Article
Immunology
Man-jun Yang, Ming Jiang, Xuan-xian Peng, Hui Li
Summary: This study investigated how water temperature affects the survival of tilapia to bacterial infection from the perspective of metabolic state. It was found that tilapia were more susceptible to infection at 33 degrees C, but the infection could be attenuated by exogenous myo-inositol. The exogenous myo-inositol inactivated the elevated TCA cycle, increasing the survival ability of tilapia at higher water temperature.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yu-Hong Xie, Ling Wang, Ming-Liang Li, Zhi-Cheng Gong, Jie Du
Summary: Exogenous myo-inositol can reduce excessive apoptosis in cisplatin-induced acute kidney injury (AKI), indicating its protective role in AKI.
Article
Biochemistry & Molecular Biology
Tomasz Antonowski, Adam Osowski, Damian Szczesny, Joanna Szablinska-Piernik, Jerzy Juskiewicz, Leslaw Lahuta, Andrzej Rynkiewicz, Joanna Wojtkiewicz
Summary: This study investigated the concentration change of myo-inositol solution in the serum of Wistar rats after oral administration. The results showed that the myo-inositol concentration reached its peak in the first hour and then rapidly declined. However, even after 24 hours, the concentration remained higher than before administration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Haonan Cao, Tianyun Guo, Xuemei Deng, Xing Huo, Shouchu Tang, Jian Liu, Xiaolei Wang
Summary: Selective photoredox reactions allow direct alkylation of unprotected myo-inositol at C4, offering a possibility for selective C-H alkylations without the need for multi-step protection-deprotection strategies.
CHEMICAL COMMUNICATIONS
(2022)
Review
Chemistry, Medicinal
Riccardo Gambioli, Gianpiero Forte, Giovanni Buzzaccarini, Vittorio Unfer, Antonio Simone Lagana
Summary: Pregnancy is a complex process, and myo-inositol may have positive effects on fertility and preventing pregnancy-related pathologies, with potential therapeutic benefits.
Review
Nutrition & Dietetics
Mariano Bizzarri, Noemi Monti, Aurora Piombarolo, Antonio Angeloni, Roberto Verna
Summary: Myo-inositol is the most abundant natural polyol among the nine structural isomers. It plays a crucial role in biochemical processes governing cellular transitions and insulin transduction. It also affects glucose metabolism and steroid hormone synthesis, and has been successfully used in the management of polycystic ovarian syndrome.
Article
Multidisciplinary Sciences
Andrew F. Paquettea, Beatrice E. Carbone, Seth Vogel, Erica Israel, Sarah D. Maria, Nikita P. Patil, Saroj Sah, Dhrubajyoti Chowdhury, Ilona Kondratiuk, Beau Labhart, Ardythe L. Morrow, Shay C. Phillips, Chenzhong Kuang, Dirk Hondmann, Neeraj Pandey, Thomas Biederer
Summary: By analyzing human milk samples from different populations, we found that the carbocyclic sugar myo-inositol promotes brain development. Myo-inositol is most abundant during early lactation when neuronal connections rapidly form in infants. It enhances synapse abundance in human excitatory neurons and cultured rat neurons in a dose-dependent manner by improving their ability to respond to transsynaptic interactions. In mice, dietary supplementation of myo-inositol increases the size of excitatory postsynaptic sites in the developing cortex. Moreover, myo-inositol is bioactive in mature brain tissue, as it increases the number and size of postsynaptic specializations and excitatory synapse density in organotypic slices. This study advances our understanding of the role of human milk in infant brain development and identifies myo-inositol as a component that promotes the formation of neuronal connections.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Chemistry, Analytical
Cristina Tortolini, Valeria Gigli, Flavio Rizzo, Andrea Lenzi, Mariano Bizzarri, Antonio Angeloni, Riccarda Antiochia
Summary: This paper describes the development of a simple voltammetric biosensor for the stereoselective discrimination of myo-inositol and D-chiro-inositol by means of bovine serum albumin adsorption onto a multi-walled carbon nanotube graphite screen-printed electrode.
Article
Food Science & Technology
Nandini Ghosh, Amitava Das, Nirupam Biswas, Sanskruti P. Mahajan, Amit K. Madeshiya, Savita Khanna, Chandan K. Sen, Sashwati Roy
Summary: Fermented Papaya Preparation (FPP) enhances the host defense mechanisms of macrophages and improves wound healing outcomes. Myo-inositol in FPP is identified as a key factor that improves macrophage function, specifically respiratory burst and phagocytosis. Myo-inositol transporters also play a significant role in this activity.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Review
Microbiology
Indu Muraleedharan Nair, Emma Condon, Barbara Doyle Prestwich, John James Mackrill
Summary: Oomycetes are pathogens that cause significant losses to agriculture, aquaculture, and forestry. This study explores the similarities and differences in the myo-inositol 1,4,5 trisphosphate signaling pathway between oomycetes and other eukaryotes.
Article
Green & Sustainable Science & Technology
Tengsheng Qiao, Yongteng Zhao, Benyong Han, Tao Li, Peng Zhao, Jun-Wei Xu, Li Huang, Xuya Yu
Summary: MI treatment significantly enhanced lipid production and nutrients removal of Monoraphidium sp. QLY-1 from molasses wastewater, by regulating key lipogenic genes expression and enhancing phytohormones contents.
Article
Veterinary Sciences
Ali Jawad, Dongjin Oh, Hyerin Choi, Mirae Kim, Lian Cai, Joohyeong Lee, Sang-Hwan Hyun
Summary: This study aimed to investigate the protective effect of Myo-Ins on boar sperm against oxidative stress during liquid preservation and determine the optimal concentration of Myo-Ins. The results showed that different concentrations of Myo-Ins had different effects on the quality of boar sperm. The addition of 2 mg/mL Myo-Ins improved sperm motility, viability, membrane integrity, mitochondrial membrane potential, and effective survival time, as well as increasing the expression of antioxidative genes.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Sarah Hostachy, Huanchen Wang, Guangning Zong, Katy Franke, Andrew M. Riley, Peter Schmieder, Barry V. L. Potter, Stephen B. Shears, Dorothea Fiedler
Summary: Inositol pyrophosphates (PP-IPs) are heavily phosphorylated messenger molecules that play important roles in various biological processes. The synthesis of stable analogs and the evaluation of their properties using different methods provide insights into the function and regulation of PP-IPs. This study reports the synthesis of a new reagent and the development of a fluorinated analog of 5PP-IP5. The results demonstrate the significant impact of small structural alterations on the properties of the analogs, which will guide future investigations.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Bridget S. O'Banion, Piet Jones, Alexander A. Demetros, Brittni R. Kelley, Leah H. Knoor, Andrew S. Wagner, Jin-Gui Chen, Wellington Muchero, Todd B. Reynolds, Daniel Jacobson, Sarah L. Lebeis
Summary: Through transcriptomic analysis and genetic manipulation experiments, researchers have found that the plant metabolite myo-inositol plays a crucial role in mediating interactions between plants and microorganisms.
Article
Pharmacology & Pharmacy
A. K. Kiani, S. Paolacci, A. E. Calogero, R. Cannarella, G. C. Di Renzo, S. Gerli, C. Della Morte, G. M. Busetto, E. De Berardinis, F. Del Giudice, L. Stuppia, F. Facchinetti, S. Dinicola, M. Bertelli
Summary: Inositol and D-chiro-inositol play crucial roles in the body, and their synthesis and absorption mechanisms are vital for preventing diseases such as neural tube defects. Inositol deficiency may contribute to the pathogenesis of various diseases, hence supplementation of these conditions with inositol is necessary.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Fisheries
Zhao-Xi Wang, Yu Zhou, Long-Feng Lu, Xiao-Bing Lu, Bo Ni, Meng-Xi Liu, Hong-Xin Guan, Shun Li, Yong-An Zhang, Songying Ouyang
FISH & SHELLFISH IMMUNOLOGY
(2020)
Article
Microbiology
Peng Zhou, Xueqing Han, Xiang Ye, Feifei Zheng, Ting Yan, Quan Xie, Yong-An Zhang, Roy Curtiss, Yang Zhou
Review
Fisheries
Chi Zhang, Jiagang Tu, Yong-An Zhang
Summary: miRNAs are single-stranded non-coding RNA molecules that play important roles in various biological processes of eukaryotes. During virus infection, miRNAs regulate virus replication in teleost fish, providing insights for novel strategies to prevent virus infection.
REVIEWS IN AQUACULTURE
(2021)
Article
Microbiology
Long-Feng Lu, Can Zhang, Zhuo-Cong Li, Xiao-Yu Zhou, Jing-Yu Jiang, Dan-Dan Chen, Yong-An Zhang, Feng Xiong, Fang Zhou, Shun Li
Summary: Zebrafish transmembrane protein 33 (TMEM33) negatively regulates interferon (IFN) production through two distinct mechanisms: interacting with and degrading MAVS via K48-linked ubiquitination, and acting as a decoy substrate for cellular TBK1 to reduce phosphorylation of MITA/IRF3. These findings reveal the role for TMEM33 in regulating cellular immune responses and expand our understanding of negative regulatory mechanisms of IFN.
Article
Immunology
Jihong Li, Shilin Ma, Zhi Li, Wei Yu, Peng Zhou, Xiang Ye, Md. Sharifull Islam, Yong-An Zhang, Yang Zhou, Jinquan Li
Summary: Aeromonas hydrophila is a pathogen in aquaculture, with a five-gene deletion mutant strain AHFGDS constructed in this study showing high attenuation and potential as a live-attenuated vaccine candidate. AHFGDS provided significant protection against the wild-type strain in grass carp, eliciting a host-adaptive immune response as supported by agglutinating antibody titer tests.
Article
Immunology
Yanqi Zhang, Xun Xiao, Yazhen Hu, Zhiwei Liao, Wentao Zhu, Rui Jiang, Chunrong Yang, Yongan Zhang, Jianguo Su
Summary: CiCXCL20a, a chemokine from grass carp, demonstrates broad-spectrum, potent bactericidal activity in addition to chemoattraction of immune cells. It kills bacteria by targeting acid lipids, perforating bacterial membrane, and neutralizing LPS, leading to bacterial leakage and death. This study shows the close functional relationship between early vertebrate chemokines and antimicrobial peptides.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Immunology
Chengjian Fan, Hang Su, Zhiwei Liao, Juanjuan Su, Chunrong Yang, Yongan Zhang, Jianguo Su
Summary: The teleost-specific Mx protein MxG in grass carp is induced by IFNs and viruses to negatively regulate antiviral responses mediated by IPS-1 and STING, facilitating virus replication. This study identified MxG as a negative regulator in the Mx family and provided insights into a novel mechanism regulating the IFN response.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Immunology
Ya-Zhen Hu, Zi-You Ma, Chang-Song Wu, Jie Wang, Yong-An Zhang, Xu-Jie Zhang
Summary: LECT2 is an important immunoregulator in vertebrates, and it has been shown to have direct antibacterial activity in teleost fish. This study discovered that teleost fish have two LECT2 genes, with gcLECT2-b having evolved to be highly expressed in mucosal immune organs and possessing direct antibacterial activity against both Gram-negative and Gram-positive bacteria.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Fisheries
Yu Zhou, Feng-Yang Li, Long-Feng Lu, Ya-Zhen Hu, Yong-An Zhang
Summary: The cGAS protein in crucian carp plays a crucial role in the interferon response, similar to its function in other mammals. It can suppress the IFN response by regulating the interaction between RIG-I and MAVS. Additionally, crucian carp cGAS can activate the IFN response by binding to specific DNA sequences, but it has inhibitory effects on specific RNA sequences.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhiwei Liao, Chunrong Yang, Rui Jiang, Wentao Zhu, Yongan Zhang, Jianguo Su
Summary: The membrane-bound Toll-like receptor 5 (TLR5) in cyprinid grass carp plays a role in detecting bacterial flagellin and dsRNA analog poly(I:C), regulating interferon response and antiviral defense. Two TLR5 paralogs, CiTLR5a and CiTLR5b, have opposite effects on virus replication. The ectodomain of CiTLR5 is essential for dsRNA-induced interferon signaling, and specific glycans affect dsRNA-IFN signaling but not flagellin-induced NF-kappa B induction. This study reveals a neofunctionalization of TLR5 in cyprinid, bridging viral and bacterial immune responses.
Article
Fisheries
Jun Yan, Guoxia Qiao, Enhui Wang, Yuqing Peng, Jiamin Yu, Hui Wu, Meiling Liu, Jiagang Tu, Yongan Zhang, Hao Feng
Summary: This manuscript investigates the role of ring finger protein 5 (bcRNF5) as a negative regulator of mitochondrial antiviral signaling protein (MAVS) in black carp. The results suggest that bcRNF5 plays a key role in host protection upon virus infection in black carp by negatively regulating the MAVS-mediated interferon signaling.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Immunology
Chi Zhang, An-Qi Liu, Chu Zhang, Lan-Hao Liu, Jianguo Su, Yong-An Zhang, Jiagang Tu
Summary: This study reveals the virus-host combat mechanism between Cyprinid herpesvirus 3 (CyHV-3) and its host. It shows that CyHV-3 evades host antiviral immunity through its ORF89 protein, while the upregulated host miR-722 targets ORF89 to impede CyHV-3 replication.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Immunology
Xu-Jie Zhang, Ya-Qin Zhong, Zi-You Ma, Ya-Zhen Hu, Jian-Guo Su, Yong-An Zhang
Summary: Complement peptides C3a, C4a, and C5a have evolved divergently in vertebrates, leading to different antibacterial properties. The net charge of these peptides plays a crucial role in determining their antibacterial activities. Furthermore, many derived peptides from C3a, C4a, and C5a in vertebrates exhibit high antibacterial activities without hemolytic activities, demonstrating the potential application in anti-infective therapy.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Immunology
Wentao Zhu, Yanqi Zhang, Zhiwei Liao, Xingchen Huo, Chunrong Yang, Yongan Zhang, Jianguo Su
Summary: This study reveals the strong antibacterial activity of type I interferon IFN1 in teleosts, which is mediated by phagocytosis and induction of immune factors and complement components. These findings shed light on the functional role of interferons in bacterial infections.
JOURNAL OF IMMUNOLOGY
(2023)
Article
Virology
Xiangmou Qin, Yong-An Zhang, Jiagang Tu
Summary: This study identified the phosphorylated sites on the phosphoprotein (P) of snakehead vesiculovirus (SHVV) and the related host kinases, and revealed the effects of phosphorylation on SHVV replication. The phosphorylation of P at T160 was found to be critical for SHVV replication and mediated by p38MAPK and GSK3 kinases. These findings provide potential targets for the development of antiviral drugs and live-attenuated vaccines against SHVV.
JOURNAL OF VIROLOGY
(2023)