4.6 Article

Antioxidant farnesylated hydroquinones from Ganoderma capense

Journal

FITOTERAPIA
Volume 111, Issue -, Pages 18-23

Publisher

ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2016.04.006

Keywords

Ganoderma capense; Aromatic meroterpenoid; Macrocyclic aromatic meroterpenoid; Antioxidant activity

Funding

  1. NSFC [81172940]
  2. CAS [KSCX2-YW-G-038, KSCX2-YW-R-194]
  3. Department of Science and Technology in Yunnan Province [20080A007]
  4. Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China [P2010-ZZ14]

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Phytochemical investigation of the fruiting bodies of Ganoderma capense led to isolation of eight aromatic meroterpenoids (1-8). Ganocapensins A and B (1, 2) possessed a thirteen-membered and a fourteen membered ether rings, respectively. The structures of new isolates including absolute configuration were elucidated on the basis of extensive spectroscopic technologies and Mosher's method. All isolated compounds showed significant antioxidant effects with IC50 values ranging from 6.00 +/- 0.11 to 820 +/- 0.30 mu g/ml in the DPPH radical scavenging assay. (C) 2016 Elsevier B.V. All rights reserved.

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