Mitochondrial DNA copy number and trimethylamine levels in the blood: New insights on cardiovascular disease biomarkers

Association of mitochondrial DNA copy number with metabolic syndrome and type 2 diabetes in 14,176 individuals

(2021) Federica Fazzini et al.   JOURNAL OF INTERNAL MEDICINE

Mitochondrial DNA Content Is Linked to Cardiovascular Disease Patient Phenotypes

(2021) Ruipeng Wei et al.   Journal of the American Heart Association

Blood contains circulating cell‐free respiratory competent mitochondria

(2020) Zahra Al Amir Dache et al.   FASEB JOURNAL

A Pilot Study on the Effects of l-Carnitine and Trimethylamine-N-Oxide on Platelet Mitochondrial DNA Methylation and CVD Biomarkers in Aged Women

(2020) Laura Bordoni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondrial DNA copy number is associated with all‐cause mortality and cardiovascular events in patients with peripheral arterial disease

(2020) A. Koller et al.   JOURNAL OF INTERNAL MEDICINE

Thinking outside the nucleus: Mitochondrial DNA copy number in health and disease

(2020) Christina A. Castellani et al.   MITOCHONDRION

Diet induced the change of mtDNA copy number and metabolism in Angus cattle

(2020) Ying Bai et al.   Journal of Animal Science and Biotechnology

Machine learning models predicting multidrug resistant urinary tract infections using “DsaaS”

(2020) Alessio Mancini et al.   BMC BIOINFORMATICS

Mitochondrial DNA and Neurodegeneration: Any Role for Dietary Antioxidants?

(2020) Laura Bordoni et al.   Antioxidants

Measurement of oxidized albumin: An opportunity for diagnoses or treatment of COVID-19

(2020) Nasim Rahmani-Kukia et al.   BIOORGANIC CHEMISTRY

Vascular reactivity stimulated by TMA and TMAO: Are perivascular adipose tissue and endothelium involved?

(2020) Carolina Baraldi A. Restini et al.   PHARMACOLOGICAL RESEARCH

Effect of Systolic and Diastolic Blood Pressure on Cardiovascular Outcomes

(2019) Alexander C. Flint et al.   NEW ENGLAND JOURNAL OF MEDICINE

TMA (trimethylamine), but not its oxide TMAO (trimethylamine-oxide), exerts hemodynamic effects - implications for interpretation of cardiovascular actions of gut microbiome.

(2019) Kinga Jaworska et al.   CARDIOVASCULAR RESEARCH

Increased Trimethylamine N-Oxide Is Not Associated with Oxidative Stress Markers in Healthy Aged Women

(2019) Robert Antoni Olek et al.   Oxidative Medicine and Cellular Longevity

TMA, A Forgotten Uremic Toxin, but Not TMAO, Is Involved in Cardiovascular Pathology

(2019) Kinga Jaworska et al.   Toxins

High Blood Pressure and Cardiovascular Disease

(2019) Flávio D. Fuchs et al.   HYPERTENSION

Gut Microbiota–Dependent TrimethylamineN-Oxide Predicts Risk of Cardiovascular Events in Patients With Stroke and Is Related to Proinflammatory Monocytes

(2018) Arash Haghikia et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Detoxification of Trimethylamine N-Oxide by the Mitochondrial Amidoxime Reducing Component mARC

(2018) Jennifer Schneider et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Longitudinal associations of lifetime adiposity with leukocyte telomere length and mitochondrial DNA copy number

(2018) Dong Hang et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Association of Body Mass Index With Lifetime Risk of Cardiovascular Disease and Compression of Morbidity

(2018) Sadiya S. Khan et al.   JAMA Cardiology

Plasmid-normalized quantification of relative mitochondrial DNA copy number

(2018) Federica Fazzini et al.   Scientific Reports

L-Carnitine Supplementation Increases Trimethylamine-N-Oxide but not Markers of Atherosclerosis in Healthy Aged Women

(2018) Joanna J. Samulak et al.   ANNALS OF NUTRITION AND METABOLISM

Association between mitochondrial DNA copy number and cardiovascular disease: Current evidence based on a systematic review and meta-analysis

(2018) Peng Yue et al.   PLoS One

Cardiac biomarkers of acute coronary syndrome: from history to high-sensitivity cardiac troponin

(2017) Pankaj Garg et al.   Internal and Emergency Medicine

Associations Between Cellular Aging Markers and Metabolic Syndrome: Findings From the CARDIA Study

(2017) Dóra Révész et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Is there a link between mitochondrial DNA and blood pressure?

(2017) P R Prestes et al.   JOURNAL OF HUMAN HYPERTENSION

Mitochondrial DNA copy number in peripheral blood cell and hypertension risk among mining workers: a case–control study in Chinese coal miners

(2017) L Lei et al.   JOURNAL OF HUMAN HYPERTENSION

Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015

(2017) Gregory A. Roth et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Trimethylamine N-oxide impairs pyruvate and fatty acid oxidation in cardiac mitochondria

(2017) Marina Makrecka-Kuka et al.   TOXICOLOGY LETTERS

Fructose-Rich Diet Affects Mitochondrial DNA Damage and Repair in Rats

(2017) Federica Cioffi et al.   Nutrients

Trimethylamine‐N‐Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3‐SOD2‐mtROS Signaling Pathway

(2017) Ming‐liang Chen et al.   Journal of the American Heart Association

Association of Mitochondrial DNA Copy Number With Cardiovascular Disease

(2017) Foram N. Ashar et al.   JAMA Cardiology

L-Carnitine intake and high trimethylamine N-oxide plasma levels correlate with low aortic lesions in ApoE−/− transgenic mice expressing CETP

(2016) Heidi L. Collins et al.   ATHEROSCLEROSIS

Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk

(2016) Weifei Zhu et al.   CELL

Troponin in Cardiovascular Disease Prevention: Updates and Future Direction

(2016) Jason Hoff et al.   Current Atherosclerosis Reports

Targeting Mitochondria in Cardiovascular Diseases

(2016) Filomena Silva et al.   CURRENT PHARMACEUTICAL DESIGN

Urinary Mitochondrial DNA Copy Number Identifies Chronic Renal Injury in Hypertensive PatientsNovelty and Significance

(2016) Alfonso Eirin et al.   HYPERTENSION

Association between Mitochondrial DNA Copy Number in Peripheral Blood and Incident CKD in the Atherosclerosis Risk in Communities Study

(2016) A. Tin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Trimethylamine N-Oxide: The Good, the Bad and the Unknown

(2016) Manuel Velasquez et al.   Toxins

Intestinal Microbiota‐Generated Metabolite Trimethylamine‐N‐Oxide and 5‐Year Mortality Risk in Stable Coronary Artery Disease: The Contributory Role of Intestinal Microbiota in a COURAGE‐Like Patient Cohort

(2016) Vichai Senthong et al.   Journal of the American Heart Association

Trimethylamine N‐Oxide Promotes Vascular Inflammation Through Signaling of Mitogen‐Activated Protein Kinase and Nuclear Factor‐κB

(2016) Marcus M. Seldin et al.   Journal of the American Heart Association

Mitochondrial degradation and energy metabolism

(2015) Su Melser et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Urinary mitochondrial DNA is a biomarker of mitochondrial disruption and renal dysfunction in acute kidney injury

(2015) Ryan M. Whitaker et al.   KIDNEY INTERNATIONAL

Smoking and Cardiovascular Disease

(2014) Barbara Messner et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mitochondrial DNA copy number in peripheral blood cells declines with age and is associated with general health among elderly

(2014) Jonas Mengel-From et al.   HUMAN GENETICS

Role of mitochondrial oxidative stress in hypertension

(2013) Sergey I. Dikalov et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mitochondrial DNA Damage Can Promote Atherosclerosis Independently of Reactive Oxygen Species Through Effects on Smooth Muscle Cells and Monocytes and Correlates With Higher-Risk Plaques in Humans

(2013) Emma Yu et al.   CIRCULATION

Mitochondrial DNA Copy Number and Oxidative DNA Damage in Placental Tissues from Gestational Diabetes and Control Pregnancies: A Pilot Study

(2013) Chunfang Qiu et al.   Clinical Laboratory

Linking the Metabolic State and Mitochondrial DNA in Chronic Disease, Health, and Aging

(2013) M. Picard et al.   DIABETES

Low Fructose and Low Salt Diets Increase Mitochondrial DNA in White Blood Cells of Overweight Subjects

(2013) R. Hernández-Ríos et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Mitochondrial dynamics: regulatory mechanisms and emerging role in renal pathophysiology

(2013) Ming Zhan et al.   KIDNEY INTERNATIONAL

Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

(2013) Robert A Koeth et al.   NATURE MEDICINE

Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk

(2013) W.H. Wilson Tang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhalable particulate matter and mitochondrial DNA copy number in highly exposed individuals in Beijing, China: a repeated-measure study

(2013) Lifang Hou et al.   Particle and Fibre Toxicology

Does mtDNA copy number mean mitochondrial abundance?

(2012) Tuncer Cayci et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Is mitochondrial DNA content a potential biomarker of mitochondrial dysfunction?

(2012) Afshan N. Malik et al.   MITOCHONDRION

Oxidative stress, anti-oxidant therapies and chronic kidney disease

(2012) DAVID M SMALL et al.   NEPHROLOGY

Decreased peripheral blood mitochondrial DNA content is related to HbA1c, fasting plasma glucose level and age of onset in Type 2 diabetes mellitus

(2011) F. X. Xu et al.   DIABETIC MEDICINE

Increased Mitochondrial DNA Copy Number in Occupations Associated with Low-Dose Benzene Exposure

(2011) Michele Carugno et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Depleted Leukocyte Mitochondrial DNA Copy Number in Metabolic Syndrome

(2011) Ching-Hui Huang et al.   Journal of Atherosclerosis and Thrombosis

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

Inflammatory molecules and pathways in the pathogenesis of diabetic nephropathy

(2011) Juan F. Navarro-González et al.   Nature Reviews Nephrology

DNA Damage Links Mitochondrial Dysfunction to Atherosclerosis and the Metabolic Syndrome

(2010) John R. Mercer et al.   CIRCULATION RESEARCH

Airborne particulate matter and mitochondrial damage: a cross-sectional study

(2010) Lifang Hou et al.   Environmental Health

Mitochondrial DNA content in peripheral blood monocytes: relationship with age of diabetes onsetand diabetic complications

(2009) J. Wong et al.   DIABETOLOGIA

Number matters: control of mammalian mitochondrial DNA copy number

(2009) Laura L. Clay Montier et al.   Journal of Genetics and Genomics

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols

Low copy number and low oxidative damage of mitochondrial DNA are associated with tumor progression in lung cancer tissues after neoadjuvant chemotherapy

(2008) C.-S. Lin et al.   Interactive Cardiovascular and Thoracic Surgery