The function and pathogenic mechanism of filamin A

Filamin A(FLNa) is an actin-binding protein, which participates in the formation of the cytoskeleton, anchors a variety of proteins in the cytoskeleton and regulates cell adhesion and migration. It is involved in signal transduction, cell proliferation and differentiation, pseudopodia formation, vesicle transport, tumor resistance and genetic diseases by binding with interacting proteins. In order to fully elucidate the structure, function and pathogenesis of FLNa, we summarized all substances which directly or indirectly act on FLNa so far, upstream and downstream targets which having effect on it, signaling pathways and their functions. It also recorded the expression and effect of FLNa in different diseases, including hereditary disease and tumors.

Automated summary

Filamin A (FLNa) is an actin-binding protein involved in the formation of the cytoskeleton and regulation of cell adhesion and migration. It plays a crucial role in signal transduction, cell proliferation and differentiation, and is associated with various diseases such as tumors and genetic disorders. Studying the structure, function, and pathogenesis of FLNa is essential for understanding its role in disease pathophysiology.