Article
Medicine, General & Internal
Yumei Cao, Su'an Tang, Xiaoyu Nie, Zuoqing Zhou, Guangfeng Ruan, Weiyu Han, Zhaohua Zhu, Changhai Ding
Summary: The study identified miR-214-3p as a key regulator in osteoarthritis, impacting ECM metabolism and cell apoptosis in cartilage by modulating the NF-kappa B signaling pathway. Targeting IKKP, decreased miR-214-3p exacerbates OA development, suggesting it as a potential novel therapeutic target for OA.
Article
Biochemistry & Molecular Biology
Karolina Golabek, Dorota Hudy, Agata Swietek, Jadwiga Gazdzicka, Natalia Dabrowska, Katarzyna Miskiewicz-Orczyk, Natalia Zieba, Maciej Misiolek, Joanna Katarzyna Strzelczyk
Summary: This study analyzed the expression of E2F2 gene and protein, as well as the miRNAs candidate targets (miR-125b-5p, miR-155-3p, and miR-214-5p) in oral squamous cell carcinoma (OSCC) tumor and margin samples. The results showed that E2F2 gene is not the target for analyzed miRNAs in OSCC, while miR-155-3p and miR-125b-5p may play roles in the pathogenesis of OSCC. Additionally, miRNAs expression in response to tobacco smoke and HPV status showed differences.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Orthopedics
Zhen Guo, Jing Li, Jiyong Tan, Sainan Sun, Qing Yan, Hao Qin
Summary: Osteoporosis is a common bone disease that increases the risk of fracture. Through experiments, it has been found that exosomes secreted by senescent osteoblasts can accelerate endothelial cell senescence through the miR-214-3p/L1CAM pathway. This study reveals the role of exosomes in the skeletal microenvironment.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Obstetrics & Gynecology
Yanqin Zhang, Xiangyu Chang, Di Wu, Mengqi Deng, Jinwei Miao, Zhaoyu Jin
Summary: Exosomal miR-214-3p can inhibit fibrosis in endometriosis by targeting CCN2, providing a potential therapeutic approach for EMs.
REPRODUCTIVE SCIENCES
(2021)
Article
Cell Biology
Jin Zhao, Fei Wang, Qingjun Tian, Jing Dong, Liuqing Chen, Rongyi Hu
Summary: The miR-214-3p/FOXM1 axis in keratinocytes presents a potential novel therapeutic target for the treatment of psoriasis, as it can alleviate hyperproliferation and apoptosis in the skin by negatively regulating FOXM1 expression.
Article
Biochemistry & Molecular Biology
Fang Liu, Lu-jing Jiang, Yue-xin Zhang, Si-ting Xu, Si-ling Liu, Jian-tao Ye, Pei-qing Liu
Summary: Myocardial infarction (MI) increases the risk of heart failure and sudden death, but effective treatments are still lacking in clinical practice. Abnormal expression of microRNAs (miRNAs) has been found to play a crucial role in cardiovascular diseases. This study investigated the involvement of miRNA-214-3p in MI. The results showed that miR-214-3p was significantly upregulated in the infarcted region in mouse hearts and in hypoxia-exposed rat cardiomyocytes, which was accompanied by increased ferroptosis. Inhibition of miR-214-3p improved cardiac function, reduced infarct size, and attenuated iron accumulation and oxidant stress. MiR-214-3p could promote ferroptosis and cellular impairments, while its inhibition protected cells from hypoxic injury. Furthermore, malic enzyme 2 (ME2) was identified as a direct target of miR-214-3p. Overexpression of ME2 ameliorated the detrimental effects induced by miR-214-3p mimic, while its depletion compromised the protective role of miR-214-3p inhibitor. These findings suggest that miR-214-3p contributes to enhanced ferroptosis during MI by suppressing ME2. Inhibition of miR-214-3p may represent a novel approach for treating MI.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Catherine Jane Messner, Saskia Schmidt, Dilek Ozkul, Carine Gaiser, Luigi Terracciano, Stephan Krahenbuhl, Laura Suter-Dick
Summary: Liver fibrosis is characterized by the accumulation of extracellular matrix, and miRNAs can serve as biomarkers for identifying this condition. In this study, miR-199a-5p, miR-214-3p, miRNA-125a-5p, and miR-99b-5p are identified as potential biomarkers associated with a fibrotic phenotype, with miR-199a-5p also being implicated in HSC activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dermatology
Jun Ma, Lei Huang, Yan-Bin Gao, Min-Xiong Li, Liang-Long Chen, Lei Yang
Summary: The circ_TNFRSF21/miR-214-3p/CHI3L1 axis plays a significant role in the progression of cSCC by enhancing cell proliferation, migration, invasion, and M2 macrophage polarization through inhibiting miR-214-3p and subsequent disinhibition of CHI3L1.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2023)
Article
Chemistry, Medicinal
Guan-Nan He, Na-Ren Bao, Shuang Wang, Man Xi, Tian-Hao Zhang, Feng-Shou Chen
Summary: Ketamine was found to suppress liver cancer cell proliferation and induce ferroptosis, potentially through regulating the lncPVT1/miR-214-3p/GPX4 axis.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Engineering, Biomedical
Wenwu Zhu, Qingjie Wang, Jian Zhang, Ling Sun, Xiu Hong, Wei Du, Rui Duan, Jianguang Jiang, Yuan Ji, Haoran Wang, Bing Han
Summary: This study investigated whether exosomes derived from miR-214 overexpressing MSCs have stronger cardioprotective ability in a rat model of AMI and its potential mechanisms. The results showed that miR-214 overexpressing exosomes enhanced endothelial cell migration and tube-like formation, reduced cardiomyocyte apoptosis, and improved survival and cardiac function in AMI rats.
BIOMATERIALS RESEARCH
(2023)
Article
Cell Biology
Bingyan Liu, Yongjun Gong, Qiyi Jiang, Shaoqiu Wu, Bo Han, Feier Chen, Quanjun Lin, Ping Wang, Dengke Yang
Summary: This study found abnormal expression of circular RNAs in pancreatic cancer tissues, and identified the role of hsa_circ_0014784 in the progression of pancreatic cancer. Bioinformatics analysis and experimental validation revealed that hsa_circ_0014784 interacts with miR-214-3p and YAP1, regulating the proliferation, invasion, and angiogenesis of pancreatic cancer.
Article
Immunology
Na Wang, Pu Li, Junqi Liu, Zhenlin Wang
Summary: Allergic rhinitis is characterized by inflammation and impairment of epithelial barrier integrity. In this study, miR-29a-3p was found to be upregulated in allergic rhinitis patients and expressed in nasal mucosa epithelial and glandular cells. The target genes of miR-29a-3p, VCL and CTNNB1, were validated and found to be associated with nasal epithelial barrier function. In mouse models, inhibition of miR-29a-3p partially alleviated the symptoms of allergic rhinitis. These findings suggest that miR-29a-3p may serve as a potential therapeutic target for allergic rhinitis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medical Laboratory Technology
Yi Liu, Shanshan Ma, Qichao Ma, Haigang Zhu
Summary: This study found that silencing LINC00665 can inhibit the progression of cutaneous melanoma (CM) and induce apoptosis through the miR-339-3p/TUBB axis.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Microbiology
Ying Qin, Lexun Lin, Shulong Yang, Zongmao Dai, Congcong Zhang, Jingjing Huang, Fengzhen Deng, Xinxin Yue, Long Ren, Yanru Fei, Wenran Zhao, Yan Wang, Zhaohua Zhong
Summary: This study found that circ_0076631 indirectly regulated the replication of CVB3 by interacting with miR-214-3p, and proposed circ_0076631 as a potential target for anti-CVB therapy.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Cell Biology
Jia-Sheng Yan, Qi Chen, Ya-Lin Li, Yun-Qiu Gao
Summary: In malignant renal cell carcinoma, hsa_circ_0065217 is abundantly expressed and plays a role in promoting tumor growth by activating ALPK2 and modulating miR-214-3p activity. Silencing hsa_circ_0065217 can reduce cancer aggressiveness, suggesting a potential therapeutic target in RCC treatment.