Laboratory evaluation and prognostication among adults and children with CEBPA ‐mutant acute myeloid leukemia

The complex genetic landscape of familial MDS and AML reveals pathogenic germline variants

(2020) Ana Rio-Machin et al.   Nature Communications

Prognostic impact of CSF3R mutations in favorable risk childhood acute myeloid leukemia

(2020) Katherine Tarlock et al.   BLOOD

Minimal residual disease detected by multiparameter flow cytometry is complementary to genetics for risk stratification treatment in acute myeloid leukemia with biallelic CEBPA mutations

(2019) Dao-Xing Deng et al.   LEUKEMIA & LYMPHOMA

CSF3R mutations were associated with an unfavorable prognosis in patients with acute myeloid leukemia with CEBPA double mutations

(2019) Long Su et al.   ANNALS OF HEMATOLOGY

Germline Predisposition to Hematolymphoid Neoplasia

(2019) Olga K Weinberg et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Companion gene mutations and their clinical significance in AML with double mutant CEBPA

(2019) Yang Zhang et al.   CANCER GENE THERAPY

A simple cytofluorimetric score may optimize testing for biallelic CEBPA mutations in patients with acute myeloid leukemia

(2019) Riccardo Marcolin et al.   LEUKEMIA RESEARCH

Myeloid lineage enhancers drive oncogene synergy in CEBPA/CSF3R mutant acute myeloid leukemia

(2019) Theodore P. Braun et al.   Nature Communications

Gain‐of‐Function Effects of N‐Terminal CEBPA Mutations in Acute Myeloid Leukemia

(2019) Luisa Schmidt et al.   BIOESSAYS

Concomitant WT1 mutations predict poor prognosis in acute myeloid leukemia patients with double mutant CEBPA

(2018) Feng-Ming Tien et al.   HAEMATOLOGICA

Mutational spectrum of acute myeloid leukemia patients with double CEBPA mutations based on next-generation sequencing and its prognostic significance

(2018) Long Su et al.   Oncotarget

Concomitant WT1 mutations predict poor prognosis in acute myeloid leukemia patients with double mutant CEBPA

(2018) Feng-Ming Tien et al.   HAEMATOLOGICA

Germline CEBPA mutations in Korean patients with acute myeloid leukemia

(2018) Hoon Seok Kim et al.   LEUKEMIA RESEARCH

Challenges in the introduction of next-generation sequencing (NGS) for diagnostics of myeloid malignancies into clinical routine use

(2018) Ulrike Bacher et al.   Blood Cancer Journal

Variable outcome and methylation status according to CEBPA mutant type in double-mutated acute myeloid leukemia patients and the possible implications for treatment

(2017) Dima El-Sharkawi et al.   HAEMATOLOGICA

CEBPAmutational analysis in acute myeloid leukaemia by a laboratory-developed next-generation sequencing assay

(2017) Christopher Wai Siong Ng et al.   JOURNAL OF CLINICAL PATHOLOGY

The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions

(2017) Hamid Bolouri et al.   NATURE MEDICINE

Variable outcome and methylation status according to CEBPA mutant type in double-mutated acute myeloid leukemia patients and the possible implications for treatment

(2017) Dima El-Sharkawi et al.   HAEMATOLOGICA

Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel

(2016) Hartmut Döhner et al.   BLOOD

CSF3R mutations have a high degree of overlap with CEBPA mutations in pediatric AML

(2016) J. E. Maxson et al.   BLOOD

Chemo-genomic interrogation of CEBPA mutated AML reveals recurrent CSF3R mutations and subgroup sensitivity to JAK inhibitors

(2016) V.-P. Lavallee et al.   BLOOD

The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia

(2016) D. A. Arber et al.   BLOOD

CEBPA –double-mutated acute myeloid leukemia displays a unique phenotypic profile: a reliable screening method and insight into biological features

(2016) Francesco Mannelli et al.   HAEMATOLOGICA

Clinical impact of GATA2 mutations in acute myeloid leukemia patients harboring CEBPA mutations: a study of the AML study group

(2016) F Theis et al.   LEUKEMIA

CEBPA –double-mutated acute myeloid leukemia displays a unique phenotypic profile: a reliable screening method and insight into biological features

(2016) Francesco Mannelli et al.   HAEMATOLOGICA

Normal karyotype acute myeloid leukemia patients with CEBPA double mutation have a favorable prognosis but no survival benefit from allogeneic stem cell transplant

(2015) Jae-Sook Ahn et al.   ANNALS OF HEMATOLOGY

Disease evolution and outcomes in familial AML with germline CEBPA mutations

(2015) K. Tawana et al.   BLOOD

Whole exome sequencing reveals a C-terminal germline variant in CEBPA-associated acute myeloid leukemia: 45-year follow up of a large family

(2015) A. Pathak et al.   HAEMATOLOGICA

Simpson's Paradox and the Impact of Different DNMT3A Mutations on Outcome in Younger Adults With Acute Myeloid Leukemia

(2015) Rosemary E. Gale et al.   JOURNAL OF CLINICAL ONCOLOGY

A Clinical Grade Sequencing-Based Assay for CEBPA Mutation Testing

(2015) Amir Behdad et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Whole exome sequencing reveals a C-terminal germline variant in CEBPA-associated acute myeloid leukemia: 45-year follow up of a large family

(2015) A. Pathak et al.   HAEMATOLOGICA

GATA2 mutations in patients with acute myeloid leukemia-paired samples analyses show that the mutation is unstable during disease evolution

(2014) Hsin-An Hou et al.   ANNALS OF HEMATOLOGY

Prognostic implications of CEBPA mutations in pediatric acute myeloid leukemia: a report from the Japanese Pediatric Leukemia/Lymphoma Study Group

(2014) H Matsuo et al.   Blood Cancer Journal

The value of allogeneic and autologous hematopoietic stem cell transplantation in prognostically favorable acute myeloid leukemia with double mutant CEBPA

(2013) R. F. Schlenk et al.   BLOOD

GATA2mutations in sporadic and familial acute myeloid leukaemia patients withCEBPAmutations

(2013) Claire L. Green et al.   BRITISH JOURNAL OF HAEMATOLOGY

CEBPAdouble-mutated acute myeloid leukaemia harbours concomitant molecular mutations in 76·8% of cases withTET2andGATA2alterations impacting prognosis

(2013) Vera Grossmann et al.   BRITISH JOURNAL OF HAEMATOLOGY

The role of different genetic subtypes of CEBPA mutated AML

(2013) A Fasan et al.   LEUKEMIA

Multilineage dysplasia does not influence prognosis in CEBPA-mutated AML, supporting the WHO proposal to classify these patients as a unique entity

(2012) U. Bacher et al.   BLOOD

A novel hierarchical prognostic model of AML solely based on molecular mutations

(2012) V. Grossmann et al.   BLOOD

GATA2 zinc finger 1 mutations associated with biallelic CEBPA mutations define a unique genetic entity of acute myeloid leukemia

(2012) P. A. Greif et al.   BLOOD

GATA2 mutations are frequent in intermediate-risk karyotype AML with biallelic CEBPA mutations and are associated with favorable prognosis

(2012) A Fasan et al.   LEUKEMIA

Gene mutation patterns and their prognostic impact in a cohort of 1185 patients with acute myeloid leukemia

(2011) Y. Shen et al.   BLOOD

Presence of FLT3-ITD and high BAALC expression are independent prognostic markers in childhood acute myeloid leukemia

(2011) A. Staffas et al.   BLOOD

Strategy for Robust Detection of Insertions, Deletions, and Point Mutations in CEBPA, a GC-Rich Content Gene, Using 454 Next-Generation Deep-Sequencing Technology

(2011) Vera Grossmann et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

A novel CCAAT/enhancer binding protein α germline variant in a case of acute myeloid leukemia

(2011) Jonathan A. Gutman et al.   LEUKEMIA & LYMPHOMA

Prognostic impact, concurrent genetic mutations, and gene expression features of AML with CEBPA mutations in a cohort of 1182 cytogenetically normal AML patients: further evidence for CEBPA double mutant AML as a distinctive disease entity

(2010) E. Taskesen et al.   BLOOD

Characterization of CEBPA mutations and promoter hypermethylation in pediatric acute myeloid leukemia

(2010) I. H. I. M. Hollink et al.   HAEMATOLOGICA

Prognostic Significance ofCEBPAMutations in a Large Cohort of Younger Adult Patients With Acute Myeloid Leukemia: Impact of DoubleCEBPAMutations and the Interaction WithFLT3andNPM1Mutations

(2010) Claire L. Green et al.   JOURNAL OF CLINICAL ONCOLOGY

Prevalence and prognostic implications of CEBPA mutations in pediatric acute myeloid leukemia (AML): a report from the Children's Oncology Group

(2009) P. A. Ho et al.   BLOOD

Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome

(2009) B. J. Wouters et al.   BLOOD

Mutant CEBPA: Priming Stem Cells for Myeloid Leukemogenesis

(2009) Tim C.P. Somervaille et al.   Cell Stem Cell

Acute Myeloid Leukemia With Biallelic CEBPA Gene Mutations and Normal Karyotype Represents a Distinct Genetic Entity Associated With a Favorable Clinical Outcome

(2009) Annika Dufour et al.   JOURNAL OF CLINICAL ONCOLOGY

A Comparison of Two Methods for Screening CEBPA Mutations in Patients with Acute Myeloid Leukemia

(2009) Jeung-Yeal Ahn et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Modeling of C/EBPα Mutant Acute Myeloid Leukemia Reveals a Common Expression Signature of Committed Myeloid Leukemia-Initiating Cells

(2008) Peggy Kirstetter et al.   CANCER CELL

Somatic CEBPA Mutations Are a Frequent Second Event in Families With Germline CEBPA Mutations and Familial Acute Myeloid Leukemia

(2008) Thomas Pabst et al.   JOURNAL OF CLINICAL ONCOLOGY

Dysregulation of the C/EBPα Differentiation Pathway in Human Cancer

(2008) Steffen Koschmieder et al.   JOURNAL OF CLINICAL ONCOLOGY