Journal
FITOTERAPIA
Volume 109, Issue -, Pages 119-124Publisher
ELSEVIER
DOI: 10.1016/j.fitote.2015.12.003
Keywords
Caryophyllene sesquiterpenoids; Pestalotiopsis sp.; NO inhibition
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Funding
- National Natural Science Foundation of China [81503218]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- Program for Changjiang Scholars and Innovative Research Team in University [IRT1193]
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Eight new caryophyllene sesquiterpenoids named pestaloporinates A-G (1-7) and 14-acetylhumulane (8) have been isolated from the solid cultures of an endophytic fungus Pestalotiopsis sp., which was obtained from the fresh stem bark of Melia azedarach Linn. Their structures as well as absolute configurations were determined by spectroscopic data, ECD experimentation, and single-crystal X-ray diffraction. Among all the isolates, compound 2 displayed potent inhibitory activity with IC50 value of 19.0 mu M during the evaluation of nitric oxide (NO) inhibition in lipopolysaccharide (LPS)-induced RAW 264.7 macrophage cells. (C) 2015 Elsevier B.V. All rights reserved.
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