Article
Engineering, Mechanical
Qi Li, Ping Zhang, Canhui Yang, Huiling Duan, Wei Hong
Summary: This study presents a method for switchable adhesion between hydrogels by inducing wrinkles through a mechanical process, allowing for enhanced and weakened adhesion, as well as easy detachment. The approach demonstrates a proof-of-concept hydrogel patch that can strongly adhere to and gently detach from a damaged hydrogel device based on the switchable hydrogel adhesion.
EXTREME MECHANICS LETTERS
(2021)
Review
Polymer Science
Bernhard V. K. J. Schmidt
Summary: Hydrogels, with their soft and tissue-like properties and high water-content, are highly promising materials with a wide range of applications including tissue engineering and drug delivery. The properties of hydrogels can be tailored through crosslinking mechanisms, shape, and composition, with multicompartment hydrogels driving progress in complex and highly functional soft materials. This review highlights the latest developments in multicompartment hydrogels, focusing on various compartments and discussing their morphologies and applications. The further development of multicompartment hydrogels will have a significant impact on biomedicine and organic devices.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Tina Helmecke, Dominik Hahn, Nadine Matzke, Lisa Ferdinand, Lars Franke, Sebastian Kuehn, Gunter Fischer, Carsten Werner, Manfred F. Maitz
Summary: This paper introduces a new polymer hydrogel platform that releases anti-inflammatory molecules in response to the inflammatory activation of human blood. The hydrogel is conjugated with anti-inflammatory peptide drugs through a peptide sequence cleaved by elastase released from activated granulocytes. The adaptive drug delivery triggered by activated granulocytes and the effect of the released drug on the respective inflammatory pathways are demonstrated.
Article
Engineering, Environmental
Ting Wang, Jing Deng, Ruijin Ran, Wenqiang Shi, Yunxia Gao, Xiang Ren, Jun Cao, Ming Zhang
Summary: An in-situ forming hydrogel (PEGBAA) with stability and anti-fouling properties can serve as a long-term vitreous substitute, consisting of functional-modified multi-arm polyethylene glycol and zwitterionic polymer.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Biomedical
Dan Zhang, Zimu Li, Li Yang, Hualin Ma, Hongzhong Chen, Xiaowei Zeng
Summary: In recent decades, drug synergy has made significant progress in clinical applications. However, creating a platform that allows single administration and multi-stage release by mimicking the natural physiological processes of the human body is a major challenge in the field of molecular pharmaceutics. Hydrogels, as a new generation of drug delivery systems, have been widely used in drug platforms due to their excellent biocompatibility and modifiability. Sequential drug delivery hydrogels (SDDHs), which combine the advantages of hydrogels and sequential release platforms, offer a promising solution for effectively navigating the complex human environment and achieving drug sequential release.
Review
Biochemistry & Molecular Biology
Aydin Bordbar-Khiabani, Michael Gasik
Summary: Smart hydrogels, a type of material that can respond to stimuli and adapt their responses based on external cues, have emerged as a promising research frontier in the field of biomedical engineering. With their high stability, physicochemical properties, and biocompatibility, smart hydrogels have the potential to be used in drug delivery systems. By changing their properties under external stimuli such as pH, temperature, electrical and magnetic fields, light, and biomolecules concentration, smart hydrogels can achieve controlled release of loaded drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biotechnology & Applied Microbiology
Calina Ciont, Amalia Mesaros, Oana Lelia Pop, Dan Cristian Vodnar
Summary: This study aims to investigate the interaction between iron oxide nanoparticles (IONPs) and probiotic cells and their impact on iron absorption, bioavailability, and microbiota variation. Through literature research and synthesis, the authors utilized a rigorous search methodology and collected 122 relevant research articles. The results showed that probiotics carrying IONPs had better treatment efficacy compared to conventional methods.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Yuanchun Du, Guangfu Feng
Summary: The development of nanocellulose hydrogels has contributed to renewable smart material technologies. These materials combine the advantages of nanocellulose and hydrogels and have applications in medicine, electricity, sensor, environmental governance, food, and agriculture. This article provides a comprehensive classification and analysis of nanocellulose hydrogels, highlighting their design innovation advantages and addressing their shortcomings.
Review
Chemistry, Multidisciplinary
Yuanchun Du, Guangfu Feng
Summary: The rapid development of nanocellulose and hydrogels has significantly contributed to the progress of renewable smart material technologies. Nanocellulose hydrogels, which combine the advantages of both materials, have emerged as pioneering materials in the green chemistry revolution. This comprehensive study provides a systematic classification and analysis of nanocellulose hydrogels, focusing on their applications in medicine, electricity, sensors, environmental governance, food, and agriculture, as well as their design innovation advantages.
Review
Polymer Science
Wenliang Zhang, Yining Liu, Yang Xuan, Shubiao Zhang
Summary: Hydrogels are widely used materials in various fields, especially in drug delivery applications. Carboxymethyl cellulose (CMC) hydrogels, with their non-toxicity, biodegradability, and biocompatibility, have attracted significant research attention for the development of drug delivery carriers.
Article
Polymer Science
Bruno Batista da Silva, Jorge Eduardo Menezes, Mardoqueu Martins da Costa, Laurita dos Santos, Rafaela Cristina Sanfelice, Adriana Pavinatto
Summary: Herpes simplex virus infections are caused by two types (1 and 2) of the virus, being endemic worldwide and a frequent public health concern. The drug of choice for treatment is acyclovir (ACV), which inhibits viral DNA polymerase. However, the topical use of ACV ointments requires frequent application due to low permeation. Therefore, the use of biomaterials such as chitosan (CS) for controlled drug release is an interesting alternative.
Review
Chemistry, Applied
S. Peers, A. Montembault, C. Ladaviere
Summary: This review focuses on the development of complex drug delivery systems composed of chitosan hydrogels embedding different types of colloids to achieve delayed drug release. The review also provides detailed information on the biomedical applications of these final systems.
CARBOHYDRATE POLYMERS
(2022)
Review
Polymer Science
Fayaz Ali, Imran Khan, Jianmin Chen, Kalsoom Akhtar, Esraa M. Bakhsh, Sher Bahadar Khan
Summary: This review discusses the application of hydrogels as carriers in drug delivery systems, and presents the fabrication strategies and applications of hydrogels in various fields.
Article
Pharmacology & Pharmacy
Leonor Vasconcelos Garcia, Diana Silva, Maria Madalena Costa, Henrique Armes, Madalena Salema-Oom, Benilde Saramago, Ana Paula Serro
Summary: Chronic wound treatment is a major contributor to global medical expenses. The development of novel wound care systems, such as wound dressings loaded with antiseptics, can offer a solution. This study investigated the potential of casein hydrogel dressings loaded with Octiset(R) or polyhexanide for treating chronic wounds. The hydrogels showed desirable physical properties and sustained controlled drug-release, while also exhibiting good antimicrobial properties and compatibility with biological systems.
Review
Biotechnology & Applied Microbiology
Yanghui Xing, Buhui Zeng, Wang Yang
Summary: Light responsive hydrogels are an important drug delivery system that can accurately control drug release by incorporating photosensitive moieties into their structures. Advances in photosensitizers have enabled the use of different light sources, and hydrogels with photosensitizers have improved therapeutic effects. Existing light responsive drug delivery systems have been applied in chemotherapy, immunotherapy, photodynamic therapy, gene therapy, and other fields.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Yimeng Su, Xiumei Zhang, Yu Gu, Huilun Xu, Ziming Liao, Liqin Zhao, Jingjing Du, Yinchun Hu, Xiaojie Lian, Weiyi Chen, Yan Wei, Yi Deng, Di Huang
Summary: Chronic inflammation from bacterial infections hampers skin regeneration. Hypoxia in the infection microenvironment impairs the effectiveness of photodynamic therapy in phototherapy. To address this issue, a nanocatalytic hydrogel with enhanced phototherapy effects for antibacterial action and promoting skin regeneration is designed. The hydrogel consists of a polyvinyl alcohol scaffold, MXene/CuS bio-heterojunction, and polydopamine. The nanocatalytic hydrogel shows good antioxidant and antibacterial properties, and promotes capillary angiogenesis and collagen deposition, making it a promising approach for treating wound infections.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Multidisciplinary
Huilun Xu, Kejun Liu, Yimeng Su, Zhengjiang Liu, Yan Wei, Yinchun Hu, Liqin Zhao, Lingfeng Chen, Xiaojie Lian, Di Huang
Summary: Cardiovascular disease is the leading cause of death and creating reliable small diameter artificial blood vessels remains a challenge. To meet the requirements, researchers have successfully developed a micro diameter vessel using polyvinyl alcohol and alginate interpenetrating polymer networks through coaxial printing. The artificial blood vessel combines high strength and mimics the compliance of natural blood vessels. It also exhibits excellent anticoagulation properties and promotes tissue integration after implantation.
COMPOSITES PART B-ENGINEERING
(2023)
Review
Chemistry, Inorganic & Nuclear
Su Yimeng, Xu Huilun, Liao Ziming, Liu Kejun, Merzougui Chaima, Zhang Xiangyu, Hu Yinchun, Wei Yan, Huang Di
Summary: This review summarizes the synthetic methods, antibacterial mechanisms, and applications of copper-based nanoparticles, and discusses the prospects of copper-based nanoparticle antibacterial agents in biomedical and clinical fields.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2023)
Article
Physics, Multidisciplinary
Wenbo Ma, Abdusalam Abdukerim, Chen Cheng, Zihao Bo, Wei Chen, Xun Chen, Yunhua Chen, Zhaokan Cheng, Xiangyi Cui, Yingjie Fan, Deqing Fang, Changbo Fu, Mengting Fu, Lisheng Geng, Karl Giboni, Linhui Gu, Xuyuan Guo, Chencheng Han, Ke Han, Changda He, Jinrong He, Di Huang, Yanlin Huang, Zhou Huang, Ruquan Hou, Xiangdong Ji, Yonglin Ju, Chenxiang Li, Jiafu Li, Mingchuan Li, Shu Li, Shuaijie Li, Qing Lin, Jianglai Liu, Xiaoying Lu, Lingyin Luo, Yunyang Luo, Yugang Ma, Yajun Mao, Nasir Shaheed, Yue Meng, Xuyang Ning, Ningchun Qi, Zhicheng Qian, Xiangxiang Ren, Changsong Shang, Xiaofeng Shang, Guofang Shen, Lin Si, Wenliang Sun, Andi Tan, Yi Tao, Anqing Wang, Meng Wang, Qiuhong Wang, Shaobo Wang, Siguang Wang, Wei Wang, Xiuli Wang, Zhou Wang, Yuehuan Wei, Mengmeng Wu, Weihao Wu, Jingkai Xia, Mengjiao Xiao, Xiang Xiao, Pengwei Xie, Binbin Yan, Xiyu Yan, Jijun Yang, Yong Yang, Chunxu Yu, Jumin Yuan, Ying Yuan, Zhe Yuan, Xinning Zeng, Dan Zhang, Minzhen Zhang, Peng Zhang, Shibo Zhang, Shu Zhang, Tao Zhang, Yingxin Zhang, Yuanyuan Zhang, Li Zhao, Qibin Zheng, Jifang Zhou, Ning Zhou, Xiaopeng Zhou, Yong Zhou, Yubo Zhou
Summary: A search is conducted for interactions from solar 8B neutrinos elastically scattering off xenon nuclei using PandaX-4T commissioning data. The energy threshold for this search is lowered compared to previous dark matter searches, and various techniques are employed to suppress background. Analyzing the data with an effective exposure of 0.48 tonne year, no significant excess of events is observed. The study provides the most stringent constraint on the solar 8B neutrino flux and a more stringent limit on the cross section between dark matter and nucleon in the mass range from 3 to 9 GeV/c2.
PHYSICAL REVIEW LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Dong Seob Kim, Di Huang, Chunhao Guo, Kejun Li, Dario Rocca, Frank Y. Gao, Jeongheon Choe, David Lujan, Ting-Hsuan Wu, Kung-Hsuan Lin, Edoardo Baldini, Li Yang, Shivani Sharma, Raju Kalaivanan, Raman Sankar, Shang-Fan Lee, Yuan Ping, Xiaoqin Li
Summary: A long-standing pursuit in materials science is to identify suitable magnetic semiconductors for integrated information storage, processing, and transfer. Van der Waals magnets have brought forth new material candidates for this purpose. Recently, sharp exciton resonances in antiferromagnet NiPS3 have been reported to correlate with magnetic order, that is, the exciton photoluminescence intensity diminishes above the Neel temperature. Here, it is found that the polarization of maximal exciton emission rotates locally, revealing three possible spin chain directions. This study shows that anisotropic exciton photoluminescence can be used to read out local spin chain directions in antiferromagnets and realize multi-functional devices via spin-photon transduction.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Analytical
Yanzuo Jiang, Di Huang, Hongjia Zhang, Wei Xu, Ting Jiang
Summary: Similar to smartphones, smart or automatic level is crucial for miniature mass spectrometers. In this study, a miniature mass spectrometer combined with intelligent algorithms was used for rapid and accurate identification. The system achieved an average accuracy of 97% in differentiating ten fruits and determining the freshness of strawberries. By utilizing molecular ions, fragment ions, and dimer ions in the full mass spectrum, a satisfactory prediction accuracy (>99%) for 63 volatile organic compounds (VOCs) was achieved.
ANALYTICAL CHEMISTRY
(2023)
Article
Astronomy & Astrophysics
R. Alfaro, C. Alvarez, J. C. Arteaga-Velazquez, D. Avila Rojas, H. A. Ayala Solares, R. Babu, E. Belmont-Moreno, K. S. Caballero-Mora, T. Capistran, A. Carraminana, S. Casanova, O. Chaparro-Amaro, U. Cotti, J. Cotzomi, E. De la Fuente, R. Diaz Hernandez, B. L. Dingus, M. A. DuVernois, M. Durocher, J. C. Diaz-Velez, C. Espinoza, K. L. Fan, N. Fraija, J. A. Garcia-Gonzalez, F. Garfias, M. M. Gonzalez, J. P. Harding, S. Hernandez-Cadena, D. Huang, F. Hueyotl-Zahuantitla, A. Iriarte, V. Joshi, S. Kaufmann, D. Kieda, J. Lee, H. Leon Vargas, J. T. Linnemann, A. L. Longinotti, G. Luis-Raya, K. Malone, O. Martinez, J. Martinez-Castro, J. A. Matthews, E. Moreno, M. Mostafa, A. Nayerhoda, L. Nellen, N. Omodei, Y. Perez Araujo, E. G. Perez-Perez, C. D. Rho, D. Rosa-Gonzalez, H. Salazar, D. Salazar-Gallegos, A. Sandoval, J. Serna-Franco, Y. Son, R. W. Springer, O. Tibolla, K. Tollefson, I. Torres, R. Torres-Escobedo, R. Turner, F. Urena-Mena, L. Villasenor, X. Wang, E. Willox, H. Zhou, C. de Leon, V. Gammaldi, E. Karukes, P. Salucci
Summary: We present the results of dark matter (DM) searches in 31 dwarf irregular (dIrr) galaxies within the field of view of the HAWC Observatory. Although no statistically significant DM signal is observed in these galaxies, we provide exclusion limits for WIMP candidates with masses between 1 and 100 TeV. The exclusion limits from dIrr galaxies are comparable to those from classical dSph galaxies and weaker than ultrafaint dSph limits by about two orders of magnitude.
ASTROPHYSICAL JOURNAL
(2023)
Article
Engineering, Biomedical
Yaping Song, Liqin Zhao, Baolong Niu, Hongyun Zhao, Yinchun Hu, Yan Wei, Di Huang, Tongxin Wang, XiaoJie Lian
Summary: In this study, a novel self-hardening β-tricalcium phosphate (β-TCP) bone cement was investigated. The addition of cellulose phosphate sodium (CF) and micrometer hydroxyapatite (HA) in β-TCP bone cement allowed for tunable setting time, mechanical properties, and anti-washout ability. The addition of CF and HA shortened the setting time and improved the compressive strength of the modified composite. The composites with CF as the curing liquid showed good anti-collapse performance. The weight loss ratio of the bone cement was between -0.18% to 12.08% in 4 weeks. Amorphous β-TCP deposited as hydroxyapatite and formed plate-like structures on the surface of the composite during the degradation process. The alkaline phosphatase activity of the composites using CF as the curing liquid remained high on the 14th day.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2023)
Article
Nanoscience & Nanotechnology
Xiaofeng Luan, Pengbin Liu, Di Huang, Haiping Zhao, Yuang Li, Sheng Sun, Wenchang Zhang, Lingqian Zhang, Mingxiao Li, Tian Zhi, Yang Zhao, Chengjun Huang
Summary: Real-time transformation is crucial for impedance flow cytometry in practice, but the translation of raw data to cellular intrinsic electrical properties is time-consuming. We proposed a fast parallel physical fitting solver that characterizes single cells' electrical properties within 0.62 ms/cell. Based on this solver, we implemented physics-informed real-time impedance flow cytometry (piRT-IFC), which showed comparable speed but higher accuracy than the fully connected neural network predictor. In addition, we demonstrated the advantages of piRT-IFC in handling unfamiliar samples without pretraining.
MICROSYSTEMS & NANOENGINEERING
(2023)
Article
Biophysics
Ziwei Liang, Yuhui Wang, Jiapu Wang, Tao Xu, Shilong Ma, Qi Liu, Liqin Zhao, Yan Wei, Xiaojie Lian, Di Huang
Summary: In this study, a complex magnetic nanocube Fe3O4 modified with PEI and HA was successfully synthesized. The drug delivery system could target tumor cells through an external magnetic field and HA-CD44 binding. Cellular experiments showed that Fe3O4- PEI@HA-RSL3 nanoparticles significantly inhibited the proliferation of hepatoma cells without cytotoxicity on normal hepatic cells. Furthermore, Fe3O4-PEI@HA-RSL3 played a vital role in ferroptosis by accelerating ROS production.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Engineering, Biomedical
Yinchun Hu, Min Kang, Xiangfei Yin, Yizhu Cheng, Zexin Liu, Yan Wei, Di Huang
Summary: The mineralized polyacrylamide (PAM-Mineralized) hydrogel demonstrated good ALP activity, cell adhesion, and biocompatibility for subchondral bone tissue engineering. It exhibited well-distributed layers of hydroxyapatite mineralization on the surface, improving the mechanical properties and osteogenic differentiation potential.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2023)
Article
Chemistry, Physical
Hao Cheng, Niuniu Wang, Yongqiang Yang, Xiong Jiao, Peide Han, Wangping Duan, Di Huang, Meiwen An, Weiyi Chen, Xiaohong Yao, Xiangyu Zhang
Summary: Graphitic carbon nitride (g-C3N4) has been widely studied as a metal-free polymeric photocatalyst for antibacterial application. However, its weak photocatalytic activity under visible light hinders its practical use. In this study, g-C3N4 was modified with Zinc (II) meso-tetrakis (4-carboxyphenyl) porphyrin (ZnTCPP) to improve its utilization of visible light and reduce electron-hole recombination. The resulting composite (ZP/CN) exhibited enhanced photocatalytic activity, achieving 99.99% bacterial inactivation within 10 minutes under visible light irradiation. The improved performance was attributed to the excellent electrical conductivity at the ZnTCPP-g-C3N4 interface. In vitro and in vivo tests demonstrated that ZP/CN not only possessed strong antibacterial activity, but also promoted angiogenesis and suppressed inflammation. Therefore, ZP/CN shows great potential as an effective platform for healing bacteria-infected wounds.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Yuhui Wang, Xiaohan Wang, Guozhen Ma, Lijie Xie, Dan Liu, Yanling Wang, Xinyu Zhao, Yingying Su, Andrei V. Perepelov, Peng Ding, Xiao Zhang, Bo Xu, Bin Liu, Di Huang
Summary: Urinary tract infection (UTI) caused by uropathogenic Escherichia coli (UPEC) is a common infectious disease, with the prevalent serogroup O4 showing high antibiotic resistance. This study developed an O-glycosylation Escherichia coli chassis to biosynthesize a polysaccharide-based glycoprotein for the development of vaccines against UPEC infection. By optimizing the expression of enzymes and fermentation conditions, a high-yield glycoprotein was produced, which effectively reduced bacterial burden in mice after vaccination.
Article
Materials Science, Multidisciplinary
Ruihuang Zhao, Pengcheng Wan, Ling Zhou, Di Huang, Haiqin Guo, Hao Xia, Junjie Du
Summary: For electron optics in graphene, the only available physical mechanism has been the propagation effect. However, this results in large-sized electronic components that need to operate at low temperatures. This paper introduces the concept of electron metasurfaces in graphene, which are the electronic counterparts of optical metasurfaces. The metasurfaces allow for the bending and splitting of electron beams, with the functionalities controlled by applied gate biases. These electron metasurfaces can shape the wavefront of electron beams within a short distance at room temperature, enabling the realization of optics-inspired electronic devices that can operate under ambient conditions. The concept of metasurface electron optics also holds promise for applications such as electron metalenses, metasurface holography, and metasurface-based digital coding technology in graphene.
Article
Engineering, Multidisciplinary
Jiamin Li, Hongru Xue, Ning Xu, Liling Gong, Ming Li, Sijia Li, Di Huang, Qingwei Zhang, Pengyu Li, Qingsui Li, Hang Yu, Yining Liu, Yadong Xue, Haixin Chen, Jiali Liu, Wanyu Zhang, Mingbin Liu, Siyu Chang, Xianzhi Lang, Xingmiao Zhao, Weijie Du, Benzhi Cai, Ning Wang, Baofeng Yang
Summary: This study investigates the regulatory role and mechanisms of long noncoding RNAs (lncRNAs) in myocardial remodeling during myocardial infarction (MI). It identifies a new conserved lncRNA called CPAL, which is upregulated in the myocardial border zone of MI mice. CPAL functions as an activator of nuclear factor kappa B (NFjB) and promotes cardiomyocyte pyroptosis. It also upregulates caspase-1 expression and facilitates the release of interleukin-18 (IL-18) and interleukin-1b (IL-1b) from cardiomyocytes. These findings suggest that CPAL could be a potential therapeutic target for protecting cardiomyocytes against ischemic injury in infarcted hearts.
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)