Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/ijms22116115
Keywords
beta-blockers; adrenergic; antibodies against nerve growth factor; aspirin; cancer; electroceuticals; local anesthetics; metformin; neurobiology of cancer; propranolol
Funding
- Slovak Research and Development Agency [APVV-17-0090]
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Research on the neurobiology of cancer has shown that drugs modulating interactions between the nervous system and tumor environments can reduce cancer progression. However, questions remain unanswered regarding the efficacy of these drugs and their integration into conventional cancer treatment and prevention.
Research on the neurobiology of cancer, which lies at the border of neuroscience and oncology, has elucidated the mechanisms and pathways that enable the nervous system to modulate processes associated with cancer initiation and progression. This research has also shown that several drugs which modulate interactions between the nervous system and the tumor micro- and macroenvironments significantly reduced the progression of cancer in animal models. Encouraging results were also provided by prospective clinical trials investigating the effect of drugs that reduce adrenergic signaling on the course of cancer in oncological patients. Moreover, it has been shown that reducing adrenergic signaling might also reduce the incidence of cancer in animal models, as well as in humans. However, even if many experimental and clinical findings have confirmed the preventive and therapeutic potential of drugs that reduce the stimulatory effect of the nervous system on processes related to cancer initiation and progression, several questions remain unanswered. Therefore, the aim of this review is to critically evaluate the efficiency of these drugs and to discuss questions that need to be answered before their introduction into conventional cancer treatment and prevention.
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