☆ 4.4 Article

The comparison of myomectomy, UAE and MRgFUS in the treatment of uterine fibroids: a meta analysis

INTERNATIONAL JOURNAL OF HYPERTHERMIA (2021)

Journal

INTERNATIONAL JOURNAL OF HYPERTHERMIA

Volume 38, Issue 2, Pages 24-29

Publisher

TAYLOR & FRANCIS LTD

DOI: 10.1080/02656736.2021.1933216

Keywords

Uterine fibroids; myomectomy; UAE; MRgFUS; re-intervention

Funding

Bureau of Science and Technology Nanchong City Program [16YFZJ0029, 18SXHZ0126]
Primary Health Development Research Center of Sichuan Province Program [SWFZ17-Y-25, SWFZ17-C-69]
Science and Technology Department of Sichuan province Program [2015JY0056]
Nanchong Federation of Social Science Associations Program [NC2016B017]
Yuzhong District Research Program of Basic Research and Frontier Technology of Chongqing [20202723]

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Abstract

This study compared the re-intervention rates of myomectomy, UAE, and MRgFUS for uterine fibroids in different follow-up times. The results showed that myomectomy had the lowest re-intervention rates in both short and long term, while MRgFUS had the highest rates, especially increasing rapidly in the 60th month after treatment.

Objective To compare the re-intervention rates of myomectomy, uterine artery embolization (UAE) and magnetic resonance-guided focused ultrasound surgery (MRgFUS) for uterine fibroids (UFs) in different follow-up time. Methods Two investigators searched PubMed for clinical studies published in English from 1 Jan 2000 to 31 Dec 2020, and independently examined the paper to select qualified studies, extracted relevant information and assessed the risk of bias. Meanwhile, a meta-analysis of 31 studies containing totally 42103 patients was conducted to compare the re-intervention rate of myomectomy, UAE and MRgFUS. Results In the meta-analysis of 42103 patients, the 12-month re-intervention rates of myomectomy, UAE and MRgFUS for UFs were 0.06 (95%CI, 0.01-0.11), 0.07 (95%CI, 0.06-0.09), and 0.12 (95%CI, 0.04-0.20) respectively. The 24-month re-intervention rates were 0.10 (95%CI, 0.04-0.16), 0.08 (95%CI, 0.01-0.17), and 0.14 (95%CI, 0.07-0.21) respectively. The 36-month re-intervention rates were 0.09 (95%CI, 0.05-0.13), 0.14 (95%CI, 0.05-0.23), and 0.22 (95%CI, 0.11-0.32) respectively. Additionally, the 60-month re-intervention rates were 0.19 (95%CI, 0.15-0.24), 0.21 (95%CI, 0.17-0.25), and 0.49 (95%CI, 0.21-0.77) respectively. Conclusions The myomectomy has the lowest re-intervention rate of the three regimens in short time and long time while the MRgFUS has the highest. The rate of MRgFUS increased rapidly in the 60th month after the treatment.

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Analysis of Clinical Efficacy and Safety of Laparoscopic Myomectomy for Uterine Fibroids

Zhaojun Zeng, Ying Liu, Jingxian Xia

Summary: This study aimed to assess the clinical efficacy and safety of laparoscopic myomectomy for uterine fibroids. The findings showed that compared to open surgery, laparoscopic myomectomy reduced intraoperative bleeding, shortened operation time and hospital stay, and lowered the incidence of postoperative complications. It also resulted in better clinical outcomes.

JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS (2023)