Article
Biochemistry & Molecular Biology
Da Tang, Guang Fu, Wenbo Li, Ping Sun, Patricia A. Loughran, Meihong Deng, Melanie J. Scott, Timothy R. Billiar
Summary: The study demonstrated that MaR1 can protect the liver against hepatic ischemia/reperfusion injury through the ALXR/Akt signaling pathway. MaR1 treatment significantly reduces liver injury, suppresses inflammatory responses, oxidative stress, and decreases hepatocyte apoptosis.
MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
S. Shehna Mahim, V. R. Anjali, V. S. Remya, S. Reshmi, C. Aruna Devi
Summary: The study investigates the effects of Bisphenol S(BPS) on fish and finds that sublethal exposure to BPS significantly influences the biomarker activities and leads to oxidative stress in fish. This indicates that BPS has oxidative potential.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Immunology
Qiwen Yu, Sanyang Chen, Hongwei Tang, Xiaodan Zhang, Ruolin Tao, Zhiping Yan, Jihua Shi, Wenzhi Guo, Shuijun Zhang
Summary: Veratric acid (VA) has protective effects against liver ischemia/reperfusion (I/R) injury by activating the Nrf2 signaling pathway, leading to increased expression of Nrf2, HO-1, and NQO-1 proteins, which helps alleviate oxidative stress and apoptosis, thus reducing liver damage.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Linas Cerniauskas, Asta Mazeikiene, Egle Mazgelyte, Egle Petrylaite, Ausra Linkeviciute-Dumce, Neringa Burokiene, Dovile Karciauskaite
Summary: Cardiovascular diseases are the leading cause of mortality worldwide. This study aimed to evaluate oxidative lipid degradation biomarkers and antioxidant defense system components in healthy women and their relationships with age, anthropometric measures, and lipid metabolism biomarkers. The findings suggest that these indices could be useful biomarkers in the research of aging, obesity, and atherosclerosis pathogenesis.
Article
Pharmacology & Pharmacy
Wenbin Luo, Yu Tao, Shengnan Chen, Hao Luo, Xiaoping Li, Shuang Qu, Ken Chen, Chunyu Zeng
Summary: This study found that rosmarinic acid (RA) can effectively protect against pulmonary ischemia/reperfusion (IR) injury by activating the PI3K/Akt signaling pathway for antioxidation and anti-apoptosis, suggesting its potential therapeutic value.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Anita Yovas, Stanely Mainzen Prince Ponnian
Summary: The study demonstrated that beta-caryophyllene exerts protective effects against myocardial infarction in rats induced with isoproterenol, by reducing heart damage, improving cardiac function, inhibiting apoptosis signaling pathways, and alleviating endothelial dysfunction. These findings suggest the potential use of beta-caryophyllene in the treatment of human myocardial infarction after clinical trials.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Marta Martin-Fernandez, Victor Arroyo, Carmen Carnicero, Rebeca Siguenza, Reyes Busta, Natalia Mora, Beatriz Antolin, Eduardo Tamayo, Patricia Aspichueta, Irene Carnicero-Frutos, Hugo Gonzalo-Benito, Rocio Aller
Summary: This study found that elevated levels of lipid peroxidation (LPO) are significantly associated with a NASH score of >= 4 in NAFLD patients. LPO levels above 315.39 μM were identified as an independent risk factor. The model showed good discrimination ability in distinguishing NASH patients. Therefore, understanding the molecular mechanisms of basal inflammation may help identify biomarkers and therapeutic targets for NASH.
Article
Environmental Sciences
Hanan Saleh, Mohamed Salama, Rehab Mohamed Hussein
Summary: This study investigated the protective effect of polyethylene glycol capped gold nanoparticles (PEG-AuNPs) on renal ischemia-reperfusion injury (I/R)-induced acute kidney injury (AKI) in diabetic mice by activating the AMPK-Nrf2 pathway. Results showed that PEG-AuNPs reduced blood urea nitrogen (BUN) and creatinine levels in diabetic mice and decreased renal damage and inflammation.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Tao Zheng, Jun Yang, Jing Zhang, Chaojun Yang, Zhixing Fan, Qi Li, Yuhong Zhai, Haiyin Liu, Jian Yang
Summary: The study found that downregulation of miR-327 could inhibit oxidative stress and apoptosis induced by H/R and TBHP in vitro experiments. Additionally, the downregulation enhanced the expression of fibroblast growth factor 10 (FGF10), activated p-PI3K and p-Akt, and promoted the translocation of Nrf2.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Yanbin Song, Yunqing Zhang, Zhaofei Wan, Junqiang Pan, Feng Gao, Fei Li, Jing Zhou, Junmin Chen
Summary: This study revealed that CTRP3 alleviates cardiac ischemia/reperfusion injury by elevating LAMP1 and activating the JIP2/JNK signaling pathway, suggesting its potential as a therapeutic target.
Review
Biochemistry & Molecular Biology
Beatrycze Nowicka, Agnieszka Trela-Makowej, Dariusz Latowski, Kazimierz Strzalka, Renata Szymanska
Summary: Plant prenyllipids, especially isoprenoid chromanols and quinols, act as efficient antioxidants protecting membranes and storage lipids from oxidative stress. Plants are vulnerable to oxidative damage due to oxygenic photosynthesis generating ROS and the photosynthetic electron transfer chain as a source of ROS. Plastidic antioxidants play a crucial role in preventing oxidative stress under various stress factors, while also contributing to physiological processes through redox signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Rui-ming Deng, Juan Zhou
Summary: Myocardial ischemia/reperfusion injury (MIRI) is a common and serious condition with no effective clinical treatments. The activation of the PI3K/Akt signaling pathway has been shown to have significant protective effects against MIRI through its involvement in antioxidant, anti-inflammatory, autophagy, mitochondrial function, and apoptosis regulation. This review highlights the molecular regulation of PI3K/Akt in MIRI, the effects of ischemic preconditioning and postconditioning, and the potential therapeutic applications of drugs targeting PI3K/Akt.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Cell Biology
Yunqing Chen, Hongyan Fan, Shijun Wang, Guanmin Tang, Changlin Zhai, Liang Shen
Summary: Ischemia-reperfusion (I/R) injury is a major cause of cell death and organ damage in various pathologies, and current treatment methods are limited. Ferroptosis, a newly discovered type of regulated cell death characterized by iron overload and lipid peroxidation accumulation, has been found to have a close association with I/R injury, making it a potential new therapeutic target. This review summarizes the current status of ferroptosis and explores its relationship with I/R injury, as well as potential treatment strategies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yifan Chen, Tongxi Li, Peng Tan, Hao Shi, Yonglang Cheng, Tianying Cai, Junjie Bai, Yichao Du, Wenguang Fu
Summary: This study investigates the protective effect of kaempferol (KAE) from Penthorum chinense Pursh on hepatic ischemia/reperfusion injury (HI/RI) and its specific mechanism. The results demonstrate that KAE pretreatment alleviates hepatocellular damage caused by ischemia/reperfusion, mainly by reducing oxidative stress and inflammation through the activation of the Nrf2/HO-1 signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Lei Mi, Nan Zhang, Jiyun Wan, Ming Cheng, Jianping Liao, Xiao Zheng
Summary: The study demonstrated that remote ischemic post-conditioning (RIPOC) can attenuate the histopathological features of intestinal mucosa in intestinal I/R injury mouse models through the ERK pathway. RIPOC also showed significant antioxidant and anti-inflammatory effects mediated via the ERK pathway, while suppressing the NF-kappa B (p65)/NLRP3 inflammatory pathways in the intestinal I/R injury mouse models.
MOLECULAR MEDICINE REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Artur Bekala, Wlodzimierz Plotek, Dorota Siwicka-Gieroba, Joanna Solek-Pastuszka, Romuald Bohatyrewicz, Jowita Biernawska, Katarzyna Kotfis, Magdalena Bielacz, Andrzej Jaroszynski, Wojciech Dabrowski
Summary: Brain injury, especially TBI, can cause dysfunction of extracerebral organs, including the heart. Melatonin, a hormone released by the pineal gland, plays a crucial role in preventing and treating TBI-induced cardiac disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Anesthesiology
Franck Verdonk, Dorien Feyaerts, Rafael Badenes, Julie A. Bastarache, Adrien Bougle, Wesley Ely, Brice Gaudilliere, Christopher Howard, Katarzyna Kotfis, Alexandre Lautrette, Matthieu Le Dorze, Babith Joseph Mankidy, Michael A. Matthay, Christopher K. Morgan, Aurelien Mazeraud, Brijesh Patel, Rajyabardhan Pattnaik, Jean Reuter, Marcus J. Schultz, Tarek Sharshar, Gentle S. Shrestha, Charles Verdonk, Lorraine B. Ware, Romain Pirracchio, Matthieu Jabaudon
Summary: The COVID-19 pandemic has posed a significant burden on healthcare systems worldwide, but it has also spurred urgent research efforts to develop treatments and find solutions. This narrative review discusses the impact of the pandemic on critical care research, highlighting the need for international collaboration, translational research, and improved triage and prediction methods. The study emphasizes the importance of future research in artificial intelligence, long-term symptom characterization, and ethical considerations.
ANAESTHESIA CRITICAL CARE & PAIN MEDICINE
(2022)
Article
Medicine, Research & Experimental
Jan Binkowski, Olga Taryma-Lesniak, Karolina Luczkowska, Anna Niedzwiedz, Kacper Lechowicz, Dominik Strapagiel, Justyna Jarczak, Veronica Davalos, Aurora Pujol, Manel Esteller, Katarzyna Kotfis, Boguslaw Machalinski, Milosz Parczewski, Tomasz K. Wojdacz
Summary: Recent studies have found that methylation changes in blood cells may serve as biomarkers for the outcomes of SARS-CoV-2 infection in COVID-19 patients. However, different studies have reported different subsets of epigenetic lesions and the significance of these changes in the pathology of the infection is still unclear. This study used methylomics and transcriptomics data from a large cohort of COVID-19 patients to identify the role of blood cells' methylome in the pathology of the disease.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Ewa Pius-Sadowska, Anna Niedzwiedz, Piotr Kulig, Bartlomiej Baumert, Anna Sobus, Dorota Roginska, Karolina Luczkowska, Zofia Ulanczyk, Szymon Wnek, Igor Karolak, Edyta Paczkowska, Katarzyna Kotfis, Milosz Kawa, Iwona Stecewicz, Piotr Zawodny, Boguslaw Machalinski
Summary: The aim of this study was to examine the CMV status, select chemokines, and complement components in COVID-19 patients and analyze their changes over time. The results showed significant differences in chemokines and complement profiles between ICU and non-ICU patients, indicating their contribution to the development of severe COVID-19. Higher concentrations of CXCL8 and CCL2 in the plasma, along with CMV seropositivity, correlated with more severe courses of the disease. Therefore, CXCL8, CCL2, and CMV seropositivity should be considered as new prognostic factors for severe COVID-19.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Wojciech Dabrowski, Mariusz Gagos, Dorota Siwicka-Gieroba, Mariusz Piechota, Jan Siwiec, Magdalena Bielacz, Katarzyna Kotfis, Andrzej Stepulak, Luiza Grzycka-Kowalczyk, Andrzej Jaroszynski, Manu L. N. G. Malbrain
Summary: This study analyzed the effect of Xn on the inflammatory response and clinical outcomes of COVID-19 patients. The results showed that compared to the control group, patients receiving Xn treatment had a significantly lower mortality rate and shorter clinical course. Xn treatment also significantly reduced plasma IL-6 concentration, D-dimer levels, and neutrophil-to-lymphocyte ratio (NLR).
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Virology
Seung Hyun Park, Sung Hwi Hong, Kwanghyun Kim, Seung Won Lee, Dong Keon Yon, Sun Jae Jung, Ziad Abdeen, Ramy Abou Ghayda, Mohamed Lemine Cheikh Brahim Ahmed, Abdulwahed Al Serouri, Waleed Al-Herz, Humaid O. Al-Shamsi, Sheeza Ali, Kosar Ali, Oidov Baatarkhuu, Henning Bay Nielsen, Enrico Bernini-Carri, Anastasiia Bondarenko, Ayun Cassell, Akway Cham, Melvin L. K. Chua, Sufia Dadabhai, Tchin Darre, Hayk Davtyan, Elena Dragioti, Barbora East, Robert Jeffrey Edwards, Martina Ferioli, Tsvetoslav Georgiev, Lilian A. Ghandour, Harapan Harapan, Po-Ren Hsueh, Saad I. Mallah, Aamer Ikram, Shigeru Inoue, Louis Jacob, Slobodan M. Jankovic, Umesh Jayarajah, Milos Jesenak, Pramath Kakodkar, Nathan Kapata, Yohannes Kebede, Yousef Khader, Meron Kifle, David Koh, Visnja Kokic Males, Katarzyna Kotfis, Ai Koyanagi, James-Paul Kretchy, Sulaiman Lakoh, Jinhee Lee, Jun Young Lee, Maria da Luz Lima Mendonca, Lowell Ling, Jorge Llibre-Guerra, Masaki Machida, Richard Makurumidze, Ziad A. Memish, Ivan Mendoza, Sergey Moiseev, Thomas Nadasdy, Chen Nahshon, Silvio A. Namendys-Silva, Blaise Nguendo Yongsi, Amalea Dulcene Nicolasora, Zhamilya Nugmanova, Hans Oh, Atte Oksanen, Oluwatomi Owopetu, Zeynep Ozge Ozguler, Konstantinos Parperis, Gonzalo Emanuel Perez, Krit Pongpirul, Marius Rademaker, Nemanja Radojevic, Anna Roca, Alfonso J. Rodriguez-Morales, Enver Roshi, Khwaja Mir Islam Saeed, Ranjit Sah, Boris Sakakushev, Dina E. Sallam, Brijesh Sathian, Patrick Schober, P. Shaik Syed Ali, Zoran Simonovic, Tanu Singhal, Natia Skhvitaridze, Marco Solmi, Kannan Subbaram, Kalthoum Tizaoui, John Thato Tlhakanelo, Julio Torales, Junior Smith Torres-Roman, Dimitrios Tsartsalis, Jadamba Tsolmon, Duarte Nuno Vieira, Sandro G. Viveiros Rosa, Guy Wanghi, Uwe Wollina, Ren-He Xu, Lin Yang, Kashif Zia, Muharem Zildzic, Jae Il Shin, Lee Smith
Summary: The novel coronavirus, SARS-CoV-2, has caused the highly contagious COVID-19 disease which has severely impacted developed and low- to middle-income countries. Nonpharmaceutical interventions (NPIs) such as social distancing, quarantine, and personal hygiene measures have been widely employed. A survey of 92 countries/territories found that quarantine and isolation at designated places were associated with lower incidence and mortality rates, while the use of sanitizer for personal hygiene reduced incidence. Mask deprivation was common regardless of economic level, and higher incidence and mortality were observed in countries/territories with higher economic levels.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Immunology
Mohammadamin Sadeghdoust, Farnaz Aligolighasemabadi, Tania Dehesh, Nima Taefehshokr, Adel Sadeghdoust, Katarzyna Kotfis, Amirhossein Hashemiattar, Amir Ravandi, Neda Aligolighasemabadi, Omid Vakili, Beniamin Grabarek, Rafal Staszkiewicz, Marek J. J. Los, Pooneh Mokarram, Saeid Ghavami
Summary: The aim of this prospective cohort study was to investigate the impact of statins on long-term respiratory symptoms and pulmonary fibrosis in COVID-19 patients with diabetes mellitus. The study found that the Non-statin group had significantly higher odds of cough and dyspnea compared to the Statin group during the follow-up period. Although there was no significant difference in pulmonary fibrosis score change between the groups, Non-statin patients with > 5 years of DM were more likely to exhibit higher fibrosis scores during follow-up.
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
(2023)
Article
Anesthesiology
Giovanna A. Lurati Buse, Eckhard Mauermann, Daniela Ionescu, Wojciech Szczeklik, Stefan De Hert, Miodrag Filipovic, Beatrice Beck-Schimmer, Savino Spadaro, Purificacion Matute, Daniel Bolliger, Sanem Cakar Turhan, Judith van Waes, Filipa Lagarto, Kassiani Theodoraki, Anil Gupta, Hans-Joerg Gillmann, Luca Guzzetti, Katarzyna Kotfis, Hinnerk Wulf, Jan Larmann, Dan Corneci, Frederique Chammartin-Basnet, Simon J. Howell
Summary: This study aimed to investigate the predictive value of self-reported functional capacity for major adverse cardiovascular events (MACEs) after noncardiac surgery. The results showed that self-reported functional capacity was associated with MACEs, but did not improve the accuracy of prediction.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Neurosciences
Dorota Siwicka-Gieroba, Sylwia Terpilowska, Chiara Robba, Katarzyna Kotfis, Alicja Wojcik-Zaluska, Wojciech Dabrowski
Summary: The aim of this study was to evaluate the concentration of apoptotic molecules in the bronchoalveolar lavage fluid (BALF) in patients after severe brain injury and analyze their correlation with clinical variables and mortality. The results showed a significant increase in the concentration of selected apoptotic factors in BALF of patients after severe brain damage, and these factors were correlated with the severity of the injury and mortality.
JOURNAL OF INTEGRATIVE NEUROSCIENCE
(2023)
Review
Critical Care Medicine
Hamid Merdji, Micah T. Long, Marlies Ostermann, Margaret Herridge, Sheila N. Myatra, Silvia De Rosa, Victoria Metaxa, Katarzyna Kotfis, Chiara Robba, Audrey De Jong, Julie Helms, Caroline E. Gebhard
Summary: Despite advancements in critical care medicine, there is limited attention to sex and gender disparities in ICU management and outcomes. Data on gender-related topics in the ICU are lacking, leading to inconsistent findings on differences in admission, clinical course, mortality, and post-ICU burdens. Sex hormones have a distinct impact on immune and cardiovascular systems, causing variations in diagnoses. Understanding and addressing sex and gender differences in the ICU setting is crucial for patient-centered care.
INTENSIVE CARE MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Igor Karolak, Rafal Hrynkiewicz, Paulina Niedzwiedzka-Rystwej, Kacper Lechowicz, Jerzy Sienko, Aleksandra Szylinska, Wojciech Dabrowski, Katarzyna Kotfis
Summary: This study evaluated the effects of potassium canrenoate on inflammatory markers in patients with COVID-19 pneumonia. The results showed significant changes in certain inflammatory markers in the potassium canrenoate group compared to the placebo group, potentially related to alleviating pulmonary fibrosis. However, these observations did not reach statistical significance, and further research is needed to investigate the potential benefits of potassium canrenoate as a treatment for COVID-19.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Marta Braksator, Magdalena Jachymek, Karina Witkiewicz, Wojciech Witkiewicz, Malgorzata Peregud-Pogorzelska, Katarzyna Kotfis, Jaroslaw Kazmierczak, Miroslaw Brykczynski
Summary: Left ventricular diastolic dysfunction is common in cardiac surgery patients and is associated with lower minimal PaO2/FiO2 index during mechanical ventilation and higher occurrence of pneumonia.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Katarzyna Kotfis, Arleta Wojciechowska, Malgorzata Zimny, Dominika Jamiol-Milc, Aleksandra Szylinska, Sebastian Kwiatkowski, Karolina Kaim, Barbara Dolegowska, Ewa Stachowska, Maciej Zukowski, Maria Pankowiak, Andrzej Torbe, Paul Wischmeyer
Summary: This study compared the effectiveness of oral carbohydrate loading (CHO) with standard fasting in patients undergoing elective cesarean delivery (CD). The results showed that the incidence of vomiting or dry retching within 24 hours after CD was lower in the CHO group compared to the standard fasting group. Additionally, CHO supplementation reduced preoperative feelings of hunger and thirst, enhancing the comfort of pregnant women.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Critical Care Medicine
Pawel Pasieka, Anna Surowka, Jakub Fronczek, Evan Skwara, Miroslaw Czuczwar, Michal Borys, Pawel Krawczyk, Miroslaw Zietkiewicz, Lukasz R. Nowak, Maciej Zukowski, Katarzyna Kotfis, Katarzyna Cwyl, Jacek Skowronek, Joanna Solek-Pastuszka, Jowita Biernawska, Pawel Grudzien, Pawel Nasilowski, Natalia Popek, Waldemar Cyrankiewicz, Katarzyna Sierakowska, Wojciech Mudyna, Szymon Bialka, Dorota Studzinska, Szymon Bernas, Mariusz Piechota, Waldemar Machala, Lukasz Sadowski, Jan Stefaniak, Radoslaw Owczuk, Malgorzata Szymkowiak, Ryszard Gawda, Natalia Kozera, Barbara Adamik, Waldemar Gozdzik, Agnieszka Wieczorek, Jaroslaw Janc, Anna Kluzik, Janusz Trzebicki, Pawel Zatorski, Wojciech Gola, Hubert Hymczak, Lukasz J. Krzych, Szymon Czajka, Urszula Kosciuczuk, Bartosz Kudlinski, Hans Flaatten, Wojciech Szczeklik
Summary: The study aims to evaluate whether there is an increased propensity to limit life-sustaining treatment (LST) among elderly patients in Poland from 2018-2019 compared to 2016-2017. The results show that clinicians in Poland have become more proactive in limiting LST in critically ill patients aged 80 and above during the studied period, although the prevalence of LST limitations in Poland remains low.
JOURNAL OF CRITICAL CARE
(2024)