Plasma ACE2 species are differentially altered in COVID‐19 patients

Experimental data using candesartan and captopril indicate no double-edged sword effect in COVID-19

(2021) Maria A Pedrosa et al.   CLINICAL SCIENCE

Plasma ACE2 activity is persistently elevated following SARS-CoV-2 infection: implications for COVID-19 pathogenesis and consequences

(2021) Sheila K. Patel et al.   EUROPEAN RESPIRATORY JOURNAL

COVID-19 vaccine candidates based on modified vaccinia virus Ankara expressing the SARS-CoV-2 spike induce robust T- and B-cell immune responses and full efficacy in mice

(2021) Juan García-Arriaza et al.   JOURNAL OF VIROLOGY

A novel ACE2 isoform is expressed in human respiratory epithelia and is upregulated in response to interferons and RNA respiratory virus infection

(2021) Cornelia Blume et al.   NATURE GENETICS

Angiotensin-Converting Enzyme 2 (ACE2) Elevation in Severe COVID-19

(2021) Roman Reindl-Schwaighofer et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Renin-angiotensin-aldosterone system peptide profiles in patients with COVID-19

(2021) Alexander Kutz et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2

(2020) Renhong Yan et al.   SCIENCE

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Circulating plasma concentrations of angiotensin-converting enzyme 2 in men and women with heart failure and effects of renin–angiotensin–aldosterone inhibitors

(2020) Iziah E Sama et al.   EUROPEAN HEART JOURNAL

Sex-Specific SARS-CoV-2 Mortality: Among Hormone-Modulated ACE2 Expression, Risk of Venous Thromboembolism and Hypovitaminosis D

(2020) Sandro La Vignera et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structural basis of receptor recognition by SARS-CoV-2

(2020) Jian Shang et al.   NATURE

Controversies of renin–angiotensin system inhibition during the COVID-19 pandemic

(2020) Andrew M. South et al.   Nature Reviews Nephrology

Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues

(2020) Meng-Yuan Li et al.   Infectious Diseases of Poverty

Sex difference and smoking predisposition in patients with COVID-19

(2020) Hua Cai   Lancet Respiratory Medicine

Bioinformatics studies on a function of the SARS-CoV-2 spike glycoprotein as the binding of host sialic acid glycans

(2020) B. Robson   COMPUTERS IN BIOLOGY AND MEDICINE

The protein expression profile of ACE2 in human tissues

(2020) Feria Hikmet et al.   Molecular Systems Biology

A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm

(2020) Michael R Garvin et al.   eLife

COVID-19, Renin-Angiotensin System and Endothelial Dysfunction

(2020) Razie Amraei et al.   Cells

Serum ACE-2, angiotensin II, and aldosterone levels are unchanged in patients with COVID-19

(2020) Marina Rieder et al.   AMERICAN JOURNAL OF HYPERTENSION

Angiotensin-converting enzyme 2 (ACE2) levels in relation to risk factors for COVID-19 in two large cohorts of patients with atrial fibrillation

(2020) Lars Wallentin et al.   EUROPEAN HEART JOURNAL

Plasma ACE2 and risk of death or cardiometabolic diseases: a case-cohort analysis

(2020) Sukrit Narula et al.   LANCET

Sex differences in circulating proteins in heart failure with preserved ejection fraction

(2020) Susan Stienen et al.   Biology of Sex Differences

Identifying Pathways and Networks Associated With the SARS-CoV-2 Cell Receptor ACE2 Based on Gene Expression Profiles in Normal and SARS-CoV-2-Infected Human Tissues

(2020) Qiushi Feng et al.   Frontiers in Molecular Biosciences

Influenza A Virus Cell Entry, Replication, Virion Assembly and Movement

(2018) Dan Dou et al.   Frontiers in Immunology

Sex differences in the aging pattern of renin–angiotensin system serum peptidases

(2017) A. Fernández-Atucha et al.   Biology of Sex Differences

Pulmonary Angiotensin-Converting Enzyme 2 (ACE2) and Inflammatory Lung Disease

(2016) Hongpeng Jia   SHOCK

Angiotensin-converting enzyme 2 inhibits lung injury induced by respiratory syncytial virus

(2016) Hongjing Gu et al.   Scientific Reports

Transmembrane Amyloid-Related Proteins in CSF as Potential Biomarkers for Alzheimer’s Disease

(2015) Inmaculada Lopez-Font et al.   Frontiers in Neurology

Characterization of Angiotensin-Converting Enzyme 2 Ectodomain Shedding from Mouse Proximal Tubular Cells

(2014) Fengxia Xiao et al.   PLoS One

Downregulation of angiotensin-converting enzyme 2 by the neuraminidase protein of influenza A (H1N1) virus

(2014) Xin Liu et al.   VIRUS RESEARCH

Angiotensin-converting enzyme 2 protects from lethal avian influenza A H5N1 infections

(2014) Zhen Zou et al.   Nature Communications

Angiotensin-converting enzyme 2 (ACE2) mediates influenza H7N9 virus-induced acute lung injury

(2014) Penghui Yang et al.   Scientific Reports

TMPRSS2 and ADAM17 Cleave ACE2 Differentially and Only Proteolysis by TMPRSS2 Augments Entry Driven by the Severe Acute Respiratory Syndrome Coronavirus Spike Protein

(2013) A. Heurich et al.   JOURNAL OF VIROLOGY

Rosiglitazone Treatment of Type 2 Diabetic db/db Mice Attenuates Urinary Albumin and Angiotensin Converting Enzyme 2 Excretion

(2013) Harshita Chodavarapu et al.   PLoS One

Angiotensin Converting Enzyme (ACE) and ACE2 Bind Integrins and ACE2 Regulates Integrin Signalling

(2012) Nicola E. Clarke et al.   PLoS One

Increased Urinary Angiotensin-Converting Enzyme 2 in Renal Transplant Patients with Diabetes

(2012) Fengxia Xiao et al.   PLoS One

A Transmembrane Serine Protease Is Linked to the Severe Acute Respiratory Syndrome Coronavirus Receptor and Activates Virus Entry

(2010) A. Shulla et al.   JOURNAL OF VIROLOGY

Trilogy of ACE2: A peptidase in the renin–angiotensin system, a SARS receptor, and a partner for amino acid transporters

(2010) Keiji Kuba et al.   PHARMACOLOGY & THERAPEUTICS

Sex differences in renal angiotensin converting enzyme 2 (ACE2) activity are 17β-oestradiol-dependent and sex chromosome-independent

(2010) Jun Liu et al.   Biology of Sex Differences

Ectodomain shedding of angiotensin converting enzyme 2 in human airway epithelia

(2009) Hong Peng Jia et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

TACE antagonists blocking ACE2 shedding caused by the spike protein of SARS-CoV are candidate antiviral compounds

(2009) Shiori Haga et al.   ANTIVIRAL RESEARCH

SARS-coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARS

(2009) G. Y. Oudit et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Differential Downregulation of ACE2 by the Spike Proteins of Severe Acute Respiratory Syndrome Coronavirus and Human Coronavirus NL63

(2009) I. Glowacka et al.   JOURNAL OF VIROLOGY

2009 H1N1 Influenza

(2009) Seth J. Sullivan et al.   MAYO CLINIC PROCEEDINGS

Angiotensin-converting enzyme 2 catalytic activity in human plasma is masked by an endogenous inhibitor

(2008) Rebecca A. Lew et al.   EXPERIMENTAL PHYSIOLOGY

Endocytosis of the receptor-binding domain of SARS-CoV spike protein together with virus receptor ACE2

(2008) Shunxin Wang et al.   VIRUS RESEARCH