Review
Multidisciplinary Sciences
Abhishek Patel, Mohammad Taufik
Summary: This paper presents the developments in extrusion-based 3D printing, addressing issues in filament and pellet-based printing. It suggests the development of a hybrid 3D printer to improve the material domain and utilize the advantages of both filament and pellet extrusion.
ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING
(2022)
Article
Engineering, Chemical
Vishal Mishra, Ch Kapil Ror, Sushant Negi, Simanchal Kar, Lakshi Nandan Borah
Summary: The utilization of waste plastic through extrusion-based additive manufacturing is investigated as a means to address environmental concerns. A mixed feedstock processing approach is used to develop sustainable three-dimensional printing filaments from recycled ABS blended with virgin ABS. The rheological and thermo-mechanical properties of the extruded filaments are examined, revealing the potential for the novel filament to replace commercially available ABS filaments in fabricating high-quality plastic parts.
POLYMER ENGINEERING AND SCIENCE
(2023)
Review
Engineering, Manufacturing
Jose Luis Perez-Castillo, Enrique Cuan-Urquizo, Armando Roman-Flores, Oscar Olvera-Silva, Victor Romero-Munoz, Alfonso Gomez-Espinosa, Rafiq Ahmad
Summary: This paper provides an overview of the state-of-the-art in curved layered fused filament fabrication (CLFFF), covering topics such as upgrading FFF machines, slicing algorithms, and mechanical property characterization. Additionally, potential future research directions and the application of CLFFF in lattice metamaterial fabrication are discussed, along with concluding remarks and recommendations for the use of CLFFF.
ADDITIVE MANUFACTURING
(2021)
Article
Engineering, Manufacturing
Joaquim Manoel Justino Netto, Amir Ilkiu Sarout, Andre Luiz Grando Santos, Alessandra de Almeida Lucas, Marcelo Aparecido Chinelatto, Jorge Lino Alves, Antonio Gaspar-Cunha, Jose Antonio Covas, Zilda de Castro Silveira
Summary: This paper presents the design and validation of an innovative 3D printer with a co-rotating twin screw extrusion unit, which offers improved mixing capacity and process flexibility. The feasibility of the design was verified through numerical calculations and extrusion tests, and successful printing of various samples was achieved.
ADDITIVE MANUFACTURING
(2022)
Article
Pharmacology & Pharmacy
Chloe Parulski, Eva Gresse, Olivier Jennotte, Alexandre Felten, Eric Ziemons, Anna Lechanteur, Brigitte Evrard
Summary: This study aims to enhance the dissolution rate of poorly soluble drugs using hot-melt extrusion coupled with fused deposition modeling. The results demonstrated that solid oral forms containing challenging drugs can be successfully prepared using hot-melt extrusion and 3D printing. The amorphous state of the drug showed improved dissolution rate, and the rate was influenced by the infill density and polymer composition of the printed forms.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Automation & Control Systems
Joaquim Manoel Justino Netto, Henrique Takashi Idogava, Luiz Eduardo Frezzatto Santos, Zilda de Castro Silveira, Pedro Romio, Jorge Lino Alves
Summary: This paper presents a systematic review on screw-assisted extrusion additive manufacturing (EAM), highlighting its importance in expanding 3D printing material range, reducing costs, and increasing material deposition rate. By identifying 61 articles describing various equipment, categorized into experimental and commercial systems, this review offers insights into the design diversity and potential research opportunities in the field.
INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Vineet R. Kulkarni, Jaidev Chakka, Faez Alkadi, Mohammed Maniruzzaman
Summary: 3D printing of pharmaceuticals aims to create personalized medication for patients on demand. The study resolves the printing lag time and manual interventions in the current FDM-based processes by using the dynamic z-axis to continuously print drug-loaded printlets.
Article
Engineering, Multidisciplinary
Chengjin Wang, Lei Zhang, Yongcong Fang, Wei Sun
Summary: In this study, a screw extrusion-based 3D printing system was developed for stent fabrication and testing. The results showed the potential of this system for customizable stent fabrication.
Review
Engineering, Manufacturing
Yanzhou Fu, Austin Downey, Lang Yuan, Avery Pratt, Yunusa Balogun
Summary: This paper presents a summary of research on real-time monitoring of additive manufacturing processes to ensure product quality and improve printing efficiency. It discusses different methods, devices, and achievements in monitoring systems for 3D printing, as well as sensor types and devices used for monitoring printer health state and printing process product quality. The review concludes with a discussion of current and future research directions in this field.
ADDITIVE MANUFACTURING
(2021)
Article
Engineering, Manufacturing
Callie E. Zawaski, Camden A. Chatham, Emily M. Wilts, Timothy E. Long, Christopher B. Williams
Summary: The study indicates that the print quality of semi-crystalline polymers in FFF is influenced by their crystallization behavior and viscosity. By altering the divalent counter-ions in semi-crystalline polymers, it is possible to improve the material's stability in the molten state and reduce layer warping during printing.
ADDITIVE MANUFACTURING
(2021)
Article
Materials Science, Ceramics
Qinglong He, Jie Jiang, Xianfeng Yang, Li Zhang, Zhe Zhou, Yuan Zhong, Zhijian Shen
Summary: A fused deposition modeling (FDM) system using screw extrusion for feeding granular feedstocks with high solid loading was developed. By optimizing key parameters and determining a processing window, constant extruded mass flow and wire diameter were achieved, leading to successful preparation of zirconia ceramic parts with complex geometries and controlled dimensional accuracy, demonstrating the potential of the technique.
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
(2021)
Article
Engineering, Manufacturing
Janez Slapnik, Irena Pulko, Rebeka Rudolf, Ivan Anzel, Mihael Bruncko
Summary: The study developed a new filament for bonded magnets based on thermoplastic polyurethane (TPU), which showed better magnetic performances and processability compared to a filament based on polyamide 12 (PA12). However, the PA12-based bonded magnets exhibited higher flexural modulus and stiffness at elevated temperatures. The study also found that the best magnetic properties were achieved with TPU filled with 92 wt% of Nd-Fe-B particles.
ADDITIVE MANUFACTURING
(2021)
Review
Materials Science, Multidisciplinary
Yubo Tao, Fangong Kong, Zelong Li, Jingfa Zhang, Xin Zhao, Qing Yin, Dan Xing, Peng Li
Summary: Fused filament fabrication (FFF), also known as fused deposition modeling (FDMTM), has gained considerable attention for its versatility, reliability, and affordability, but faces challenges in fabricating durable, performing, and functional parts. The presence of voids leads to weak mechanical properties in FFF-printed parts, highlighting the importance of understanding the challenges presented by void formation.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2021)
Review
Pharmacology & Pharmacy
Suresh Bandari, Dinesh Nyavanandi, Nagireddy Dumpa, Michael A. Repka
Summary: Interest in 3D printing for pharmaceutical applications has been on the rise, with HME-based FDM 3D printing being extensively investigated for patient-focused dosage. By investigating crucial pharmaceutical polymers, formulation and process parameters, HME-coupled FDM 3D printing can be established to pave the way for developing continuous drug delivery systems for personalized therapy.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Polymer Science
Rafael Guerra Silva, Maria Josefina Torres, Jorge Zahr Vinuela, Aristides Gonzalez Zamora
Summary: By utilizing fused filament fabrication technology, it is possible to produce 3D miniature polymer lattice structures with complex topologies, even though there may be some difficulties and restrictions in the production process.
Article
Pharmacology & Pharmacy
G. Verstraete, A. Samaro, W. Grymonpre, V. Vanhoorne, B. Van Snick, M. N. Boone, T. Hellemans, L. Van Hoorebeke, J. P. Remon, C. Vervaet
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2018)
Article
Pharmacology & Pharmacy
A. Samaro, P. Janssens, V. Vanhoorne, J. Van Renterghem, M. Eeckhout, L. Cardon, T. De Beer, C. Vervaet
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2020)
Article
Chemistry, Physical
Bahaa Shaqour, Ines Reigada, Zaneta Gorecka, Emilia Choinska, Bart Verleije, Koen Beyers, Wojciech Swieszkowski, Adyary Fallarero, Paul Cos
Review
Pharmacology & Pharmacy
Bahaa Shaqour, Aseel Samaro, Bart Verleije, Koen Beyers, Chris Vervaet, Paul Cos
Review
Automation & Control Systems
Bahaa Shaqour, Mohammad Abuabiah, Salameh Abdel-Fattah, Adel Juaidi, Ramez Abdallah, Waleed Abuzaina, Mohammad Qarout, Bart Verleije, Paul Cos
Summary: Fused filament fabrication 3D printing technology shows great potential but the processability of materials may be a limiting factor. Recent research has focused on optimizing the process to ensure product quality and properties.
INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
S. Henry, A. Samaro, F. H. Marchesini, B. Shaqour, J. Macedo, V. Vanhoorne, C. Vervaet
Summary: Extrusion-based 3D printing is being utilized for personalized medicine production in the medical field, but further research is needed to fully understand the interplay between material properties, process parameters, and printer-dependent variables for optimal printing behavior. This study characterizes various polymers and polymer-drug blends to determine their mechanical, thermal, and rheological properties, and links these properties to the quality of the end-product. Insights gained from this research will aid in accelerating pharmaceutical formulation development for 3D printed medications.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Bahaa Shaqour, Juliana Aizawa, Clara Guarch-Perez, Zaneta Gorecka, Lars Christophersen, Wim Martinet, Emilia Choinska, Martijn Riool, Bart Verleije, Koen Beyers, Claus Moser, Wojciech Swieszkowski, Sebastian A. J. Zaat, Paul Cos
Summary: Additive manufacturing technology has been widely utilized for producing highly complex structures and tools, such as the extrusion nozzle designed by the researchers. This technology has shown promising results in hot melt extrusion of drug-loaded tubes. The study focused on investigating the loading of ciprofloxacin within the TPU polymeric matrix and the physicochemical properties of the produced tubes.
Article
Engineering, Manufacturing
Bahaa Shaqour, Zaneta Gorecka, Agnieszka Chmielewska, Bartlomiej Wysocki, Marcin Heljak, Maarten Gernaey, Bart Verleije, Koen Beyers, Chris Vervaet, Emilia Choinska, Wojciech Swiezkowski, Paul Cos
Summary: This study proposes a method for designing and manufacturing a nozzle that can be fitted onto a 3D printer, enabling the production of scaffolds with hollow fibers. Numerical simulations and experimental analyses were conducted to study the melt flow behavior within the nozzle. This approach can be used to produce scaffolds that best suit the intended application.
ADDITIVE MANUFACTURING
(2022)
Article
Multidisciplinary Sciences
Augusto Vazquez-Rodriguez, Bahaa Shaqour, Clara Guarch-Perez, Emilia Choinska, Martijn Riool, Bart Verleije, Koen Beyers, Vivian J. A. Costantini, Wojciech Swieszkowski, Sebastian A. J. Zaat, Paul Cos, Antonio Felici, Livia Ferrari
Summary: In this study, drug-eluting antibacterial catheters were developed to prevent catheter-related infections. The catheters released niclosamide in a sustained manner and exhibited antibacterial activity against Staphylococcus aureus and Staphylococcus epidermidis. The efficacy of the catheters in preventing implant colonization and reducing bacterial colonization of peri-catheter tissue was validated in an in vivo biomaterial-associated infection mouse model.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Clara Guarch-Perez, Bahaa Shaqour, Martijn Riool, Bart Verleije, Koen Beyers, Chris Vervaet, Paul Cos, Sebastian A. J. Zaat
Summary: A bone fixation plate coating made of a composite material consisting of poly-epsilon-caprolactone, hydroxyapatite, and halloysite nanotubes, loaded with gentamicin sulphate, was successfully developed using fused filament fabrication 3D printing technology. The composite exhibited excellent mechanical and thermal properties. In vitro release kinetics showed sustained release of bactericidal concentrations of gentamicin sulphate. In both ex vivo and in vivo mouse models, the composite demonstrated complete antimicrobial killing and prevention of infection, respectively. The ability to use 3D printing technology for personalized implants was also highlighted.
Review
Chemistry, Physical
Mohammad Abuabiah, Natago Guile Mbodj, Bahaa Shaqour, Luqman Herzallah, Adel Juaidi, Ramez Abdallah, Peter Plapper
Summary: Laser Wire-Feed Metal Additive Manufacturing (LWAM) is a process that uses a laser to heat and melt a metallic alloy wire, which is then placed on a substrate or previous layer to create a three-dimensional metal part. LWAM technology offers advantages such as speed, cost effectiveness, precision control, and the ability to create complex geometries with improved metallurgical properties. However, it is still in the early stages of development and integration into the industry.
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)