Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 14, Pages -Publisher
MDPI
DOI: 10.3390/ijms22147260
Keywords
colorectal cancer; metastasis; neutrophil; extracellular DNA; therapeutics
Funding
- Cancerfonden [19 0428 Pj]
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This review highlights the roles of neutrophil extracellular traps (NETs) in colorectal cancer (CRC) progression and metastasis, as well as the potential of targeting NETs as a therapeutic strategy for colon cancer.
Neutrophils form sticky web-like structures known as neutrophil extracellular traps (NETs) as part of innate immune response. NETs are decondensed extracellular chromatin filaments comprising nuclear and cytoplasmic proteins. NETs have been implicated in many gastrointestinal diseases including colorectal cancer (CRC). However, the regulatory mechanisms of NET formation and potential pharmacological inhibitors in the context of CRC have not been thoroughly discussed. In this review, we intend to highlight roles of NETs in CRC progression and metastasis as well as the potential of targeting NETs during colon cancer therapy.
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