Article
Immunology
Laura E. Martinez-Gomez, Isabel Ibarra-Gonzalez, Cynthia Fernandez-Lainez, Teresa Tusie, Hortensia Moreno-Macias, Carlos Martinez-Armenta, Guadalupe Elizabeth Jimenez-Gutierrez, Paola Vazquez-Cardenas, Patricia Vidal-Vazquez, Juan P. Ramirez-Hinojosa, Ana P. Rodriguez-Zulueta, Gilberto Vargas-Alarcon, Gustavo Rojas-Velasco, Fausto Sanchez-Munoz, Rosalinda Posadas-Sanchez, Felipe de J. Martinez-Ruiz, Dulce M. Zayago-Angeles, Mariana L. Moreno, Edith Barajas-Galicia, Gerardo Lopez-Cisneros, Nadia C. Gonzalez-Fernandez, Silvestre Ortega-Pena, Brigida Herrera-Lopez, Jessel Olea-Torres, Manuel Juarez-Arias, Maritza Rosas-Vasquez, Sara Aileen Cabrera-Nieto, Jonathan J. Magana, Maria del Carmen Camacho-Rea, Carlos Suarez-Ahedo, Irma Coronado-Zarco, M. Y. Valdespino-Vazquez, Gabriela Angelica Martinez-Nava, Carlos Pineda, Marcela Vela-Amieva, Alberto Lopez-Reyes
Summary: This study aimed to characterize the profile of amino acids and acylcarnitines in COVID-19 patients. The findings suggest that metabolic imbalance may affect disease progression in COVID-19 patients, and phenylalanine may serve as a potential metabolic biomarker for evaluating disease severity.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Dan H. Barouch
Summary: This article reviews the protective effects of vaccination and prior infection on severe Covid-19, and proposes future research directions.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Multidisciplinary Sciences
Qin Liu, Qi Su, Fen Zhang, Hein M. Tun, Joyce Wing Yan Mak, Grace Chung-Yan Lui, Susanna So Shan Ng, Jessica Y. L. Ching, Amy Li, Wenqi Lu, Chenyu Liu, Chun Pan Cheung, David S. C. Hui, Paul K. S. Chan, Francis Ka Leung Chan, Siew C. Ng
Summary: By integrating clinical features and multi-omics data, the authors identified specific gut microbiome patterns associated with disease severity and development of post-acute COVID-19 syndrome. These findings highlight the potential utility of host phenotype and multi-kingdom microbiota profiling as a prognostic tool for patients with COVID-19.
NATURE COMMUNICATIONS
(2022)
Editorial Material
Immunology
Rustom Antia, M. Elizabeth Halloran
Summary: The article discusses the basic concepts underlying the transition from an epidemic to an endemic state, as well as the implications of this transition for COVID-19.
Article
Microbiology
Michael T. Hawkes, Michael F. Good
Summary: According to a mathematical epidemiological model, childhood vaccination against COVID-19 can have modest public health benefits, including reducing child morbidity and mortality and decreasing adult cases, hospitalizations, and mortality. However, the ethical considerations and global social justice, especially in terms of prioritizing children in high-income settings over vulnerable adults in low-income settings, should also be taken into account.
Article
Multidisciplinary Sciences
Marcia C. Castro, Sun Kim, Lorena Barberia, Ana Freitas Ribeiro, Susie Gurzenda, Karina Braga Ribeiro, Erin Abbott, Jeffrey Blossom, Beatriz Rache, Burton H. Singer
Summary: The study found that COVID-19 in Brazil is spreading rapidly across municipalities with distinct spatial and temporal patterns of clustering, trajectories, and speed. Analysis shows that inadequate policy measures have led to high transmission and mortality burdens. The current surge in cases and deaths, along with the circulation of concerning variants, highlights the need for government to strengthen prevention and control measures.
Article
Medicine, General & Internal
Peter Chen, Ajay Nirula, Barry Heller, Robert L. Gottlieb, Joseph Boscia, Jason Morris, Gregory Huhn, Jose Cardona, Bharat Mocherla, Valentina Stosor, Imad Shawa, Andrew C. Adams, Jacob Van Naarden, Kenneth L. Custer, Lei Shen, Michael Durante, Gerard Oakley, Andrew E. Schade, Janelle Sabo, Dipak R. Patel, Paul Klekotka, Daniel M. Skovronsky
Summary: LY-CoV555, a neutralizing antibody, showed promising results in reducing viral load, improving symptoms, and lowering the risk of hospitalization among patients with mild or moderate Covid-19. While one of the doses appeared to accelerate the decline in viral load, others did not show significant effects by day 11.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Constantinos Kurt Wibmer, Frances Ayres, Tandile Hermanus, Mashudu Madzivhandila, Prudence Kgagudi, Brent Oosthuysen, Bronwen E. Lambson, Tulio de Oliveira, Marion Vermeulen, Karin van der Berg, Theresa Rossouw, Michael Boswell, Veronica Ueckermann, Susan Meiring, Anne von Gottberg, Cheryl Cohen, Lynn Morris, Jinal N. Bhiman, Penny L. Moore
Summary: The SARS-CoV-2 virus in the B.1.351 variant discovered in South Africa can evade neutralization by most antibodies when expressed, but does not affect binding by convalescent plasma. This suggests the potential for reinfection with antigenically distinct variants and predicts reduced efficacy of spike-based vaccines.
Article
Multidisciplinary Sciences
Emanuele Andreano, Ida Paciello, Silvia Marchese, Lorena Donnici, Giulio Pierleoni, Giulia Piccini, Noemi Manganaro, Elisa Pantano, Valentina Abbiento, Piero Pileri, Linda Benincasa, Ginevra Giglioli, Margherita Leonardi, Piet Maes, Concetta De Santi, Claudia Sala, Emanuele Montomoli, Raffaele De Francesco, Rino Rappuoli
Summary: In this study, Andreano and Paciello et al. provide insights into the functional and genetic characteristics of the Omicron BA.1 and BA.2 cross-protective antibody response. Their findings reveal that SARS-CoV-2 vaccines can induce neutralizing antibodies that cross-neutralize the Omicron variants and SARS-CoV-1 virus.
NATURE COMMUNICATIONS
(2022)
Review
Public, Environmental & Occupational Health
Sazada Siddiqui, Heba Waheeb Saeed Alhamdi, Huda Ahmed Alghamdi
Summary: COVID-19 is highly contagious and has caused major disruptions around the world. Prevention is crucial through measures such as self-isolation and vaccination.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Medicine, Research & Experimental
William R. Morgenlander, Stephanie N. Henson, Daniel R. Monaco, Athena Chen, Kirsten Littlefield, Evan M. Bloch, Eric Fujimura, Ingo Ruczinski, Andrew R. Crowley, Harini Natarajan, Savannah E. Butler, Joshua A. Weiner, Mamie Z. Li, Tania S. Bonny, Sarah E. Benner, Ashwin Balagopal, David Sullivan, Shmuel Shoham, Thomas C. Quinn, Susan H. Eshleman, Arturo Casadevall, Andrew D. Redd, Oliver Laeyendecker, Margaret E. Ackerman, Andrew Pekosz, Stephen J. Elledge, Matthew Robinson, Aaron A. R. Tobian, H. Benjamin Larman
Summary: This study found strong correlation between the functionality of COVID-19 convalescent plasma and polyclonal antibody targeting of specific peptides in the SARS-CoV-2 spike protein. Antibody responses to specific coronaviruses correlated with the development of highly neutralizing antibodies against CoV-2. Plasma donations reactive to the CoV-2 spike receptor binding domain had higher neutralizing titers.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Pediatrics
Marco Roversi, Umberto Raucci, Giuseppe Pontrelli, Stefania Ranno, Michela Ambrosi, Antonio Torelli, Mara Pisani, Luana Coltella, Livia Piccioni, Luna Colagrossi, Marilena Agosta, Barbara Scialanga, Antonino Reale, Carlo Federico Perno, Paolo Rossi, Alberto Villani
Summary: This study reviewed data of children tested for COVID-19 and found that children without fever or contact with infected individuals were SARS-CoV-2 negative, which could help save resources and improve care.
PEDIATRIC RESEARCH
(2022)
Article
Virology
Tugce N. Yigenoglu, Naim Ata, Fevzi Altuntas, Semih Basci, Mehmet Sinan Dal, Serdal Korkmaz, Sinem Namdaroglu, Abdulkadir Basturk, Tuba Hacibekiroglu, Mehmet H. Dogu, Kursat Dal, Mehmet A. Erkurt, Burhan Turgut, Mustafa Mahir Ulgu, Osman Celik, Ersan Imrat, Suayip Birinci
Summary: This study shows that patients with hematological malignancy have a higher risk of COVID-19-related severe events compared to those without cancer, with higher rates of ICU admission, mechanical ventilation support, and death. It confirms the heightened vulnerability of patients with hematological malignancy during the current pandemic.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Pediatrics
Karthi Nallasamy, Suresh Kumar Angurana, Muralidharan Jayashree, Joseph L. Mathew, Arun Bansal, Mini P. Singh, Ishani Bora, P. N. M. Laxmi, Sanjay Verma, Naveen Sankhyan, Vikas Suri, Rashmi Ranjan Guru, Goverdhan Dutt Puri
Summary: During the early stage of the pandemic, most children hospitalized with COVID-19 had a history of household contact and presented with either asymptomatic or mild illness. Severe and critical cases were more common in young infants and children with comorbidities.
INDIAN JOURNAL OF PEDIATRICS
(2021)
Article
Infectious Diseases
Chang-Sheng Xia, Minghua Zhan, Yudong Liu, Zhi-Hong Yue, Ying Song, Feifei Zhang, Hui Wang
Summary: This study assessed the levels of protective antibodies in SARS survivors with and without the COVID-19 vaccine, and found that SARS survivors have protective antibodies against SARS-CoV-2 even without vaccination, and generate a stronger antibody response after vaccination compared to controls.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Pediatrics
Nina Dwi Putri, Yogi Prawira, Tartila Tartila, Madeleine Ramdhani Jasin, Henny Adriani Puspitasari, Niken Wahyu Puspaningtyas, Wahyuni Indawati, Mulya Rahma Karyanti, Darmawan Budi Setyanto, Ari Prayitno, Irene Yuniar, Fatima Safira Alatas, Eka Laksmi Hidayati, Riski Muhaimin, Titis Prawitasari, Amanda Soebadi, Dina Muktiarti, Fitri Primacakti, Anisa Rahmadhany, Gilbert Sterling Octavius, Mulyadi M. Djer, Aryono Hendarto, Rismala Dewi, Nastiti Kaswandani, Antonius Hocky Pudjiadi
Summary: This study aimed to describe the characteristics of patients with MIS-C in a tertiary referral hospital in Indonesia. The study found that the number of MIS-C cases in Indonesia is relatively low. Most patients required mechanical ventilation and intubation, and inflammatory markers and coagulation factor parameters were elevated. Survivors had a shorter time to MIS-C diagnosis, longer hospital stays, and a different treatment plan compared to non-survivors.
JOURNAL OF TROPICAL PEDIATRICS
(2022)
Article
Medicine, General & Internal
Lianpan Dai, Lidong Gao, Lifeng Tao, Sri R. Hadinegoro, Musabaev Erkin, Zhifang Ying, Peng He, Rodman T. Girsang, Hugo Vergara, Javed Akram, Hindra Satari, Tanwir Khaliq, Ume Sughra, Ana P. Celi, Fangjun Li, Yan Li, Zhiwei Jiang, Dilbar Dalimova, Jaloliddin Tuychiev, Shahlo Turdikulova, Aamer Ikram, Nancy Flores Lastra, Fan Ding, Mahendra Suhardono, Eddy Fadlyana, Jinghua Yan, Zhongyu Hu, Changgui Li, Ibrokhim Y. Abdurakhmonov, George F. Gao
Summary: The ZF2001 vaccine has been shown to be safe and effective against symptomatic and severe-to-critical Covid-19 in a large cohort of adults for at least 6 months after full vaccination.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Infectious Diseases
Andry Juliansen, Rivaldo S. Heriyanto, Charista L. Budiputri, Fellisa Meliani, Michelle P. Muljono, Shally Chandra, Gilbert S. Octavius
Summary: This study assessed the ability of warning signs to predict severe dengue infection in pediatric patients. It found that six warning signs were significantly associated with severe dengue infection, and identified 1.5 warning signs as the optimal cut-off for predicting severe dengue infection.
JOURNAL OF PEDIATRIC INFECTIOUS DISEASES
(2022)
Review
Medicine, General & Internal
Gilbert Sterling Octavius, Ricardo Tan, Teodorus Alfons Pratama, Charista Lydia Budiputri, Fellisa Meliani, Rivaldo Steven Heriyanto, Rusli Muljadi, Andry Juliansen
Summary: This review summarizes the cardiac abnormalities that may develop during PIMS-TS in children. The findings highlight the need for increased vigilance and not underestimating the consequences in pediatric COVID-19 patients.
MEDICAL JOURNAL OF INDONESIA
(2022)
Article
Nutrition & Dietetics
Setyo Handryastuti, Hardiono D. Pusponegoro, Surastuti Nurdadi, Anita Chandra, Feka A. Pramita, Amanda Soebadi, Ivan R. Widjaja, Achmad Rafli
Summary: This study shows that children with stunting and undernutrition exhibit lower cognitive, motor, and adaptive behavior abilities, with stunted children showing a more significant decline. Additionally, children with undernutrition have below-average abilities in all domains, even before stunting occurs.
JOURNAL OF NUTRITION AND METABOLISM
(2022)
Review
Engineering, Industrial
Elkana Timotius, Gilbert Sterling Octavius
Summary: This study assessed the impact of workplace stress on productivity and provided directions for future research. By analyzing the perspectives of industrial engineering, management, and medicine, the study found that workplace stress can worsen relationships at home and between superiors and subordinates, as well as lead to the development of diseases, ultimately negatively affecting productivity. Therefore, stress management is crucial.
INDUSTRIAL ENGINEERING AND MANAGEMENT SYSTEMS
(2022)
Letter
Pediatrics
Shally Chandra, Charista Lydia Budiputri, Fellisa Meliani, Michelle Patricia Muljono, Rivaldo Steven Heriyanto, Andry Juliansen, Gilbert Sterling Octavius
INDIAN JOURNAL OF PEDIATRICS
(2023)
Review
Endocrinology & Metabolism
Gilbert Sterling Octavius, Ayesha Shakila, Mariska Meliani, Anita Halim
Summary: This study aimed to describe the prevalence of vitamin D deficiency in Indonesian children and adolescents. Through meta-analysis, the prevalence of hypovitaminosis D in Indonesia was calculated as 33%, with higher rates in females. Immediate strategies for detecting and treating vitamin D deficiency in Indonesian children and adolescents are recommended.
ANNALS OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
(2023)
Review
Surgery
Gilbert Sterling Octavius, Michelle Patricia Muljono, Charista Lydia Budiputri
Summary: This study examined the diagnostic accuracy of serum Pentraxin-3 in diagnosing acute appendicitis in patients with acute abdominal pain. The results showed that serum Pentraxin-3 had a sensitivity of 90.3% and a specificity of 91.2%. It can be used as a confirmation test for acute appendicitis but not to exclude it.
Review
Pediatrics
Gilbert Sterling Octavius, Michelle Imanuelly, Johan Wibowo, Nadia Khoirunnisa Heryadi, Melanie Widjaja
Summary: This systematic review and meta-analysis examined the diagnostic parameters of the IVC/Ao ratio for predicting clinically significant dehydration in pediatric patients. The results suggest that the IVC/Ao ratio is insufficient to exclude or confirm significant dehydration in pediatric patients.
CLINICAL AND EXPERIMENTAL PEDIATRICS
(2023)
Review
Pediatrics
Gilbert Sterling Octavius, Vamela Adman Daleni, Yulita Delfia Sari Sagala
Summary: Due to high entry barriers, implementing the NBS program in countries, especially those just starting, can be daunting. This review discusses Indonesia's barriers to NBS implementation and their future implications. Relevant literature and grey literature were searched for information. The barriers Indonesia faces in implementing NBS include lack of prevalence data, ethical issues, infrastructure, cost-benefit analysis, logistical issues, government support, patient issues, lack of commitments, and a shortage of healthcare workers and training. Government support, proper infrastructure, and a single-payer system are necessary to accelerate NBS programs in Indonesia.
Article
Pediatrics
Antonius Hocky Pudjiadi, Nina Dwi Putri, Stephanie Wijaya, Fatima Safira Alatas
Summary: This study aimed to explore the factors contributing to mortality and its management among pediatric sepsis patients at a single center in Indonesia. The results showed that the mortality rate of pediatric sepsis was 76.1% among 176 records with outcome identified. Mortality was significantly associated with septic shock at triage, number of organ failure, intensive care unit admission, inotropic use, septic shock and severe sepsis during hospitalization. Death within the first 24 hours occurred in 41.8% of subjects, mostly due to septic shock.
JOURNAL OF TROPICAL PEDIATRICS
(2023)
Article
Pediatrics
Fatima Safira Alatas, Aldisa Ayu Pratiwi, Agnes Kurniawan, Antonius Hocky Pudjiadi
Summary: The article highlights the endemic problem of soil-transmitted helminth infection in Indonesia, which can lead to reinfection despite personalized therapy and mass treatment. The case series demonstrates the association between multiple helminth infections, chronic bloody diarrhea, and stunted growth in children. Pediatricians are alerted to consider untreated helminthic infections as part of the differential diagnosis in children with gastrointestinal bleeding. Environmental surveillance in high-risk areas is recommended to prevent reinfection and growth alteration. Early routine fecal analysis is advised in endemic areas. Correct diagnosis, prompt treatment, and source control are crucial in preventing long-term complications.
JOURNAL OF CHILD SCIENCE
(2022)
