Journal
INTERNATIONAL JOURNAL OF CANCER
Volume 149, Issue 9, Pages 1628-1638Publisher
WILEY
DOI: 10.1002/ijc.33731
Keywords
immunosuppression; immunotherapy; metastasis; neutrophils; PMN-MDSC
Categories
Funding
- Bundesministerium fur Bildung und Forschung, SERPENTINE/ERA PerMed network
- Deutsche Forschungsgemeinschaft [259332240/RTG 2099]
- Deutsches Krebsforschungszentrum [CA181]
Ask authors/readers for more resources
This review summarizes the origin of polymorphonuclear myeloid-derived suppressor cells (PMN-MDSC) and their relation to classical neutrophils, outlining their metastasis promoting features and promising strategies for targeting them to enhance the efficacy of cancer immunotherapy.
Myeloid-derived suppressor cells (MDSC) represent a highly immunosuppressive population that expands in tumor bearing hosts and inhibits both T and NK cell antitumor effector functions. Among MDSC subpopulations, the polymorphonuclear (PMN) one is gaining increasing interest since it is a predominant MDSC subset in most cancer entities and inherits unique properties to facilitate metastatic spread. In addition, further improvement in distinguishing PMN-MDSC from neutrophils has contributed to the design of novel therapeutic approaches. In this review, we summarize the current view on the origin of PMN-MDSC and their relation to classical neutrophils. Furthermore, we outline the metastasis promoting features of these cells and promising strategies of their targeting to improve the efficacy of cancer immunotherapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available