Article
Biochemistry & Molecular Biology
Maria Laura Flores-Caceres, Cristina Ortega-Villasante, Pablo Carril, Juan Sobrino-Plata, Luis E. Hernandez
Summary: Cadmium (Cd) and mercury (Hg) are soil pollutants that cause oxidative stress. The tolerance of plants is regulated by signalling processes, such as the accumulation of sHSPs and activation of antioxidant enzymes. This study focused on the early responses of alfalfa seedlings to Cd and Hg exposure and found that ethylene plays a role in the response to metal stress. The findings suggest that ethylene modulation could be a potential strategy to enhance plant tolerance to heavy metals.
Article
Biochemistry & Molecular Biology
Rosaria Notariale, Pasquale Perrone, Luigi Mele, Gennaro Lettieri, Marina Piscopo, Caterina Manna
Summary: Phosphatidylserine translocation is a significant mechanism in human erythrocytes. Olive oil phenols can prevent cell alterations induced by mercury or calcium ionophore, protecting the red blood cells. The bioactive compounds in olive oil have important implications for human health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Food Science & Technology
Sajad Fakhri, Seyed Zachariah Moradi, Zeinab Nouri, Hui Cao, Hui Wang, Haroon Khan, Jianbo Xiao
Summary: Integrin receptors play a role in cardiovascular diseases and modulation of the integrin pathway can trigger downstream antioxidant pathways for cardioprotection. Plant polyphenols, as safe and effective phytochemicals, have the potential to treat cardiovascular diseases.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Sarita Pyatha, Haesoo Kim, Daeun Lee, Kisok Kim
Summary: Parkinson's disease is a neurodegenerative disorder that is associated with exposure to environmental toxins, particularly heavy metals. These metals contribute to the development and progression of the disease through proinflammatory responses, disruption of redox homeostasis, and induction of oxidative stress.
Article
Multidisciplinary Sciences
Bertil Wegmann, Patricia Tatemoto, Stefan Miemczyk, Johnny Ludvigsson, Carlos Guerrero-Bosagna
Summary: Heavy metals can impact fetal neurodevelopmental processes by crossing the placental and blood brain barriers. This study measured metal levels in cord blood and serum samples of children with and without ASD. The results suggest that prenatal aluminum levels may indicate later ASD incidence, potentially related to increased exposure to aluminum and lithium during pregnancy, while zinc exposure during pregnancy may be higher in controls. Additionally, there is strong evidence of increased mercury levels in 5-year-old children with ASD compared to controls.
SCIENTIFIC REPORTS
(2023)
Article
Microbiology
Marina Robas Mora, Vanesa M. Fernandez Pastrana, Daniel Gonzalez Reguero, Laura L. Gutierrez Oliva, Agustin Probanza Lobo, Pedro A. Jimenez Gomez
Summary: The study investigated the impact of inoculating the SAICEUPSM(T) strain on the antioxidant capacity and mercury bioaccumulation of lupinus plants under high mercury concentration soil conditions. The results showed that the strain exerted a phytoprotective effect, reducing the enzymatic response to oxidative stress and enhancing plant growth and biomass accumulation under mercury stress. The inoculation significantly decreased mercury uptake by the plants, indicating potential for agricultural applications in mercury-contaminated environments.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Albino Carrizzo, Rosario Lizio, Paola Di Pietro, Michele Ciccarelli, Antonio Damato, Eleonora Venturini, Patrizia Iannece, Eduardo Sommella, Pietro Campiglia, Philipp Ockermann, Carmine Vecchione
Summary: The research demonstrated that Healthberry 865(R) has a significant vasodilatory effect on resistance artery function in mice, mediated by nitric oxide release through the PI3K/Akt signaling pathway. It also exerts an antioxidant effect by modulating NADPH oxidase. The selective action of different anthocyanins mediates the cardiovascular properties of Healthberry 865(R), reducing oxidative stress and improving nitric oxide bioavailability.
Article
Environmental Sciences
Hai Duc Nguyen, Min-Sun Kim
Summary: This study assessed the link between mixed heavy metals (cadmium, lead, and mercury) and the 10-year risk of cardiovascular diseases (CVDs) in pre- and post-menopausal Korean women. The results showed that exposure to a mixture of heavy metals, especially mercury, was more strongly associated with the 10-year risk of CVDs in postmenopausal women. Several key molecular mechanisms and genes related to CVD development were identified.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Peripheral Vascular Disease
Leslie Marisol Lugo-Gavidia, Dylan Burger, Vance B. Matthews, Janis M. Nolde, Marcio Galindo Kiuchi, Revathy Carnagarin, Dennis Kannenkeril, Justine Chan, Anu Joyson, Lakshini Y. Herat, Omar Azzam, Markus P. Schlaich
Summary: Microparticles are small cell vesicles derived from the cell membrane, with growing evidence linking them to cardiovascular disease through inflammation, endothelial function, and thrombosis. Research on the direct causal link between microparticle release and their implications on physiological and pathological conditions is ongoing.
Article
Thermodynamics
Dariusz Luszkiewicz, Maria Jedrusik, Arkadiusz Swierczok, Mariola Kobylanska-Pawlisz
Summary: The article presents the results of experiments on adding sulphide based additives to the CaCO3 slurry in Wet Flue Gas Desulphurization plant (WFGD), both in laboratory and full-scale. Full-scale tests were conducted on two WFGD installations that clean flue gas from burning hard coal and lignite. The study investigated the effects of sodium sulphide addition to the CaCO3 slurry on reducing mercury emissions and precipitation of heavy metals. The results show significant reduction of mercury emissions (up to 89% for hard coal and 90% for lignite) and decrease in heavy metal concentration in wastewater (with mercury precipitation efficiency reaching 88% for lignite and 83% for hard coal).
Article
Chemistry, Inorganic & Nuclear
Jincymol Kappen, Sinduja Bharathi, S. Abraham John
Summary: The galvanic reaction between graphene quantum dot (GQD)-stabilized silver nanoparticles (AgNP)-modified glassy carbon (GC) surface and Hg(II) leads to the complete dissolution of AgNPs within 15 minutes and the subsequent growth of Hg(0) as a flower on the GQD surface. This unique anti-amalgamation reaction is caused by direct deposition of Hg(0) by available oxygen functional groups and strong adsorption on the GQD graphene surface, followed by subsequent growth of Hg(0) as a flower due to the galvanic reaction between AgNPs and Hg(II).
INORGANIC CHEMISTRY
(2021)
Article
Engineering, Environmental
Meifeng Li, Xiaoling Wang, Guidong Gong, Yi Tang, Yaoyao Zhang, Junling Guo, Xuepin Liao, Bi Shi
Summary: A polyphenol-functionalized collagen-based artificial liver (PAL) was constructed for heavy metals excretion and free radicals scavenging therapy. PAL showed high adsorption capacities for heavy metal ions and outstanding biocompatibility even in complex serum environment.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Reproductive Biology
Andrea Palomar, Roberto Gonzalez-Martin, Silvia Perez-Deben, Yassmin Medina-Laver, Alicia Quinonero, Francisco Dominguez
Summary: Mercury concentrations above 250 nM induce oxidative stress and impair cell viability as well as decidualization, a key functional feature of primary human endometrial cells.
BIOLOGY OF REPRODUCTION
(2022)
Article
Engineering, Environmental
Colin A. Cooke, Jason H. Curtis, William F. Kenney, Paul Drevnick, Peter E. Siegel
Summary: Lead and mercury emissions and deposition have long histories extending into preindustrial times, but the timing, magnitude, and persistence of preindustrial emissions remain unclear. This study uses a well-dated sediment core from Lake Antoine, Grenada to assess the past 3000 years of tropical lead and mercury deposition. The results show that preindustrial increases in lead and mercury concentrations can be explained by variations in mineral and organic matter inputs from the watershed, reflecting climate-driven changes in the lake level. There is no evidence that preindustrial use of lead and mercury raised deposition rates in this remote ecosystem. Industrial-era accumulation rates in Lake Antoine have been accelerated by land use and land cover change within the crater rim, but global industrial pollution is still evident. After correcting for watershed inputs, recent atmospheric deposition rates of lead and mercury are in close agreement with monitoring data, challenging previous assessments that suggested preindustrial use of mercury raised atmospheric deposition rates globally.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Green & Sustainable Science & Technology
Guo Lin, Biao Zeng, Xun Liu, Jing Li, Baoping Zhang, Libo Zhang
Summary: In recent years, heavy metal pollution in water has become an increasingly serious global environmental problem. Zr-MOF-NAC has been successfully synthesized and used to efficiently capture mercury ions from wastewater. The study demonstrated that Zr-MOF-NAC showed the best adsorption effect at pH = 5.0, with a maximum adsorption capacity of 644 mg/g. Furthermore, it exhibited excellent selectivity and reusability.
JOURNAL OF CLEANER PRODUCTION
(2022)
Article
Biochemistry & Molecular Biology
Gennaro Lettieri, Rosaria Notariale, Alessia Ambrosino, Alfredo Di Bonito, Antonella Giarra, Marco Trifuoggi, Caterina Manna, Marina Piscopo
Summary: This study investigates the effects of exposure to different concentrations of mercury ions on sperm and PL proteins of Mytilus galloprovincialis, revealing potential DNA damage and adverse effects on the reproductive system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Monica Iannotta, Carmela Belardo, Maria Consiglia Trotta, Fabio Arturo Iannotti, Rosa Maria Vitale, Rosa Maisto, Serena Boccella, Rosmara Infantino, Flavia Ricciardi, Benito Fabio Mirto, Franca Ferraraccio, Iacopo Panarese, Pietro Amodeo, Lea Tunisi, Luigia Cristino, Michele D'Amico, Vincenzo di Marzo, Livio Luongo, Sabatino Maione, Francesca Guida
Summary: The study demonstrates that N-palmitoyl-D-glucosamine (PGA) acts as a TLR4 antagonist, effectively inhibiting inflammatory response and showing beneficial effects in various experimental settings, including prevention and alleviation of keratitis and peripheral neuropathy. PGA stands out for its high stability and anti-inflammatory activity, suggesting its potential as a valuable tool for the development of new TLR4 modulating drugs targeting the cytokine storm and chronic inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Serena Boccella, Francesca Guida, Monica Iannotta, Fabio Arturo Iannotti, Rosmara Infantino, Flavia Ricciardi, Claudia Cristiano, Rosa Maria Vitale, Pietro Amodeo, Ida Marabese, Carmela Belardo, Vito de Novellis, Salvatore Paino, Enza Palazzo, Antonio Calignano, Vincenzo Di Marzo, Sabatino Maione, Livio Luongo
Summary: Neuropathic pain, a complex disease involving the whole pain neuraxis, remains untreatable; however, treatment with PEA-OXA shows promise in alleviating symptoms associated with neuropathic pain.
Correction
Neurosciences
Serena Boccella, Francesca Guida, Monica Iannotta, Fabio Arturo Iannotti, Rosmara Infantino, Flavia Ricciardi, Claudia Cristiano, Rosa Maria Vitale, Pietro Amodeo, Ida Marabese, Carmela Belardo, Vito de Novellis, Salvatore Paino, Enza Palazzo, Antonio Calignano, Vincenzo Di Marzo, Sabatino Maione, Livio Luongo
Article
Biochemistry & Molecular Biology
Gennaro Lettieri, Rosaria Notariale, Nadia Carusone, Antonella Giarra, Marco Trifuoggi, Caterina Manna, Marina Piscopo
Summary: The exposure of Mytilus galloprovincialis to doses of HgCl2 induced alterations in protamine-like protein properties, affecting their ability to bind and protect DNA. Turbidity assays and fluorescence spectroscopy confirmed mercury-induced structural rearrangements and conformational changes, while salt-induced release analyses showed decreased PL-DNA binding. These findings provide insight into the molecular mechanism of mercury-related infertility in mussels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Rosmara Infantino, Consalvo Mattia, Pamela Locarini, Antonio Luigi Pastore, Sabatino Maione, Livio Luongo
Summary: Chronic pain, especially neuropathic pain, is a significant untreated disease that affects quality of life and imposes huge costs on the national health system. Opioids, while powerful analgesics, have limitations in managing neuropathic pain, leading to interest in alternatives like buprenorphine. Further research is needed to explore buprenorphine's unique pharmacological characteristics and potential benefits.
Article
Anesthesiology
Francesca Guida, Monica Iannotta, Gabriella Misso, Flavia Ricciardi, Serena Boccella, Virginia Tirino, Michela Falco, Vincenzo Desiderio, Rosmara Infantino, Gorizio Pieretti, Vito de Novellis, Gianpaolo Papaccio, Livio Luongo, Michele Caraglia, Sabatino Maione
Summary: Neuropathic pain has long-term effects on affective and cognitive functions, and this study demonstrates the impact of neuropathic pain on brain circuits and gene expression. These findings provide insights into the long-term consequences of peripheral nerve injury and highlight the need for better treatment options.
Article
Biochemistry & Molecular Biology
Gennaro Lettieri, Nadia Carusone, Rosaria Notariale, Marina Prisco, Alessia Ambrosino, Shana Perrella, Caterina Manna, Marina Piscopo
Summary: In this study, the effects of exposure to different concentrations of mercury chloride on the reproductive health of Mytilus galloprovincialis were analyzed. The results showed that mercury exposure led to alterations in gonadal morphology, hypo-expression of stress genes, decreased expression of steroidogenic enzymes and PL protein genes, and abnormal sperm chromatin structure.
Article
Biochemistry & Molecular Biology
Rosaria Notariale, Pasquale Perrone, Luigi Mele, Gennaro Lettieri, Marina Piscopo, Caterina Manna
Summary: Phosphatidylserine translocation is a significant mechanism in human erythrocytes. Olive oil phenols can prevent cell alterations induced by mercury or calcium ionophore, protecting the red blood cells. The bioactive compounds in olive oil have important implications for human health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Rosmara Infantino, Concetta Schiano, Livio Luongo, Salvatore Paino, Gelsomina Mansueto, Serena Boccella, Francesca Guida, Flavia Ricciardi, Monica Iannotta, Carmela Belardo, Ida Marabese, Gorizio Pieretti, Nicola Serra, Claudio Napoli, Sabatino Maione
Summary: This study aimed to investigate the effectiveness of a co-ultramicronized combination of N-palmitoylethanolamide and luteolin (PEALut) in a mouse model of thalamic hemorrhage (TH)-induced central post-stroke pain (CPSP). The results showed that repeated administrations of PEALut significantly reduced mechanical hypersensitivity and prevented the development of depressive-like behavior in TH mice. Additionally, PEALut restored synaptic plasticity and monoamine levels in the mice. The overexpression of MED1 in human autopsied brain specimens after stroke indicated the translational potential of these findings. These results provide a foundation for further investigation of depression in TH-induced CPSP and propose PEALut as an adjuvant treatment.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Neurosciences
Carmela Belardo, Nicola Alessio, Martina Pagano, Emanuela De Dominicis, Rosmara Infantino, Michela Perrone, Monica Iannotta, Umberto Galderisi, Barbara Rinaldi, Damiana Scuteri, Giacinto Bagetta, Enza Palazzo, Sabatino Maione, Livio Luongo
Summary: Chronic social isolation leads to stress, obesity, neuroendocrine disorders, and behavioral sequelae, but treatment with PEA-OXA can alleviate these issues.
Article
Neurosciences
Enza Palazzo, Serena Boccella, Ida Marabese, Michela Perrone, Carmela Belardo, Monica Iannotta, Damiana Scuteri, Emanuela De Dominicis, Martina Pagano, Rosmara Infantino, Giacinto Bagetta, Sabatino Maione
Summary: This study evaluated the effect of homo-AMPA on pain control in diabetic neuropathic mice and found that homo-AMPA decreased mechanical allodynia and affected pain-responding neurons. The study also suggested that mGluR8 could be the target of homo-AMPA.