Preclinical Development of FA5, a Novel AMP-Activated Protein Kinase (AMPK) Activator as an Innovative Drug for the Management of Bowel Inflammation

Activation of autophagy and suppression of apoptosis by dapagliflozin attenuates experimental inflammatory bowel disease in rats: Targeting AMPK/mTOR, HMGB1/RAGE and Nrf2/HO-1 pathways

(2021) Hany H. Arab et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Targeting immunometabolism as an anti-inflammatory strategy

(2020) Eva M. Pålsson-McDermott et al.   CELL RESEARCH

The Regulation of Intestinal Mucosal Barrier by Myosin Light Chain Kinase/Rho Kinases

(2020) Younggeon Jin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

AMPK is essential for IL-10 expression and for maintaining balance between inflammatory and cytoprotective signaling

(2020) Diwakar Guragain et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

GPA peptide inhibits NLRP3 inflammasome activation to ameliorate colitis through AMPK pathway

(2020) Zhao Deng et al.   Aging-US

Mediators of the Resolution of the Inflammatory Response

(2019) Michelle A. Sugimoto et al.   TRENDS IN IMMUNOLOGY

Novel Pharmacological Therapy in Inflammatory Bowel Diseases: Beyond Anti-Tumor Necrosis Factor

(2019) Cristiano Pagnini et al.   Frontiers in Pharmacology

The Metabolic Signature of Macrophage Responses

(2019) Antonella Viola et al.   Frontiers in Immunology

Berberine improved experimental chronic colitis by regulating interferon-γ- and IL-17A-producing lamina propria CD4+ T cells through AMPK activation

(2019) Masahiro Takahara et al.   Scientific Reports

Metformin inhibits inflammatory signals in the gut by controlling AMPK and p38 MAP kinase activation

(2018) Davide Di Fusco et al.   CLINICAL SCIENCE

Metformin, A New Era for an Old Drug in the Treatment of Immune Mediated Disease?

(2018) Mark Schuiveling et al.   CURRENT DRUG TARGETS

Critical role of ROCK2 activity in facilitating mucosal CD4 + T cell activation in inflammatory bowel disease

(2018) Wenjing Yang et al.   JOURNAL OF AUTOIMMUNITY

The Hypoxia–Adenosine Link during Intestinal Inflammation

(2018) Jessica L. Bowser et al.   JOURNAL OF IMMUNOLOGY

Immunopathogenesis of inflammatory bowel disease and mechanisms of biological therapies

(2018) Bani Ahluwalia et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

A Versatile New Model of Chemically Induced Chronic Colitis Using an Outbred Murine Strain

(2018) Monica Barone et al.   Frontiers in Microbiology

A Decade of Th9 Cells: Role of Th9 Cells in Inflammatory Bowel Disease

(2018) Shachi Pranjal Vyas et al.   Frontiers in Immunology

Metformin and Autoimmunity: A “New Deal” of an Old Drug

(2018) Francesco Ursini et al.   Frontiers in Immunology

The Transient Receptor Potential Vanilloid 1 Is Associated with Active Inflammation in Ulcerative Colitis

(2018) Joel Jesús Toledo-Mauriño et al.   MEDIATORS OF INFLAMMATION

Nutritional Modulation of AMPK-Impact upon Metabolic-Inflammation

(2018) Claire Lyons et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Repression of MicroRNA Function Mediates Inflammation-associated Colon Tumorigenesis

(2017) Takeshi Yoshikawa et al.   GASTROENTEROLOGY

Genetic and Transcriptomic Bases of Intestinal Epithelial Barrier Dysfunction in Inflammatory Bowel Disease

(2017) Maaike Vancamelbeke et al.   INFLAMMATORY BOWEL DISEASES

Targeting Metabolism as a Novel Therapeutic Approach to Autoimmunity, Inflammation, and Transplantation

(2017) Ian A. Bettencourt et al.   JOURNAL OF IMMUNOLOGY

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

AMPK Maintains Cellular Metabolic Homeostasis through Regulation of Mitochondrial Reactive Oxygen Species

(2017) Rebecca C. Rabinovitch et al.   Cell Reports

Palmitate-induced lipotoxicity alters acetylation of multiple proteins in clonal β cells and human pancreatic islets

(2017) Federica Ciregia et al.   Scientific Reports

The AMP analog AICAR modulates the Treg/Th17 axis through enhancement of fatty acid oxidation

(2016) Guido A. Gualdoni et al.   FASEB JOURNAL

Killer Cell Lectin-like Receptor G1 Inhibits NK Cell Function through Activation of Adenosine 5′-Monophosphate–Activated Protein Kinase

(2016) Bojana Müller-Durovic et al.   JOURNAL OF IMMUNOLOGY

The AMPK enzyme-complex: from the regulation of cellular energy homeostasis to a possible new molecular target in the management of chronic inflammatory disorders

(2015) Luca Antonioli et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Mitochondria in the Regulation of Innate and Adaptive Immunity

(2015) Samuel E. Weinberg et al.   IMMUNITY

Glucagon-like peptide 1 protects INS-1E mitochondria against palmitate-mediated beta-cell dysfunction: a proteomic study

(2015) Federica Ciregia et al.   Molecular BioSystems

Adenosine 5'-Monophosphate-Activated Protein Kinase Promotes Macrophage Polarization to an Anti-Inflammatory Functional Phenotype

(2014) D. Sag et al.   JOURNAL OF IMMUNOLOGY

Adenosine 5′-Monophosphate–Activated Protein Kinase Regulates IL-10–Mediated Anti-Inflammatory Signaling Pathways in Macrophages

(2014) Yanfang Peipei Zhu et al.   JOURNAL OF IMMUNOLOGY

Dammarane Triterpenes as Potential SIRT1 Activators from the Leaves of Panax ginseng

(2014) Jun-Li Yang et al.   JOURNAL OF NATURAL PRODUCTS

Defective expression of SIRT1 contributes to sustain inflammatory pathways in the gut

(2014) R Caruso et al.   Mucosal Immunology

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat

(2014) Vijay Morampudi et al.   Jove-Journal of Visualized Experiments

AICAR-induced activation of AMPK negatively regulates myotube hypertrophy through the HSP72-mediated pathway in C2C12 skeletal muscle cells

(2013) Tatsuro Egawa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Role of the A2Breceptor-adenosine deaminase complex in colonic dysmotility associated with bowel inflammation in rats

(2013) L Antonioli et al.   BRITISH JOURNAL OF PHARMACOLOGY

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

AMP-activated protein kinase, stress responses and cardiovascular diseases

(2012) Shaobin Wang et al.   CLINICAL SCIENCE

AMPK and SIRT1: a long-standing partnership?

(2010) Neil B. Ruderman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

AMPK agonist downregulates innate and adaptive immune responses in TNBS-induced murine acute and relapsing colitis

(2010) Aiping Bai et al.   BIOCHEMICAL PHARMACOLOGY

Animal Research: Reporting In Vivo Experiments: The ARRIVE Guidelines

(2010) Carol Kilkenny et al.   JOURNAL OF GENE MEDICINE

Metabolic Shifts in Immunity and Inflammation

(2010) D. J. Kominsky et al.   JOURNAL OF IMMUNOLOGY

Novel Anti-Inflammatory Action of 5-Aminoimidazole-4-carboxamide Ribonucleoside with Protective Effect in Dextran Sulfate Sodium-Induced Acute and Chronic Colitis

(2010) A. Bai et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The Blockade of Adenosine Deaminase Ameliorates Chronic Experimental Colitis through the Recruitment of Adenosine A2A and A3 Receptors

(2010) L. Antonioli et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease

(2009) S. Brand   GUT

Beyond AICA riboside: In search of new specific AMP-activated protein kinase activators

(2008) Bruno Guigas et al.   IUBMB LIFE