Journal
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
Volume 17, Issue 11, Pages 1221-1229Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/1744666X.2021.1982384
Keywords
Crohn's disease; Inflammatory bowel disease; Meta-analysis; Methylenetetrahydrofolate reductase; Polymorphism; Ulcerative colitis
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Funding
- National Natural Science Foundation of China [81901379]
- Major Projects of the Education Department of Sichuan Province [18ZA0158]
- Chendu Medical College [CYZ17-17, CYTD17-05]
- First Affiliated Hospital of Chengdu Medical College [CYFYGQ-001]
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The association between MTHFR polymorphisms and susceptibility to IBD and ulcerative colitis has been studied in this meta-analysis, with a significant association found for the MTHFR 1298 A > C polymorphism.
Objective The association between genetic variants in methylenetetrahydrofolate reductase (MTHFR) and risk for inflammatory bowel disease (IBD) has been widely studied. However, the results are equivocal. In this meta-analysis, we aimed to determine the association between MTHFR polymorphisms and susceptibility to IBD. Methods We retrieved studies from the PubMed, Web of Science, Ovid, and China National Knowledge Infrastructure databases. Data were analyzed using STATA software; odds ratios (OR) and confidence intervals (CI) were calculated using fixed or random effects models. Results A marginally significant association of the MTHFR 677 C > T polymorphism and patients' IBD risk was observed in the overall analysis (OR = 1.11, 95% CI, 1.01-1.23), but not in the analysis of high-quality studies. However, for the MTHFR 1298 A > C polymorphism, a significant association was found between the MTHFR 1298 AC/CC genotypes and IBD risk in the overall analysis (OR = 1.26, 95% CI, 1.10-1.44), in the high-quality studies (OR = 1.20, 95% CI, 1.02-1.41), and in patients with ulcerative colitis (OR = 1.28, 95% CI, 1.10-1.48). Conclusions Evidence from this meta-analysis indicates that the MTHFR 1298 A > C polymorphism may be responsible for susceptibility to IBD and ulcerative colitis.
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