Article
Oncology
Tae Jin Kwon, Tae Jun Kim, Hyuk Lee, Yang Won Min, Byung-Hoon Min, Jun Haeng Lee, Jae J. Kim
Summary: Statins have been found to reduce the risk of gastric cancer recurrence in H. pylori-negative patients who underwent endoscopic resection for early gastric cancer. There is a dose-response relationship between statin use and the risk of metachronous gastric cancer.
Editorial Material
Microbiology
Agustina Taglialegna
Summary: In this study, Sharafutdinov et al. report the identification of a single nucleotide polymorphism in the gene encoding the HtrA protease of Helicobacter pylori that is linked to gastric cancer.
NATURE REVIEWS MICROBIOLOGY
(2023)
Article
Medicine, General & Internal
Ji Eun Kim, Tae Jun Kim, Hyuk Lee, Yeong Chan Lee, Hwe Hoon Chung, Yang Won Min, Byung-Hoon Min, Jun Haeng Lee, Jae J. Kim
Summary: Aspirin use was not associated with a lower risk of metachronous gastric cancer in H. pylori-negative patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Tomohiko Yasuda, Hyun Seok Lee, Su Youn Nam, Hiroto Katoh, Yuko Ishibashi, Somay Yamagata Murayama, Hidenori Matsui, Hiroki Masuda, Emiko Rimbara, Nobuyuki Sakurazawa, Hideyuki Suzuki, Hiroshi Yoshida, Yasuyuki Seto, Shumpei Ishikawa, Seong Woo Jeon, Masahiko Nakamura, Sachiyo Nomura
Summary: Genetic analysis and culturing techniques for gastric non-Helicobacter pylori Helicobacter (NHPH) are advancing, with NHPH reported to accompany certain gastric conditions. A study on Korean gastric cancer patients found a low percentage positive for NHPH, suggesting it may play a role in gastric cancer development, albeit with lower pathogenicity compared to H. pylori.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Yoshiaki Usui, Yukari Taniyama, Mikiko Endo, Yuriko N. Koyanagi, Yumiko Kasugai, Isao Oze, Hidemi Ito, Issei Imoto, Tsutomu Tanaka, Masahiro Tajika, Yasumasa Niwa, Yusuke Iwasaki, Tomomi Aoi, Nozomi Hakozaki, Sadaaki Takata, Kunihiko Suzuki, Chikashi Terao, Masanori Hatakeyama, Makoto Hirata, Kokichi Sugano, Teruhiko Yoshida, Yoichiro Kamatani, Hidewaki Nakagawa, Koichi Matsuda, Yoshinori Murakami, Amanda B. Spurdle, Keitaro Matsuo, Yukihide Momozawa
Summary: This study reveals that certain genetic variants associated with Helicobacter pylori infection can increase the risk of gastric cancer. Individuals carrying these genetic variants and infected with H. pylori have an even higher risk of developing gastric cancer.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Silvia Salvatori, Irene Marafini, Federica Laudisi, Giovanni Monteleone, Carmine Stolfi
Summary: H. pylori infection contributes to the onset and development of gastric cancer through the mechanisms of chronic inflammation and DNA damage to gastric epithelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemical Research Methods
Lusheng Song, Minkyo Song, Charles S. Rabkin, Stacy Williams, Yunro Chung, Jennifer Van Duine, Linda M. Liao, Kailash Karthikeyan, Weimin Gao, Jin G. Park, Yanyang Tang, Jolanta Lissowska, Ji Qiu, Joshua LaBaer, M. Constanza Camargo
Summary: This study evaluated humoral responses to a nearly complete H. pylori immunoproteome among GC cases and controls, finding higher prevalence of certain antibodies in controls and lower seroprevalence in GC cases, suggesting immune protection and potential changes in specific proteins.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Dan Li, Sheng-Fang Jiang, Nan Ye Lei, Shailja C. Shah, Douglas A. Corley
Summary: This large-scale retrospective cohort study in the United States investigated the incidence of noncardia gastric adenocarcinoma (NCGA) after Helicobacter pylori eradication therapy. The findings showed a significantly reduced risk of NCGA after 8 years of treatment compared to no treatment. This study highlights the potential for substantial gastric cancer prevention through H pylori eradication. Evaluation: 8 out of 10.
Review
Microbiology
Victor E. Reyes
Summary: Helicobacter pylori infection is a major risk factor for gastric cancer and is associated with chronic inflammation and DNA damage. Understanding the mechanisms of H. pylori-induced carcinogenesis and immune evasion is crucial for preventing gastric cancer and reducing the burden of this disease.
Review
Microbiology
Sushil Kumar, Girijesh Kumar Patel, Uday C. Ghoshal
Summary: Gastric cancer is associated with chronic inflammation, parasitic infections, dietary habits, and host genetic factors. Research on the process of H. pylori-induced inflammation and gastric precursor lesions suggests that gut microbiota and parasitic infections may modulate risk, while genetic polymorphisms and exosomes play a role in the development of gastric carcinoma.
Review
Biotechnology & Applied Microbiology
Linqi Zhu, Yue Huang, Hong Li, Shihe Shao
Summary: Infection with Helicobacter pylori may promote the occurrence and progression of gastric cancer by influencing the tumor microenvironment (TME).
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Olga Sokolova, Michael Naumann
Summary: Gastric cancer is a major cause of cancer-related deaths globally, and its development is influenced by genetic predisposition, environmental factors, and Helicobacter pylori infection. Matrix metalloproteinases (MMPs) play an active role in the progression of gastric cancer, with bacterial dependence being less significant in later stages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Surinder M. Soond, Andrey A. Zamyatnin
Summary: The relationship between pathogens and the increased risk of cancer has attracted significant attention, particularly the contribution of Helicobacter pylori infection to the risk of developing gastric cancer. Research is increasingly focusing on the mechanisms by which the microorganism affects host cells and the importance of the host immune system in disease progression.
Article
Oncology
Ken Namikawa, Norio Tanaka, Yuki Ota, Manabu Takamatsu, Mayuko Kosugi, Yoshitaka Tokai, Shoichi Yoshimizu, Yusuke Horiuchi, Akiyoshi Ishiyama, Toshiyuki Yoshio, Toshiaki Hirasawa, Sayuri Amino, Rie Furuya, Osamu Gotoh, Tomoko Kaneyasu, Izuma Nakayama, Yu Imamura, Tetsuo Noda, Junko Fujisaki, Seiichi Mori
Summary: This study compared the genomic differences between HP-exposed and HP-naive diffuse-type gastric cancer (DGC) and found that they develop along different molecular pathways. This finding provides a basis for early detection strategies in high incidence settings.
JOURNAL OF PATHOLOGY
(2022)
Article
Oncology
Qun Zhang, Ying Ni, Xiaofei Zhi, Jiwei Wang, Zheng Li, Jie Tang, Linjun Wang, Weizhi Wang, Zekuan Xu
Summary: In patients with gastric cancer infected with H. pylori, the expression of APRIL was upregulated and promoted the proliferation, migration, invasion, viability, and metastasis of GC cells through miR-145. Furthermore, APRIL induced gastric tumorigenicity by activating the NF-kappa B pathway. These findings lay the groundwork for a more in-depth analysis of APRIL in gastric cancer risk and prognosis.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Psychiatry
Takeshi Nishiyama, Satoshi Sumi, Hiroto Watanabe, Futoshi Suzuki, Yukiko Kuru, Tomoko Shiino, Takuma Kimura, Chaochen Wang, Yingsong Lin, Maya Ichiyanagi, Kou Hirai
COMPREHENSIVE PSYCHIATRY
(2020)
Article
Multidisciplinary Sciences
Chaochen Wang, Tatsunori Ikemoto, Atsuhiko Hirasawa, Young-Chang Arai, Shogo Kikuchi, Masataka Deie
Article
Oncology
Shamima Akter, Zobida Islam, Tetsuya Mizoue, Norie Sawada, Hikaru Ihira, Shoichiro Tsugane, Yuriko N. Koyanagi, Hidemi Ito, Chaochen Wang, Akiko Tamakoshi, Keiko Wada, Chisato Nagata, Kenta Tanaka, Yuri Kitamura, Mai Utada, Kotaro Ozasa, Yumi Sugawara, Ichiro Tsuji, Taichi Shimazu, Keitaro Matsuo, Mariko Naito, Keitaro Tanaka, Manami Inoue
Summary: Smoking has been consistently associated with an increased risk of colorectal cancer, particularly in Japanese men and women. The study showed a dose-response relationship between smoking and CRC risk, with higher risks observed in male participants for overall CRC, colon, and rectal cancer. There was no significant gender difference in the association between smoking and CRC risk.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Madoka Iwase, Keitaro Matsuo, Yuriko N. Y. Koyanagi, Hidemi Ito, Akiko Tamakoshi, Chaochen Wang, Mai Utada, Kotaro Ozasa, Yumi Sugawara, Ichiro Tsuji, Norie Sawada, Shiori Tanaka, Chisato Nagata, Yuri Kitamura, Taichi Shimazu, Tetsuya Mizoue, Mariko Naito, Keitaro Tanaka, Manami Inoue
Summary: This study found that frequent and high alcohol consumption are risk factors for premenopausal breast cancer in Asian populations, similar to previous studies in Western countries. However, no significant association was observed in postmenopausal women, indicating the need for larger investigations in Asia.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Taro Takeuchi, Yuri Kitamura, Tomotaka Sobue, Mai Utada, Kotaro Ozasa, Yumi Sugawara, Ichiro Tsuji, Miyuki Hori, Norie Sawada, Shoichiro Tsugane, Yuriko N. Koyanagi, Hidemi Ito, Chaochen Wang, Akiko Tamakoshi, Keiko Wada, Chisato Nagata, Taichi Shimazu, Tetsuya Mizoue, Keitaro Matsuo, Mariko Naito, Keitaro Tanaka, Manami Inoue
Summary: Among Japanese women, the use of female hormones increased the risk of breast cancer in premenopausal women, while having more births decreased the risk of breast cancer in postmenopausal women.
Article
Public, Environmental & Occupational Health
Maki Inoue-Choi, Neal D. Freedman, Eiko Saito, Shiori Tanaka, Mayo Hirabayashi, Norie Sawada, Shoichiro Tsugane, Yoshiaki Usui, Hidemi Ito, Chaochen Wang, Akiko Tamakoshi, Taro Takeuchi, Yuri Kitamura, Mai Utada, Kotaro Ozasa, Yumi Sugawara, Ichiro Tsuji, Keiko Wada, Chisato Nagata, Taichi Shimazu, Tetsuya Mizoue, Keitaro Matsuo, Mariko Naito, Keitaro Tanaka, Kota Katanoda, Manami Inoue
Summary: A study in Japan found that even smoking a small number of cigarettes per day is associated with increased mortality risks. Both male and female low-intensity smokers had higher all-cause mortality risks compared to non-smokers, and the risk further increased with higher cigarette consumption.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Nutrition & Dietetics
Chaochen Wang, Suzana Almoosawi, Luigi Palla
Summary: The study examines the relationship between food and eating time, showing that unhealthy foods consumed in the evening/night are typically highly processed and rich in added sugar or saturated fat. Undiagnosed diabetics are more likely to consume unhealthy foods at night compared to other groups.
FRONTIERS IN NUTRITION
(2021)
Article
Gastroenterology & Hepatology
Shogo Kikuchi, Yuki Obata, Tae Sasakabe, Sayo Kawai, Chaochen Wang, Yingsong Lin
Summary: This study evaluated the carcinogenic effect of H. pylori infection on gastric cancer in Japan. The results suggest that the risk ratio of gastric cancer between individuals with and without a history of H. pylori infection may exceed 20.
Correction
Public, Environmental & Occupational Health
Maki Inoue-Choi, Neal D. Freedman, Eiko Saito, Shiori Tanaka, Mayo Hirabayashi, Norie Sawada, Shoichiro Tsugane, Yoshiaki Usui, Hidemi Ito, Chaochen Wang, Akiko Tamakoshi, Taro Takeuchi, Yuri Kitamura, Mai Utada, Kotaro Ozasa, Yumi Sugawara, Ichiro Tsuji, Keiko Wada, Chisato Nagata, Taichi Shimazu, Tetsuya Mizoue, Keitaro Matsuo, Mariko Naito, Keitaro Tanaka, Kota Katanoda, Manami Inoue
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Nutrition & Dietetics
Yuanying Li, Hiroshi Yatsuya, Chaochen Wang, Mayu Uemura, Masaaki Matsunaga, Yupeng He, Maythet Khine, Atsuhiko Ota
Summary: The present study aimed to derive dietary patterns using reduced rank regression and investigate their association with the risk of developing metabolic syndrome and its components. The study found that a healthy dietary pattern was inversely associated with the incidence of metabolic syndrome, while an unhealthy dietary pattern was positively associated with its occurrence.
Article
Dermatology
Chaochen Wang, Toshihiko Aranishi, Catherine Reed, Peter Anderson, Jenny Austin, Victoria A. A. Davis, Emily Quinones, James Piercy
Summary: This study investigated the disconnect between patients and physicians in terms of treatment satisfaction in atopic dermatitis (AD) in Japan. It found that the main reasons for dissatisfaction were treatment efficacy and usability. Inconsistent treatment satisfaction influenced treatment patterns, clinical characteristics, and patient-reported outcomes.
DERMATOLOGY AND THERAPY
(2023)
Article
Oncology
Yuriko Koyanagi, Keitaro Matsuo, Hidemi Ito, Chaochen Wang, Akiko Tamakoshi, Yumi Sugawara, Ichiro Tsuji, Ayami Ono, Shoichiro Tsugane, Norie Sawada, Keiko Wada, Chisato Nagata, Taro Takeuchi, Tetsuhisa Kitamura, Mai Utada, Ritsu Sakata, Tetsuya Mizoue, Sarah Krull Abe, Manami Inoue
Summary: The effect of body mass index (BMI) on esophageal and gastric carcinogenesis varies depending on subtype or subsite. In this study, a pooled analysis of 10 population-based cohort studies in Japan, we observed an inverse association between BMI and esophageal squamous cell carcinoma, but a positive association with gastric cardia cancer. Additionally, a positive association was found for overweight or obese individuals with esophageal adenocarcinoma and gastric cardia cancer. The study highlights the subtype- or subsite-specific impact of BMI on upper gastrointestinal cancer in the Japanese population.
Article
Dermatology
Chaochen Wang, Hitoe Torisu-Itakura, Takao Hanada, Takashi Matsuo, Zhihong Cai, Satoshi Osaga, Toshihiko Aranishi
Summary: Real-world evidence on the persistence of IL-17 inhibitors (IL-17i) among Japanese patients with psoriasis, including its subtypes, is lacking. This study found that the persistence rates of IL-17is were over 50% in patients with psoriasis and its subtypes (PsO, PsA, GPP or EP) in Japan for up to 36 months.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2023)
Article
Medicine, Research & Experimental
Chaochen Wang, Tomoko Ishizuka, Masaru Tanaka, Koji Matsuo, Hannah Knight, Niamh Harvey, Liane Gillespie-Akar, Theresa Hunter Gibble
Summary: This study investigated the prevalence of bowel urgency (BU) in Japanese patients with inflammatory bowel disease (IBD) and compared the clinical outcomes and health-related quality of life (HRQoL) between patients with and without BU. The results showed that patients with BU had worse clinical outcomes and HRQoL compared to patients without BU.
ADVANCES IN THERAPY
(2023)