Letter
Medicine, General & Internal
Peter W. W. Marks, Robert M. M. Califf, Paul A. A. Offit
Summary: The author of this letter criticizes Offit's viewpoint and presents evidence that shows the bivalent boosters have better immunogenicity against emerging variants. Therefore, the author suggests that the bivalent boosters should be deployed throughout the entire population, including against SARS-CoV-2 omicron subvariants BA.4 and BA.5 as well as the ancestral strain.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Immunology
Hironori Nakagami
Summary: An outbreak of COVID-19 caused by SARS-CoV-2 is currently ongoing, with vaccine candidates using different technologies classified into four groups. RNA vaccines and adenovirus vector vaccines have been urgently approved and administered worldwide, while safety and efficacy evaluations should be continuously monitored over a long time period.
INTERNATIONAL IMMUNOLOGY
(2021)
Editorial Material
Medicine, General & Internal
Lawrence O. Gostin, Daniel A. Salmon, Heidi J. Larson
Summary: This Viewpoint discusses the possibility of US states, businesses, health care facilities, and schools and universities mandating coronavirus vaccination as a requirement for employment or service.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Review
Biochemistry & Molecular Biology
Qinrui Huang, Jiawei Zeng, Jinghua Yan
Summary: The ongoing COVID-19 pandemic has accelerated the development of mRNA vaccines, with positive results reported and future challenges ahead.
JOURNAL OF GENETICS AND GENOMICS
(2021)
Review
Medicine, General & Internal
Dan H. Barouch
Summary: This article reviews the protective effects of vaccination and prior infection on severe Covid-19, and proposes future research directions.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Immunology
Masayuki Miyasaka
Summary: Understanding the mechanism of vaccine-induced protection and immune correlates is crucial for developing next-generation COVID-19 vaccines.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Javier Castrodeza-Sanz, Ivan Sanz-Munoz, Jose M. Eiros
Summary: In recent decades, improvements in traditional vaccines have led to the development of more processed vaccines with better tolerability profiles but lower immunogenicity. Adjuvants provide a good solution to enhance the immunogenicity of these vaccines with improved tolerability and fewer side effects. The approval of protein-based vaccines in 2022 and 2023 further expanded the options. Adjuvanted vaccines can induce potent immune responses in populations with weak or insufficient immune systems, such as the elderly, and could play a crucial role in completing global COVID-19 vaccination efforts in the present and future.
Editorial Material
Medicine, General & Internal
Eric J. Rubin, Lindsey R. Baden, Peter Marks, Stephen Morrissey
Summary: This article is an interview discussing the ongoing role of the FDA in authorizing new vaccines. Peter Marks, director of the FDA's Center for Biologics Evaluation and Research, joins the editors to provide insights on the agency's efforts in the COVID-19 vaccine authorization process.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Chemistry, Physical
Chiara Rinoldi, Seyed Shahrooz Zargarian, Pawel Nakielski, Xiaoran Li, Anna Liguori, Francesca Petronella, Dario Presutti, Qiusheng Wang, Marco Costantini, Luciano de Sio, Chiara Gualandi, Bin Ding, Filippo Pierini
Summary: This article reviews the latest developments in RNA therapy, focusing on the development, characteristics, and applications of nanotechnology-assisted RNA delivery drugs. It discusses the importance and challenges of RNA drugs in the field of treatment, as well as possible future directions for development.
Article
Cardiac & Cardiovascular Systems
Biykem Bozkurt, Ishan Kamat, Peter J. Hotez
Summary: Myocarditis is a rare complication of COVID-19 mRNA vaccines, predominantly affecting young adult and adolescent males, with most patients showing improvement in symptoms. Possible mechanisms include molecular mimicry between viral proteins and self-antigens, dysregulated immune pathways, immune response to mRNA, and dysregulated cytokine expression.
Article
Virology
Qutaiba A. Al Khames Aga, Waseem H. Alkhaffaf, Tagreed H. Hatem, Kawthar F. Nassir, Yazan Batineh, Abdullah T. Dahham, Dimah Shaban, Luma A. Al Khames Aga, Manhal Y. R. Agha, Muaamar Traqchi
Summary: This study investigated the adverse effects associated with three different COVID-19 vaccines and found that local reactions were more common with Pfizer and AstraZeneca vaccines, while systemic events were more prevalent with AstraZeneca and Pfizer vaccines. There was no correlation between age or gender and the duration of adverse effects, and some participants reported unusual symptoms like swelling of eyelids and severe allergic reactions. Overall, Pfizer, AstraZeneca, and Sinopharm vaccines were deemed safe, with Sinopharm showing lower prevalence of adverse effects compared to the others.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Business, Finance
Kam Fong Chan, Zhuo Chen, Yuanji Wen, Tong Xu
Summary: Global stock markets show positive reactions when human clinical trials on COVID-19 vaccines commence, especially for leading candidates and those entering phase III trials, as well as those developed by the U.S. and China.
FINANCE RESEARCH LETTERS
(2022)
Review
Immunology
Duduzile Ndwandwe, Charles S. Wiysonge
Summary: The COVID-19 pandemic has led to significant advancements in vaccine development, with billions of doses administered worldwide by mid-2021. However, it is crucial to ensure equal access and optimal uptake of vaccines in all countries in order to bring an end to the pandemic.
CURRENT OPINION IN IMMUNOLOGY
(2021)
Editorial Material
Critical Care Medicine
Tina V. Hartert, Marianna Sockrider
Summary: COVID-19 is a severe disease with a range of symptoms. Three vaccines have been developed and authorized in the US to prevent the spread of the virus, but public health measures like social distancing and wearing face coverings are still necessary to stop the spread.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Editorial Material
Medicine, General & Internal
Eric J. Rubin, Lindsey R. Baden, Kathleen M. Neuzil, Stephen Morrissey
Summary: The interview discussed the future development of vaccines against Covid-19 and other infectious diseases.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
