Glucocorticoid Signaling and Epigenetic Alterations in Stress-Related Disorders

Factors related to age at depression onset: the role of SLC6A4 methylation, sex, exposure to stressful life events and personality in a sample of inpatients suffering from major depression

(2021) Simon Sanwald et al.   BMC Psychiatry

Food and nutritional insecurity is associated with depressive symptoms mediated by NR3C1 gene promoter 1F methylation

(2021) Aline Ribeiro Borçoi et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Alcohol consumption, depression, overweight and cortisol levels as determining factors for NR3C1 gene methylation

(2021) Júlia de Assis Pinheiro et al.   Scientific Reports

The FKBP5 genotype and childhood trauma effects on FKBP5 DNA methylation in patients with psychosis, their unaffected siblings, and healthy controls

(2021) Marina Mihaljevic et al.   PSYCHONEUROENDOCRINOLOGY

The Relationships Between Stress, Mental Disorders, and Epigenetic Regulation of BDNF

(2020) Zhuang Miao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Epigenetic modification of the oxytocin receptor gene: implications for autism symptom severity and brain functional connectivity

(2020) Elissar Andari et al.   NEUROPSYCHOPHARMACOLOGY

Effect of interaction between a specific subtype of child abuse and the FKBP5 rs1360780 SNP on DNA methylation among patients with bipolar disorder

(2020) Taku Saito et al.   JOURNAL OF AFFECTIVE DISORDERS

Differential promoter methylation and G-712A polymorphism of brain-derived neurotrophic factor in post-traumatic stress disorder patients of Li and Han populations in Hainan province

(2020) Juncheng Guo et al.   GENE

Increases in Bdnf DNA Methylation in the Prefrontal Cortex Following Aversive Caregiving Are Reflected in Blood Tissue

(2020) Hannah B. D. Duffy et al.   Frontiers in Human Neuroscience

Clinical correlates of the NR3C1 gene methylation at various stages of psychosis

(2020) Błażej Misiak et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Adverse Childhood Experiences and Methylation of the FKBP5 Gene in Patients with Psychotic Disorders

(2020) Błażej Misiak et al.   Journal of Clinical Medicine

Associations Between Maternal Community Deprivation and Infant DNA Methylation of the SLC6A4 Gene

(2020) Kelly DeLano et al.   Frontiers in Public Health

Biological correlates of early life stressful events in major depressive disorder

(2020) Rosana Carvalho Silva et al.   PSYCHONEUROENDOCRINOLOGY

Early-life stress effects on BDNF DNA methylation in first-episode psychosis and in rats reared in isolation

(2020) Helene A. Fachim et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Methylation of the FKBP5 gene in association with FKBP5 genotypes, childhood maltreatment and depression

(2019) Johanna Klinger-König et al.   NEUROPSYCHOPHARMACOLOGY

Differential BDNF methylation in combat exposed veterans and the association with exercise

(2019) Joanne Voisey et al.   GENE

Identification of dynamic glucocorticoid-induced methylation changes at the FKBP5 locus

(2019) Tobias Wiechmann et al.   Clinical Epigenetics

Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation

(2019) Agorastos Agorastos et al.   Frontiers in Psychiatry

Stress, epigenetics and depression: A systematic review

(2019) Caroline Park et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Influence of early adversity on cortisol reactivity, SLC6A4 methylation and externalizing behavior in children of alcoholics

(2019) Anurag Timothy et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Glucocorticoid-Driven NLRP3 Inflammasome Activation in Hippocampal Microglia Mediates Chronic Stress-Induced Depressive-Like Behaviors

(2019) Xiujing Feng et al.   Frontiers in Molecular Neuroscience

Developmental conditions modulate DNA methylation at the glucocorticoid receptor gene with cascading effects on expression and corticosterone levels in zebra finches

(2019) Blanca Jimeno et al.   Scientific Reports

BDNF genetic variants and methylation: effects on cognition in major depressive disorder

(2019) Alex Ferrer et al.   Translational Psychiatry

Epigenetic Modifications in Stress Response Genes Associated With Childhood Trauma

(2019) Shui Jiang et al.   Frontiers in Psychiatry

Adverse Childhood Experience, Genes, and PTSD Risk in Soldiers: A Methylation Study

(2019) Michael R Hossack et al.   MILITARY MEDICINE

The role of oxytocin receptor gene (OXTR) DNA methylation (DNAm) in human social and emotional functioning: a systematic narrative review

(2018) Catherine Maud et al.   BMC Psychiatry

Importance of the brain corticosteroid receptor balance in metaplasticity, cognitive performance and neuro-inflammation

(2018) E.R. de Kloet et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Childhood Trauma, DNA Methylation of Stress-related Genes, and Depression

(2018) Hao Peng et al.   PSYCHOSOMATIC MEDICINE

Oxytocin receptor gene methylation and substance use problems among young African American men

(2018) Steven M. Kogan et al.   DRUG AND ALCOHOL DEPENDENCE

Oxytocin receptor gene methylation in male and female PTSD patients and trauma-exposed controls

(2018) L. Nawijn et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Epigenetic variability in the human oxytocin receptor (OXTR) gene: A possible pathway from early life experiences to psychopathologies

(2018) Eline J. Kraaijenvanger et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Allele-specific DNA methylation level of FKBP5 is associated with post-traumatic stress disorder

(2018) Jee In Kang et al.   PSYCHONEUROENDOCRINOLOGY

Neighborhood characteristics influence DNA methylation of genes involved in stress response and inflammation: The Multi-Ethnic Study of Atherosclerosis

(2017) Jennifer A. Smith et al.   Epigenetics

Epigenetic programming by stress and glucocorticoids along the human lifespan

(2017) A S Zannas et al.   MOLECULAR PSYCHIATRY

Association of Serotonin Transporter Gene AluJb Methylation with Major Depression, Amygdala Responsiveness, 5-HTTLPR/rs25531 Polymorphism, and Stress

(2017) Ilona Schneider et al.   NEUROPSYCHOPHARMACOLOGY

Life stress, glucocorticoid signaling, and the aging epigenome: Implications for aging-related diseases

(2017) Nils C. Gassen et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Associations among oxytocin receptor gene (OXTR) DNA methylation in adulthood, exposure to early life adversity, and childhood trajectories of anxiousness

(2017) J. P. Gouin et al.   Scientific Reports

Holocaust Exposure Induced Intergenerational Effects on FKBP5 Methylation

(2016) Rachel Yehuda et al.   BIOLOGICAL PSYCHIATRY

Epigenetic evidence for involvement of the oxytocin receptor gene in obsessive–compulsive disorder

(2016) Carolina Cappi et al.   BMC NEUROSCIENCE

Direct GR Binding Sites Potentiate Clusters of TF Binding across the Human Genome

(2016) Christopher M. Vockley et al.   CELL

BDNF rs6265 methylation and genotype interact on risk for schizophrenia

(2016) Gianluca Ursini et al.   Epigenetics

Effect of Maternal Stress Prior to Conception on Hippocampal BDNF Signaling in Rat Offspring

(2016) Somayeh Niknazar et al.   MOLECULAR NEUROBIOLOGY

An epigenetic mechanism links socioeconomic status to changes in depression-related brain function in high-risk adolescents

(2016) J R Swartz et al.   MOLECULAR PSYCHIATRY

SLC6A4 methylation as an epigenetic marker of life adversity exposures in humans: A systematic review of literature

(2016) Livio Provenzi et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Acute stress enhances heterodimerization and binding of corticosteroid receptors at glucocorticoid target genes in the hippocampus

(2016) Karen R. Mifsud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stress, the Stress System and the Role of Glucocorticoids

(2015) Nicolas C. Nicolaides et al.   NEUROIMMUNOMODULATION

Gene–Stress–Epigenetic Regulation of FKBP5: Clinical and Translational Implications

(2015) Anthony S Zannas et al.   NEUROPSYCHOPHARMACOLOGY

Glucocorticoid receptor gene (NR3C1) methylation processes as mediators of early adversity in stress-related disorders causality: A critical review

(2015) Helena Palma-Gudiel et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

The brain mineralocorticoid receptor and stress resilience

(2015) Freija ter Heegde et al.   PSYCHONEUROENDOCRINOLOGY

Adverse Life Events and Allele-Specific Methylation of the Serotonin Transporter Gene (SLC6A4) in Adolescents

(2015) Lisette J. van der Knaap et al.   PSYCHOSOMATIC MEDICINE

The permissive role of glucocorticoids in neuroinflammatory priming

(2015) Matthew G. Frank et al.   Current Opinion in Endocrinology Diabetes and Obesity

Neighborhood crime and depressive symptoms among African American women: Genetic moderation and epigenetic mediation of effects

(2015) Man-Kit Lei et al.   SOCIAL SCIENCE & MEDICINE

Chronic corticosterone-mediated dysregulation of microRNA network in prefrontal cortex of rats: relevance to depression pathophysiology

(2015) Y Dwivedi et al.   Translational Psychiatry

DNA Methylation of the Serotonin Transporter Gene in Peripheral Cells and Stress-Related Changes in Hippocampal Volume: A Study in Depressed Patients and Healthy Controls

(2015) Linda Booij et al.   PLoS One

Genome-wide DNA methylation in neonates exposed to maternal depression, anxiety, or SSRI medication during pregnancy

(2014) Amy L Non et al.   Epigenetics

Epigenetic Modification of the Glucocorticoid Receptor Gene Is Linked to Traumatic Memory and Post-Traumatic Stress Disorder Risk in Genocide Survivors

(2014) V. Vukojevic et al.   JOURNAL OF NEUROSCIENCE

Ultradian corticosterone pulses balance glutamatergic transmission and synaptic plasticity

(2014) Ratna Angela Sarabdjitsingh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recent advances in the molecular mechanisms determining tissue sensitivity to glucocorticoids: novel mutations, circadian rhythm and ligand-induced repression of the human glucocorticoid receptor

(2014) Nicolas C Nicolaides et al.   BMC Endocrine Disorders

Glucocorticoid receptor gene (NR3C1) methylation following stressful events between birth and adolescence. The TRAILS study

(2014) L J van der Knaap et al.   Translational Psychiatry

Site-specific methylation changes in the glucocorticoid receptor exon 1F promoter in relation to life adversity: systematic review of contributing factors

(2014) Nikolaos P. Daskalakis et al.   Frontiers in Neuroscience

Mineralocorticoid receptor blockade during a rat’s first violent encounter inhibits its subsequent propensity for violence.

(2013) Menno R. Kruk et al.   BEHAVIORAL NEUROSCIENCE

Association of SLC6A4 methylation with early adversity, characteristics and outcomes in depression

(2013) Hee-Ju Kang et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Chronic exposure to exogenous glucocorticoids primes microglia to pro-inflammatory stimuli and induces NLRP3 mRNA in the hippocampus

(2013) Matthew G. Frank et al.   PSYCHONEUROENDOCRINOLOGY

Allele-specific epigenetic modification: a molecular mechanism for gene–environment interactions in stress-related psychiatric disorders?

(2013) Torsten Klengel et al.   Epigenomics

Chronic Social Instability Induces Anxiety and Defective Social Interactions Across Generations

(2012) Lorena Saavedra-Rodríguez et al.   BIOLOGICAL PSYCHIATRY

Individual variation and longitudinal pattern of genome-wide DNA methylation from birth to the first two years of life

(2012) Deli Wang et al.   Epigenetics

Environmental Stress Affects DNA Methylation of a CpG Rich Promoter Region of Serotonin Transporter Gene in a Nurse Cohort

(2012) Jukka S. Alasaari et al.   PLoS One

Dynamically changing effects of corticosteroids on human hippocampal and prefrontal processing

(2011) Marloes J.A.G. Henckens et al.   HUMAN BRAIN MAPPING

Rapid non-genomic effects of corticosteroids and their role in the central stress response

(2011) Femke L Groeneweg et al.   JOURNAL OF ENDOCRINOLOGY

Epigenetic modification of hippocampal Bdnf DNA in adult rats in an animal model of post-traumatic stress disorder

(2011) Tania L. Roth et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Mineralocorticoid and glucocorticoid receptors at the neuronal membrane, regulators of nongenomic corticosteroid signalling

(2011) Femke L. Groeneweg et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

A Randomized Trial on Mineralocorticoid Receptor Blockade in Men: Effects on Stress Responses, Selective Attention and Memory

(2011) Sandra Cornelisse et al.   NEUROPSYCHOPHARMACOLOGY

Expression and Regulation of the Fkbp5 Gene in the Adult Mouse Brain

(2011) Sebastian H. Scharf et al.   PLoS One

Epigenetic Regulation ofBDNFGene in Response to Stress

(2011) Manabu Fuchikami et al.   Psychiatry Investigation

Chromatin and heritability: how epigenetic studies can complement genetic approaches

(2011) Ewan Birney   TRENDS IN GENETICS

Molecular Signature of Mineralocorticoid Receptor Signaling in Cardiomyocytes: From Cultured Cells to Mouse Heart

(2010) Celine Latouche et al.   ENDOCRINOLOGY

Rapid Glucocorticoid Receptor-Mediated Inhibition of Hypothalamic-Pituitary-Adrenal Ultradian Activity in Healthy Males

(2010) G. M. Russell et al.   JOURNAL OF NEUROSCIENCE

Serum levels of brain-derived neurotrophic factor in major depressive disorder: state–trait issues, clinical features and pharmacological treatment

(2010) M L Molendijk et al.   MOLECULAR PSYCHIATRY

Metaplasticity of amygdalar responses to the stress hormone corticosterone

(2010) H. Karst et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic Epidemiology of Common Complex Disease: Prospects for Prediction, Prevention, and Treatment

(2010) Caroline L. Relton et al.   PLOS MEDICINE

Prospects for epigenetic research within cohort studies of psychological disorder: A pilot investigation of a peripheral cell marker of epigenetic risk for depression

(2009) C.A. Olsson et al.   BIOLOGICAL PSYCHOLOGY

Stress and disorders of the stress system

(2009) George P. Chrousos   Nature Reviews Endocrinology

Epigenetics: Definition, Mechanisms and Clinical Perspective

(2009) Cathérine Dupont et al.   SEMINARS IN REPRODUCTIVE MEDICINE

Epigenomic Profiling Reveals DNA-Methylation Changes Associated with Major Psychosis

(2008) Jonathan Mill et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Long-lasting depression-like behavior and epigenetic changes of BDNF gene expression induced by perinatal exposure to methylmercury

(2008) Natalia Onishchenko et al.   JOURNAL OF NEUROCHEMISTRY

The coming out of the brain mineralocorticoid receptor

(2007) Marian Joëls et al.   TRENDS IN NEUROSCIENCES