Journal
HIPPOCAMPUS
Volume 31, Issue 8, Pages 817-844Publisher
WILEY
DOI: 10.1002/hipo.23337
Keywords
cardiorespiratory fitness; exercise; magnetic resonance imaging; perfusion; white matter
Categories
Funding
- National Institutes of Health [T32GM081760, 5T32AG055381-03, R01 DK095172]
- Alicia Koplowitz Foundation
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Physical activity, particularly aerobic exercise, shows promise in promoting hippocampal structure and function throughout the lifespan, despite significant heterogeneity in study methods and populations of interest.
The hippocampus is particularly susceptible to neurodegeneration. Physical activity, specifically increasing cardiorespiratory fitness via aerobic exercise, shows promise as a potential method for mitigating hippocampal decline in humans. Numerous studies have now investigated associations between the structure and function of the hippocampus and engagement in physical activity. Still, there remains continued debate and confusion about the relationship between physical activity and the human hippocampus. In this review, we describe the current state of the physical activity and exercise literature as it pertains to the structure and function of the human hippocampus, focusing on four magnetic resonance imaging measures: volume, diffusion tensor imaging, resting-state functional connectivity, and perfusion. We conclude that, despite significant heterogeneity in study methods, populations of interest, and scope, there are consistent positive findings, suggesting a promising role for physical activity in promoting hippocampal structure and function throughout the lifespan.
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