Oxytocin and Fear Memory Extinction: Possible Implications for the Therapy of Fear Disorders?

Common and dissociable effects of oxytocin and lorazepam on the neurocircuitry of fear

(2020) Ann-Kathrin Kreuder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of carbonic anhydrases in extinction of contextual fear memory

(2020) Scheila Daiane Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective sub-nucleus effects of intra-amygdala oxytocin on fear extinction

(2020) Ozge Gunduz-Cinar et al.   BEHAVIOURAL BRAIN RESEARCH

A Fear Memory Engram and Its Plasticity in the Hypothalamic Oxytocin System

(2019) Mazahir T. Hasan et al.   NEURON

Oxytocin receptors in the dorsolateral bed nucleus of the stria terminalis (BNST) bias fear learning toward temporally predictable cued fear

(2019) Daisy Martinon et al.   Translational Psychiatry

Zebrafish oxytocin neurons drive nocifensive behavior via brainstem premotor targets

(2019) Caroline L. Wee et al.   NATURE NEUROSCIENCE

Oxytocin- and arginine vasopressin-containing fibers in the cortex of humans, chimpanzees, and rhesus macaques

(2018) Christina N. Rogers et al.   AMERICAN JOURNAL OF PRIMATOLOGY

Oxytocin Signaling in the Lateral Septum Prevents Social Fear during Lactation

(2018) Rohit Menon et al.   CURRENT BIOLOGY

Neuropeptide oxytocin enhances μ opioid receptor signaling as a positive allosteric modulator

(2018) Yoshiyuki Meguro et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Augmenting Prolonged Exposure therapy for PTSD with intranasal oxytocin: A randomized, placebo-controlled pilot trial

(2018) Julianne C. Flanagan et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Excitatory connections between the prelimbic and infralimbic medial prefrontal cortex show a role for the prelimbic cortex in fear extinction

(2018) Roger Marek et al.   NATURE NEUROSCIENCE

The Oxytocin Receptor: From Intracellular Signaling to Behavior

(2018) Benjamin Jurek et al.   PHYSIOLOGICAL REVIEWS

Oxytocin facilitates adaptive fear and attenuates anxiety responses in animal models and human studies—potential interaction with the corticotropin-releasing factor (CRF) system in the bed nucleus of the stria terminalis (BNST)

(2018) Michael Janeček et al.   CELL AND TISSUE RESEARCH

Oxytocin in metabolic homeostasis: implications for obesity and diabetes management

(2018) C. Ding et al.   Obesity Reviews

Effects of Oxytocin on Fear Memory and Neuroinflammation in a Rodent Model of Posttraumatic Stress Disorder

(2018) Sheng-Chiang Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Critical evaluation of current data analysis strategies for psychophysiological measures of fear conditioning and extinction in humans

(2018) L.J. Ney et al.   INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY

Sex-dependent regulation of social reward by oxytocin receptors in the ventral tegmental area

(2018) Johnathan M. Borland et al.   NEUROPSYCHOPHARMACOLOGY

Post-retrieval oxytocin facilitates next day extinction of threat memory in humans

(2018) Jingchu Hu et al.   PSYCHOPHARMACOLOGY

Rodent models of impaired fear extinction

(2018) Nicolas Singewald et al.   PSYCHOPHARMACOLOGY

Oxytocin in the amygdala and not the prefrontal cortex enhances fear and impairs extinction in the juvenile rat

(2017) Milly Kritman et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Postnatal development of neurotransmitter systems and their relevance to extinction of conditioned fear

(2017) Jee Hyun Kim et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Oxytocin in the medial prefrontal cortex attenuates anxiety: Anatomical and receptor specificity and mechanism of action

(2017) Sara Sabihi et al.   NEUROPHARMACOLOGY

Oxytocin Modulates Nociception as an Agonist of Pain-Sensing TRPV1

(2017) Yelena Nersesyan et al.   Cell Reports

Amount of fear extinction changes its underlying mechanisms

(2017) Bobae An et al.   eLife

Oxytocin in General Anxiety and Social Fear: A Translational Approach

(2016) Inga D. Neumann et al.   BIOLOGICAL PSYCHIATRY

Assembling the Puzzle: Pathways of Oxytocin Signaling in the Brain

(2016) Valery Grinevich et al.   BIOLOGICAL PSYCHIATRY

Age and sex differences in oxytocin and vasopressin V1a receptor binding densities in the rat brain: focus on the social decision-making network

(2016) Caroline J. W. Smith et al.   Brain Structure & Function

A Cortical Circuit for Sexually Dimorphic Oxytocin-Dependent Anxiety Behaviors

(2016) Kun Li et al.   CELL

A Distributed Network for Social Cognition Enriched for Oxytocin Receptors

(2016) Mariela Mitre et al.   JOURNAL OF NEUROSCIENCE

Intranasal Oxytocin Normalizes Amygdala Functional Connectivity in Posttraumatic Stress Disorder

(2016) Saskia B J Koch et al.   NEUROPSYCHOPHARMACOLOGY

Extinction of fear is facilitated by social presence: Synergism with prefrontal oxytocin

(2016) Naama Brill-Maoz et al.   PSYCHONEUROENDOCRINOLOGY

Local oxytocin tempers anxiety by activating GABAA receptors in the hypothalamic paraventricular nucleus

(2016) Adam S. Smith et al.   PSYCHONEUROENDOCRINOLOGY

Oxytocin-dependent consolation behavior in rodents

(2016) J. P. Burkett et al.   SCIENCE

Modulation of Fear Extinction by Stress, Stress Hormones and Estradiol: A Review

(2016) Ursula Stockhorst et al.   Frontiers in Behavioral Neuroscience

Oxytocin Facilitates the Extinction of Conditioned Fear in Humans

(2015) Monika Eckstein et al.   BIOLOGICAL PSYCHIATRY

Exposure to a mildly aversive early life experience leads to prefrontal cortex deficits in the rat

(2015) Antonios Stamatakis et al.   Brain Structure & Function

Revisiting the Role of Infralimbic Cortex in Fear Extinction with Optogenetics

(2015) F. H. Do-Monte et al.   JOURNAL OF NEUROSCIENCE

Finding the engram

(2015) Sheena A. Josselyn et al.   NATURE REVIEWS NEUROSCIENCE

Stress and Fear Extinction

(2015) Stephen Maren et al.   NEUROPSYCHOPHARMACOLOGY

Repeated restraint stress-induced atrophy of glutamatergic pyramidal neurons and decreases in glutamatergic efflux in the rat amygdala are prevented by the antidepressant agomelatine

(2015) C.A. Grillo et al.   NEUROSCIENCE

Brain sites involved in fear memory reconsolidation and extinction of rodents

(2015) Elisabetta Baldi et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Pharmacology of cognitive enhancers for exposure-based therapy of fear, anxiety and trauma-related disorders

(2015) N. Singewald et al.   PHARMACOLOGY & THERAPEUTICS

Oxytocin prevents ethanol actions at δ subunit-containing GABAAreceptors and attenuates ethanol-induced motor impairment in rats

(2015) Michael T. Bowen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of the Medial Prefrontal Cortex in the Conditioning and Extinction of Fear

(2015) Thomas F. Giustino et al.   Frontiers in Behavioral Neuroscience

Prefrontal inputs to the amygdala instruct fear extinction memory formation

(2015) O. Bukalo et al.   Science Advances

Efficacy of oxytocin administration early after psychotrauma in preventing the development of PTSD: study protocol of a randomized controlled trial

(2014) Jessie L Frijling et al.   BMC Psychiatry

Oxytocin׳s role in anxiety: A critical appraisal

(2014) Kai MacDonald et al.   BRAIN RESEARCH

Modulation of the extinction of fear learning

(2014) Jociane C. Myskiw et al.   BRAIN RESEARCH BULLETIN

Mechanisms to medicines: elucidating neural and molecular substrates of fear extinction to identify novel treatments for anxiety disorders

(2014) Olena Bukalo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Oxytocin Modulates Female Sociosexual Behavior through a Specific Class of Prefrontal Cortical Interneurons

(2014) Miho Nakajima et al.   CELL

Oxytocinase in the Female Rat Hypothalamus: A Novel Mechanism Controlling Oxytocin Neurones During Lactation

(2014) V. A. Tobin et al.   JOURNAL OF NEUROENDOCRINOLOGY

Long-Range Connectivity Defines Behavioral Specificity of Amygdala Neurons

(2014) Verena Senn et al.   NEURON

Amygdala Microcircuits Controlling Learned Fear

(2014) Sevil Duvarci et al.   NEURON

Oxytocin Modulation of Amygdala Functional Connectivity to Fearful Faces in Generalized Social Anxiety Disorder

(2014) Stephanie M Gorka et al.   NEUROPSYCHOPHARMACOLOGY

Modulation of Resting-State Amygdala-Frontal Functional Connectivity by Oxytocin in Generalized Social Anxiety Disorder

(2014) Sonam Dodhia et al.   NEUROPSYCHOPHARMACOLOGY

Evolution of oxytocin pathways in the brain of vertebrates

(2014) H. Sophie Knobloch et al.   Frontiers in Behavioral Neuroscience

Memory reconsolidation

(2013) Cristina M. Alberini et al.   CURRENT BIOLOGY

Fear extinction deficits following acute stress associate with increased spine density and dendritic retraction in basolateral amygdala neurons

(2013) Mouna Maroun et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The Basolateral Amygdala Is Critical for Learning about Neutral Stimuli in the Presence of Danger, and the Perirhinal Cortex Is Critical in the Absence of Danger

(2013) N. M. Holmes et al.   JOURNAL OF NEUROSCIENCE

Exposure to a fearful context during periods of memory plasticity impairs extinction via hyperactivation of frontal-amygdalar circuits

(2013) J. M. Stafford et al.   LEARNING & MEMORY

Prefrontal parvalbumin interneurons shape neuronal activity to drive fear expression

(2013) Julien Courtin et al.   NATURE

Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin

(2013) Gül Dölen et al.   NATURE

Implications of memory modulation for post-traumatic stress and fear disorders

(2013) Ryan G Parsons et al.   NATURE NEUROSCIENCE

From Pavlov to PTSD: The extinction of conditioned fear in rodents, humans, and anxiety disorders

(2013) Michael B. VanElzakker et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Repeated restraint stress exerts different impact on structure of neurons in the lateral and basal nuclei of the amygdala

(2013) M.A. Padival et al.   NEUROSCIENCE

Immunohistochemical localization of oxytocin receptors in human brain

(2013) M.L. Boccia et al.   NEUROSCIENCE

Fear response failed to return in AAB extinction paradigm accompanied with increased NR2B and GluR1 per845 in hippocampal CA1

(2013) L. Xue et al.   NEUROSCIENCE

Stress enhances fear by forming new synapses with greater capacity for long-term potentiation in the amygdala

(2013) A. Suvrathan et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Oxytocinergic manipulations in corticolimbic circuit differentially affect fear acquisition and extinction

(2013) Nisrine Lahoud et al.   PSYCHONEUROENDOCRINOLOGY

The effect of intranasal oxytocin treatment on conditioned fear extinction and recall in a healthy human sample

(2013) Dean Acheson et al.   PSYCHOPHARMACOLOGY

Ensemble coding of context-dependent fear memory in the amygdala

(2013) Caitlin A. Orsini et al.   Frontiers in Behavioral Neuroscience

Oxytocin regulates changes of extracellular glutamate and GABA levels induced by methamphetamine in the mouse brain

(2012) Jia Qi et al.   ADDICTION BIOLOGY

A critical review of the influence of oxytocin nasal spray on social cognition in humans: Evidence and future directions

(2012) Adam J. Graustella et al.   HORMONES AND BEHAVIOR

Guidelines for the pharmacological treatment of anxiety disorders, obsessive–compulsive disorder and posttraumatic stress disorder in primary care

(2012) Borwin Bandelow et al.   INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE

The Nonpeptide Oxytocin Receptor Agonist WAY 267,464: Receptor-Binding Profile, Prosocial Effects and Distribution of c-Fos Expression in Adolescent Rats

(2012) C. Hicks et al.   JOURNAL OF NEUROENDOCRINOLOGY

Evoked Axonal Oxytocin Release in the Central Amygdala Attenuates Fear Response

(2012) H. Sophie Knobloch et al.   NEURON

Genetic Strain Differences in Learned Fear Inhibition Associated with Variation in Neuroendocrine, Autonomic and Amygdala Dendritic Phenotypes

(2012) Marguerite C Camp et al.   NEUROPSYCHOPHARMACOLOGY

Neural and cellular mechanisms of fear and extinction memory formation

(2012) Caitlin A. Orsini et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Enhanced Extinction of Aversive Memories by High-Frequency Stimulation of the Rat Infralimbic Cortex

(2012) Mouna Maroun et al.   PLoS One

Central administration of oxytocin receptor ligands affects cued fear extinction in rats and mice in a timepoint-dependent manner

(2012) Iulia Toth et al.   PSYCHOPHARMACOLOGY

Stress-enhanced fear learning in rats is resistant to the effects of immediate massed extinction

(2012) Virginia A. Long et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Fear Extinction as a Model for Translational Neuroscience: Ten Years of Progress

(2011) Mohammed R. Milad et al.   Annual Review of Psychology

Early postnatal stress alters extracellular signal-regulated kinase signaling in the corticolimbic system modulating emotional circuitry in adult rats

(2011) Shuhei Ishikawa et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Cost of disorders of the brain in Europe 2010

(2011) Anders Gustavsson et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

The size and burden of mental disorders and other disorders of the brain in Europe 2010

(2011) H.U. Wittchen et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

The oxytocin/vasopressin receptor family has at least five members in the gnathostome lineage, inclucing two distinct V2 subtypes

(2011) Daniel Ocampo Daza et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Medial frontal hyperactivity to sad faces in generalized social anxiety disorder and modulation by oxytocin

(2011) Izelle Labuschagne et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Oxytocin suppresses basal glutamatergic transmission but facilitates activity-dependent synaptic potentiation in the medial prefrontal cortex

(2011) Ipe Ninan   JOURNAL OF NEUROCHEMISTRY

Physiological identification and infralimbic responsiveness of rat intercalated amygdala neurons

(2011) Alon Amir et al.   JOURNAL OF NEUROPHYSIOLOGY

Different Fear States Engage Distinct Networks within the Intercalated Cell Clusters of the Amygdala

(2011) D. Busti et al.   JOURNAL OF NEUROSCIENCE

Hippocampal and Prefrontal Projections to the Basal Amygdala Mediate Contextual Regulation of Fear after Extinction

(2011) C. A. Orsini et al.   JOURNAL OF NEUROSCIENCE

Central Amygdala Activity during Fear Conditioning

(2011) S. Duvarci et al.   JOURNAL OF NEUROSCIENCE

Medial prefrontal cortex activation facilitates re-extinction of fear in rats

(2011) C.-h. Chang et al.   LEARNING & MEMORY

Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine

(2011) Andreas Meyer-Lindenberg et al.   NATURE REVIEWS NEUROSCIENCE

Learning-Induced Changes in mPFC–BLA Connections After Fear Conditioning, Extinction and Reinstatement of Fear

(2011) Rose-Marie Vouimba et al.   NEUROPSYCHOPHARMACOLOGY

Oxytocin Selectively Gates Fear Responses Through Distinct Outputs from the Central Amygdala

(2011) D. Viviani et al.   SCIENCE

Chronic Stress Causes Amygdala Hyperexcitability in Rodents

(2010) J. Amiel Rosenkranz et al.   BIOLOGICAL PSYCHIATRY

Prefrontal control of fear: more than just extinction

(2010) Francisco Sotres-Bayon et al.   CURRENT OPINION IN NEUROBIOLOGY

Neuronal circuits of fear extinction

(2010) Cyril Herry et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Rescue of Impaired Fear Extinction and Normalization of Cortico-Amygdala Circuit Dysfunction in a Genetic Mouse Model by Dietary Zinc Restriction

(2010) N. Whittle et al.   JOURNAL OF NEUROSCIENCE

Dendritic Growth in Medial Prefrontal Cortex and Cognitive Flexibility Are Enhanced during the Postpartum Period

(2010) B. Leuner et al.   JOURNAL OF NEUROSCIENCE

Lack of Medial Prefrontal Cortex Activation Underlies the Immediate Extinction Deficit

(2010) S. C. Kim et al.   JOURNAL OF NEUROSCIENCE

Activation of the infralimbic cortex in a fear context enhances extinction learning

(2010) B. M. Thompson et al.   LEARNING & MEMORY

Genetic dissection of an amygdala microcircuit that gates conditioned fear

(2010) Wulf Haubensak et al.   NATURE

Encoding of conditioned fear in central amygdala inhibitory circuits

(2010) Stephane Ciocchi et al.   NATURE

Synaptic correlates of fear extinction in the amygdala

(2010) Taiju Amano et al.   NATURE NEUROSCIENCE

Oxytocin Reduces Background Anxiety in a Fear-Potentiated Startle Paradigm

(2010) Galen Missig et al.   NEUROPSYCHOPHARMACOLOGY

Oxytocin Attenuates Amygdala Reactivity to Fear in Generalized Social Anxiety Disorder

(2010) Izelle Labuschagne et al.   NEUROPSYCHOPHARMACOLOGY

Dissociable Roles of Prelimbic and Infralimbic Cortices, Ventral Hippocampus and Basolateral Amygdala in the Expression and Extinction of Conditioned Fear

(2010) Demetrio Sierra-Mercado et al.   NEUROPSYCHOPHARMACOLOGY

Early stress exposure impairs synaptic potentiation in the rat medial prefrontal cortex underlying contextual fear extinction

(2010) C. Judo et al.   NEUROSCIENCE

Single-Unit Activity in the Medial Prefrontal Cortex during Immediate and Delayed Extinction of Fear in Rats

(2010) Chun-hui Chang et al.   PLoS One

Involvement of the prelimbic prefrontal cortex on cannabidiol-induced attenuation of contextual conditioned fear in rats

(2009) José Inácio Lemos et al.   BEHAVIOURAL BRAIN RESEARCH

Systemic Propranolol Acts Centrally to Reduce Conditioned Fear in Rats Without Impairing Extinction

(2009) Jose Rodriguez-Romaguera et al.   BIOLOGICAL PSYCHIATRY

Single prolonged stress: toward an animal model of posttraumatic stress disorder

(2009) Shigeto Yamamoto et al.   DEPRESSION AND ANXIETY

Evidence That Oxytocin Exerts Anxiolytic Effects via Oxytocin Receptor Expressed in Serotonergic Neurons in Mice

(2009) M. Yoshida et al.   JOURNAL OF NEUROSCIENCE

Sustained Conditioned Responses in Prelimbic Prefrontal Neurons Are Correlated with Fear Expression and Extinction Failure

(2009) A. Burgos-Robles et al.   JOURNAL OF NEUROSCIENCE

Systemic or intra-amygdala injection of a benzodiazepine (midazolam) impairs extinction but spares re-extinction of conditioned fear responses

(2009) G. Hart et al.   LEARNING & MEMORY

Reciprocal patterns of c-Fos expression in the medial prefrontal cortex and amygdala after extinction and renewal of conditioned fear

(2009) E. Knapska et al.   LEARNING & MEMORY

Oxytocin enhances the inhibitory effects of diazepam in the rat central medial amygdala

(2009) D. Viviani et al.   NEUROPHARMACOLOGY

A randomized controlled trial of intranasal oxytocin as an adjunct to exposure therapy for social anxiety disorder

(2009) Adam J. Guastella et al.   PSYCHONEUROENDOCRINOLOGY

Impaired extinction of learned fear in rats selectively bred for high anxiety - evidence of altered neuronal processing in prefrontal-amygdala pathways

(2008) Patrik Muigg et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Fear Conditioning and Extinction Differentially Modify the Intrinsic Excitability of Infralimbic Neurons

(2008) E. Santini et al.   JOURNAL OF NEUROSCIENCE

Distinct contributions of the basolateral amygdala and the medial prefrontal cortex to learning and relearning extinction of context conditioned fear

(2008) V. Laurent et al.   LEARNING & MEMORY

Amygdala intercalated neurons are required for expression of fear extinction

(2008) Ekaterina Likhtik et al.   NATURE

Switching on and off fear by distinct neuronal circuits

(2008) Cyril Herry et al.   NATURE

Neural Circuitry Underlying the Regulation of Conditioned Fear and Its Relation to Extinction

(2008) Mauricio R. Delgado et al.   NEURON

Influence of trait anxiety on brain activity during the acquisition and extinction of aversive conditioning

(2008) J. Barrett et al.   PSYCHOLOGICAL MEDICINE

Hippocampal low-frequency stimulation and chronic mild stress similarly disrupt fear extinction memory in rats

(2007) René Garcia et al.   NEUROBIOLOGY OF LEARNING AND MEMORY