Overcoming thickened pathological skin in psoriasis via iontophoresis combined with tight junction-opening peptide AT1002 for intradermal delivery of NF-κB decoy oligodeoxynucleotide

Characteristics of unique endocytosis induced by weak current for cytoplasmic drug delivery

(2020) Tasuku Torao et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Noninvasive transdermal delivery of liposomes by weak electric current

(2020) Mahadi Hasan et al.   ADVANCED DRUG DELIVERY REVIEWS

Non-invasive delivery of biological macromolecular drugs into the skin by iontophoresis and its application to psoriasis treatment

(2020) Tatsuya Fukuta et al.   JOURNAL OF CONTROLLED RELEASE

Topical delivery of siRNA into skin using ionic liquids

(2020) Vimisha Dharamdasani et al.   JOURNAL OF CONTROLLED RELEASE

Treatment of psoriasis with NFKBIZ siRNA using topical ionic liquid formulations

(2020) Abhirup Mandal et al.   Science Advances

Low systemic exposure and calcemic effect of calcipotriol/betamethasone ointment in rats with imiquimod-induced psoriasis-like dermatitis

(2018) Kyosuke Satake et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Differential expression of tumor-associated genes and altered gut microbiome with decreased Akkermansia muciniphila confer a tumor-preventive microenvironment in intestinal epithelial Pten-deficient mice

(2018) Cody Howe et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Non-invasive delivery strategies for biologics

(2018) Aaron C. Anselmo et al.   NATURE REVIEWS DRUG DISCOVERY

Psoriasis pathogenesis and the development of novel targeted immune therapies

(2017) Jason E. Hawkes et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Biologics in patients with skin diseases

(2017) Mylène S. Veilleux et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A self-adherent, bullet-shaped microneedle patch for controlled transdermal delivery of insulin

(2017) Keum-Yong Seong et al.   JOURNAL OF CONTROLLED RELEASE

Activation of Langerhans cells promotes the inflammation in imiquimod-induced psoriasis-like dermatitis

(2017) Chunying Xiao et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

An Optimized Method for Extracting Bacterial RNA from Mouse Skin Tissue Colonized by Mycobacterium ulcerans

(2017) Marie Robbe-Saule et al.   Frontiers in Microbiology

Faint electric treatment-induced rapid and efficient delivery of extraneous hydrophilic molecules into the cytoplasm

(2016) Mahadi Hasan et al.   JOURNAL OF CONTROLLED RELEASE

The novel functional nucleic acid iRed effectively regulates target genes following cytoplasmic delivery by faint electric treatment

(2016) Mahadi Hasan et al.   SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS

Anti-cancer vaccination by transdermal delivery of antigen peptide-loaded nanogels via iontophoresis

(2015) Mao Toyoda et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Economic Burden of Psoriasis in the United States

(2015) Elizabeth A. Brezinski et al.   JAMA Dermatology

Electric Stimulus Opens Intercellular Spaces in Skin

(2013) Susumu Hama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NF-κB: An essential transcription factor in psoriasis

(2012) A.M. Goldminz et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Development of an Efficient Transdermal Delivery System of Small Interfering RNA Using Functional Peptides, Tat and AT-1002

(2011) Tamae Uchida et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Noninvasive and efficient transdermal delivery of CpG-oligodeoxynucleotide for cancer immunotherapy

(2011) Kaoru Kigasawa et al.   JOURNAL OF CONTROLLED RELEASE

Therapeutic Effects on Atopic Dermatitis by Anti-RelA Short Interfering RNA Combined with Functional Peptides Tat and AT1002

(2011) T. Uchida et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The active Zot domain (aa 288–293) increases ZO-1 and myosin 1C serine/threonine phosphorylation, alters interaction between ZO-1 and its binding partners, and induces tight junction disassembly through proteinase activated receptor 2 activation

(2010) Simeon E. Goldblum et al.   FASEB JOURNAL

Potential use of iontophoresis for transdermal delivery of NF-κB decoy oligonucleotides

(2010) Irhan Ibrahim Abu Hashim et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Noninvasive and persistent transfollicular drug delivery system using a combination of liposomes and iontophoresis

(2010) Kazuaki Kajimoto et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Alteration of Tight Junction Proteins Is an Early Event in Psoriasis

(2009) Nina Kirschner et al.   AMERICAN JOURNAL OF PATHOLOGY

Noninvasive delivery of siRNA into the epidermis by iontophoresis using an atopic dermatitis-like model rat

(2009) K. Kigasawa et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Interplay between keratinocytes and immune cells—Recent insights into psoriasis pathogenesis

(2008) Giulia Tonel et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Transdermal drug delivery

(2008) Mark R Prausnitz et al.   NATURE BIOTECHNOLOGY

Two-Minute Skin Anesthesia Through Ultrasound Pretreatment and Iontophoretic Delivery of a Topical Anesthetic: A Feasibility Study

(2008) Egilius L. H. Spierings et al.   PAIN MEDICINE

Enhanced nasal absorption of hydrophilic markers after dosing with AT1002, a tight junction modulator

(2007) Keon-Hyoung Song et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Effect of the six-mer synthetic peptide (AT1002) fragment of zonula occludens toxin on the intestinal absorption of cyclosporin A

(2007) K SONG et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS