves chronic gastritis effectively by increasing activation of the antioxidant system.

Automated summary

Bupropion has a protective effect on ethanol-induced chronic gastritis, promoting healing and suppressing inflammatory response. The study findings suggest that bupropion can effectively alleviate gastritis symptoms and enhance the activity of the antioxidant system.