Article
Biochemistry & Molecular Biology
Meng Huang, Yan Wang, Zhenning Wang, Qiaozhen Qin, Heyang Zhang, Shuirong Liu, Jiantong Cui, Yu Zhang, Xiaoxia Jiang, Lulu Xu
Summary: The study shows that miR-134-5p inhibits osteoclast formation through targeting the Itgb1 gene and regulating the MAPK pathway, suggesting it could be a potential target for osteoporosis therapy.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Cell Biology
Hong-Yi Zhou, Fan Jiang, Zhong Cao, Qi-Yun Shen, Yu-Jing Feng, Zhen-Huan Hou
Summary: The study reveals that propofol can attenuate cobalt chloride-induced injury in PC12 cells by decreasing apoptosis and improving oxidative stress, potentially through mediating miR-134.
HISTOLOGY AND HISTOPATHOLOGY
(2021)
Article
Oncology
Guiyue Cai, Ruitao Zou, Huizhi Yang, Jiahao Xie, Xiaoxuan Chen, Chunchan Zheng, Sujun Luo, Na Wei, Shuang Liu, Rongyi Chen
Summary: This study investigates the regulatory effect of the circ_0084043-miR-134-5p axis on melanoma and its impact on the expression levels of Pyk2, RAC1, Cyclin D1, MMP2, and MMP9. The results show that PCDH9, regulated by the circ_0084043-miR-134-5p axis, can suppress the malignant behavior of melanoma.
FRONTIERS IN ONCOLOGY
(2022)
Article
Clinical Neurology
Rukiye Tekdemir, Yavuz Selvi, Kursat Altinbas, Nadir Kocak
Summary: This study found that miRNAs play an important role in the pathogenesis of bipolar disorder and may serve as biomarkers for diagnosis and screening of the disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Cell Biology
Andras Tomesz, Laszlo Szabo, Richard Molnar, Arpad Deutsch, Richard Darago, Bence L. Raposa, Nowrasteh Ghodratollah, Timea Varjas, Balazs Nemeth, Zsuzsanna Orsos, Eva Pozsgai, Jozsef L. Szentpeteri, Ferenc Budan, Istvan Kiss
Summary: Specific gene and miRNA expression patterns can serve as potential early biomarkers for harmful environmental carcinogen exposures. This research aimed to develop an assay panel using several miRNAs for the rapid screening of potential carcinogens. The study examined the expression changes of miR-124-1, miR-212, miR-132, miR-134, and miR-155 in the spleen, liver, and kidneys of mice following DMBA treatment. The results showed significant changes in the expression of miR-134, miR-132, and miR-124-1, suggesting their suitability as biomarkers for screening potential chemical carcinogens and monitoring the protective effects of chemopreventive agents.
Article
Pharmacology & Pharmacy
Weijian Tan, Qinhua Zheng, Kexin Feng, Xiaolin Feng, Wenting Zhong, Caiyu Liao, Shangjian Li, Yuntong Liu, Wenzhong Hu
Summary: Oxidative stress plays a role in aging and neurodegenerative disorders, and foods containing phenolic compounds may have preventive effects against Alzheimer's disease. Gastrodia elata, a traditional Chinese medicinal and food plant, has shown potential for the prevention and treatment of Alzheimer's disease. The study suggests that Gastrodia elata polyphenols have neuroprotective benefits that can prevent or treat Alzheimer's disease and could be used as a reference for the development of functional foods or drugs.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Instruments & Instrumentation
Chen Jing, Li Yan, Zhang Wei, Shoumin Zhang, Guangwen Yin, Jiangan Zhang, Xuesong Jia, Hongxiang Chen, Ziyu Duan, Jianguo Li
Summary: This study demonstrates the anti-tumor effect of miR-134 in sSCC through the use of TPGS-based PEGylated liposomes. Results show that miR-134 specifically targets FOXM1 in cancer cells, leading to inhibition of cell proliferation and migration, as well as induction of apoptosis. Tumors treated with TP-miR-LP showed significantly slower growth compared to other formulations in a xenograft animal model, highlighting the translational potential of miR-134 for sSCC treatment.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Article
Medicine, Research & Experimental
Yuqin Ding, Yuting Huang, Fanrong Zhang, Lijie Gong, Chenlu Liang, Kaijing Ding, Xiangming He, Xiaowen Ding, Yiding Chen
Summary: Our study investigated the role of lncRNA TDRKH-AS1 in breast cancer (BC). We found that TDRKH-AS1 was upregulated in BC tissues and cell lines, and its high expression was associated with advanced stages and poor outcomes in BC patients. Knockdown of TDRKH-AS1 inhibited BC cell proliferation and invasion. Mechanistically, TDRKH-AS1 acted as a sponge for miR-134-5p, thereby promoting the expression of cAMP response element-binding protein 1 (CREB1), a downstream target of miR-134-5p. In vivo experiments confirmed the tumor-promoting role of TDRKH-AS1 in BC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Robert J. Forster, David C. Henshall, Hany El Naggar, Yann Pellegrin, Norman Delanty
Summary: This study reports the detection of a key biomarker in epilepsy, miR-134, using an environmentally sensitive electrochemiluminescent luminophore, [Ru(DPPZ)(2)PIC](2+). The ability of the sensor to quantify miR-134 in unprocessed plasma samples from healthy volunteers and people with epilepsy is demonstrated.
BIOELECTROCHEMISTRY
(2022)
Article
Cell Biology
Tsu-Yang Chao, Theresa Kordass, Wolfram Osen, Stefan B. Eichmueller
Summary: The miRNAs miR-134-3p and miR-224-3p were found to directly interact with the SOX9 gene and inhibit its expression in breast cancer cells. These two miRNAs were down-regulated in breast cancer tissues, suggesting their potential role as tumor suppressors in breast cancer progression.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Cardiac & Cardiovascular Systems
Linfeng Li, Xiangwang He, Min Liu, Libing Yun, Bin Cong
Summary: This study found that cardiac miR-126-5p and miR-499a-5p were downregulated in CAD-SCD patients, and their combination had good diagnostic capabilities. These miRNAs are expected to serve as novel biomarkers for CAD-SCD and help differentiate the detailed causes in SCD cases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Environmental Sciences
Jing Song, Wenjing Li, Chunman Yuan, Ting Gao, Xiaoting Lu, Linping Wang, Qiao Niu
Summary: This study aims to explore a potential biomarker and mechanism for cognitive dysfunction following aluminum exposure. It was found that occupational aluminum exposure elevated miR-134-3p expression in the plasma of workers accompanied by cognitive impairment. Further experiments validated the involvement of miR-134-3p in aluminum neurotoxicity by targeting the zDHHC3-AMPARs axis. This finding may contribute to the development of potential biomarkers or therapeutic targets for cognitive dysfunction.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Zhila Izadi, Ebrahim Barzegari, Amin Iranpanah, Soraya Sajadimajd, Hossein Derakhshankhah
Summary: This study demonstrates that aminoglycosidic antibiotics, gentamycin and neomycin, can bind to miR-34a and protect PC12 cells from oxidative stress induced by H2O2. The findings provide further insight into the role of miR-34a in stroke-induced cell viability.
Article
Environmental Sciences
Rili Hao, Junlin Ge, Xinyu Song, Feng Li, Dongxiao Sun-Waterhouse, Dapeng Li
Summary: This study revealed that cadmium can induce cytotoxicity and neurotoxicity in PC12 cells through both apoptosis and ferroptosis, with involvement of the miR-34a-5p/Sirt1 axis. Knocking out miR-34a-5p alleviated cadmium-induced damage, highlighting the critical role of miRNAs as regulators in cadmium toxicity.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Medicine, Research & Experimental
Zheng Lv, Shao Yin, Ziguan Cheng, Kekai Wang
Summary: This study demonstrates that Lenalidomide (LEN) alleviates H2O2-induced injury of PC12 cells by blocking the Notch signaling pathway, suggesting its potential as a treatment for spinal cord injury.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)