The PFKFB3 Inhibitor AZ67 Inhibits Angiogenesis Independently of Glycolysis Inhibition

Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model

(2020) Ayesha Singh et al.   Scientific Reports

Small molecule 3PO inhibits glycolysis but does not bind to 6‐phosphofructo‐2‐kinase/fructose‐2,6‐bisphosphatase‐3 (PFKFB3)

(2020) Besa Emini Veseli et al.   FEBS LETTERS

PFKFB3-mediated endothelial glycolysis promotes pulmonary hypertension

(2019) Yapeng Cao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting PFKFB3 alleviates cerebral ischemia-reperfusion injury in mice

(2019) Olga Burmistrova et al.   Scientific Reports

6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 and 4: A pair of valves for fine-tuning of glucose metabolism in human cancer

(2018) Mei Yi et al.   Molecular Metabolism

TGF-β1 targets Smad, p38 MAPK, and PI3K/Akt signaling pathways to induce PFKFB3 gene expression and glycolysis in glioblastoma cells

(2017) Ana Rodríguez-García et al.   FEBS Journal

Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy

(2016) Anna Rita Cantelmo et al.   CANCER CELL

In Vivo Study of Human Endothelial-Pericyte Interaction Using the Matrix Gel Plug Assay in Mouse

(2016) Ke Yuan et al.   Jove-Journal of Visualized Experiments

Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase PFKFB3

(2015) Scott Boyd et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting the Warburg Effect in cancer; relationships for 2-arylpyridazinones as inhibitors of the key glycolytic enzyme 6-phosphofructo-2-kinase/2,6-bisphosphatase 3 (PFKFB3)

(2014) Darby G. Brooke et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Antiangiogenesis Strategies Revisited: From Starving Tumors to Alleviating Hypoxia

(2014) Rakesh K. Jain   CANCER CELL

An introduction to the wound healing assay using live-cell microscopy

(2014) James E. N. Jonkman et al.   Cell Adhesion & Migration

PFKFB3 activation in cancer cells by the p38/MK2 pathway in response to stress stimuli

(2013) Laura Novellasdemunt et al.   BIOCHEMICAL JOURNAL

Role of PFKFB3-Driven Glycolysis in Vessel Sprouting

(2013) Katrien De Bock et al.   CELL

Role of Endothelial Cell Metabolism in Vessel Sprouting

(2013) Katrien De Bock et al.   Cell Metabolism

Partial and Transient Reduction of Glycolysis by PFKFB3 Blockade Reduces Pathological Angiogenesis

(2013) Sandra Schoors et al.   Cell Metabolism

Targeting 6-Phosphofructo-2-Kinase (PFKFB3) as a Therapeutic Strategy against Cancer

(2013) B. F. Clem et al.   MOLECULAR CANCER THERAPEUTICS

Matrigel plug assay: evaluation of the angiogenic response by reverse transcription-quantitative PCR

(2012) Daniela Coltrini et al.   ANGIOGENESIS

Intussusceptive Angiogenesis: A Biologically Relevant Form of Angiogenesis

(2012) Ward De Spiegelaere et al.   JOURNAL OF VASCULAR RESEARCH

Basic and Therapeutic Aspects of Angiogenesis

(2011) Michael Potente et al.   CELL

The role of pericytes in angiogenesis

(2011) Domenico Ribatti et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting

(2010) Lars Jakobsson et al.   NATURE CELL BIOLOGY

Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization

(2009) Massimiliano Mazzone et al.   CELL

Nrarp Coordinates Endothelial Notch and Wnt Signaling to Control Vessel Density in Angiogenesis

(2009) Li-Kun Phng et al.   DEVELOPMENTAL CELL

Regulation of glucose metabolism by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases in cancer

(2009) Abdullah Yalcin et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth

(2008) B. Clem et al.   MOLECULAR CANCER THERAPEUTICS