Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 15, Pages -Publisher
MDPI
DOI: 10.3390/ijms22157787
Keywords
bladder cancer treatment; curcumin; sulforaphane; resveratrol; quercetin; 6-gingerol; delphinidin; epigallocatechin-3-gallate; gossypol
Funding
- Academia Sinica
- Ministry of Science and Technology, Taiwan
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Bladder cancer is the second most common genitourinary cancer, with high recurrence risk. Natural substances such as curcumin and sulforaphane may play an important role in the treatment of bladder cancer.
Bladder cancer (BC) is the second most common genitourinary cancer. In 2018, 550,000 people in the world were diagnosed with BC, and the number of new cases continues to rise. BC is also characterized by high recurrence risk, despite therapies. Although in the last few years, the range of BC therapy has considerably widened, it is associated with severe side effects and the development of drug resistance, which is hampering treatment success. Thus, patients are increasingly choosing products of natural origin as an alternative or complementary therapeutic options. Therefore, in this article, we aim to elucidate, using the available literature, the role of natural substances such as curcumin, sulforaphane, resveratrol, quercetin, 6-gingerol, delphinidin, epigallocatechin-3-gallate and gossypol in the BC treatment. Numerous clinical and preclinical studies point to their role in the modulation of the signaling pathways, such as cell proliferation, cell survival, apoptosis and cell death.
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