Article
Genetics & Heredity
Yuhua Huang, Ruhui Tian, Junwei Xu, Zhiyong Ji, Yuxiang Zhang, Liangyu Zhao, Chao Yang, Peng Li, Erlei Zhi, Haowei Bai, Sha Han, Jiaqiang Luo, Jingpeng Zhao, Jing Zhang, Zhi Zhou, Zheng Li, Chencheng Yao
Summary: Through whole-exome sequencing, we identified two novel genetic variants within SYCE1 that are associated with meiotic arrest and male infertility.
BMC MEDICAL GENOMICS
(2022)
Article
Endocrinology & Metabolism
Jian Song, Yanwei Sha, Xiaojun Liu, Xuhui Zeng, Xiuling Zhao
Summary: Non-obstructive azoospermia (NOA) affects 10% of infertile men worldwide, and genetic studies have discovered several monogenic mutations responsible for idiopathic NOA cases. This study identified three novel TEX11 mutations in NOA patients and found histological abnormalities in the testicular biopsy specimens. These findings expand the understanding of NOA genetic variants and highlight the importance of TEX11 screening for clinical diagnosis of azoospermia patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Reproductive Biology
Xiangyan Dai, Xinkai Cheng, Jianfei Huang, Yanping Gao, Deshou Wang, Zhi Feng, Gang Zhai, Qiyong Lou, Jiangyan He, Zhijian Wang, Zhan Yin
Summary: Our study demonstrates the crucial role of Rbm46 in zebrafish reproduction, showing that disruption of Rbm46 leads to masculinization and infertility by impairing germ cell progression through meiosis prophase I. Rbm46 may be involved in posttranscriptional regulation of key genes essential for germ cell development during gametogenesis.
BIOLOGY OF REPRODUCTION
(2021)
Article
Obstetrics & Gynecology
Yang Li, Yufan Wu, Jianteng Zhou, Huan Zhang, Yuanwei Zhang, Hui Ma, Xiaohua Jiang, Qinghua Shi
Summary: Mutations in the ZSWIM7 gene, particularly the homozygous frameshift mutation (c.231_232del), may lead to male infertility by affecting meiotic recombination processes. This study provides direct clinical evidence of the correlation between ZSWIM7 mutations and male infertility.
HUMAN REPRODUCTION
(2021)
Article
Obstetrics & Gynecology
Xuefeng Xie, Ghulam Murtaza, Yang Li, Jianteng Zhou, Jingwei Ye, Ranjha Khan, Long Jiang, Ihsan Khan, Muhammad Zubair, Hao Yin, Hanwei Jiang, Wei Liu, Baolu Shi, Xiaoning Hou, Chenjia Gong, Suixing Fan, Yuewen Wang, Xiaohua Jiang, Yuanwei Zhang, Huan Zhang, Hui Ma, Qinghua Shi
Summary: Variants in the HFM1 gene are responsible for male infertility due to non-obstructive azoospermia (NOA) with impaired crossover formation and meiotic metaphase I (MMI) arrest. This conclusion is supported by a small sample study and mouse models.
HUMAN REPRODUCTION
(2022)
Review
Cell Biology
Nila M. Pazhayam, Carolyn A. Turcotte, Jeff Sekelsky
Summary: Proper number and placement of meiotic crossovers are crucial for chromosome segregation, with failures leading to aneuploidy and infertility. Meiotic crossovers are formed through homologous repair of double-strand breaks, and their placement is intricately patterned through interference, assurance, and suppression mechanisms. The mechanisms behind crossover patterning are largely unknown, with key players acting at different scales and considerable overlap between known patterning phenomena.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Genetics & Heredity
Albert Salas-Huetos, Frank Tuettelmann, Margot J. Wyrwoll, Sabine Kliesch, Alexandra M. Lopes, Joao Concalves, Steven E. Boyden, Marius Woeste, James M. Hotaling, Liina Nagirnaja, Donald F. Conrad, Douglas T. Carrell, Kenneth I. Aston
Summary: This study identified novel TERB2 variants associated with idiopathic NOA and highlighted the potential role of MTC genes in spermatogenic impairment. Variants in MTC genes may be an important cause of NOA in both consanguineous and outbred populations.
Article
Genetics & Heredity
Bo Chen, Gengzhen Zhu, An Yan, Jing P. He, Yang Liu, Lin P. Li, Xuerui Yang, Chen P. Dong, Kehkooi Kee
Summary: Deficiency in the adhesion molecule IGSF11, expressed in both somatic cells and germ cells, leads to male infertility in mice, highlighting its importance in meiosis progression. IGSF11 is required for pericentric heterochromatin dissociation in both somatic and germ cells during diplotene in mouse primary spermatocytes.
Article
Cell Biology
Kazi Nazrul Islam, Maitri Mitesh Modi, Kellee Renee Siegfried
Summary: The SMC1β protein plays a crucial role in meiosis in vertebrates, primarily involved in meiosis in both fish and mammals. In zebrafish, Smc1b is essential for the leptotene to zygotene transition in spermatogenesis, with key differences in Smc1b requirement for meiosis observed among vertebrates.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Editorial Material
Genetics & Heredity
Charles Addo Nyarko, Annaliese S. Mason
Summary: Polyploids need to segregate homologous chromosomes correctly, which is not only determined by sequence similarity but also under strong genetic control that may vary between lineages. Factors such as partner availability and genome structure may also influence the level of sequence similarity required for crossover formation.
TRENDS IN GENETICS
(2022)
Article
Obstetrics & Gynecology
Chunbo Xie, Weili Wang, Chaofeng Tu, Lanlan Meng, Guangxiu Lu, Ge Lin, Lin-Yu Lu, Yue-Qiu Tan
Summary: Meiosis is a crucial stage in the life cycle of sexually reproducing species, and understanding the molecular mechanisms of meiotic recombination is of great importance in comprehending the causes of human infertility and developing personalized treatments.
HUMAN REPRODUCTION UPDATE
(2022)
Article
Genetics & Heredity
Shoaib Nawaz, Muhammad Imran Ullah, Beenish Samreen Hamid, Jalwa Nargis, Mehboob Nawaz, Shabir Hussain, Wasim Ahmad
Summary: The study investigated a large consanguineous family of Pakistani origin segregating male infertility in an autosomal recessive manner, identifying a loss-of-function homozygous variant in the MLH3 gene as the cause of severe oligozoospermia leading to male infertility. Previous studies have shown an association between infertility and gene knockout in mice.
JOURNAL OF HUMAN GENETICS
(2021)
Review
Cell Biology
Funda M. Kar, Andreas Hochwagen
Summary: Germ cells rely on a complex network of surveillance mechanisms to ensure the production of euploid gametes during meiosis. Dynamic protein phosphorylation, controlled by kinases and phosphatases, plays a crucial role in regulating chromosomal and cellular behavior throughout meiotic prophase. This review discusses common principles and detailed examples of how phosphorylation events are utilized to ensure faithful passage of chromosomes from one generation to the next.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Developmental Biology
Weili Wang, Lanlan Meng, Jiaxin He, Lilan Su, Yong Li, Chen Tan, Xilin Xu, Hongchuan Nie, Huan Zhang, Juan Du, Guangxiu Lu, Mengcheng Luo, Ge Lin, Chaofeng Tu, Yue-Qiu Tan
Summary: Meiosis is a crucial process for gametogenesis and fertility, and meiotic recombination plays a significant role in ensuring accurate chromosome segregation and generating genetic diversity. Researchers have discovered that SHOC1 gene mutations have a strong clinical relevance to patients with non-obstructive azoospermia (NOA), shedding light on the mechanistic understanding of SHOC1 during meiotic recombination.
MOLECULAR HUMAN REPRODUCTION
(2022)
Article
Multidisciplinary Sciences
Stephanie Durand, Qichao Lian, Juli Jing, Marcel Ernst, Mathilde Grelon, David Zwicker, Raphael Mercier
Summary: This study proposes a model for crossover patterning, suggesting that the diffusion of HEI10 along the synaptonemal complex leads to a coarsening process that creates well-spaced crossover-promoting foci. The findings support this model and provide insight into the mechanistic basis of crossover control during meiosis.
NATURE COMMUNICATIONS
(2022)
Article
Engineering, Aerospace
Xiangrui Zou, Ningfei Wang, Junlong Wang, Chao Wang, Lei Han, Baolu Shi
Summary: This study simulated an aluminum nanoparticle-air jet flame and analyzed its mixing and burning properties. By validating the model and studying the flow field characteristics and particle combustion, the behavior and influencing factors of nano-sized aluminum particles in combustion were revealed.
AEROSPACE SCIENCE AND TECHNOLOGY
(2022)
Article
Materials Science, Ceramics
Debao Liu, Baolu Shi, Chenqi Wang, Zeshuai Li, Xianbo Wang, Baosheng Xu, Lijie Qu
Summary: In this study, SiC ceramic aerogels with in-situ growth of SiC nanowires were successfully synthesized using the PDCs method. The morphology, microstructure, and phase composition of the samples were investigated using various techniques. The results revealed the diameter and length of the SiC nanowires, and the formation mechanism was systematically studied. This method can also be applied to synthesize other Si-based porous ceramic aerogels with nanowires.
CERAMICS INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Hui Ma, Tao Li, Xuefeng Xie, Long Jiang, Jingwei Ye, Chenjia Gong, Hanwei Jiang, Suixing Fan, Huan Zhang, Baolu Shi, Beibei Zhang, Xiaohua Jiang, Yang Li, Jianteng Zhou, Jianze Xu, Xingxia Zhang, Xiaoning Hou, Hao Yin, Yuanwei Zhang, Qinghua Shi
Summary: This study found that RAD51AP2 plays a specific role in the formation of crossovers on XY chromosomes in the pseudoautosomal region, and its mutation leads to compromised DSB repair in PARs.
Article
Biochemistry & Molecular Biology
Chenjia Gong, Tanveer Abbas, Zubair Muhammad, Jianteng Zhou, Ranjha Khan, Hui Ma, Huan Zhang, Qinghua Shi, Baolu Shi
Summary: The MSH5 c.1126del mutation may cause meiotic recombination failure and infertility in humans. The study of human spermatocytes also reveals the importance of MutS γ in synapsis and meiotic recombination.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Materials Science, Ceramics
De-Bao Liu, Bao-Lu Shi, Yi-Guang Wang, Bao-Sheng Xu
Summary: A novel YSZ(f)-(La1/5Nd1/5Sm1/5Gd1/5Yb1/5)(2)Zr2O7 porous ceramic material was prepared using a foam-gelcasting-freeze drying process. The material exhibited high strength, low thermal conductivity, and low thermal cycling shrinkage, making it a promising candidate for high-temperature thermal insulation applications.
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2022)
Article
Materials Science, Multidisciplinary
Debao Liu, Xinlei Jia, Baolu Shi, Yiguang Wang, Baosheng Xu
Summary: A novel quinary high-entropy rare earth disilicate porous ceramics were synthesized using a sol-gel/vacuum freeze-drying method combined with high-temperature calcination process. The as-prepared (5RE1/5)2Si2O7 porous ceramics exhibited high porosity, low thermal conductivity, and high compressive strength, indicating its potential application as high-temperature thermal insulation materials.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Article
Energy & Fuels
Wen-xiong Chao, Bao-lu Shi, Hui Ruan, Wei Dong
Summary: This study addresses the cavitation prevention requirements for a high-speed centrifugal pump in the aerospace temperature control system. It investigates the effect of blade inlet width on cavitation performance and proposes a method of twisting the blade inlet to prevent cavitation. By conducting tests and simulations, the cavitation performance of four different groups of impellers under negative inlet pressure conditions is studied, and it is found that the centrifugal impeller with suspended forward-extended blades shows a significant improvement in cavitation performance under high-speed and negative pressure conditions.
FRONTIERS IN ENERGY RESEARCH
(2022)
Article
Thermodynamics
Kuanyu Wang, Dingjiang Xie, Qing Cao, Jie Hu, Yong Tang, Baolu Shi, Ningfei Wang
Summary: This study presents the design of an axial/tangential swirl jet burner to achieve stable combustion of CH4/O2/CO2; the flame lift-off is influenced by the oxygen mole fraction of the oxidant flow, while the critical fuel flow rate is affected by the oxygen mole fraction.
EXPERIMENTAL THERMAL AND FLUID SCIENCE
(2022)
Article
Engineering, Aerospace
Xiangrui Zou, Lei Han, Rui Xue, Chaoqi Xu, Wenbo Zhuang, Baolu Shi
Summary: Solid rocket motors (SRMs) are widely used in space exploration due to their advantages of high energy density, compact structure, and fast response. Aluminum powder is commonly employed as a fuel additive in SRMs to enhance density and specific impulse. The burning behaviors of aluminum particles in SRMs are complex. To investigate the detailed combustion characteristics of aluminum agglomerates in SRMs, this study develops a computational framework that integrates propellant combustion model, agglomeration and burning models of aluminum particles into a multiphase flow approach. The model is validated using experimental results and the effects of agglomerate size, coarse-to-fine ratio of ammonium perchlorate, and pressure on the combustion properties of aluminum particles and specific impulse are analyzed.
Article
Materials Science, Multidisciplinary
Yintao Zhou, Baolu Shi, Qingzhao Chu, Lijuan Liao
Summary: In this study, the oxidation process of Aluminum nanoparticles (ANPs) in different atmospheres was investigated. It was found that in mixture atmospheres, ANPs experience a shorter ignition delay and undergo a new reaction called re-oxidation. By adjusting the contents of O2, CO2, and H2O, the ignition delay time and reaction heat release can be tailored for optimal ANPs combustion performance. This research provides a theoretical basis for precise regulation of ANPs energy release.
COMPUTATIONAL MATERIALS SCIENCE
(2023)
Article
Energy & Fuels
Chao Wang, Ying Liu, Kang Niu, Jia Li, Qing Cao, Xiuchen Zhao, Hongyang Li, Ningfei Wang, Baolu Shi
Summary: In order to improve the combustion efficiency of widely used micro-aluminum particles, it is critical to enhance their ignition and combustion performances by breaking through the intrinsic Al2O3 layer. This study proposed a facile electroless plating method to coat mu Al particles with a ternary-shelled nickel-phosphorus-copper alloy. The resulting Al@Ni-P-Cu composites exhibited improved heat release, decreased initial oxidation temperature, shorter laser ignition delay time, and higher maximum flame temperature compared to raw mu Al particles.
Article
Endocrinology & Metabolism
Xiaoning Hou, Aurang Zeb, Sobia Dil, Jianteng Zhou, Huan Zhang, Baolu Shi, Zubair Muhammad, Ihsan Khan, Qamar Zaman, Wasim Akbar Shah, Xiaohua Jiang, Limin Wu, Hui Ma, Qinghua Shi
Summary: A homozygous frameshift mutation in the KASH5 gene was identified in a consanguineous family, leading to reproductive failure in five siblings. The mutation resulted in the absence of KASH5 protein expression, causing non-obstructive azoospermia in the affected brother and diminished ovarian reserve and recurrent miscarriage in the sisters.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hongying Hao, Baolu Shi, Jiacheng Zhang, Ao Dai, Wenhao Li, Haidi Chen, Wenya Ji, Chenjia Gong, Chang Zhang, Jing Li, Li Chen, Bin Yao, Peng Hu, Hao Yang, Juergen Brosius, Shanshan Lai, Qinghua Shi, Cheng Deng
Summary: A study identified a gene called C11orf94 that encodes a transmembrane protein crucial for sperm binding to oocytes. The deletion of C11orf94 significantly decreased male fertility in mice, as sperm from C11orf94-deficient mice failed to bind to the oocyte membrane. Proteomics analysis revealed that C11orf94 influenced the expression of multiple gene products essential for sperm-oocyte binding and fusion.
MOLECULAR BIOMEDICINE
(2022)
Article
Polymer Science
Baolu Shi, Long Xie, Bin Ma, Zhiliang Zhou, Baosheng Xu, Lijie Qu
Summary: SiO2 aerogels with unique structural characteristics and good optical transparency have the potential to be used in aerogel glass for thermal insulation.